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Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer.

IntroductionBreast cancer is one of the malignancies which tend to involve the bone marrow, but initial presentation with diffuse bone marrow metastasis from an occult breast cancer is very rare. Prognosis is generally very poor for marrow metastasis from solid tumors except that breast cancer is a treatable disease even in such a dismal condition.CaseA 64-year-old woman's headache was found to result from diffuse adenocarcinoma metastasis in the bone marrow from an unknown primary site. Intensive immunohistochemistry study of bone marrow biopsy specimen confirmed the disease nature to be an e

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… Figure 9 Change of serum CA 15-3 (blue diamond) and alkaline phosphatase (orange square) levels (iu/ml) along the clinical course. Green arrow: tamoxifen commencement date (September 21, 2017). Figure 10 PET/CT scans. …

Оценка функции верхнего лимфа с использованием технологий виртуальной реальности для взрослых с неврологическими расстройствами: систематический обзор.

Справочная информация: Виртуальная реальность (ВП) все чаще изучается в качестве инструмента для оценки состояния верхних конечностей (УЛ) у взрослых с неврологическими расстройствами. Этот обзор обобщает имеющиеся данные оценок UL на основе VR путем анализа их психометрических свойств и потенциальной роли в клинических и исследовательских условиях. Методы: Этот систематический обзор проводился в соответствии с руководящими принципами представления отчетности о систематических обзорах инструментов оценки результатов (PRRISMA-COSMIN) и был в перспективе зарегистрирован в ПРОСПЕРО. Добыча данных

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… Diamond P.T. Assessing upper extremity motor function in practice of virtual activities of daily living IEEE Trans. Neural Syst. Rehabil. Eng. 2015 23 287 296 10.1109/TNSRE.2014.2360149 25265612 PMC4532436 34. Adams R.J. Ellington A.L. Armstead K. Sheffield K. Patrie J.T. Diamond P.T. …

Risk factors for infections in patients with multiple myeloma: a systematic review and meta-analysis.

BACKGROUND: Multiple myeloma (MM) is a malignant clonal disease originating from plasma cells. Patients with MM are prone to infections due to factors such as impaired immune function, bone marrow suppression, and anticancer therapy. A systematic review and meta-analysis of risk factors for infections in patients with MM provides evidence-based guidance for clinical risk assessment and intervention. METHODS: Search databases such as PubMed, Web of Science, Embase, Cochrane Library, from the establishment of the database to July 20, 2025, to include observational studies evaluating risk factor

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… Forest plot displaying odds ratios with ninety-five percent confidence intervals for six studies on the left, overall effect shown with a diamond at one point seven two, and associated weights listed on the right. … Pooled overall odds ratio is 1.70 with a 95 percent confidence interval of 1.11 to 2.62, shown as a diamond. Study weights range from about 9 to 28 percent, with I-squared at 6.8 percent and p-value 0.368. …

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy.

During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. Indeed, type I IFNs are now appreciated as a critical component of dendritic cell (DC) driven T cell responses to cancer. Here we focus on IFN-α and IFN-β, and their antitumor effects, impact on immune responses and their use as therapeutic agents. IFN-α/β share many properties, including activation of the JAK-STAT signaling pathway and induction of a variety of cellular p

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… Among the different DC subsets, using bone marrow chimera experiments, Diamond and collaborators have demonstrated that Ifnar1 −/− CD8α + DCs lose their capability to cross present tumor antigens and as a consequence, when regressor tumors are transplanted, the host is no longer able to immune reject …

Обработка возвращенных/отсутствующих t()11;14Множественный синдром миеломы и инфракрасного синдрома высокой степени риска с венецоклаксом.

Пациенты с множественной миеломой (ММ) имеют свойственный им риск вторичных миелоидных заболеваний. В тех случаях, когда эти гематоологические магнации сопутствуют друг другу, необходимы новаторские подходы к лечению. Венецоклакс (VEN), ингибитор BCL2, используется в сочетании с Azacitidine в острой миэлоидной лейкемии, в пробной среде при миэлодипластическом синдроме повышенного риска (MDS) и в t()11; 14) MM в спасательной системе. В этой связи мы представим доклад о параллельном рассмотрении дел, связанных с МОБ и t, сопряженных с высоким риском (см.11; 14) MM у пациента, использующего венер

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… PMC8282231 32972803 11 Maclachlan K. , Diamond B. , Maura F. et al., Second Malignancies in Multiple Myeloma; Emerging Patterns and Future Directions , Best Practice & Research Clinical Haematology . ( 2020 ) 33 , no. 1, 10.1016/j.beha.2020.101144 . PMC7544243 32139010 12 Boquoi A. , Banahan S. …

Воздействие Fampridine на когницию у пациентов с множественным склерозом (MS): систематический обзор и метаанализ.

