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Predictors of Anxiety Trajectories in Cohort of First-Year College Students.

OBJECTIVE: The transition to college is a period of growth and vulnerability for young adult health and well-being and provides a critical w … were significant predictors of anxiety symptoms. Third, the personality traits of extraversion and neuroticism were significant predictors of anxiety symptoms. Fourth, perceived sleep duration, quality, and satisfaction were significant predictors of anxiety symptoms. Fifth, sleep duration estimates collected by a biometric wearable were also a significant p …

[Pain and depression: cognitive and behavioural mediators of a frequent association].

LITERATURE FINDINGS: The comorbidity between chronic pain and depression is high: in the general population setting, the odds ratio for suff … hardiness or internal locus of control play a protective role on these evaluations, whereas others (neuroticism, negative affectivity or external locus of control) are risk factors for depression. Low perceived social support is also related to depression. On the contrary, self-efficiency is linked with low levels of depression. Self-management therapies focu …

Physical modalities in chronic pain management.

The following conclusions can be made based on review of the evidence: There is limited but positive evidence that select physical modalitie … lude depression, high trait anxiety, a powerful others locus of control, obesity, narcotic use, and neuroticism. The effect on pain by various modalities is generally strongest in the short-term period immediately after the intervention series, but effects can last as long as 1 year after treatment (e.g., with massage). Most research has tested the effect of …

Transnational information brokerage and migration chains among Nigerian health workers in Canada and Nigeria.

Burn injury is often a devastating event with long-term physical and psychosocial effects. Burn scars after deep dermal injury are cosmetica … bles such as low social support, emotion and avoidant coping styles, and personality traits such as neuroticism and low extraversion, negatively affect adjustment after burn injury. Few studies of psychological treatments in burn patients are available. From general trauma literature, it is concluded that cognitive (behavioral) and pharmacological (selective …

Oestrogen therapy and the menopausal syndrome.

Sixty-four patients with severe menopausal symptoms completed a four month double-blind placebo trial with conjugated equine oestrogens (pre … ssion), the General Health Questionnaire and the Eysenck Personality Index (formula: see text) (for neuroticism). We observed a highly significant placebo effect extending for six months in all three, the improvement with premarin over placebo being non-significant. We must conclude that these tests are not sufficiently sensitive to assess psychological or sy …

TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder.

Evidence suggests that depression is a risk factor for dementia; however, the relationship between the two conditions is not fully understood. A novel gene (TOMM40) has been consistently associated with Alzheimer's disease (AD), but has received no attention in depression. We conducted a three-level cross-sectional study to investigate the association of the TOMM40 rs2075650 SNP with depression. We recruited a community sample of 1220 participants (571 controls, 649 lifetime depression) to complete a psychiatric background questionnaire, the Brief Symptom Inventory, and Big Five Inventory at L

Prevalence and risk factors of loneliness among patients with hematological malignancies.

To identify independent factors for predicting loneliness in patients with hematological malignancies. It is an observational cross-sectional study. 157 patients with hematologic malignancies were enrolled between March 2020 and May 2020. The sociodemographic characteristics and psychometric properties (coping styles, self-esteem, big 5 personality traits, and hope) were tested for correlation with loneliness. Multivariate hierarchical regression analysis was then utilized to identify independent risk factors for loneliness. The patients exhibited a mean global score of 36.25 that corresponded

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… The big 5 personality test describes 5 main dimensions of personality: extraversion (also referred to as extroversion), agreeableness, openness, conscientiousness, and neuroticism. … Of the 5 dimensions, including extraversion, agreeableness, conscientiousness, neuroticism, and openness, the highest score was identified for agreeableness (mean score, 3.93; SD, 0.46), while the lowest score was observed for neuroticism (mean score, 2.59; SD, 0.6). …

Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis.

Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) analyses is generally performed in bulk post-mortem adult tissue. However, genetic risk loci are enriched in regulatory elements active during neocortical differentiation, and regulatory effects of risk variants may be masked by heterogeneity in bulk tissue. Here, we map e/sQTLs, and allele-specific expression in cultured cells representing two major developmental stages, primary human neural progenitors (

Mendelian randomization analysis of the causal relationship between allergic rhinitis and depression and underlying mediation mechanisms.

BACKGROUND: Epidemiological studies have documented an association between allergic rhinitis (AR) and depression (DE), but causal interpreta … activity ratio, light-intensity physical activity, moderate-to-vigorous activity, loneliness (LON), neuroticism (NEU), immunoglobulin E (IgE), interleukin-6, and fasting insulin-to estimate conditional effects. Pleiotropy and heterogeneity were assessed using MR-Egger intercepts, Cochran's Q and MR-PRESSO. RESULTS: Across 2 AR instrument sets and 2 depressio …

Progression of Transdiagnostic Stages From Childhood to Young Adulthood.

IMPORTANCE: Transdiagnostic clinical staging models for mental disorders are receiving increased attention. However, their underlying assump … g adulthood (1661 participants; weighted, 7466 participants; OR, 2.07; 95% CI, 1.07-4.01). Level of neuroticism in adolescence mediated 18% of the association between stage 1a in adolescence and stage 1b in young adulthood. CONCLUSIONS AND RELEVANCE: In this cohort study, young people with mental health problems meeting criteria for early clinical stages wer …

Psychological predictors of symptoms of urinary tract infection and bacteriuria in patients treated with clean intermittent catheterization: a prospective 7-year study.

