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Crowdfunding for complementary and alternative medicine: What are cancer patients seeking?

BackgroundComplementary and alternative medicine (CAM) is increasingly being integrated into conventional medical care for cancer, used to counter the side effects of conventional cancer treatment, and offered as an alternative to conventional cancer care. Our aim is to gain a broader understanding of trends in CAM interventions for cancer and crowdfunding campaigns for these interventions.MethodsGoFundMe campaigns fundraising for CAM were retrieved through a database of crowdfunding campaign data. Search terms were drawn from two National Institutes of Health lists of CAM cancer interventions

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… The authors additionally identified similar terms and labels for each identified CAM treatment to identify alternative language used by crowdfunders to fundraise (for example, cannabis synonyms include marijuana and cannabidiol). … Cannabis products including cannabidiol (CBD) and Rick Simpson Oil (RSO) (n = 211, 15.1%) were frequently praised as offering more “natural” alternatives for pain relief and managing treatment side effects. …

Каннабиноиды в условиях хронической боли: обзор истории, эффективности, применения и рисков.

Справочная информация/цели: Хроническая боль по-прежнему является широко распространенной и сложной проблемой в области здравоохранения, которая зачастую является устойчивой к обычным методам лечения, таким, как опиоиды, которые сопряжены со значительным риском зависимости и неблагоприятных последствий. Каннабиноиды, биоактивные соединения, полученные на заводе Cannabis Sativa, и их синтетические аналоги стали потенциальной альтернативой обезболиванию, используя их взаимодействие с эндоканнабиноидной системой для модуляции боли и воспаления. Методы: Были рассмотрены и обобщены нынешняя, развив

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… They include phytocannabinoids, those produced by plants of the Cannabis genus, include tetrahydrocannabinol (THC), cannabidiol (CBD), and dronabinol [ 31 ]. Synthetic and endogenous variants have also been characterized and studied, including anandamide and 2-arachidonoylglycerol (2-AG). … Furthermore, the ratio of THC to cannabidiol (CBD) varies widely, with some studies utilizing pure THC, others using high-CBD formulations, and some employing synthetic analogs such as nabilone or dronabinol. …

Ion Channels in Multiple Myeloma: Pathogenic Role and Therapeutic Perspectives.

Ion channels are pore-forming proteins that allow ions to flow across plasma membranes and intracellular organelles in both excitable and non-excitable cells. They are involved in the regulation of several biological processes (i.e., proliferation, cell volume and shape, differentiation, migration, and apoptosis). Recently, the aberrant expression of ion channels has emerged as an important step of malignant transformation, tumor progression, and drug resistance, leading to the idea of "onco-channelopathy". Here, we review the contribution of ion channels and transporters in multiple myeloma (

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… TRPV2 expression by CD138 + MM cells correlates with an increased susceptibility to cannabidiol-induced MM cell death. … The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2. Int. J. Cancer. 2014;134:2534–2546. doi: 10.1002/ijc.28591. 93. …

Assessment of the availability of repurposed orphan drugs in India.

India has a massive burden of rare diseases (RDs), with an estimated 96 million people living with RDs but limited options for treatment. Repurposing drugs used for other common conditions are essential alternative for RDs due to their cost-effectiveness and reduced timeline. India's patent regime prevents the evergreening of drugs, and a large generic manufacturing industry provides ample opportunity to explore the potential of repurposed drugs for treating RDs, known as repurposed orphan drugs (ROD). However, there is no portal or other source for information on orphan drugs in India. This s

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… Cannabidiol is regulated by the Central Bureau of Narcotics under the Narcotic Drugs And Psychotropic Substances, Act, of 1985. … Thus Cannabidiol should be easily available to patients in India. Thus 172 drugs(A1.1, B1 and B2) were listed in one of the Indian regulatory databases in the same form as approved by the USFDA. …

Alternative Cancer Therapeutics: Unpatentable Compounds and Their Potential in Oncology.

Cancer remains a leading cause of death globally. Cancer patients often seek alternative therapies in addition to, or instead of, conventional treatments like chemotherapy, radiation, and surgery. The progress in medical advancements and early detection provides more treatment options; however, the development of cancer drugs requires a significant amount of time, demands substantial investments, and results in an overall low percent of regulatory approval. The complex relationship between patent protection and pharmaceutical innovation complicates cancer drug development and contributes to hi

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… Cannabidiol (CBD), both as a solitary agent and in conjunction with other compounds, has been demonstrated to effectively induce apoptosis in cancer cells; inhibit their migration and invasion in vitro; reduce tumor dimensions, vascularization, growth, and mass; and enhance survival rates, as well as … Phytochemicals (e.g., Cannabidiol, CBD) | Phytocannabinoids from the cannabis plant exhibit a variety of proposed mechanisms, including anti-inflammatory, antioxidant, and anticonvulsant effects. …

Cannabis-based medicines and medical cannabis for adults with cancer pain.

