Результаты поиска

Comparison of transjugular and transfemoral approaches for leadless pacemaker implantation in Asian patients: an exploratory study.

BACKGROUND: The transjugular approach has recently gained attention as a viable alternative for leadless pacemaker implantation. However, clinical data in Asian populations, who often present with smaller body size and vascular anatomy, remain limited. This study aimed to evaluate the safety and efficacy of the transjugular approach compared with the conventional transfemoral route in an Asian cohort. METHODS: We retrospectively analyzed 112 patients who underwent leadless pacemaker implantation between March 2021 and June 2025 at a single center. Patients were categorized by access route: tr…

Measurement Properties of English and Chinese Versions of HeartQoL in a Multiethnic Asian Cohort With Cardiovascular Disease.

OBJECTIVES: To evaluate the measurement properties of the HeartQoL questionnaire in assessing health-related quality of life (HRQoL) among multiethnic Asian patients with cardiovascular diseases (CVDs). METHODS: A cross-sectional survey was conducted among 556 CVD patients from 2 tertiary hospitals in Singapore. Patients self-assessed HRQoL using HeartQoL (a heart-disease-specific measure) and EuroQol 5-Dimension 5-Level (EQ-5D-5L) (a generic measure). HeartQoL includes a global scale and 2 subscales (physical and emotional), with higher values indicating better HRQoL. Measurement properties …

PROSPECTS FOR THE DEVELOPMENT OF TECHNOLOGY OF ADHESIVE FILMS WITH ASIAN MINT (MENTHA ASIATICA BORISS.) EXTRACT.

UNLABELLED: The results of the development, standardization and biological evaluation of an innovative two-layer mucoadhesive dental film containing Mentha asiatica Boriss. extract and lidocaine hydrochloride for the treatment of inflammatory diseases of the oral cavity are presented. MATERIALS AND METHODS: Ethanol extract of Mentha asiatica Boriss. was obtained by Soxhlet extraction followed by freeze-drying. The chemical composition was determined by GC-MS, which revealed 1,8-cineole oxide and piperitenone. The analytical method demonstrated high linearity (R²>0.995), sensitivity (LOD=0.01

Safety and Clinical Outcome of Subcutaneous Implantable Cardioverter-Defibrillators in an Asian Population: A Prospective Study.

BACKGROUND: There is limited data on long-term safety and efficacy of subcutaneous implantable cardioverter defibrillator (S-ICD) in Asian patients with a lower body mass index (BMI) due to smaller body build. METHODS: We performed a 2 year prospective study in 5 Asian cities from May 2017 to May 2018 to investigate the safety and feasibility of S-ICD for primary or secondary prevention of sudden cardiac death in an Asian population. RESULTS: We enrolled 75 S-ICD recipients (77% males; age 49.6 ± 16.8 years) with a mean BMI of 24.6 ± 5.0 (range 15.9-40.9) with 67% (50/75) with BMI ≤ 23. The …

Morphometric and Anatomical Analysis of the Deltoid Ligament Complex: A Cadaveric Study in the Southeast Asian Population.

Introduction The deltoid ligament complex (DLC) confers stability of the ankle joint. This study quantitatively analyzes the morphometry of the DLC in the Southeast Asian population, highlighting anatomical variations relevant to surgical procedures. Methodology Seven embalmed amputated limbs were dissected. The width and length of the superficial and deep layers with their corresponding bands were measured using a metric ruler. Results The mean width of the superficial layer of the DLC was 20.43 + 2.72 mm at the origin, 20.00 + 1.07 mm at midway, and 15.29 + 1.28 mm at insertion. The tibionav…

Urolithiasis Causes Osteoporosis in Asians: Genetic Evidence from Mendelian Randomization and Pathway Analysis.

BACKGROUND: It is an indisputable fact that patients with urolithiasis are prone to osteoporosis (OP), but the specific mechanism of their association is unclear. Previous studies have focused on the mediation of environmental factors such as diet; however, the potential of urolithiasis itself to induce OP remains uncertain. METHODS: In this study, we used data from the Japan BioBank (6638 urolithiasis and 7788 OP cases) to investigate the direct causal relationship and mechanism between urolithiasis and OP, applying Mendelian randomization, genetic correlation analysis, colocalization, and p

Evaluation of efficacy and safety for the energy delivery and skin tightness of monopolar radiofrequency device in Asian.

