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Association Between Cannabinoid Receptor-1 Gene Polymorphism and the Risk of Diabetic Nephropathy Among Patients with Type 2 Diabetes Mellitus.

BackgroundThe cannabinoid receptor 1 (CNR1) gene polymorphism is reportedly associated with components of metabolic syndrome and coronary artery diseases in patients with type 2 diabetes mellitus (T2DM). We investigated whether the common variant rs10493353 polymorphism is associated with diabetic nephropathy (DN) in T2DM patients.Patients and methodsT2DM patients with DN were enrolled as a case group, and patients with only T2DM as a control group. Demographic data and biochemical parameters were collected. The polymerase chain reaction-based restriction fragment length polymorphism technique

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… The role of cystatin C in improving GFR estimation in the general population. Am J Kidney Dis . 2012;59(1):32–40. doi: 10.1053/j.ajkd.2011.09.001 22. Magee C, Grieve DJ, Watson CJ, Brazil DP. Diabetic nephropathy: a tangled web to unweave. …

Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review.

More than 150 cases of Fanconi syndrome (FS) or hypophosphatemia osteomalacia induced by low-dose adefovir dipivoxil (ADV) have been reported since 2002, when ADV was introduced for the long-term treatment of hepatitis B virus (HBV) infection. Because the life expectancy of HBV-infected individuals has increased, the adverse effects of long-term treatment with antiviral therapies are increasingly observed, and nephrotoxicity is one of the most severe adverse effects of ADV. Therefore, the number of cases may be far higher than reported. Moreover, ADV-induced FS is often misdiagnosed or diagnos

Recent advances in understanding and treating immunoglobulin light chain amyloidosis.

Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction. Owing to its diverse clinical presentations and a tendency to mimic common medical conditions, AL amyloidosis is often diagnosed late and results in dismal outcomes. Early referral to a specialized center with expertise in management of AL amyloidosis is always recommended. The availability of sensitive biomarkers and novel therapies is reforming our approach to how we manage AL amy

Impact of hospital variation in hematologic malignancy patient proportions on outcomes of chronic lymphocytic leukemia patients undergoing cardiac surgery: insights from nationwide data analysis.

OBJECTIVE: This study aimed to investigate the impact of the proportion of hematologic malignancy patients in hospitals on the prognosis of chronic lymphocytic leukemia (CLL) patients undergoing cardiac surgery. Perioperative management of CLL patients is complex, particularly regarding immunosuppression and infection risks. METHODS: This retrospective study utilized data from the National Inpatient Sample (NIS) from 2010 to 2021. Adult CLL patients undergoing cardiac surgery were included, categorizing hospitals into five quintiles based on hematologic malignancy patient proportions. Outcome

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… Simultaneously, close monitoring of early detection levels of novel AKI biomarkers, such as Cystatin C, Hepcidin, and Kidney Injury Molecule- 1 (KIM- 1), is also essential [ 16 , 17 ]. …

Наблюдение за пациентами из Смолдинга Миэломы, которые продвинулись к активным болезням, связано с благоприятными результатами.

< < Множественная миелома > > (ШМ) является предвестником активной множественной миеломы (ММ). Хотя наблюдение является стандартным, данные о его эффективности в деле предотвращения необратимых осложнений являются ограниченными. two- Совпадающие с соответствующими ретроспективными когортными исследованиями 57 пациентов, прошедших через SMM (pSMM) 57 Пациенты novo MM (dnMM), соответствующие возрасту и году диагностики. Основными конечными точками были ущерб конечной организации и отсутствие прогресса в выживании (PFS). 40 месяцев. При активной диагностике MM были отмечены необратимы

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… New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N. Engl. J. Med. 2021;385:1737–1749. doi: 10.1056/NEJMoa2102953. 16. Rajkumar S.V. Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management. Am. J. …

Light-Chain Amyloidosis: The Great Impostor.

Light-chain amyloidosis (AL) is a disease of protean manifestations due to a wide spectrum of organs that can be affected. The disorder is caused by the deposition of an extracellular amorphous material, the amyloid, which is produced by malignant plasma cells. The latter usually reside in the bone marrow; plasma cell infiltration is often low, in sharp contrast to what we observe in multiple myeloma. The disease may run below the physician's radar for a while before clinical suspicion is raised and targeted tests are performed. In this short review, we try to answer most of the questions that

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… Non-ATTR hereditary amyloidosis consists of other inherited gene mutations (apolipoprotein AI and AII, fibrinogen Aa, lysozyme, gelsolin, and cystatin C) AA amyloidosis: this is related to a chronic inflammatory condition and is characterized by the extracellular deposition of fibrils derived from the …

The Key Role of Hepcidin-25 in Anemia in Multiple Myeloma Patients with Renal Impairment.