У пациентов с множественным склерозом (MS) когнитивное расстройство (CI) представляет собой неисправимое осложнение. Fampridine используется для улучшения ходьбы по предметам с MS, а также для улучшения когнитивного восприятия, хотя результаты являются разнородными. Поэтому мы намеревались проводить систематический обзор и метаанализ для изучения воздействия фамфридина на когнитивное сознание пациентов с MS. МЕТОДЫ: Мы провели всеобъемлющий поиск в PubMed, EMBASE, Scopus, Web of Science, Google-ученик, а также серый поиск, включая ссылки на справочные материалы и резюме конференций в январе 1t

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… Diamond BJ, Johnson SK, Kaufman M, Graves L. Relationships between information processing, depression, fatigue and cognition in multiple sclerosis. Arch Clin Neuropsychol. 2008;23:189–99. doi: 10.1016/j.acn.2007.10.002. 38. Ruano L, Portaccio E, Goretti B, et al. …

Editorial: Novel techniques of minimally invasive spine surgery for various pathologies.

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… Lisheng et al. described one case of central calcified thoracic disc herniation (CCTDH) treated with modified PTES via a unilateral posterolateral approach under local anesthesia and conscious sedation, with the help of a flexible power diamond drill. …

Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: interim analysis of the GMMG-CONCEPT trial.

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… Landgren O Hultcrantz M Diamond B Lesokhin AM Mailankody S Hassoun H Safety and effectiveness of weekly carfilzomib, lenalidomide, dexamethasone, and daratumumab combination therapy for patients with newly diagnosed multiple myeloma: the MANHATTAN nonrandomized clinical trial JAMA Oncol 2021 7 Jun 862 …

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this pathway is frequently altered in breast cancer due to mutations at or aberrant expression of: HER2, ERalpha, BRCA1, BRCA2, EGFR1, PIK3CA, PTEN, TP53, RB as well as other oncogenes and tumor suppressor genes. In some breast cancer cases, mutations at certain components of this pathway (e.g., PIK3CA) are associated with a better prognosis than breast cancers lacking these mutations. The expression of this pathway and upstre

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… The downstream transcription factors regulated by this pathway are indicated in yellow diamond shaped outlines. The Ras/Raf/MEK/ERK pathway also interacts with key proteins involved in protein translation (indicated in green ovals). … Other key proteins inactivated by PI3K/PTEN/Akt/mTORC1 pathway (e.g., TSC, PTEN, beta-catenin, Foxo and 4E-BP1 are indicated by black ovals, diamonds and rectangles. Red arrows indicate activating events in pathways. Blocked black arrows indicating inactivating events in pathways. …

Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review.

Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase th

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… Diamond C., Taylor T. H., Im T., Anton-Culver H. Presentation and outcomes of systemic non-Hodgkin's lymphoma: A comparison between patients with acquired immunodeficiency syndrome (AIDS) treated with highly active antiretroviral therapy and patients without AIDS. …

Analysis of differential gene immune infiltration and clinical characteristics of skin cutaneous melanoma based on systems biology and drug repositioning methods to identify drug candidates for skin cutaneous melanoma.

Skin cutaneous melanoma (SKCM) has a low early detection rate and a high mortality rate. There are many problems such as side effects and drug resistance in existing therapeutic drugs. Current studies have confirmed that SKCM pathogenesis-related genes promote the invasion and metastasis of cutaneous melanoma, but their roles in the tumor microenvironment (TME) remain unclear. Network pharmacology provides new opportunities for drug repurposing and repositioning, and is a fast, safe, and inexpensive drug discovery method to find new drugs for the treatment of SKCM. In this study, based on 3 da

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… Red ovals represent skin melanoma-related genes in the OMIM database, green diamonds represent skin melanoma-related genes in the KEGG pathway, and purple triangles represent skin melanoma-related genes in the PheGenI database. … Red ovals represent skin melanoma-related genes in the OMIM database, green diamonds represent skin melanoma-related genes in the KEGG pathway, and purple triangles represent skin melanoma-related genes in the PheGenI database. …

Ancient genes establish stress-induced mutation as a hallmark of cancer.

