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Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

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… † | 23/90 (25.6%) USA, n/N (%) | 15/90 (16.7%) France, n/N (%) | 8/90 (8.9%) Switzerland, n/N (%) | 7/90 (7.8%) Austria, n/N (%) | 6/90 (6.7%) Netherlands, n/N (%) | 4/90 (4.4%) Italy, n/N (%) | 4/90 (4.4%) Finland, n/N (%) | 4/90 (4.4%) Poland, n/N (%) | 4/90 (4.4%) Belgium, n/N (%) | 3/90 (3.3%) Croatia …

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes.

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from U

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… Valerianova (National CR) ; Croatia: M. Sekerija (National CR) ; Cyprus: V. Scoutellas; A. Demetriou (National CR) ; Czech Republic: L. Dušek; D. Krejici (National CR) ; Denmark: H. Storm (National CR) ; Estonia: M. Mägi; K. Innos* (National CR) ; Finland: N. Malila; J. …

The European Gaucher Alliance: a survey of member patient organisations' activities, healthcare environments and concerns.

BackgroundThe European Gaucher Alliance (EGA) was established in 1994 and constituted in 2008 as an umbrella group supporting patient organisations for Gaucher disease. Every two years, the EGA conducts a questionnaire survey of member associations to help develop its priorities and annual work programme. Results of the latest survey are presented.MethodsBetween June 2012 and April 2013, the 36 members and associate members of the EGA were asked to complete a questionnaire detailing membership numbers, disease specific treatments used by patients, means of access to treatment, availability of

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… Three patient associations (from Croatia, Paraguay and Moldova), which joined the EGA between June and September 2013, are not included in the survey. …

Estimation of Future Patient Populations Eligible for Radioligand Therapies in the EU and the UK: A Modelling Study.

BackgroundThe eligible patient population for radioligand therapies (RLTs) has the potential to grow rapidly in the coming years. European healthcare systems may be ill-prepared to provide the additional treatment capacity required on top of current workload. To address this challenge, data on the size of the eligible patient pool and the potential utilisation of RLTs are needed.MethodsThe maximum pool of patients theoretically eligible for RLTs over the next decade was estimated for the 27 EU member states (EU-27) using incidence data, and additionally for France, Germany, Italy, Spain (EU-4)

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… 2022 (ECIS) | Time from EMA approval – reimbursement (in days) c | Eligible patient pool 2025 | 2030 | 2035 Austria | Yes | 8,978,929 | 250 | 200–300 | 1100–1900 | 2300–3400 Belgium | Yes | 11,617,623 | 600 | 300–400 | 1800–3100 | 3900–5700 Bulgaria | No | 6,838,937 | 780 | 200 | 600–1000 | 1200–1700 Croatia …

Оценка свойств сообщаемых пациентами итоговых показателей сексуального здоровья населения в целом: систематический обзор в соответствии с руководящими принципами КОСМИН 2.0.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Сексуальное здоровье играет решающую роль в общем здоровье и качестве жизни взрослых. В настоящее время в мире существуют различные меры по оценке состояния сексуального здоровья с различных аспектов, о которых сообщают пациенты. Однако качество этих инструментов измерения не было оценено в достаточной степени. АИМ: Проведение систематического обзора существующих ПМР, используемых для оценки сексуального здоровья населения в целом, оценка их методологического качества и измерительных свойств и представление соответствующих рекомендаций. МЕТОДЫ: Систематический обзор пров

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… Norwegian adults 35.8 ±(13.3) Rebecca et al. 2018 [ 47 ] SaRDS Male/Female Australia Intimate partner >18 Pascoal et al. 2016 [ 48 ] SPS Male/Female America/Portugal Adults >18 Stephanie et al. 2013 [ 49 ] QSE Male/Female America American adults 18–60 Aleksandar et al. 2010 [ 50 ] NSSS Male/Female Croatia …

Mass spectrometry-based proteomics and metabolomics in multiple myeloma: a systematic review of prognostic biomarkers and minimal residual disease monitoring.