BACKGROUND: Pain is a common symptom in people with cancer; 30% to 50% of people with cancer will experience moderate-to-severe pain. This c … rt of treatment. We found five RCTs assessing oromucosal nabiximols (tetrahydrocannabinol (THC) and cannabidiol (CBD)) or THC alone involving 1539 participants with moderate or severe pain despite opioid therapy. The double-blind periods of the RCTs ranged between two and five weeks. Four studies with a parallel design and 1333 participants were available for …

Regional differences in oesophageal motor function.

GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC:CBD, High THC, High CBD] in a range of medical conditions. The cannabis for this programme is grown in a secret location in the UK. It is expected that the product will be marketed in the US in late 2003. GW's cannabis-based products include selected phytocannabinoids from cannabis plants, including D9 tetrahydrocannabinol (THC) and cannabidiol (CBD). The company is investigating their use in three delivery systems, including sublingual spray, subling…

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

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… /or cannabinol/or dronabinol/ (19282) 69 Endocannabinoids/ (7320) 70 exp Receptors, Cannabinoid/ (11163) 71 (Cannabis or cannabinol or cannabinoid* or cannabidiol or bhang or cannador or charas or ganja or ganjah or hashish or hemp or marihuana or marijuana or nabilone or cesamet or cesametic or ajulemic … word, candidate term word] (65483) 59 or/55‐58 (530251) 60 cannabis/ (47237) 61 medical cannabis/ (4522) 62 exp cannabinoid receptor/ (18353) 63 cannabis addiction/ (12255) 64 “cannabis use”/or cannabis smoking/ (20148) 65 exp cannabinoid/ (93136) 66 (Cannabis or cannabinol or cannabinoid* or cannabidiol …

The challenge of chemotherapy-related cognitive impairment: assessing and managing cognitive decline after cancer treatment.

Chemotherapy-related cognitive impairment (CRCI) refers to a decline in cognitive function in patients during and after cancer treatment and is mainly associated with the use of cytotoxic chemotherapy (CT). As CT is still an essential component in the treatment of many cancers and taking into account the fact that cancer survival rates are increasing, CRCI may negatively impact the quality of life and working capacity of a growing number of individuals, especially those treated with curative intent in conditions such as breast cancer. There is still a need to address several issues related to

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… Other evaluated strategies associated with benefits were treatment with melatonin [ 70 ] and cannabidiol [ 71 ]; however, studies have only involved a small number of cancer patients. … List of abbreviations ALL, Acute lymphoblastic leukemia; APOE ε4, epsilon 4 allele of the Apolipoprotein E gene; BDNA, Brain-Derived Neurotrophic Factor; BBB, Blood–brain barrier; CBD, Cannabidiol; CBT, Cognitive behavioural therapy; CNS, Central nervous system; COMT, Catechol-O-methyltransferase; CRCD …

Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis.

BackgroundSpasticity and chronic neuropathic pain are common and serious symptoms in people with multiple sclerosis (MS). These symptoms inc … an oromucosal spray with a plant derived equal (1:1) combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) (13 studies), synthetic cannabinoids mimicking THC (7 studies), an oral THC extract of Cannabis sativa (2 studies), inhaled herbal Cannabis (1 study) against placebo. One study compared dronabinol, THC extract of Cannabis sativa and placebo, o …

Использование каннабиса и риск возникновения периодонтита и негативных последствий для здоровья полости рта: систематический анализ литературы.

