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[A NEW MULTIPLE SCLEROSIS DIAGNOSIS IN A PATIENT WITH INTERMEDIATE UVEITIS].

Uveitis is a group of about 30 intra-ocular inflammatory diseases; multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central nervous system (CNS). Intermediate uveitis has been reported to be the most common type of uveitis in association with MS. The mechanism associating MS and uveitis is not clear, but previous data suggest a genetic predisposition may play a role. In addition, MS patients presenting with uveitis prior to the onset of neurological symptoms tend to demonstrate a milder form of the disease with moderate progression. This observation may be attr…

Роль мозжечка в множестве проблем со склерозом и инвалидностью.

Фон: Усталость является распространенным и изнурительным симптомом у людей с множественным склерозом (PwMS), что существенно снижает качество жизни. В то время как мозжечок традиционно ассоциируется с управлением мотором, появляющиеся данные указывают на его участие в когнитивных, эмоциональных и интеграционных функциях. Цель этого исследования заключалась в изучении взаимосвязи между компонентами усталости (физической, когнитивной и психосоциальной), клинической инвалидностью и мозговыми структурными изменениями в ПМС, полученными с помощью магнитного резонансного изображения (MRI). Методы: У

Совпадение в аннотации оригинала
Background: Fatigue is a prevalent and debilitating symptom in people with multiple sclerosis (pwMS), significantly impairing quality of life. While the cerebellum is traditionally associated with motor control, emerging evidence suggests its involvement in cognitive, emotional, and integrative functions. This study aimed to explore the relationship between …

Джанкарло Коми: наследие в неврологии и многочисленных склерозовых исследованиях.

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… He was one of those physicians who made a lasting impact on multiple sclerosis (MS) research and treatment. He authored over 1,000 scientific papers published in prestigious international journals, edited several scientific books, and had an h-index of 100. … Professor Comi also championed the Patient-Reported Outcome for Multiple Sclerosis (PROMS) initiative at the 35th ECTRIMS Congress, emphasizing the importance of patient-reported outcomes in MS research and care. …

Роль CD20+T клеток в раннем множественном склерозе.

Релапсирующий множественный склероз (RRMS) — хроническое иммунное заболевание центральной нервной системы (CNS), характеризующееся эпизодическими рецидивами неврологических симптомов. Ранняя диагностика и лечение пациентов имеют ключевое значение для предотвращения рецидивов и необратимого ущерба для ЦНС. Вместе с тем развитие методов лечения, ориентированных на ранние МЗ, сдерживается отсутствием знаний о патогенезе ранней МЗ. В RRMS повреждение нервной ткани вызывается иммунными клетками CNS, в том числе Т. Таким образом, цель этого исследования заключалась в изучении ранних случаев инфильтр

Совпадение в аннотации оригинала
Relapsing-remitting multiple sclerosis (RRMS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by episodic relapses of neurological symptoms. Early diagnosis and treatment of patients is key to prevent relapses and irreversible damage to the CNS. However, development of therapies targeting early MS is constrained by the …

Когнитивный резерв при множественном склерозе: роль депрессии и усталости.

В ряде докладов указывается, что когнитивный резерв (CR) может защитить от когнитивных нарушений в MS. Усталость и депрессия широко распространены в MS. Однако их влияние на участие в деятельности, направленной на создание ЧР, остается неясным. ЦЕЛИ: Данное исследование было направлено на обеспечение более глубокого понимания понятия CR-building в MS, путем изучения того, как CR отличается у людей с MS (pwMS) по сравнению с неврологическими здоровыми людьми, а также путем изучения того, как распространенные симптомы MS взаимодействуют с CR-building. В общей сложности в этом перекрестном исслед

Совпадение в полном тексте источника
… Supplemental Material sj-docx-1-msj-10.1177_13524585251338757 – Supplemental material for Cognitive reserve in multiple sclerosis: The role of depression and fatigue Supplemental material, sj-docx-1-msj-10.1177_13524585251338757 for Cognitive reserve in multiple sclerosis: The role of depression and … fatigue by Clara Stein, Fiadhnait O’Keeffe, Méadhbh Brosnan, Claire Flynn, Christopher McGuigan and Jessica Bramham in Multiple Sclerosis Journal …

