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Sarcopenia, malnutrition, and fatigue in de Novo Parkinson's disease- support for early rehabilitation.

OBJECTIVE: Sarcopenia (loss of muscle strength/mass) reduces physical performance (walking, strength, mobility) and is common in Parkinson's disease (PD), but data on newly diagnosed, untreated patients ("de novo") are scarce. Fatigue is frequent in PD and linked to physical decline and malnutrition, key sarcopenia risk factors. We aimed to describe sarcopenia prevalence, malnutrition risk, and fatigue in de novo PD and explore differences based on fatigue presence. METHODS: Participants (n = 49) underwent physical tests [chair stand test (CST), hand grip strength, gait speed, Timed Up and Go…

Marginal Gap Distance and Dynamic Fatigue Performance of Esthetic Crowns for Primary Teeth.

BACKGROUND: The growing demand for esthetic restorative materials highlights the need to evaluate their marginal accuracy and fracture resistance to ensure optimal clinical outcomes for primary molars. AIM: The aim was to assess the vertical marginal gap distance and fracture resistance of esthetic restorative materials after cyclic loading. DESIGN: Forty extracted primary molars were randomly divided into four groups: Group I, stainless steel veneered crowns with tooth-colored material; Group II, prefabricated monolithic zirconia crowns; Group III, yttria-partially stabilized zirconia compu

Crack Propagation by Activated Avalanches during Creep and Fatigue from Elastic Interface Theory.

The growth of cracks combines materials science, fracture mechanics, and statistical physics. The importance of fluctuations in the crack velocity is fundamental since it signals that the crack overcomes local barriers such as tough spots by avalanches. In ductile materials the omnipresent plasticity close to the crack tip influences the growth by history effects, which we here study in polymethylmetacrylate by various fatigue and creep protocols. We show how the crack tip local history may be encompassed in a time- and protocol-dependent length scale, which allows us to apply a statistical fr…

Fatigue Properties and Degradation of Cured Epoxy Adhesives Under Water and Air Environments.

In this study, specimens cured with an epoxy adhesive were subjected to fatigue tests, which were conducted under air and water atmospheres at room temperature, because few studies have been conducted on the deformation behavior versus time (number of cycles) of the combined degradation due to moisture and cyclic stress. The epoxy adhesive was cured into plates and then cut into dumbbell-shaped specimens. Micro surface cracks were introduced into the specimen surfaces. The fatigue limit of smooth specimens without cracks in water improved compared to that in air. However, when a pre-crack was …

Wuwei Ganlu counters exercise-induced fatigue via mitochondrial reinforcement and redox-inflammatory modulation.

ETHNOPHARMACOLOGICAL RELEVANCE: Wuwei Ganlu is a Tibetan medicated-bath formula, and traditionally applied for limb stiffness, "yellow-water" effusion, and joint swelling. However, its efficacy against exercise-induced fatigue and mechanisms remain unclear. AIM OF THE STUDY: This study evaluated the anti-fatigue activity of WGL and explored mitochondrial and redox-inflammatory mechanisms. MATERIALS AND METHODS: UPLC-Q-Orbitrap-MS/MS was used to analyze the constituents of WGL. Network pharmacology prioritized mitochondrial and inflammatory hubs. Docking tested ligand-target feasibility. Kunm…

More Than Pain and Stiffness: Persistent Fatigue and Sleep Disturbance in Polymyalgia Rheumatica.

OBJECTIVE: We aimed to examine fatigue and sleep disturbance in patients with recently diagnosed polymyalgia rheumatica (PMR) compared to age- and gender-matched controls, including associated characteristics and change over an 18-month follow-up period. METHODS: Patients meeting the 2012 European Alliance of Associations for Rheumatology/American College of Rheumatology classification criteria for PMR were prospectively recruited, together with matched controls. Assessments were undertaken 3 months after the commencement of glucocorticoids and again 18 months later. Fatigue was quantified us…

Brainstem atrophy is associated with fatigue in myelin oligodendrocyte glycoprotein antibody-associated disease.