Cancer is sometimes depicted as a reversion to single cell behavior in cells adapted to live in a multicellular assembly. If this is the case, one would expect that mutation in cancer disrupts functional mechanisms that suppress cell-level traits detrimental to multicellularity. Such mechanisms should have evolved with or after the emergence of multicellularity. This leads to two related, but distinct hypotheses: 1) Somatic mutations in cancer will occur in genes that are younger than the emergence of multicellularity (1000 million years [MY]); and 2) genes that are frequently mutated in cance

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… Boxplots in lower panel show distribution quartiles; black vertical lines are medians, yellow diamonds are means and black dots are outliers. … Boxplots in lower panel show distribution quartiles; black vertical lines are medians, yellow diamonds are means and black dots are outliers. (B) Equivalent plots for cancer data (ICGC release 19). …

Genome Instability in Multiple Myeloma: Facts and Factors.

Multiple myeloma (MM) is a malignant neoplasm of terminally differentiated immunoglobulin-producing B lymphocytes called plasma cells. MM is the second most common hematologic malignancy, and it poses a heavy economic and social burden because it remains incurable and confers a profound disability to patients. Despite current progress in MM treatment, the disease invariably recurs, even after the transplantation of autologous hematopoietic stem cells (ASCT). Biological processes leading to a pathological myeloma clone and the mechanisms of further evolution of the disease are far from complete

Integrative Hematology: State of the Art.

Blood cancers are a group of diseases with thus far frequently poor prognosis. Although many new drugs, including target therapies, have been developed in recent years, there is still a need to expand our therapeutic armamentarium to better deal with these diseases. Integrative hematology was conceived as a discipline that enriches the patient's therapeutic possibilities with the use of supplements, vitamins and a nutritional approach aiming at improving the response to therapies and the clinical outcome. We will analyze the substances that have proved most useful in preclinical and clinical s

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… Diamond T.H. Manoharan A. Ramakrishna R. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: A randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study Am. J. … Diamond T.H. Alexander W. Manoharan A. Golombick T. Use of Curcumin in Multiple Myeloma patients intolerant of steroid therapy Clin. Case Rep. 2020 8 739 744 10.1002/ccr3.2735 32274049 PMC7141712 93. …

Comprehensive analysis of mRNA-microRNA-lncRNA expression profiles in post-traumatic elbow heterotopic ossification using RNA sequencing and experimental validation.

BackgroundThis study aimed to profile the molecular signatures of post-traumatic elbow heterotopic ossification (HO) to identify key regulators and potential therapeutic targets.MethodsTotal RNA from post-traumatic elbow HO tissues (n=4) and normal bone tissues (n=6) was subjected to high-throughput sequencing to identify differentially expressed mRNAs (DEGs), microRNAs (DEMs), and lncRNAs (DELs). Bioinformatics analyses included Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, protein-protein interaction network construction, and transcription factor (TF)

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… The circles indicates DEGs (red indicates upregulated genes, and blue indicates the downregulated genes), the diamonds indicates TFs, and the squares indicates microRNAs. ENCODE, Encyclopedia of DNA Elements; TF, transcription factor; DEG, differentially expressed gene. … The circles indicates DEGs (red indicates upregulated genes, and blue indicates the downregulated genes), the diamonds indicates TFs, and the squares indicates microRNAs. TF, transcription factor; DEG, differentially expressed gene. …

Cytomegalovirus infection in patients receiving bispecific antibodies for multiple myeloma and B-cell malignancies: a single-center cohort and meta-analysis.