Инфекция, релапсы и псево-релапсы у лиц с множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Инфекции связаны с повышенным риском рецидива и псевдовоспламенения у лиц с множественным склерозом (МС). Вместе с тем связь с рецидивами и псевдоотзывами после SARS-CoV-2 Инфекции (COVID) по сравнению с другими инфекциями в MS плохо понимаются. Поэтому мы сравнили случаи рецидива и псевдовосхода после COVID и других инфекций с неинфицированными участниками с MS. МЕТОДЫ: весна 2023, мы опросили участников Североамериканского исследовательского комитета по регистрации множественных склерозов на предмет того, были ли у них инфекция COVID, другие инфекции, рецидивы и

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Infections are associated with an increased risk of relapse and pseudo-relapse in persons with multiple sclerosis (MS). However, the relationship with relapses and pseudo-relapses after SARS-CoV-2 infections (COVID) vs other infections in MS is poorly understood. Therefore, we compared the occurrence of relapse and pseudo-relapse a…

Analysis of Evusheld safety and efficacy in multiple sclerosis patients.

BACKGROUND: In December 2021, the U.S. Food and Drug Administration issued emergency use authorization for the combination monoclonal antibodies tixagevimab and cilgavimab (Evusheld - AstraZeneca) for COVID-19 pre-exposure prophylaxis. While COVID-19 vaccination is recommended for multiple sclerosis (MS) patients, there is concern for insufficient antibody response in patients receiving B-cell depleting therapies. The literature is sparse regarding the safety and efficacy of Evusheld use in MS patients. OBJECTIVE: We sought to investigate the administration, safety, and efficacy of Evusheld i…

Genetic variants of folate metabolism and the risk of multiple sclerosis.

BACKGROUND AND AIMS: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown cause. Alterations in one-carbon metabolism have impact in the pathophysiology by genetic susceptibility to MS and increased the risk of MS. The aim of this study was to investigate the contribution of the gene polymorphism on Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR), Methionine Synthase (MTR) enzymes and of the essential factors (homocysteine, Hcy; cysteine, Cys; and vitamin B12, VitB12) in folate metabolism. METHODS: Eligible …

Biomarkers of response to ocrelizumab in relapsing-remitting multiple sclerosis.

OBJECTIVE: To ascertain the changes of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) values in relapsing-remitting multiple sclerosis (RRMS) patients treated with ocrelizumab and their association with treatment response. METHODS: Multicenter prospective study including 115 RRMS patients initiating ocrelizumab treatment between February 2020 and March 2022 followed during a year. Serum samples were collected at baseline and every 3 months to measure sNfL and sGFAP levels using single-molecule array (SIMOA) technology. Based on age and body mass index, sNfL…

Multiple sclerosis in a patient with Takayasu's Arteritis: A case report.

BACKGROUND: Multiple sclerosis (MS) and Takayasu's arteritis (TAK) are two autoimmune diseases that affect the Central nervous system (CNS), but the relationship between them has not been established. CASE PRESENTATION: Here we report the emergence of MS during treatment. Takayasu's arteritis in a 24-year-old Iranian woman with a severe presentation. She was treated aggressively with IV methylprednisolone 1 g/day for 3 days and continued with oral prednisolone, also IV cyclophosphamide monthly. After 2 months, loss of vision led to a diagnosis of Optic neuritis (ON) caused by concomitant MS. …

Sleep and cognitive outcomes in multiple sclerosis; a systematic review.

BackgroundMultiple sclerosis (MS) is a disabling disease of the central nervous system. People living with MS often have co-existing sleep disorders and cognitive dysfunction. The objective of this study was to scrutinize the relationship between cognitive outcomes and sleep conditions in MS.MethodsThis study followed the Joanna Briggs Institute's (JBI) and PRISMA guidelines. PubMed, Scopus, Embase, and Web of Science databases were searched and original studies delineating the relationship between sleep status and cognitive findings in MS patients‌ were included. The risk of bias was assessed…

Screening for dysphagia in patients with relapsing-remitting multiple sclerosis.