Каннабис широко употребляется во всем мире. К числу общих методов потребления относятся курение, оплодотворение и потребление съедобных веществ. Несмотря на все более широкое использование каннабиса, его воздействие на лечение и лечение расстройств, связанных с оральным здоровьем, по-прежнему недостаточно изучено. Каннабис ассоциируется с негативными оральными последствиями, такими, как периодонтит, ксеростомия, кариес и ингивит. Эти отрицательные оральные эффекты осложняют стоматологическую помощь. Был проведен систематический обзор литературы с целью поиска баз данных PubMed, EMBASE и Cochra

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… The plant contains several active cannabinoids, primarily delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), delta-8-THC, and cannabinol. … criteria Participants | Epilepsy, multiple sclerosis, ulcerative colitis, Crohn’s disease, cannabis use disorder (unless in context of oral treatment), cancer pain (unless in context of oral treatment), alcohol use disorder Intervention | Synthetic cannabinoid agonists, cannabinoid antagonists, opiates, cannabidiol …

Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Oncologic Patients-A New Promise? Preliminary Results.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common, often debilitating side effect of several chemotherapeutic agents, particularly taxanes and platinum compounds. Current management strategies remain limited, with few agents demonstrating consistent efficacy. Our aim was to evaluate the efficacy and safety of a novel topical cream containing 1% amitriptyline and 0.5% ketamine in alleviating CIPN symptoms in oncology patients.MethodsA prospective observational study was conducted at Barzilai Medical Center following the approval of the local ethics committee. Thirty-seven

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… Showed in vitro studies that THC or CBD alone attenuates mechanical allodynia associated with paclitaxel-induced peripheral neuropathy; however, when THC is combined with cannabidiol (CBD), a synergistic effect leads to reduced neuropathic pain [ 41 ]. … Single and combined effects of Δ(9)-tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain Br. J. Pharmacol. 2017 174 2832 2841 10.1111/bph.13887 28548225 PMC5554313 42. Barnes R.C. Blanton H. Dancel C.L. Castro-Piedras I. Rorabaugh B.R. Morgan D.J. …

Cytokine-induced killer cells: new insights for therapy of hematologic malignancies.

BackgroundCytokine-induced killer (CIK) cells are a novel subgroup of immune effectors, classified as one of the modified T cell-mediated arms for immunotherapy. These cells exert MHC-unrestricted cytotoxicity against both hematological and solid malignancies with low incidence of treatment-related severe complications. This study reviews the application of CIK cells in treating cases with hematologic malignancies.Main bodyCIK cells consist of CD3+/CD56+ natural killer (NK) T cells, CD3-/CD56+ NK cells, and CD3+/CD56- cytotoxic T cells. In this regard, the CD3+/CD56+ NK T cells are the primary

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… They also highlighted that combining cannabidiol with CIK cell therapy in MM patients not only enhances the cytotoxicity of CIK cells against MM cells but also has protective effects on CIK cells. … However, the protective effect on CIK cells was replaced with cytotoxic effects after increasing the cannabidiol concentration to more than one µM, indicating that combining cannabinoids with CIK therapy requires additional considerations in the future. …

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

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… docking [ 13 ] | MDD (INV) [ 38 , 39 , 40 , 41 ] Pregabalin | GWAS [ 23 ] | MDD (SA) [ 23 ] Gabapentin | GWAS [ 23 ] | MDD (SA) [ 23 ] Cycloserine | GWAS [ 23 ] | BP depression (INV) [ 42 ], MDD (SA, INV) [ 23 , 36 ] Risperidone | GWAS [ 23 ] | Extrapyramidal symptoms, suicidal ideation (INV) [ 43 ] Cannabidiol … Cannabidiol is a propitious agent for MDD due to its effects on involved pathways in this disorder. Sho-saiko-to, a traditional Chinese medicine, showed antidepressant effects in mice upon its influence on the serotonergic system in the central nervous system. …

Концептуализация комплексного ухода за многими миеломами: роль питания, дополнительных услуг и дополнительных услуг.

Множественная миелома (ММ) — вторая по распространенности гематологическая гелингология, масштабы которой в последние годы значительно возросли. Прогноз ММ радикально изменился с введением новых лекарственных средств, повышающих ожидаемую продолжительность жизни; рецидивы являются обычным явлением во время болезни и характеризуются увеличением числа отказов от лечения. Кроме того, пациенты ММ сталкиваются с проблемами, связанными с качеством жизни, в то время как обычное лечение может быть ограничено. Это включает боль в костях и диализ из-за осложнений острой почечной недостаточности. Поэтому

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… different cell lines express CB1/CB2 receptors for cannabinoids, their anti-cancer potential has been extensively investigated recently, in in vitro and in vivo models: among the various plant components most studied for their antiapoptotic activity are delta-trans-9-tetrahydrocannabinol (THC) and cannabidiol … Abbreviations ASCO | American Society of Clinical Oncology ASCT | Autologous stem cell transplantation BIPN | Bortezomib-induced peripheral neuropathy CAR-T | Chimeric Antigen Receptor T cell CB1 | Cannabinoid type 1 receptors CB2 | Cannabinoid type 2 receptors CBD | Cannabidiol CIPN | Chemotherapy-induced …

Visual analysis of the research frontiers, hotspots and trends of exercise therapy intervention in tumor-related sleep-wake disorders.