Monopolar radiofrequency(MRF) treatment is known to induce collagen contraction and remodeling in dermis. This study was conducted to evaluate safety of MRF in pre-clinical study first, and efficacy and safety in lifting and tightening of the face and upper neck in the clinical study. In pre-clinical setting, thermal imaging, and clinical and dermoscopic photography of after the procedure, and 7, 14, 30 days later were recorded. In clinical study, 23 subjects were enrolled and got 1 treatment. They were followed up at 4, 12, 24 weeks, and assessed using clinical photography. Changes in elastic

The L-Lift: A Novel Technique for Jawline Contouring Using Calcium Hydroxylapatite in Southeast Asians.

The aging process changes the youthful facial contour from heart-shaped to triangular. Lower face rejuvenation and jawline contouring procedures can help prevent or reduce these changes. Traditional approaches for lower face rejuvenation and jawline contouring include surgical facelifts; however, using less invasive procedures to achieve these outcomes is becoming increasingly popular. This article introduces the L-Lift, a novel technique for jawline contouring in Southeast Asians. The L-Lift involves administering sequential calcium hydroxylapatite injections along the lower border of the man…

Intraosseous Lipoma of the Maxillary Sinus: First Documented Case in an Asian Patient and Review of the Literature.

BACKGROUND: Intraosseous lipomas are extremely rare benign tumors composed of mature adipocytes, accounting for only 0.1% of all bone tumors. These lesions are particularly uncommon in the maxillofacial region, with only seven cases of intraosseous lipoma in the maxilla reported to date. This report presents the first documented case of an intraosseous lipoma located in the maxillary sinus of an Asian patient. CASE PRESENTATION: A 41-year-old female with a history of thalassemia minor presented with discomfort in the right maxillary sinus area. A computed tomography scan revealed a well-demar…

Более ранний возраст возникновения множественного склероза у азиатских пациентов в северо-восточной части Соединенных Штатов.

Клинический курс множественного склероза (MS) зависит от демографического состава пациентов, хотя в Соединенных Штатах (США) практически не проводится исследований по проблеме MS среди населения Азии. На сегодняшний день одно исследование, проведенное в США, показывает, что азиатские пациенты в США имеют более молодой возраст при возникновении симптомов и диагностике, а также более короткий период задержки с диагностированием по сравнению с неазиатскими пациентами. Ни одно исследование не сравнивало клинический курс MS у азиатских иммигрантов и пациентов, родившихся в США. ЦЕЛЬ: Настоящее иссл

Совпадение в аннотации оригинала
BACKGROUND: The clinical course of multiple sclerosis (MS) is influenced by patient demographics, though there is little research on MS in the Asian population in the United States (US). To date, one US-based study suggests that Asian patients in the US have a younger age at symptom onset and diagnosis, and a shorter lag time to diagnosis when compared to no…

A review of the epidemiology of invasive fungal infections in Asian patients with hematological malignancies (2011-2021).

The incidence of invasive fungal infection (IFI) is increasing, especially among patients diagnosed with hematological malignancies due to their immunocompromised nature. Other risk factors include advanced age, exposure to immunosuppressants, neutropenia, and catheter use. Some of the most common IFI organisms reported are Candida and Aspergillus species, and other fungal species, including Scedosporium, Trichosporon, Cryptococcus, and Fusarium have also increasingly been reported in the past years. However, the epidemiologic data on IFI among patients with hematological malignancies in Asian…

Amputation in patients with extremity soft tissue sarcoma: the experience of an East Asian referral center.

BACKGROUND: This study aimed to investigate the characteristics and clinical outcomes in a series of patients with extremity soft tissue sarcoma (STS) who underwent amputation at a large East Asian referral center. PATIENTS AND METHODS: Of the 652 patients who underwent surgery for extremity STS, data of 37 consecutive patients who underwent amputation were reviewed retrospectively. The median follow-up period was 96.0 months (range, 15-216). The patients were classified in to three cohorts. The primary localized (PL) group included patients who underwent amputation as a primary surgical proc…

Evaluation of combining ultrapulse CO2 with fractional CO2 laser for the treatment of atrophic scars in Asians.