BACKGROUND: In multiple sclerosis (MS), dysphagia is an important and common clinical symptom. Although often overlooked and underdiagnosed, it can have a significant impact on a patient's life, including social integration, and it can lead to malnutrition, aspiration pneumonia, and suffocation, i.e., life-threatening complications. Early detection of dysphagia is essential to prevent these risks. However, the optimal screening method and the inter-relationship between different methods used for dysphagia screening are not clear. The aim of this study was to compare the diagnostic performance …

Establishment of the Diagnostic Signature of Ferroptosis Genes in Multiple Sclerosis.

Ferroptosis is a novel form of membrane-dependent cell death that differs from other cell death modalities such as necrosis, apoptosis, and autophagy. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system primarily affecting brain and spinal cord neurons. Although the pathogenesis of these two conditions may seem unrelated, recent studies have indicated a connection between ferroptosis and multiple sclerosis. In fact, ferroptosis plays a significant role in the development of MS, as evidenced by the presence of elevated iron levels and iron metabolism abnormal…

A review of Bruton's tyrosine kinase inhibitors in multiple sclerosis.

Bruton's tyrosine kinase (BTK) inhibitors are an emerging class of therapeutics in multiple sclerosis (MS). BTK is expressed in B-cells and myeloid cells, key progenitors of which include dendritic cells, microglia and macrophages, integral effectors of MS pathogenesis, along with mast cells, establishing the relevance of BTK inhibitors to diverse autoimmune conditions. First-generation BTK inhibitors are currently utilized in the treatment of B-cell malignancies and show efficacy in B-cell modulation. B-cell depleting therapies have shown success as disease-modifying treatments (DMTs) in MS, …

[Optical coherence tomography angiography in the diagnosis of multiple sclerosis].

PURPOSE: This study analyzes the main changes in retinal microcirculation in patients with multiple sclerosis (MS) and their relationship with the type of disease course. MATERIAL AND METHODS: 159 patients (318 eyes) were examined. The groups were formed according to the type of course and duration of MS: group 1 - 37 patients (74 eyes; 23.27%) with relapsing-remitting MS (RRMS) less than 1 year; group 2 - 47 patients (94 eyes; 29.56%) with RRMS from 1 year to 10 years; group 3 - 44 patients (86 eyes; 27.05%) with RRMS >10 years; group 4 - 32 patients (64 eyes; 20.12%) with secondary progress…

Impact of sex on clinical outcome in early Multiple Sclerosis.

BACKGROUND: Previous evidence suggests sex differences in the clinical course of relapsing remitting multiple sclerosis (RRMS), but comprehensive early-stage prospective studies are lacking. We aim to quantify the impact of sex on clinical outcomes in early-stage RRMS. METHODS: Utilizing prospective cohort data, we assessed the impact of biological sex on time-to-relapse, disability progression (Expanded Disability Status Scale [EDSS]), extremity function (Nine-Hole Peg Test, Timed-25-food walk test), cognition (Paced Auditory Serial Addition Test, Symbol Digit Modalities Test), quality-of-li…

Characteristics and predictors of sexual dysfunction in men with multiple sclerosis.

PURPOSE: To validate and culturally adapt the Sexual Health Inventory for Men (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), to compare the frequency and severity of erectile dysfunction (ED) and premature ejaculation (PE) in male individuals with MS (mwMS) in comparison with healthy controls (HC) and to investigate predictors of the severity of ED and PE in mwMS. METHODS: 216 consecutive mwMS and 37 HC completed IIEF-5 and PEDT. Additionally, 114 mwMS completed the Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI-2), Composite Autonomic System Score-31 (CO

A Case of Primary Biliary Cholangitis in a Patient With Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease that causes demyelination in the brain and spinal cord, leading to significant neurological disability in young adults. Patients with MS are predisposed to other autoimmune disorders, though the co-occurrence of MS and primary biliary cholangitis (PBC) is rare. PBC is an autoimmune liver disease that affects bile ducts, leading to cholestasis and liver cirrhosis, predominantly in women aged over 40 years. We report the case of an 81-year-old woman with a history of MS and hypertension, bedridden for 10 years, who was admitted with a sev…