BACKGROUND: Fatigue is a common symptom in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), but its underlying mechanisms are not well understood. OBJECTIVE: To investigate MRI volumetric changes associated with fatigue in MOGAD patients. METHODS: Forty-three MOGAD patients and 29 healthy controls (HC) were recruited from January 2020 to December 2022. Brain volumes, including the brainstem and its subregions (midbrain, superior cerebellar peduncle [SCP], pons, and medulla), were analyzed using FreeSurfer v7.1. Volumetric measures were compared between groups, adjuste…

Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank.

BACKGROUND: Progress in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) research is being slowed by the relatively small-scale studies being performed whose results are often not replicated. Progress could be accelerated by analyses of large population-scale projects, such as UK Biobank (UKB), which provide extensive phenotype and genotype data linked to both ME/CFS cases and controls. METHODS: Here, we analysed the overlap and discordance among four UKB-defined ME/CFS cohorts, and additional questionnaire data when available. RESULTS: A total of 5,354 UKB individuals were linked…

Does quadriceps contractile fatigue influence rehabilitation outcomes in COPD-chronic respiratory failure patients?

BACKGROUND: In patients with moderate COPD, response to pulmonary rehabilitation including exercise training varies according to the presence of peripheral muscle fatigue (pMF) of quadriceps. This study investigates the role of pMF in predicting pulmonary rehabilitation outcomes in more severe COPD patients who have already developed chronic respiratory failure (COPD-CRF). METHODS: A post hoc analysis of a prospective randomised controlled trial was performed at Istituti Clinici Scientifici Maugeri Lumezzane (Brescia, Italy), involving 30 COPD-CRF patients undergoing a pulmonary rehabilitatio…

Postural sway in multiple sclerosis patients: interaction of vision, surface, and fatigue effects.

INTRODUCTION: Postural control impairments are common in patients with multiple sclerosis (MS), resulting in postural instability and increased fall risk. Sensory inputs are crucial to maintain balance adequately. Additionally, fatigue is one of the common and most disabling symptoms of MS, possibly contributing to postural deficits. Previous studies have examined the effects of fatigue and altered sensory conditions on postural control in patients with MS. The present study aimed to extend this knowledge by jointly assessing these factors within the same experimental framework, providing addi…

Дифференциальный утомительный профиль у пациентов с постковидным состоянием, Фибромиалгией и множественным склерозом.

Фон/цели: Усталость является распространенным и изнурительным симптомом в состоянии после COVID (PCC), фибромиалгии и множественном склерозе (MS). Хотя эти условия имеют клиническое сходство, основополагающие механизмы усталости в этих условиях могут различаться и оставаться недостаточно понятными. Цель этого исследования заключалась в сопоставлении интенсивности и характеристик усталости в этих трех условиях для выявления общих и отличительных особенностей. Методы: Мы провели перекрестное исследование, в котором приняли участие 429 человек: 219 человек с ПХК, 112 человек с фибромиалгией и 98

Совпадение в аннотации оригинала
Background/Objectives: Fatigue is a prevalent and debilitating symptom in Post-COVID Condition (PCC), fibromyalgia, and multiple sclerosis (MS). Although these conditions share clinical similarities, the underlying mechanisms of fatigue across these conditions may differ and remain poorly understood. This study aimed to compare the intensity and characterist…

Глубокий секвенирование тяжелых цепных репертуаров в миальгическом энцефаломиелите/хроническом синдроме усталости.

Myalgic ensphalomyelit/хронический синдром усталости (ME/CFS) является распространенным и изнурительным хроническим заболеванием неизвестной аэтологии. Реагирование на хроническую инфекцию и аутоиммунную реакцию было предложено в качестве двух механизмов, которые потенциально лежат в основе патогенеза МЕ/КФС. Чтобы изучить эти гипотезы болезни, мы описали антигенные рецепторы клеток В с помощью адаптивной последовательности репертуарных репертуаров иммунного рецептора. Мы сравнили репертуары B-клектора (BCR) 25 пациентов с мягким/умеренным ME/CFS, 36 пациентов с тяжелым ME/CFS, 21 здоровый кон

Совпадение в аннотации оригинала
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common and debilitating chronic illness of unknown aetiology. Chronic infection and autoimmune responses have been proposed as two mechanisms that potentially underlie the pathogenesis of ME/CFS. To explore these disease hypotheses, we characterised the antigen-specific receptors of B cells usi…

Fatigue-induced changes in electromyographic activity after repeated racing turns: a pilot study.

