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37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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Bone-modifying therapy in multiple myeloma: a comprehensive review.

Multiple myeloma (MM) is a clonal hematologic malignancy characterized by plasma cell proliferation in the bone marrow. One of the most common clinical presentations is skeletal-related events (SREs), characterized by osteolysis of the bone, leading to a significant morbidity and mortality. The main aim of this review article is to provide an overview of the pathogenesis and evidence-based, guideline-recommended treatment of SREs. MM bone homeostasis is altered by numerous pathways and cytokines, leading to the pathogenesis of bone and osteolytic lesions. Historically, bisphosphonates were the

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… vitamin D, application of zoledronic acid in order to prevent rebound effect Free Market Cost | USA | Zoledronic acid 4 mg/5 ml: 3.60 - 167.66 USD | Pamidronate 60 mg: 5.45 USD | Denosumab (Xgeva) 120 mg/1,7 ml: 2,435.11 USD Denosumab (Wyost) 120 mg/1.7 ml 3 : 2,264.65 USD EU representative nation (Croatia …

Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects.

Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic cancer vaccines emerged to try to improve anticancer drugs' efficiency and to deliver them to the target site. Cancer vaccines are considered a viable therapeutic technique for most solid tumors. Vaccines boost antitumor immunity by delivering tumor antigens, nucleic acids, entire cells, and peptides. Cancer vaccines are designed to induce lon

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… IntechOpen; Rijeka, Croatia: 2018. p. 6. 67. Laidlaw B.J., Craft J.E., Kaech S.M. The Multifaceted Role of CD4(+)T Cells in CD8(+) T Cell Memory. Nat. Rev. Immunol. 2016;16:102–111. doi: 10.1038/nri.2015.10. 68. Thorsson V., Gibbs D.L., Brown S.D., Wolf D., Bortone D.S., Ou Yang T. …

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

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… IntechOpen; Rijeka, Croatia: 2020. Drug Repurposing (DR): An Emerging Approach in Drug Discovery. 36. Roessler H.I., Knoers N.V.A.M., van Haelst M.M., van Haaften G. Drug Repurposing for Rare Diseases. Trends Pharmacol. Sci. 2021;42:255–267. doi: 10.1016/j.tips.2021.01.003. 37. …

Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.

BackgroundGenetic studies have found that a germline BRCA1 gene mutation is the origin of highly increased cancer risk. Clinical studies have suggested that increased cancer risk in type-2 diabetes may be attributed to unhealthy lifestyle factors and bad habits.PurposePatients with either BRCA1 gene mutation or type-2 diabetes similarly exhibit increased cancer risk, insulin resistance, and fertility disorders. It was suggested that these three alterations derive from a common genomic failure, and its recognition may shed light on the unsolved secret of cancer.Results(1) Germline mutations on

Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals.

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact. The emergence of several variants during the pandemic has presented numerous challenges in preventing and managing this disease. The development of vaccines has played a pivotal role in controlling the pandemic, with a significant portion of the global population being vaccinated. This, along with the emergence of less virulent SARS-CoV-2 variants, has led to a reduction in the severity of COVID-19 outcomes for the overall population. Nevertheless, i

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… users with COVID-19 ( n = 447) | 242 (76.5) | 58 (13.0) | 41 (9.2) | – Sparks 2021 [ 113 ] March 2020–April 2021 Multinational | Individuals with RA and COVID-19 receiving immunosuppressive treatments ( n = 1388) | – | Retrospective | 203 (14.6) | – | – | – Tilch 2022 [ 50 ] February 2020–October 2021 Croatia …

Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges.

Uncontrolled inflammation is a salient factor in multiple chronic inflammatory diseases and cancers. In this review, we provided an in-depth analysis of the relationships and distinctions between uncontrolled inflammation, fibrosis and cancers, while emphasizing the challenges and opportunities of developing novel therapies for the treatment and/or management of these diseases. We described how drug delivery systems, combination therapy and the integration of tissue-targeted and/or pathways selective strategies could overcome the challenges of current agents for managing and/or treating chroni

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… IntechOpen; Rijeka, Croatia: 2017. [(accessed on 15 August 2021)]. TGF-β Activation and Signaling in Angiogenesis. Available online: https://www.intechopen.com/chapters/53316 . 116. Lyden D., Young A.Z., Zagzag D., Yan W., Gerald W., O’Reilly R., Bader B.L., Hynes R.O., Zhuang Y., Manova K. …

Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality.

