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Use of semaglutide and tirzepatide among people with multiple sclerosis.

BACKGROUND AND OBJECTIVES: Little is known about glucagon-like peptide-1 receptor agonists (GLP1RAs) use in multiple sclerosis. We described the frequency and characteristics associated with use. METHODS: A cross-sectional survey of NARCOMS Registry participants captured use of GLP1RAs semaglutide and tirzepatide. Multivariable logistic regression explored factors associated with use. RESULTS: Among 4181 eligible participants, 7.4% had ever and 5.5% currently used these GLP1RAs. Ever users were younger and had more cardiometabolic conditions. 37.3% of never users had an indication for GLP1RA…

Infections as part of the multiple sclerosis prodrome: A systematic review.

BACKGROUND AND AIM: Evidence has highlighted the prodromal phase of multiple sclerosis (MS), reflected in increased healthcare usage, hospital admissions and prescriptions. Despite increasing interest in the role of infections in MS susceptibility and severity, infections in the prodrome have not been systematically reviewed. We examined how infections are defined and measured within the MS prodrome and synthesised existing evidence. METHODS: We conducted a systematic review of studies investigating infection-related events in the 10 years preceding MS onset. RESULTS: 3523 papers were screen…

Association of epiretinal membranes with disability in people with multiple sclerosis.

BACKGROUND: Epiretinal membranes (ERMs) consist of glial and fibrocellular tissue, potentially arising from pathologic microgliosis, macrogliosis, and/or retinal pigment epithelium (RPE) cell migration. The clinical relevance of ERMs in people with multiple sclerosis (PwMS) remains largely unstudied. OBJECTIVES: To investigate ERM prevalence and their associations with retinal layer thicknesses and disability measures in PwMS. METHODS: PwMS exhibiting ERMs (ERM+) were matched 1:1 with PwMS without ERMs (ERM-) by optic neuritis (ON) history, multiple sclerosis (MS) subtype, age, sex, and race…

Multiple Sclerosis in a Person With Hirschprung's Disease: A Case Report.

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Hirschsprung's disease is a condition characterized by absence of nerves in the intestines, secondary to failure of migration of neural crest cells therein. Co-occurrence of these conditions is reported previously in a family with a stop mutation in the EDNRB gene. In the present report we present the case of a 26-year-old man who presented with complaints of left facial weakness, episodic generalized headaches, and imbalance. He was previously diagnosed with Hirschsprung's disease and had undergone…

The Art of Sequencing Disease-Modifying Therapies in Multiple Sclerosis.

Over the past decade, therapeutic paradigms in multiple sclerosis have shifted toward a "hit-hard-and-early" approach to suppress inflammatory activity and delay progression. However, adverse events, safety concerns, aging, comorbidities, and life circumstances frequently necessitate treatment transitions during the patient journey. Sequencing decisions generally arise from 3 scenarios: insufficient efficacy, tolerability or safety issues, and conceptual considerations such as family planning or exit strategies for discontinuation. Discontinuation or de-escalation of therapy is associated with…

Vertical saccadic slowing is associated with fatigue in multiple sclerosis.

BACKGROUND: Fatigue is one of the most prevalent and disabling symptoms of multiple sclerosis (MS), frequently showing weak correlation with physical disability or MRI lesion burden. Central activation models link fatigue to dysfunction of brainstem arousal pathways, particularly the Ascending Reticular Activating System (ARAS). Because vertical saccades are generated in the mesencephalon and interact with these arousal networks, they may provide an objective marker of central fatigue. OBJECTIVES: To examine the relationship between vertical saccadic parameters and fatigue severity in MS, adj…

Social and socioeconomic factors and cognitive outcomes in multiple sclerosis.

BACKGROUND: Race and social and socioeconomic conditions are associated with disability outcomes in people with multiple sclerosis (MS). Given that cognitive impairment is common in MS, social and structural factors may also relate to cognitive outcomes. OBJECTIVE: To investigate associations between social and socioeconomic factors and cognitive function in adults with MS and to determine whether these associations differ by race. METHODS: We conducted a secondary analysis of data from 274 adults with MS (average age 50.9 ± 11.9 years; 77.4% female; 72.3% White). Key social and socioeconomi…

Нацеливание мозга с использованием наноколлоидов для борьбы с множественным склерозом.

Множественный склероз (MS) вызывает сенсорную и моторную недостаточность, ломая милиновую оболочку, которая мешает электрическим импульсам достигать затронутых нейронов. Основными препятствиями на пути лечения MS являются барьер на кровеносном мозге (BBB) и непредвиденные побочные эффекты от неадекватной адресации. Наномедицина используется для доставки терапевтических химических веществ для нанесения повреждений, с тем чтобы устранить ограничения, связанные с существующими подходами к терапии MS. Нанотерапия, основанная на глубоком проникновении ББД и выборочной адресации, дала многообещающие

Совпадение в аннотации оригинала
Multiple sclerosis (MS) causes sensory and motor deficiencies by breaking the myelin sheath, which inhibits electrical impulses from reaching affected neurons. The blood-brain barrier (BBB) and unanticipated side effects from inadequate targeting are major hurdles to MS treatment. Nanomedicines are being used to deliver therapeutic chemicals to lesions in or…

Neurological sequela of COVID-19 in adults with multiple sclerosis.