ObjectiveTo systematically understand the research frontiers, hotspots and development trends of exercise therapy in the intervention of tumor-related sleep-wake disorders, and to provide scientific basis for follow-up research.MethodsDownloaded the original research papers on February 26, 2024, from the Web of Science core collection database, on tumor-associated sleep-wake disorders. The data that met the inclusion criteria were imported into the Bibliometric Analysis Platform (http://biblimetric.com), CiteSpace 6.3.R1 and VOSviwer1.6.20 software for visual analysis, and imported into Excel2

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… Omega-3, cannabidiol, acupuncture, and cognitive behavioral therapy may help improve sleep quality ( 21 – 23 ). Exercise therapy combined with mindfulness-based stress reduction is effective in reducing the incidence of sleep-wake disorders in cancer patients ( 19 ). … Role of cannabidiol for improvement of the quality of life in cancer patients: potential and challenges . Int J Mol Sci . ( 2022 ) 23 : 12956 . doi: 10.3390/ijms232112956 36361743 PMC9654506 23 Liou KT Root JC Garland SN Green J Li Y Li QS . …

Cannabis-based medicines for chronic neuropathic pain in adults.

BACKGROUND: This review is one of a series on drugs used to treat chronic neuropathic pain. Estimates of the population prevalence of chroni … and compared an oromucosal spray with a plant-derived combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) (10 studies), a synthetic cannabinoid mimicking THC (nabilone) (two studies), inhaled herbal cannabis (two studies) and plant-derived THC (dronabinol) (two studies) against placebo (15 studies) and an analgesic (dihydrocodeine) (one study). We …

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.

Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, a

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… Other drugs such as alendronate, benzocaine, cannabidiol, dupilumab, finasteride, isotretinoin, methimazole, mianserin, midodrine, pantoprazole, pseudoephedrine/fexofenadine, and varenicline have also been reported [ 126 , 140 – 150 ]. … Cannabidiol-induced acute generalized exanthematous pustulosis. Dermatitis. 2018;29(6):345–6. doi: 10.1097/DER.0000000000000422. 142. Wu L, Ali K, Qiu Y, Li M, Da J. Dupilumab-induced acute generalized exanthematous pustulosis in a 17-year-old female chinese patient with atopic dermatitis. …

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.

INTRODUCTION: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for use of medical cannabis, patients' reasons, and prescribed indications must be better understood. METHODS: Based on the Joanna Briggs Institute guidelines, a scoping review was conducted to map the current evidence regarding the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. A searc

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… Highet BH Lesser ER Johnson PW Kaur JS Tetrahydrocannabinol and Cannabidiol Use in an Outpatient Palliative Medicine Population Am J Hosp Palliat Med 2020 37 8 589 593 10.1177/1049909119900378 31986898 53. … Yeshurun M Shpilberg O Herscovici CLS Dreyer J Peck A Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation Results of a Phase II Study Biology of Blood and Marrow Transplantation 2015 21 10 1770 5 26033282 10.1016/j.bbmt.2015.05.018 64. …

Autophagic mechanisms in longevity intervention: role of natural active compounds.

The term 'autophagy' literally translates to 'self-eating' and alterations to autophagy have been identified as one of the several molecular changes that occur with aging in a variety of species. Autophagy and aging, have a complicated and multifaceted relationship that has recently come to light thanks to breakthroughs in our understanding of the various substrates of autophagy on tissue homoeostasis. Several studies have been conducted to reveal the relationship between autophagy and age-related diseases. The present review looks at a few new aspects of autophagy and speculates on how they m

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… Cannabidiol, a natural compound from Cannabis sativa L. (Cannabaceae) extended lifespan and improved neuronal health in C. elegans by induction of autophagy (Ref. 226 ). Figure 5. Autophagy-related pathways regulated by natural compounds in neurological aging (Figure created with Biorender.com). … aggregation (Ref. 202 ) Alkaloids Dendrobine in vivo Rat model of AD Autophagy induction Increases autophagic flux (Ref. 207 ) Alkaloids n -butylidenephthalide in vivo SOD1-G93A mouse model of Amyotrophic lateral sclerosis (ALS) Autophagy inhibition Inhibits LC3-II and caspase 3 (Ref. 216 ) Cannabinoids Cannabidiol …