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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.

BACKGROUND: Central post-stroke pain (CPSP) is a debilitating neuropathic condition that significantly impairs quality of life and is challenging to manage. Salvia miltiorrhiza (Danshen), a traditional Chinese herb, has demonstrated efficacy against neuropathic pain, but its active analgesic components and underlying mechanisms remain unclear. This study investigated the therapeutic potential of Danshenol B, an active component of Danshen, in a CPSP mouse model, focusing on its mechanism of action via the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)/N

Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy.

Cytokine release syndrome (CRS) embodies a mixture of clinical manifestations, including elevated circulating cytokine levels, acute systemic inflammatory symptoms and secondary organ dysfunction, which was first described in the context of acute graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation and was later observed in pandemics of influenza, SARS-CoV and COVID-19, immunotherapy of tumor, after chimeric antigen receptor T (CAR-T) therapy, and in monogenic disorders and autoimmune diseases. Particularly, severe CRS is a very significant and life-threatening co

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… genes (Sheih et al., 2020) 109 CAR-T cells | CRS recovery stage | Heterogeneity of CAR-T cells contributes to variations in efficacy and toxicity in LBCL (Deng et al., 2020) 164 COVID-19 PBMC | 76 COVID-19 patients and 69 healthy donors | Enhanced plasma levels of inflammatory mediators, including EN-RAGE … SARS-CoV-2: a storm is raging. J. Clin. Investig. 2020;130:2202–2205. doi: 10.1172/JCI137647. 5. Grupp SA, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 2013;368:1509–1518. doi: 10.1056/NEJMoa1215134. 6. Maude SL, et al. …

Роман CCL3-HMGB1 Ось сигнала регулирует выражение остеоцита РАНКЛ в множестве миеломы.

Множественная миелома (ММ) — клональная плазменная клетка, вызывающая изнурительное заболевание костей. Остеолитическое разрушение, которое является отличительной чертой MM, вызвано увеличением остеокластного числа и усилившейся ресорбцией костей, главным образом в результате чрезмерного производства RANKL, главного регулятора образования остеокласта, в пределах ниши опухоли. Ранее мы сообщали, что остеоциты, самые изобилие клеток в костной нише, поощряют прогрессию опухоли и поддерживают болезнь костей MM, перепроизводяя RANKL. Однако молекулярные механизмы, лежащие в основе регулирования РАН

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… This notion is supported by our observation of an increased prevalence in double RANKL + -HMGB1 + osteocytes in MM patients, and it is consistent with prior findings showing that extracellular HMGB1 binds to RAGE receptors in osteocytes and increases RANKL expression. 25 These results uncover a new regulatory …

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial.

Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessme

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… Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling Arch. Pharm. Res. 2018 41 655 663 10.1007/s12272-015-0662-z 26391026 51. Poetini M.R. Araujo S.M. de Paula M.T. Bortolotto V.C. …

[Cost-effectiveness analysis of schizophrenic patient care settings: impact of an atypical antipsychotic under long-acting injection formulation].

UNLABELLED: Schizophrenia is a disease affecting the young adults and amounts to approximately 300,000 people in France. The French public p … nce of a diabetes; these effects were not taken into account in the model, their impact on the cove-rage of schizophrenic patients and on resources utilisation being poorly known. Only direct medical costs were considered in the pharmaco-economic analysis. Two types of costs were identified: hospital costs and community care costs. The stays in overnig …

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.

Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host's immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal li

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… PD induced by ligatures around the maxillary second molars Treatment: treatment with subcutaneous injections of 0.5 ml of 0.78 mg/ml Etanercept or RAGE (intraperitoneal injections of 0.8 ml of 1.25 g/l ARA) 3 times a week for 5 weeks | Anti-TNF- α treatment has a positive impact on the subgingival microbial …

New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions.

Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affects various organs leading to a reduced quality of life. The condition often requires enduring immunosuppressive therapy, which can also lead to the development of severe side effects. Several approaches including small molecule inhibitors, antibodies, cytokines, and cellular therapies are now being developed for the treatment of cGvHD, and some of these therapies have been or are currently tested in clinical trials. In this review, we discuss these emerging therapi

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… In another murine model of liver fibrosis, nilotinib decreased TNF-α, TGF-β, receptor for advance glycation endproducts (RAGE), and high-mobility group box 1 protein (HMGB1) mRNA expression, decreased nitric oxide levels and increased glutathione peroxidase activity, with significant reduction of fibrosis … Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat. Chonnam Med J (2017) 53:118–26. 10.4068/cmj.2017.53.2.118 84. Chen GL, Carpenter PA, Broady R, Gregory TK, Johnston LJ, Storer BE, et al. …

Перенос Митохондрии для ремонта миелина.