BACKGROUND: Possible interactions in neuropsychiatric presentations of multiple sclerosis (MS) and COVID-19 may occur, which has been proposed in previous, albeit limited, literature. OBJECTIVES: Examine COVID-19 disease outcomes and changes in neuropsychiatric symptoms among patients with MS. METHODS: A retrospective cohort study using electronic medical records from the National COVID Cohort Collaborative (N3C) database was conducted. 26,963 adults with MS diagnosed with COVID-19 were included in the study, and propensity score matched to 80,889 neurologically healthy adults with COVID-19.…

Стероидомические изменения в цереброспинальной жидкости женщин с множественным склерозом.

Множественный склероз (MS) — долгосрочная болезнь, которая вызывает воспаление и повреждение нервной системы. В ходе этого исследования была проведена оценка стерейдомичных изменений, связанных с НР, у 57 женщин, страдающих НР на фолликулярной фазе, и 17 - на лютнической фазе, а также в области контроля за возрастом и фазой. Данные свидетельствуют о том, что 1) неочищенные и спаренные стероиды тесно связаны между кровью и ССБ. 2) У пациентов с синдромом MS более низкие уровни неочищенных стероидов по сравнению с контрольными. Однако неизменными уровнями содержания спаренных стероидов является

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a long-term disease that causes inflammation and damage to the nervous system. This study evaluated steroidomic alterations related to MS in 57 female MS patients during the follicular phase and 17 during the luteal phase, as well as in age- and phase-matched controls. The data showed that (1) unconjugated and conjugated steroids w…

Воздействие окислительного стресса на симптомы, связанные с множественным склерозом.

Множественный склероз (MS) является хроническим, подстрекательским и дегенеративным заболеванием, затрагивающим центральную нервную систему, патофизиология которого неизвестна. Окисляющий стресс, как представляется, играет важную роль в инициировании и увековечении подстрекательских и нейродегенеративных процессов, связанных с MS. Мы проанализировали параметры, связанные с окислительным стрессом у людей с множественным склерозом (pwMS) и у здоровых людей. В то же время общий объем антиоксидантов (TAC), 4-гидроксинонал (4-HNE) и 8-гидрокси-2-деоксигуанозин (8-OHdG) были ниже в PwMS. Уровни TAC

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic, inflammatory and degenerative disease affecting the central nervous system, the pathophysiology of which is unknown. Oxidative stress appears to play a significant role in the initiation and the perpetuation of the inflammatory and neurodegenerative processes associated with MS. We have analysed parameters relating to ox…

Multiple Sclerosis in the Greenlandic population. A nationwide cohort study.

BACKGROUND: The Global Burden of Disease Group modelled a surprisingly high prevalence of Multiple Sclerosis (MS) in the Greenlandic population in 2016 of 290 per 100,000, higher than that in Denmark, a high-risk country of MS. OBJECTIVE: Obtain accurate data on the burden (prevalence and incidence rates) of MS in Greenland, 1973 - 2014, overall and according to ethnicity. METHODS: Greenlandic prevalence and incidence rates were estimated using validated data from the Danish Multiple Sclerosis Registry (Greenlandic citizens suspected of MS were until 2014 supposed to be transferred to Denmar…

Обзор множественного склероза: диагностика, причины и лечение симптомов.

Множественный склероз (MS) — постепенное аутоиммунное заболевание, которое влияет на центральную нервную систему. Это чрезвычайно изменчивая и сложная болезнь, имеющая последствия, которые изменяют жизнь и потенциально ограничивают жизнь. За последние 30 лет значительно изменился уровень ухода за лицами, живущими с синдромом MS, и произошли изменения в доступности и видах лечения. Улучшилось также знание причин и патологии НР. В этой статье дается обзор MS в целях обеспечения того, чтобы медсестры имели современное представление о состоянии здоровья на основе последних данных о его причинах, л

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a progressive autoimmune disease that affects the central nervous system. It is a hugely variable and complex disease, with life-changing and potentially life-limiting effects. Care for people living with MS has evolved significantly over the past 30 years, with developments in the availability and type of treatments. Knowledge of …

Angiogenesis and Hypoxia Biomarkers Are Dysregulated in Progressive Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative CNS disorder characterized by a state of "virtual hypoxia." Angiogenesis, one of the main homeostatic responses to hypoxia, has been implicated in the pathophysiology of MS. The study objective was to determine whether angiogenic and hypoxia-related molecules are dysregulated in the serum and CNS of patients with progressive multiple sclerosis (PMS). METHODS: Baseline serum samples were obtained from a phase II trial of Ibudilast in PMS (n = 203 analyzed) and matched to healthy controls (n = 53). P…

Белая материя в кризисе: Олигодендроциты и патофизиология множественного склероза.

Множественный склероз — это хроническое нервно-дегенеративное расстройство центральной нервной системы с иммунной подоплекой, характеризующееся широко распространенным обезвоживанием, аксонной травмой и прогрессивным неврологическим расстройством. Патофизиология множественного склероза включает сложные взаимодействия между иммунными клетками и постоянными клетками центральной нервной системы, при этом олигодендроциты (милиновые глиальные клетки) играют центральную роль как в наступлении, так и в развитии болезни. Дисфункция олигодендроцитов, включая снижение регенеративной способности, повышен

Совпадение в аннотации оригинала
Multiple sclerosis is a chronic, immune-mediated neurodegenerative disorder of the central nervous system, characterized by widespread demyelination, axonal injury, and progressive neurological impairment. The pathophysiology of multiple sclerosis involves complex interactions between immune cells and central nervous system resident cells, with oligodendrocy…