BACKGROUND: Bispecific antibodies (BsAbs) are transformative therapies for multiple myeloma (MM) and B-cell malignancies. Cytomegalovirus (CMV) infection has been reported as a potential complication of unclear clinical magnitude. METHODS: We conducted a retrospective study of MM patients treated with BsAbs at our institution (2020-2025), alongside a systematic review and meta-analysis of clinical trials and observational studies evaluating BsAbs for MM, B-cell lymphoma, and acute lymphoblastic leukemia. Study outcomes included clinically significant CMV infection (csCMVi), any CMV DNAemia, an

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… Each plot includes study names, effect sizes with confidence intervals, and study weights, with summary diamonds and heterogeneity statistics at the bottom of each panel. Red dashed lines indicate reference values for cumulative incidence. … Forest plot graphic with three panels labeled a, b, and c, each comparing cumulative incidence and effect size (ES) for studies grouped by routine versus no CMV DNAemia monitoring; panels represent csCMVi, any CMV DNAemia, and CMV disease, respectively, with summary diamonds, confidence intervals, and …

CAR-T Plus Radiotherapy: A Promising Combination for Immunosuppressive Tumors.

Radiotherapy (RT) is the standard-of-care treatment for more than half of cancer patients with localized tumors and is also used as palliative care to facilitate symptom relief in metastatic cancers. In addition, RT can alter the immunosuppressive tumor microenvironment (TME) of solid tumors to augment the anti-tumor immune response of immune checkpoint blockade (ICB). The rationale of this combination therapy can also be extended to other forms of immunotherapy, such as chimeric antigen receptor T cell (CAR-T) therapy. Similar to ICB, the efficacy of CAR-T therapy is also significantly impact

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… Cancer Immunol Immunother ( 2014 ) 63 ( 3 ): 259–71 . doi: 10.1007/s00262-013-1506-7 PMC3944132 24357146 18 Vanpouille-Box C Alard A Aryankalayil MJ Sarfraz Y Diamond JM Schneider RJ . DNA Exonuclease Trex1 Regulates Radiotherapy-Induced Tumour Immunogenicity . … Nat Rev Clin Oncol ( 2021 ) 18 ( 1 ): 9 – 34 . doi: 10.1038/s41571-020-0403-1 32710082 PMC9721352 100 Vanpouille-Box C Diamond JM Pilones KA Zavadil J Babb JS Formenti SC . TGFbeta Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity . …

How we manage smoldering multiple myeloma.

Smoldering myeloma (SMM) is an asymptomatic stage characterized by bone marrow plasma cells infiltration between 10-60% in absence of myeloma-defining events and organ damage. Until the revision of criteria of MM to require treatment, two main prognostic models, not overlapping each other, were proposed and used differently in Europe and in US. Novel manageable drugs, like lenalidomide and monoclonal antibodies, with high efficacy and limited toxicity, improvement in imaging and prognostication, challenge physicians to offer early treatment to highrisk SMM. Taking advantage from the debates of

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… Golombick T Diamond TH Manoharan A Ramakrishna R. … Golombick T Diamond TH Manoharan A Ramakrishna R. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebocontrolled cross-over 4g study and an open-label 8g extension study . …

Определение биологических границ монотерапии Daratumumumab: долгосрочные исследования из исследования CENTAURUS по множественной миеломе, вызывающей повышенный риск.

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… Blood 2024 ; 144 : 773 . 10.1182/blood-2024-201057 14 Landgren O Diamond B Pandey A A phase 2 trial of teclistamab plus daratumumab combination therapy for high-risk smoldering multiple myeloma: first pre-planned analysis (the REVIVE Study). …

The Rates of Cement Leakage Following Vertebroplasty in Osteoporotic versus Metastatic Disease.

Introduction Percutaneous vertebroplasty is used for symptomatic osteoporotic fractures and osteolytic neoplasms. We performed a retrospective study to analyze the pattern of leaks in the two cohorts. Material and Methods Vertebroplasties performed over a 7-year period at a tertiary orthopaedic center were included in the study and divided into osteoporotic and neoplastic groups. The incidence and pattern of cement leaks in each group were documented and analyzed. Results There were 75 leaks of a cohort of 211 vertebroplasties with a relatively equal proportion in osteoporotic and neoplastic g

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… Diamond T H, Champion B, Clark W A. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med. 2003;114(04):257–265. doi: 10.1016/s0002-9343(02)01524-3. 4. Garfin S R, Yuan H A, Reiley M A. …