Various treatment modalities have been applied to atrophic scars. Fractional CO2 laser treatment has attracted increasingly more attention b … ation. This treatment combined two CO2 lasers is an effective and safe choice for atrophic scars in Asians.

Minorities' Diminished Psychedelic Returns: Income and Educations Impact on Whites, Blacks, Hispanics, and Asians.

Growing evidence suggests that the race and ethnic minority population may experience fewer protective effects of psychedelics on mental hea … actors (education level and family income) and race/ethnic differences (White, Black, Hispanic, and Asian). The analysis employed a series of nested ordinary least-square regression models using Stata 18. The results indicate that, after controlling for socioeconomic status, there is no association between Black and Hispanic psychedelic use and distress …

South Asians and the Role of Bystanders in Domestic Violence Prevention: Results from a Pilot Study.

PURPOSE: Domestic violence manifests in unique ways in South Asian immigrant communities. Given the need to uphold family honor, formal help-seeking remains minimal within this community. Individuals experiencing victimization rely on friends and family members as informal sources of support. These friends and family members may also be bystanders who witness victimization. Therefore, the goal of this study was to examine differences in participant responses to an online interactive bystander intervention developed for South Asians. METHODS: To get community response to the intervention, B.R.…

Validation of the first-trimester machine learning model for predicting pre-eclampsia in an Asian population.

OBJECTIVES: To evaluate the performance of an artificial intelligence (AI) and machine learning (ML) model for first-trimester screening for pre-eclampsia in a large Asian population. METHODS: This was a secondary analysis of a multicenter prospective cohort study in 10 935 participants with singleton pregnancies attending for routine pregnancy care at 11-13+6 weeks of gestation in seven regions in Asia between December 2016 and June 2018. We applied the AI+ML model for the first-trimester prediction of preterm pre-eclampsia (<37 weeks), term pre-eclampsia (≥37 weeks), and any pre-eclampsia, …

Femoral and tibial phenotypes of varus alignment in a Southeast Asian arthritic population: a descriptive study.

INTRODUCTION: Knowledge of femoral and tibial morphology is important for patient-specific surgery in both joint reconstruction and preservation procedures. Studies evaluating morphological variance in femoral and tibial alignments in Asian populations are scarce. This is the first descriptive study evaluating the femoral and tibial phenotypes of varus alignment in a Southeast Asian population. METHODS: Long-leg coronal standing radiographs of 2021 limbs were obtained, and the hip-knee-ankle angle, mechanical lateral distal femoral angle, medial proximal tibial angle and joint line convergenc…

Sonographic Sling Position and the Outcome of the Tension-Free Vaginal Tape-Obturator in Asian Chinese.

INTRODUCTION AND HYPOTHESIS: The objective was to assess the sonographic tension-free vaginal tape-obturator (TVT-O) position and the outcome in Asian Chinese women. METHODS: A prospective cohort study of 254 patients who underwent TVT-O surgery between 2013 and 2022. The sonographic position of the TVT-O was recorded and correlated with the outcomes, including the subjective cure rates, Incontinence Impact Questionnaire 7 (IIQ-7), and retention of urine. RESULTS: A total of 92.9% reported no stress urinary incontinence after the operation. The IIQ-7 score significantly improved after TVT-O …

Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom.

This study assessed the contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people. Five genes (ABCB4, ABCB11, ATP8B1, NR1H4, TJP2) were interrogated by exome sequencing data of 5236 volunteers. Included were non-synonymous or loss of function (LoF) variants with a minor allele frequency < 5%. Variants were filtered, and annotated to perform rare variant burden analysis, protein structure, and modelling analysis in-silico. Out of 314 non-synonymous variants, 180 fulfilled the inclusion criteria and were mostly heterozygou

Comparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism.

INTRODUCTION: Evocalcet is an oral calcimimetic agent with proven efficacy and safety in treating secondary hyperparathyroidism (SHPT) in Japanese patients on dialysis. METHODS: This randomized, double-blind, intrapatient dose-adjustment, parallel-group, international multicenter study compared the efficacy and safety of evocalcet versus cinacalcet for 52 weeks in East Asian hemodialysis patients with SHPT. RESULTS: In total, 203 and 200 patients were randomized to receive evocalcet or cinacalcet, respectively (overall, 70.1% had baseline intact parathyroid hormone (PTH) levels ≥500 pg/ml, w…