INTRODUCTION: Current multiple myeloma (MM) risk stratification, anchored on the Revised International Staging System (R-ISS), provides a static snapshot of disease but fails to capture its dynamic biological evolution, functional tumor-microenvironment crosstalk, and real-time treatment response. Mass spectrometry (MS)-based proteomic and metabolomic profiling has emerged as a high-sensitivity tool for both novel biomarker discovery and minimal residual disease (MRD) monitoring. This systematic review evaluates the independent prognostic value and clinical utility of quantitative MS-based pro

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… Edited by: Hadi Goubran Messiha , University of Saskatchewan, Canada Reviewed by: Ivan Šoša , University of Rijeka, Croatia Yunhui Xiang , Sichuan International Travel and Healthcare Center (Chengdu Customs District Port Clinic), China Data availability statement The original contributions presented …

An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms.

Propolis is a natural compound collected by honeybees from different parts of plants. Honeybees produce a sticky component besides honey by mixing the tree resin and other botanical sources with saliva called propolis or bee glue. Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. According to a recent research, natural products are becoming increasingly essential in cancer prevent

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… The anticancer potential of water-soluble derivatives of propolis (WSDP) from Brazil and Croatia was reported on MCF-7 (breast cancer), HeLa (cervical cancer), and V19 (lung fibroblast hamster) cells. …

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… journal.pone.0078999 24260143 PMC3832519 Appendix The 87 countries with level 1 or 2 quality and life expectancy for males in 1990 >60 years: Albania, Argentina, Armenia, Australia, Austria, Azerbaijan, Bahamas, Barbados, Belarus, Belgium, Belize, Brazil, Brunei, Bulgaria, Canada, Columbia, Costa Rica, Croatia …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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… Università degli studi di Genova, Genoa, Italy; 5 Department of Pediatric Rheumatology, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Türkiye; 6 ASST Papa Giovanni XXIII, Bergamo; 7 IRCCS Meyer Children’s Hospital, florence, Italy; 8 Children’s Hospital Zagreb, Zagreb, Croatia … Child Health, Kolkata, India; 15 Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 16 Department of Pediatrics, Department of pulmology, allergology, clinical immunology and rheumatology, Children’s Hospital Zagreb, Zagreb, Croatia …

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

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… 76·8) | 79·1 (78·4–79·7) | 70·5 (70·4–70·7) | 74·3 (73·6–75·0) | 65·6 (62·5–68·3) | 67·7 (64·5–70·5) | 61·1 (58·5–63·4) | 63·7 (60·7–66·4) Bulgaria | 75·5 (75·4–75·7) | 78·6 (77·9–79·2) | 68·2 (68·1–68·3) | 71·3 (70·6–72·1) | 65·2 (62·2–67·8) | 67·7 (64·7–70·5) | 59·4 (56·9–61·6) | 62·2 (59·5–64·5) Croatia … (16·3–16·6) | 17·4 (16·9–17·9) | 13·6 (13·6–13·7) | 15·1 (14·6–15·5) | 11·8 (10·6–12·9) | 12·4 (11·1–13·6) | 9·8 (8·8–10·7) | 10·6 (9·4–11·7) Bulgaria | 16·0 (15·9–16·1) | 18·0 (17·5–18·5) | 12·8 (12·7–12·8) | 14·2 (13·8–14·7) | 11·6 (10·4–12·6) | 13·0 (11·7–14·3) | 9·2 (8·3–10·1) | 10·2 (9·1–11·2) Croatia …

17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

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Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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Европейский статус карты CAR-T и будущие направления улучшения доступа к клеточной терапии CAR для гематологовых маньяков.

Несмотря на свои большие надежды, осуществление терапии CAR-T является индивидуализированным, технически сложным и дорогостоящим лечением, которое по-прежнему сопряжено с трудностями, что затрудняет доступ пациентов в различных странах и внутри стран. С тех пор 2018, six в Европе (т.е. Европейская экономическая зона; утвержден ЕС) 15 Гематологические признаки злоумышленничества. Чтобы лучше понять доступ пациентов к коммерческой терапии CAR-T, одобренной ЕС, мы провели оценку нынешнего положения дел в целом. 30 Страны, в которых одобрение ЕС действительно, плюс Соединенное Королевство, рассмат

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… Greece | 6.0 | 6 | 10.0 Sweden | 5.7 | 6 | 10.6 Finland b | 5.3 | 3 | 5.6 Germany | 5.3 | 45 | 84.6 France | 5.3 | 35 | 66.5 Denmark b | 5.0 | 3 | 6.0 Slovenia b | 4.7 | 1 | 2.1 The Netherlands | 4.4 | 8 | 18.2 Portugal | 3.8 | 4 | 10.4 Ireland b | 3.8 | 2 | 5.3 The United Kingdom | 3.3 | 23 | 69.1 Croatia …

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review.