Обезвоживание является общей характеристикой нейро-воспалительных и дегенеративных заболеваний центральной нервной системы (КНС), таких, как множественный склероз (МС). Часто это связано с нарушениями межклеточной связи, биоэнергетики и метаболического баланса в сочетании с митохондриальной дисфункцией в таких клетках, как олигодендроциты, нейроны, астроциты и микроглиа. Несмотря на то, что нынешние методы лечения MS сосредоточены на иммуномодуляции, они не могут остановить или обратить вспять прогресс демиэлизации. Последние достижения подчеркивают межклеточный митохондриальный обмен в качест

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… for coating cells or viruses, has improved the metabolic function of M2 type macrophages. 139 Additionally, simple modification of mitochondria with a sugar such as O-GlcNAcylation has been suggested to protect against mitochondria antiglycation, autophagy and oxidative stress stimulation via RAGE …

Флюидные биомаркеры в демиелионирующих синдромах: прошлое, настоящее и перспективы.

По-прежнему продолжается работа над диагностическим алгоритмом демиелионирующих расстройств центральной нервной системы, а также поиск идеальных биомаркеров. Так называемый "идеальный" биомаркер должен обеспечивать точное различие между наиболее распространенными демиелионирующими патологиями ЦНС и подтипами одной и той же патологии (например, переход от релапсирующего многоразового склероза к вторичному прогрессивному фенотипу). Достижения в области технологии способствовали проведению этого исследования, и в нижеследующих разделах мы всесторонне проанализируем большинство из них, охарактериз

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… endocrine manner [ 49 ]); however, at pathological concentrations—achieved secondary to astrocyte damage—it exerts neurotoxic effects through the release of inflammatory mediators, stimulation of microglia to produce nitric oxide (NO), and interaction with the receptor for advanced glycation end products (RAGE …

Perspectives of bereaved relatives of patients with haematological malignancies concerning preferred place of care and death: A qualitative study.

BACKGROUND: People with haematological malignancies have different end-of-life care patterns from those with other cancers and are more likely to die in hospital. Little is known about patient and relative preferences at this time and whether these are achieved. AIM: To explore the experiences and reflections of bereaved relatives of patients with leukaemia, lymphoma or myeloma, and examine (1) preferred place of care and death; (2) perceptions of factors influencing attainment of preferences; and (3) changes that could promote achievement of preferences. DESIGN: Qualitative interview study

Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to significant global health burden, including both acute infections and persistent post-acute sequelae, also known as Long COVID (LC) in survivors. While clinical management has reduced case-fatality rates, a substantial proportion of patients develop LC, a heterogeneous syndrome with long-term symptoms. This complex continuum requires therapeutic strategies for both the acute and chronic phases. Plasma proteomics has emerged as a powerful tool in precision medicin

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… Elevated RAGE levels in ICU patients requiring invasive ventilation indicate early alveolar injury [ 34 ]. Both RAGE and angiopoietin-2 (ANG-2) are associated with endothelial injury and progressive vascular damage affecting the lungs and kidneys. …

Воспаление и воспаление болезней, маркеры и посредники: роль КПИ в некоторых воспламенительных заболеваниях

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Alzheimer's Disease: Cellular and Pharmacological Aspects.

Alzheimer's disease was described more than 100 years ago and despite the fact that several molecules are being tested for its treatment, which are in phase III trials, the disease continues to progress. The main problem is that these molecules function properly in healthy neurons, while neuronal pathology includes plasma membrane disruption, malfunction of various organelles, and hyperphosphorylation of Tau and amyloid plaques. The main objective of this article is the discussion of a neuronal restoration therapy, where molecules designed for the treatment of Alzheimer's disease would probabl

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… Azeliragon is a receptor for advanced glycation endproducts (RAGE) inhibitor. Studies have shown that it can reduce amyloid plaques, and studies in Alzheimer’s patients at a dose of 5 mg/day have shown that treatment for 18 months improves mild to moderate cognitive impairment [ 41 ]. …

Metformin Increases Survival in Hypopharyngeal Cancer Patients with Diabetes Mellitus: Retrospective Cohort Study and Cell-Based Analysis.

Hypopharyngeal squamous cell carcinoma (HSCC) is usually diagnosed at an advanced stage, leading to a poor prognosis. Even after improvement of surgical techniques, chemotherapy, and radiation technology, the survival rate of HSCC remains poor. Metformin, which is commonly used for type 2 diabetes mellitus (DM), has been suggested to reduce the risk of various cancer types. However, only a few clinical studies mentioned the relationship between metformin use and HSCC. Hence, the aim of this study was to elucidate the specific effect and mechanism of action of metformin in hypopharyngeal cancer

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… Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation. Front. Immunol. 2019;10:109. doi: 10.3389/fimmu.2019.00109. 55. Chen Y.W., Huang M.Z., Chen C.L., Kuo C.Y., Yang C.Y., Chiang-Ni C., Chen Y.M., Hsieh C.M., Wu H.Y., Kuo M.L., et al. …

RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… ESCG‐O‐10 Decreased serum soluble rage concentrations correlate with the severity of histologic lesions in dogs with chronic inflammatory enteropathies A.I. Cabrera Garcia 1 , J. Suchodolski 2 , J.M. Steiner 2 , R.M. … In a pilot study, systemic concentrations of the decoy receptor sRAGE (soluble RAGE) were decreased in dogs with CIE and normalized only in those dogs with clinical remission after induction therapy. …

Exploring the Vasculitis-Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications.