The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as w

The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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… , Germany , 9 Universitaetsklinikum Dresden, Dresden, Germany , 10 Ospedale Civile, Pescara, Italy , 11 University Hospital, Essen, Germany , 12 Chaim Sheba Medical Center, Tel Aviv University, Ramat Gan, Israel , 13 University Hospital Erlangen, Erlangen, Germany , 14 University of Zagreb, Zagreb, Croatia …

ePoster.

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… Habek 1 1 University Hospital Center Zagreb, Zagreb, Croatia; 2 University of Zagreb, School of Medicine, Zagreb, Croatia Background and aims: The Quantitative Sudomotor Axon Reflex Test (QSART) is the gold standard for evaluating sudomotor function within the Composite Autonomic Scoring Scale (CASS … , Zagreb, Croatia; 4 Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia Background and aims: Gastrointestinal autonomic symptoms are frequently reported by people with MS (pwMS) but remain insufficiently characterized, with prevalence estimates varying widely across …

Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities.

New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens. This difference has led to an intensified search for additional potent vaccine adjuvants that meet safety and efficacy criteria and confer long-term protection. This review provides an overview of protein-based adjuvants (PBAs) obtained from different organisms, including bacteria, mollusks, plants, and humans. Notably, despite structural differences, all PBAs show significant immunostimulatory properties, eliciting B-cell- a

Abstract

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… Vuga 1 1 Sestre Milosrdnice University Hospital Center, Department of Clinical Chemistry, Zagreb, Croatia, 2 Faculty of Pharmacy and Biochemistry University of Zagreb, Zagreb, Croatia Background: In the recent years platelet aggregation testing has expanded in the assessment of the effectiveness of …

Influence of Hypoxia on Tumor Heterogeneity, DNA Repair, and Cancer Therapy: From Molecular Insights to Therapeutic Strategies.

Hypoxia, characterized by a reduction in tissue oxygen levels, is a hallmark of many solid tumors and affects a range of cellular processes, including DNA repair. In low-oxygen conditions, cancer cells often suppress key DNA repair pathways such as homologous recombination (HR), leading to the accumulation of DNA damage and increased genomic instability. These changes not only drive tumor progression but also contribute to resistance against conventional therapies. Hypoxia significantly reduces the effectiveness of oxygen-dependent treatments, including radiotherapy and many chemotherapeutic a

Utilization of Stem Cells in Medicine: A Narrative Review.

Regenerative medicine holds significant promise for addressing diseases and irreversible damage that are challenging to treat with conventional methods, making it a prominent research focus in modern medicine. Research on stem cells, a key area within regenerative medicine due to their self-renewal capabilities, is expanding, positioning them as a novel therapeutic option. Stem cells, utilized in various treatments, are categorized based on their differentiation potential and the source tissue. The term 'stem cell' encompasses a broad spectrum of cells, which can be derived from embryonic tiss

Abstracts 12th PCNE working conference 'Partnering for better patient outcomes: challenges and opportunities 3-6 February 2021, University of Basel, Switzerland (was held online).

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Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… P1234: Respiratory syncytial virus infections in Croatia, 1994–99 A. Lukic-Grlic, G. Mlinaric-Galinovic, V. Drazenovic, A. Barisin, A. Bace, V. Hresic-Krsulovic, R. Sim, B. Berberovic, E. …

Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

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Неделя ГЭЭ 2018 Презентации на плакате

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Determining Risk Factors Associated with Cardiovascular Complications in Patients with Acute Leukemia: A Systematic Review.

BackgroundPatients with acute leukemia (AL) are at heightened risk of cardiovascular complications due to both disease-related and treatment-related factors. These complications include heart failure, arrhythmias, myocardial infarction, and thromboembolic events which may significantly impact morbidity and mortality.ObjectiveTo identify the risk factors contributing to cardiovascular complications in patients with acute leukemia.MethodsThis systematic review was conducted according to the PRISMA reporting guideline. Multiple databases including PubMed, Scopus, IEEE Xplore, the Cochrane Library

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… Additional contributions came from Austria, India, Greece, Croatia, Japan, and Switzerland (each with two studies), and single studies were from Romania, the United Arab Emirates, Slovenia, Colombia, Egypt, Serbia, Denmark, and Kosovo. …

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in

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… InTech Rijeka, Croatia 2011 141 158 9. Talib W.H. Alsalahat I. Daoud S. Abutayeh R.F. Mahmod A.I. Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation Molecules 2020 25 5319 10.3390/molecules25225319 33202681 PMC7696819 10. Rayan A. Raiyn J. …