Background and objectives: Anemia is common in multiple myeloma (MM) and is caused by a complex pathomechanism, including impaired iron homeostasis. Our aim is to evaluate the biomarkers of iron turnover: serum soluble transferrin receptor (sTfR) and hepcidin-25 in patients at various stages of MM in relation with markers of anemia, iron status, inflammation, renal impairment and burden of the disease and as predictors of mortality. Materials and methods: Seventy-three MM patients (six with smoldering and 67 with symptomatic disease) were recruited and observed for up to 27 months. Control gro

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… Neutrophil Gelatinase--Associated Lipocalin and Cystatin C Are Sensitive Markers of Renal Injury in Patients With Multiple Myeloma Clin. Lymphoma Myeloma Leuk. 2016 16 29 35 10.1016/j.clml.2015.10.003 26632077 43. Chae H. Ryu H. Cha K. Kim M. Kim Y. Min C.-K. …

Изучение протеомных иммунопрофилей: общие неврологические и иммунологические пути в множестве склерозов и типов 1 Болит диабет.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Интерес к изучению типа 1 Уровень сахарного диабета (T1DM) и множественного склероза (MS) возрос в связи с их значительным негативным воздействием на качество жизни пациентов и серьезными последствиями для системы здравоохранения. Хотя клинические симптомы T1DM отличаются от таких симптомов MS, как поджелудочная неисправность β-клеток в T1DM и демиелинация в центральной нервной системе (CNS) в MS, обе патологии рассматриваются в качестве аутоиммунных заболеваний с общими патогенными путями, которые включают, в частности, автофагию, воспаление и дегенерацию. Учитывая труд

Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study.

BACKGROUND: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm. OBJECTIVE: The aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy. METHODS: Characteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024. RES

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… Exploring renal function assessment: creatinine, cystatin C, and estimated glomerular filtration rate focused on the European Kidney Function Consortium equation . Ann Lab Med. ( 2024 ) 44 : 135 – 43 . 10.3343/alm.2023.0237 37909162 PMC10628758 27. …

Abstracts From the 42nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand held on June 16-18, 2024

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… We calculated eGFR using serum creatinine, cystatin C, or both. Cardiovascular events were arrythmia, heart failure, and ischaemic heart disease. … The sex-eGFR interaction was more apparent using cystatin C, and creatinine+cystatin C (all interaction p<0.001). …

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy.

Extracellular vesicles (EVs) as membrane structures of cellular origin participating in intercellular communication are involved in the molecular mechanisms of the development of various variants of polyneuropathy. Taking into account the increasing role of the protein corona of EVs and protein-protein interactions on the surface of EVs in the pathogenesis of various diseases, we focused our attention in this review on the role of intravesicular proteins and the protein corona of EVs in the development of chemotherapy-induced polyneuropathy (CIPN). It has been shown that EVs are effectively in

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… Vesicular markers are successfully used as markers of an increased risk of cardiovascular disease complications in obesity, DM2, and metabolic syndrome (perilipin A, cystatin C, CD14, miR21, disulfide isomerase levels on CD31-positive BBs) [ 3 , 5 , 6 , 7 ]. …

Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches.

Despite significant advancements in oncology, conventional chemotherapy remains the primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of the most prevalent and severe adverse effects associated with these cytotoxic agents. While platinum compounds are well-known for their nephrotoxic potential, other drugs including antimetabolites, alkylating agents, and antitumor antibiotics are also associated. The onset of AKI poses substantial risks, including heightened morbidity and mortality rates, prolonged hospital stays, treatment interruptions, and the need for

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… Neutrophil gelatinase-associated lipocalin (NGAL), released during renal injury, can be identified as early as three hours post-cisplatin infusion, with higher levels after twelve hours, showing effectiveness in early CIA detection compared to traditional markers, cystatin C, and albuminuria ( 26 , 119 … Urinary neutrophil gelatinase-associated lipocalin levels predict cisplatin-induced acute kidney injury better than albuminuria or urinary cystatin C levels. Kaohsiung J Med Sci. (2013) 29:304–11. doi: 10.1016/j.kjms.2012.10.004 120. Tekce BK, Uyeturk U, Tekce H, Uyeturk U, Aktas G, Akkaya A. …

Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial.

Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma. Sixty recruited donors were randomized in a placebo-controlled, double-blinded study with pre-seasonal, 7-week, oral supplementation with the AbM-based extract AndosanTM. Before and after the pollen season, questionnaires were answered for allergic rhino-conjunctivitis, asthma, and medication; serum IgE was measured, and Bet v 1-induced basophil activation was determ

Идентификация сигнатуры, связанной с микроглией, в экспериментальном аутоиммунном энцефаломиелите.

Множественный склероз (MS) — хроническое нервно-воспалительное расстройство, характеризующееся демиелинизацией и иммунной диагностикой, и микроглией играет центральную роль в прогрессии заболеваний. Несмотря на это, конкретные микроглиальные генные сигнатуры, способствующие НР, по-прежнему недостаточно характеризуются. МЕТОДЫ: Мы использовали экспериментальную аутоиммунную модель мышьяка-энцефаломиэлита (EAE) и провели последовательность RNA для выявления дифференциально выраженных RNA (DEmRNA), длинных некодирующих RNA (DElncRNA), циркулярных RNA (DEcirRNA) и микроRNA (DEmiRNA) в микроглии. П

Plasma Cell Myeloma: Биохимический анализ диагноза, лечения и умного нанокарьера - терапевтического развития.