PURPOSE: Alpine skiing races are physically demanding events characterized by numerous repeated near-maximal activations of the lower limb muscles. Although this type of task is known to induce neuromuscular fatigue, electromyographic activity (EMG) adaptations after repeated maximal-intensity skiing have not been previously investigated. METHODS: Six skiers completed a 6-turns section with (FAT) and without performing 30 giant slalom (GS) turns (CONT). Isometric knee extensors maximal force (Fmax) was measured before and immediately after both conditions. On-snow EMG activity of VM, VL, RF, …

Research on brain functional network property analysis and recognition methods targeting brain fatigue.

At present, researches on brain fatigue recognition are still in the stage of single task and simple brain region network features, while researches on high-order brain functional network features and brain region state mechanisms during fatigue in multi-task scenarios are still insufficient, making it difficult to meet the needs of fatigue recognition under complex conditions. Therefore, this study utilized functional near-infrared spectroscopy (fNIRS) technology to explore the correlation and differences in the low-order and high-order brain functional network attributes of three task induce…

Increased risk of chronic fatigue syndrome following pneumonia: A population-based Cohort study.

BACKGROUND: Chronic fatigue syndrome (CFS) has been linked to several conditions, including infections, immune system changes, or emotional stress. Our study aimed to assess the risk of CFS after a pneumonia diagnosis using data from National Health Insurance Research Database of Taiwan. METHODS: In this nested case-control study, we identified 2,000,000 adult patients from a nationwide population-based health insurance claims database spanning from January 1, 2000, to December 31, 2017. Each case diagnosed with a pathogenic infection was matched with a corresponding control using propensity …

Shenling Baizhu San alleviates central fatigue through SIRT1-PGC-1α-Mediated mitochondrial biogenesis.

ETHNOPHARMACOLOGICAL RELEVANCE: Shenling Baizhu San (SLBZS) is a Traditional Chinese Medicine (TCM) formula composed of 10 medicinal herbs, historically used to strengthen the spleen, replenish qi, and alleviate fatigue-related symptoms. SLBZS originates from the 'Taiping Huimin Heji Ju Fang' of the Song Dynasty. Central fatigue (CF), a subtype of fatigue, is considered in TCM to be closely associated with spleen deficiency. However, there is currently a lack of research on SLBZS's therapeutic effects on CF and the pharmacological mechanisms underlying its potential benefits. AIM OF THE STUDY…

Personality Traits and Self-Reported Vocal Fatigue and Other Voice Measures Among Teachers.

BACKGROUND: Previous research has examined the correlation between certain personality traits and specific voice disorders. These studies indicated that a predictive relationship exists between an individual's personality and their likelihood of experiencing certain types of voice disorders. The personality type classified as "extravert" was most commonly correlated with voice problems associated with high vocal use such as inflammation or nodules. AIM: The purpose of this study was to determine if a relationship exists between self-reported vocal fatigue, demographic characteristics, such as…

Client Perceptions of the Individual Packer Managing Fatigue Program: A Mixed-Method Evaluation.

Fatigue is common, but under-recognized in Parkinson's disease (PD), with limited treatment options. The aim of this study is to explore the experience of people with PD (PwPD) regarding content and delivery of the individual Packer Managing Fatigue program. This mixed-method study (n = 12) was conducted concurrently with a pilot randomized controlled trial. Data were collected using questionnaires, interviews, and focus groups. Five themes emerged: the program is helpful; the program has strengths; areas for improvement; individual online delivery is feasible; and more support from occupation…