Результаты поиска

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

Совпадение в полном тексте источника
… The influx of Ca 2+ also triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum via IP 3 receptors and ryanodine receptors (RyR), which further increases the concentration of Ca 2+ in the cytoplasm. …

Invited Lectures : Overviews Purinergic signalling: past, present and future.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Bone targeted nano-drug and nano-delivery.

There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consisting of small organic molecules have a short circulation half-life and do not effectively reach the diseased tissue site. This coupled with repeatedly high dose usage that leads to severe side effects. With the advance in nanotechnology, drugs contained within a nano-delivery device or drugs aggregated into nanoparticles (nano-drugs) have shown promises in targeted drug delivery. The ability to design nanoparticles to target bone has attracted many researchers to develop n

Совпадение в полном тексте источника
… Through ryanodine receptors (RyR), excess Ca 2+ can be transferred from ER to endo-lysosomes to avoid ER stress. …

Translational Strategies to Target Metastatic Bone Disease.

Metastatic bone disease is a common and devastating complication to cancer, confounding treatments and recovery efforts and presenting a significant barrier to de-escalating the adverse outcomes associated with disease progression. Despite significant advances in the field, bone metastases remain presently incurable and contribute heavily to cancer-associated morbidity and mortality. Mechanisms associated with metastatic bone disease perpetuation and paralleled disruption of bone remodeling are highlighted to convey how they provide the foundation for therapeutic targets to stem disease escala

Совпадение в полном тексте источника
… Additionally, heightened release of TGF-β causes maladaptive modifications to the calcium (Ca 2+ )-channel regulators, the ryanodine receptors. Ultimately, Ca 2+ leakage across these channels reduces membrane voltage potential and decreases muscle strength [ 59 ]. …

Cyclic nucleotide phosphodiesterases as drug targets.

Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick return to the basal steady state levels. This often takes place in subcellular nanodomains. Thus, PDEs govern short-term protein phosphorylation, long-term protein expression, and even epigenetic mechanisms by modulating cyclic nucleotide levels

Совпадение в полном тексте источника
… Sensors targeted to plasma membrane nanodomains ( Perera et al, 2015 ; Bastug-Özel et al, 2019 ) and SR domains in close proximity to the ryanodine receptor ( Berisha et al, 2021 ) and SR Ca 2+ ATPase ( Sprenger et al, 2015 ) could reveal that cardiac hypertrophy and heart failure lead to a dramatic … PDE4D resides in a close spatial relationship to the type 2 ryanodine receptor (RyR2), and its disappearance increases RyR2 phosphorylation by PKA, resulting in increased Ca 2+ leakage from the SR prompting arrhythmias ( Lehnart et al, 2005 ). …

G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers.

G protein-coupled receptors (GPCRs) are the largest and most diverse class of membrane proteins, mediating cellular responses to a wide range of extracellular stimuli. GPCRs initiate complex intracellular signaling networks that regulate vital physiological functions and are associated with numerous diseases, including various types of cancer. Their conserved seven-transmembrane (7TM) structure enables these signaling networks by allowing interactions with multiple ligands and intracellular effectors. In several types of tumors, abnormal GPCR signaling promotes carcinogenesis by supporting imm

Совпадение в полном тексте источника
… PKA phosphorylates a variety of effectors in the heart, including voltage‐gated L‐type Ca2+ channels, troponin I, myosin‐binding protein‐C, phospholamban, and the cardiac RYR2 (ryanodine receptor) [ 73 ]. …

Management of patients with an electrical storm or clustered ventricular arrhythmias: a clinical consensus statement of the European Heart Rhythm Association of the ESC-endorsed by the Asia-Pacific Heart Rhythm Society, Heart Rhythm Society, and Latin-American Heart Rhythm Society.

Electrical storm (ES) is a state of electrical instability, manifesting as recurrent ventricular arrhythmias (VAs) over a short period of time (three or more episodes of sustained VA within 24 h, separated by at least 5 min, requiring termination by an intervention). The clinical presentation can vary, but ES is usually a cardiac emergency. Electrical storm mainly affects patients with structural or primary electrical heart disease, often with an implantable cardioverter-defibrillator (ICD). Management of ES requires a multi-faceted approach and the involvement of multi-disciplinary teams, but

Совпадение в полном тексте источника
… , with resulting prolongation in APD, whereas more sustained adrenergic stimulation (like during exercise) does not have such an effect due to the protective role of the intact countervailing I Ks current. 39 In CPVT, adrenergic stimulation plays an essential role in increasing calcium leak through ryanodine …

Physiological functions and pharmacological targeting of transient receptor potential channels.

Transient receptor potential (TRP) channels represent an extensive and diverse protein family fulfilling salient roles as versatile cellular sensors and effectors. The pivotal role of TRP and related ion channels in sensory processes has been well documented. Over the last few years, a new concept has emerged that TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions such as maintenance of body temperature, blood pressure, transmitter release from neurons, mineral and energy homeostasis, and reproduction. This notion is further supported by more than 20 he

61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Keywords Pancreatic cancer, HSP70, Immunotherapy, Stroma, Dendritic cells 009 Platelet deactivation ameliorates hepatic fibrosis by modulating inflammation, intrahepatic microbiome and reduces hepatic stellate cell activation via ryanodine-receptor-2 Adil Bhat , Sudrishti Chaudhary, Gaurav Yadav, … Multi-omics of APT identified decreases in expression of Ryanodine-receptor-2 (RyR2), Arginase-1 and Kynurenine-3-monooxygenase correlate with the reduction in α-SMA and degree of hepatic fibrosis (r2>0.75; p <0.05). …

Прогресс в развитии лекарственных средств на основе пептида: платформы для доставки, терапевтические средства и вакцины.

Успешное утверждение лекарств на основе пептида можно отнести на счет совместных усилий по целому ряду дисциплин. Интеграция новых методов разработки и синтеза лекарственных средств, отображение библиотечных технологий, систем доставки, достижений в области биоинженерии и искусственного интеллекта в значительной степени ускорила разработку новейших лекарств на основе пептида, эффективно устраняя препятствия, связанные с их характером, такие, как быстрое обезвреживание и деградация, необходимость субколичественной инъекции, ведущей к усилению дискомфорта пациентов, и в конечном итоге продвигая

Abstracts - IANCON 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

34th Европейский конгресс патологии - резюме.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Резюме докладов 51st Конференция Европейского общества генетики человека: плакаты

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.