Плазменная миелома (ПХМ) классифицируется как рак крови и характеризуется аномальным распространением плазменных клеток в костном мозге и чрезмерным производством моноколональных иммуноглобулинов, что приводит к постоянному повреждению жизненно важных органов. Несмотря на то, что стратегии лечения улучшились благодаря разработке протеазонных ингибиторов (ИП), иммуноводных препаратов (ИМИД) и моноклонных антител (mAbs), ПХМ остается неизлечимым заболеванием из-за молекулярной неоднородности и развития сопротивляемости лекарствам. В этом обзоре мы обсуждаем биохимические и молекулярные основы, л

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… Serum creatinine, microalbuminuria, and cystatin C remain the primary markers for monitoring PCM-induced kidney damage and guiding therapy adjustments based on glomerular filtration rate. …

Бремя хронической почечной болезни по категориям KDIGO Glomerular Filtration Standard and Albuminuria: системный обзор.

ВВЕДЕНИЕ: Заболевание почек: улучшение глобальных результатов (KDIGO) 2012 Руководящие принципы рекомендуют категоризировать пациентов по гломерулярной скорости фильтрации (GFR) и альбуминурии для прогнозирования хронического заболевания почек (CKD). Цель этого систематического обзора заключалась в изучении эпидемиологического бремени ОВД, стратифицированного КДИГО 2012 категории. МЕТОДЫ: МЕДЛИНЕ и Эмбасе были найдены для наблюдения за пациентами с ККД, результаты которых были стратифицированы в соответствии с KDIGO 2012 классификация. В числе исследованных результатов можно назвать распростра

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… Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012;60:207–216. doi: 10.1053/j.ajkd.2012.03.011. …

Новый тип нарушения почечной функции после радикальной нефрэктомии при почечной карциноме: ретроспективное исследование клинических, интраоперационных и постоперационных факторов риска.

ОБЗОР: Радикальная нефрэктомия является рекомендованным методом лечения локализованного нефрогенного карциномы, когда частичная нефрэктомия не возможна. Этот подход обычно применяется у пациентов с нормальной контрлатеральной нефридой и отсутствием предшествующего хронического почечного заболевания (ХПО). Основная проблема с операцией заключается в потенциальном долгосрочном влиянии на почечную функцию. ЦЕЛИ: Оценить риск развития хронического почечного заболевания после радикальной нефрэктомии. МЕТОДЫ И ПРОЕКТ: Это ретроспективное когортное исследование пациентов с нормальной предоперационн

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… New creatinine – and cystatin C-based equations to estimate GFR without race. N Engl J Med 2021; 385: 1737–1749. 20. Yang X, Zhang T, Zhou H, et al. Acute kidney injury as an independent predicting factor for stage 3 or higher chronic kidney disease after nephrectomy. …

An open-label phase II trial of sotrovimab (VIR-7831) prophylaxis against COVID-19 infection in immunocompromised individuals with impaired SARS-CoV-2 humoral immunity.

BACKGROUND: Immunocompromised individuals have a limited humoral immune response to SARS-CoV-2 vaccination and are at higher risk of severe COVID-19. Sotrovimab is a monoclonal antibody (mAb) targeting a conserved SARS-CoV-2 spike protein epitope. METHODS: This phase II open-label study evaluated the safety and tolerability of sotrovimab pre-exposure prophylaxis in immunocompromised adults with impaired vaccine response. Between February and June 2022 in the northeastern region of the USA, participants received sotrovimab 500 mg IV on Treatment Day (TD) 1 and 2000 mg IV on TD2 due to the spre

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… New creatinine- and Cystatin C–based equations to estimate GFR without race. N Engl J Med. 2021;385:1737–1749. doi: 10.1056/NEJMOA2102953/SUPPL_FILE/NEJMOA2102953_DISCLOSURES.PDF. 26. …

Risk factors for infections in patients with multiple myeloma: a systematic review and meta-analysis.

BACKGROUND: Multiple myeloma (MM) is a malignant clonal disease originating from plasma cells. Patients with MM are prone to infections due to factors such as impaired immune function, bone marrow suppression, and anticancer therapy. A systematic review and meta-analysis of risk factors for infections in patients with MM provides evidence-based guidance for clinical risk assessment and intervention. METHODS: Search databases such as PubMed, Web of Science, Embase, Cochrane Library, from the establishment of the database to July 20, 2025, to include observational studies evaluating risk factor

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… Clinical implications and predictive value of the creatinine−cystatin C ratio in patients with multiple myeloma and renal impairment . Oncol Lett . ( 2024 ) 27 : 134 . doi: 10.3892/ol.2024.14267 , PMID: 38362231 PMC10867728 55 Jamshed S Ammad-Ud-Din M Celotto K Minhas IUH Bress J Hillengass J . …

Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.

Introductionand Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, MethodsA total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.ResultsThe median age at diagnosis of diabetes was 35 years

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… New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med 2021. 385 1737–1749. ( 10.1056/NEJMOA2102953) 33. American Diabetes Association Professional Practice Committee . 11. Chronic kidney disease and risk management: standards of care in diabetes – 2024. …