During the COVID-19 pandemic, elderly patients with underlying condition, such as tumors, had poor prognoses after progressing to severe pneumonia and often had poor response to standard treatment. Mesenchymal stem cells (MSCs) may be a promising treatment for patients with severe pneumonia, but MSCs are rarely used for patients with carcinoma. Here, we reported a 67-year-old female patient with lung adenocarcinoma who underwent osimertinib and radiotherapy and suffered from radiation pneumonitis. Unfortunately, she contracted COVID-19 and that rapidly progressed to severe pneumonia. She respo

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… F | 10 | No | Hypertension | / | BM | 2×10 6 /kg VD | Remission | Discharged on day 10 Yilmaz 2020 ( 88 ) | Turkey | M | 51 | No | MOF cardiac arrest brain involvement | Avigan, Tocilizumab | UC | 3×10 6 /kg VD+IV×4d With anti-thromboembolic | Remission | Discharged on day 40 Primorac 2021 ( 90 ) | Croatia …

Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers.

Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer. This aberra

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… Rijeka, Croatia: InTech; 2012. pp. 275–296. 49. Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000;2(10):737–744. doi: 10.1038/35036374. 50. Nakada M, Kita D, Futami K, et al. …

Oral Presentations

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Thrombosis in Neuromuscular Medicine: Current Evidence, Unmet Needs, and Future Directions.

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is an important but under-recognised complication in neuromuscular diseases. In adults, emerging epidemiological data suggests increased VTE occurrence in conditions such as Amyotrophic Lateral Sclerosis, myotonic dystrophy, myasthenia gravis, inflammatory neuropathies, inflammatory myopathies, and POEMS syndrome. This heightened risk reflects not only disease-related immobility but also disorder-specific biological mechanisms, including inflammation, endothelial dysfunction and cardiomyopathy-related stasis.

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… IntechOpen; Rijeka, Croatia: 2018. Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease. 38. Arai H., Tanabe Y., Hachiya Y., Otsuka E., Kumada S., Furushima W., Kohyama J., Yamashita S., Takanashi J.-I., Kohno Y. …

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy.

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with l

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… InTechOpen; Rijeka, Croatia: 2013. pp. 3–35. 10. Surh Y.J. Cancer Chemoprevention with Dietary Phytochemicals. Nat. Rev. Cancer. 2003;3:768–780. doi: 10.1038/nrc1189. 11. Krzyzanowska J., Czubacka A., Oleszek W. Dietary Phytochemicals and Human Health. In: Giardi M.T., Rea G., Berra B., editors. …

Резюме ЭСП 2013.

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… Bulimbasic * * Dubrava University Hospital, Dept. of Pathology, Zagreb, Croatia Objective: Phyllodes tumors (PTs) are rare fibroepithelial tumors of the breast with wide biological potential, classified as benign, borderline or malignant. …

Potential Associations between Vascular Biology and Hodgkin's Lymphoma: An Overview.

Hodgkin's lymphoma (HL) is a lymphatic neoplasm typically found in the cervical lymph nodes. The disease is multifactorial, and in recent years, the relationships between various vascular molecules have been explored in the field of vascular biology. The connection between vascular biology and HL is intricate and the roles of several pathways remain unclear. This review summarizes the cellular and molecular relationships between vascular biology and HL. Proteins associated with various functions in vascular biology, including cytokines (TNF-α, IL-1, IL-13, and IL-21), chemokines (CXCL10, CXCL1

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… IntechOpen; Rijeka, Croatia: 2023. Lymph Node Cytology: Morphology and Beyond. 47. Sharma S.K. Basics of Hematopoietic Stem Cell Transplant. Springer Nature Publishing; Berlin/Heidelberg, Germany: 2023. 48. Aldinucci D., Gloghini A., Pinto A., De Filippi R., Carbone A. …