OBJECTIVE: One of the major clinical problems in relation to clean intermittent catheterization (CIC) are symptoms of urinary tract infectio … ess (General Health Questionnaire; GHQ-28; Spielberger State-Trait Anxiety Inventory; STAI X-1) and neuroticism (Eysenck Personality Questionnaire; EPQ-N). The results from selected assessments done 7 years earlier were used to predict reported UTI and findings of bacteriuria in urine samples in 1995. RESULTS: Clinical UTI symptoms were reported by 35% of th …

Depressive symptoms and associated factors among obstetrics and gynecology first-year residents.

BACKGROUND: Medical training is a high-stress period, and residents in surgical specialties face elevated risk for depression due to demandi … increased depressive symptoms included history of depression, higher baseline depressive symptoms, neuroticism, a difficult early family environment, and not being in a committed relationship. Internship-related factors associated with worsening symptoms included fewer sleep hours, longer work hours, and reported medical errors. CONCLUSION: More than one-th …

Functional Somatic Disorders in Individuals With a History of Sexual Assault.

IMPORTANCE: An increasing number of sexual assaults (SAs) are reported. Prior studies show that SA is associated with functional somatic dis … sex, emotional distress, life adversity or trauma, subjective social status, somatic comorbidities, neuroticism, health anxiety, perceived stress, and self-efficacy. RESULTS: Among the 4229 adults (53.9% women; median age, 56 [IQR, 47-64] years) from the DanFunD cohort, SA was associated with incident FSD (RR, 1.69; 95% CI, 1.17-2.44), single-organ FSD (RR, …

Advances in neoadjuvant therapy for locally advanced head and neck squamous cell carcinoma (Review).

PURPOSE: Identifying factors that affect recovery or restoration of neurological function is a key goal of rehabilitation in neurology and o … -3 years earlier by perimetric visual field tests. RESULTS: Two NEO-FFI personality factors (lower neuroticism, higher conscientiousness) and the presence of physiological Flammer signs were associated with greater recovery as were individual items of the factors openness and agreeableness. Single NEO-FFI item analysis revealed that recovery relates to great …

The self-medication behaviors of residents and the factors related to the consideration of drug efficacy and safety-A cross-sectional study in China.

Background: Over-the-counter (OTC) drugs facilitates residents self-medication. However, inappropriate self-medications have become a seriou … ercial medical insurance, free medical treatment to cover their medical cost, respondents with high neuroticism, high health literacy were more likely to consider drug safety as an important factor (p < 0.05). Eastern respondents, employed, main way of medical expenses borne was Out-of-pocket Payment, those with chronic disease were more likely to consider dr …

The impact of early life stress on psychophysiological, personality and behavioral measures in 740 non-clinical subjects.

Early Life Stress (ELS) has been associated with a range of adverse outcomes in adults, including abnormalities in electrical brain activity … asures of personality revealed that subjects who experienced ELS had significantly higher levels of neuroticism (F1,264=13.39, p=.000) and openness (F1,264=17.11, p=.000), but lower levels of conscientiousness, than controls (F1,264=4.08, p=.044). The number of ELS events experienced was shown to be a significant predictor of scores on the DASS questionnaire …

Comparative Efficacy and Acceptability of Transdiagnostic Psychotherapies for Emotional Disorders: Protocol for a Network Meta-Analysis of Randomized Controlled Trials.

BACKGROUND: Emotional disorders-primarily anxiety and unipolar depressive disorders-are highly prevalent, disabling, and frequently comorbid. Disorder‑specific cognitive behavioral therapy (DS‑CBT) is considered a gold standard treatment, yet it can be inefficient in the context of high comorbidity and service constraints. Transdiagnostic psychotherapies that target shared maintaining mechanisms (eg, emotion dysregulation and neuroticism) have been developed, including the Unified Protocol, transdiagnostic behavior therapy, emotion regulation therapy, and various transdiagnostic internet-deliv…

DRD4 Exon 3 Gene Polymorphisms in Patients Diagnosed with Polysubstance Use Disorder and Co-Occurrence of a Depressive Episode.

BACKGROUND: There has been a noticeable and systematic growth of the use of psychoactive substances over the past few decades. Dual diagnosi … teers showed significantly higher scores on both the STAI status and features scale and the NEO-FFI Neuroticism and Openness Scale, as well as lower scores on the Extraversion, Agreeableness, and Conscientiousness NEO-FFI scales. In the DRD4 exon 3 gene polymorphism, the s allele was more frequent in the PUD MDD compared to the l allele, which was less freque …

Stress and personality.

Stress is an adaptation reaction of living organisms in response to internal or external threats to homeostasis. It is considered as a compl … f situational factors and in connection with permanent personality and temperamental traits,such as neuroticism, extraversion, sense of humour, persistence, fatalism, conscientiousness, andopenness to experience. Positive affect has been associated with positive reappraisal (reframing) ofstressful situations, goal-directed problem-focused coping, using spirit …

Electrophysiological correlates of anxious rumination.

EEG coherence and EEG power response were recorded as 63 participants engaged in one of three experimental conditions: 'personal rumination' … uenced by rumination. This was largely in line with expectation. Also, mood state was influenced by neuroticism and state anxiety. Our EEG results are consistent with Gray and McNaughton's [Gray, J.A., McNaughton, N., 2000. The neuropsychology of Anxiety: An Anquiry into the Functions of the Septo-Hippocampal System. 2nd ed. Oxford University Press, Oxford.] …