This review systematically examines the association between vasculitis and malignancies by summarizing the risk of tumor-associated vasculitis, their clinical characteristics, and proposed pathogenic mechanisms across different vasculitic subtypes. Relevant case reports and mechanistic studies are integrated to provide a comprehensive overview of this entity. The findings offer practical value for rheumatologists in distinguishing primary vasculitis from malignancy-associated forms and optimizing patient surveillance, and for oncologists in improving recognition of tumor-associated vasculitis

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… H., et al., “Elevated Neutrophil Extracellular Traps by HBV‐mediated S100A9‐TLR4/RAGE‐ROS Cascade Facilitate the Growth and Metastasis of Hepatocellular Carcinoma,” Cancer Communications 43, no. 2 (2023): 225–245. 24. …

Progress in Biological Therapies for Adult-Onset Still's Disease.

Adult-onset Still's disease (AOSD) is a rare multifactorial autoinflammatory disorder of unknown etiology, characterized by an excessive release of cytokines triggered by dysregulated inflammation and articular and systemic manifestations. The clinical spectrum of AOSD ranges from self-limiting forms with mild symptoms to life-threatening cases and presents clinical and biological similarities with the juvenile form (sJIA). Nowadays, the advances in biologic agents no longer limit the treatment to NSAIDs, glucocorticoids, or conventional synthetic DMARDs. The blockade of IL-1 and IL-6 is effec

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… articular AOSD is principally driven by IL-6 and tumor necrosis factor (TNF)-α. 8 Several chemokines, including CXC-chemokine ligand 10 (CXCL10), CXCL13, and macrophage migration inhibitory factor (MIF)), the proteins S100 A8/A9 and A12 and the advanced glycation end products (AGEs) and their receptors (RAGE …

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy.

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are associated with several causes, including toxic agent exposure, among which the antineoplastic compounds are responsible for the so called Chemotherapy-Induced Peripheral Neuropathy (CIPN). Several clinical features are related to the use of anticancer drugs which exert their action by affecting different mechanisms and structures of the peripheral nervous system: the axons (axonopathy) or the dorsal root ganglia (DRG) ne

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… In contrast, other authors suggested that HMGB-1 from non-macrophage cells played a key role in the onset of OIPN, probably through the activation of TLR4, RAGE and CXCL12/CXCR4 signaling ( 42 ). …

Nano-formulations in disease therapy: designs, advances, challenges, and future directions.

Nano-formulations, as an innovative drug delivery system, offer distinct advantages in enhancing drug administration methods, improving bioavailability, promoting biodegradability, and enabling targeted delivery. By exploiting the unique size advantages of nano-formulations, therapeutic agents, including drugs, genes, and proteins, can be precisely reorganized at the microscale level. This modification not only facilitates the precise release of these agents but also significantly enhances their efficacy while minimizing adverse effects, thereby creating novel opportunities for treatment of a

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… PPTP was utilized to functionalize mesoporous silica NPs (MSN) encapsulating dexamethasone (Dex), while simultaneously condensing RAGE small interfering RNA (siRAGE) and serving as a gatekeeper for MSN to prevent premature leakage of Dex. … The excessive ROS generated during IR injury degraded PPTP, leading to the controlled release of siRAGE and Dex, thereby achieving effective silencing of RAGE and a synergistic anti-inflammatory effect. …

Natural Products as Anticancer Agents: Current Status and Future Perspectives.

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are cu

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… Similarly, Pterostilbene induces apoptosis, autophagy, S-phase cell cycle arrest, and inhibiting MDR1 expression via downregulation of RAGE/P13k/Akt pathways [ 38 ]. Epigallocatechin gallate induces G2/M cell cycle arrest and also suppresses MDR levels [ 39 ]. … Quercetin, a natural flavonoid, has been shown to facilitate cell death and chemosensitivity in pancreatic cells by RAGE/P13/AKT/mTOR axis [ 41 ]. Muthusamy et al. showed that ferulic acid reverses the P-gp mediated MDR by inhibiting P13K/AKT/Nf-kβ pathway in a tumor xenograft model [ 42 ]. 2.2. …