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Baseline Functional Performance Predicts Better Long-Term Self-Reported Physical Function After Auto-HSCT.

Background/Objectives: Determination of baseline predictors of longer-term quality of life (QOL) after autologous hematopoietic stem cell transplantation (Auto-HSCT) may identify patients with the greatest supportive care needs. We hypothesized that baseline older age, weight loss, and worse functional performance would negatively predict QOL over two years post-HSCT. Methods: Physical function, body composition, and QOL were assessed before (PRE) and one month (1MO) after Auto-HSCT in U.S. Veterans (N = 23). QOL and survival were also assessed approximately every six months for two years afte

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… Plasma sex hormones including 17-hydroxypregnenolone (ng/mL), 17-hydroxyprogesterone (ng/mL), androstenedione (ng/mL), androsterone (ng/mL), dehydroepiandrosterone (DHEA; ng/mL), dihydrotestosterone (DHT; ng/mL), pregnenolone (ng/mL), progesterone (ng/mL), and total testosterone (ng/mL) were analyzed … Func., Short Form-36 Health Survey: Social Function; PANAS, Positive and Negative Affect Schedule; Pos., Positive; PHQ-8, Patient Health Questionnaire-8; RAPA AE, Rapid Assessment of Physical Activity: Aerobic Exercise; HCT-CI, hematopoietic cell transplant-comorbidity index; Lat, latissimus; DHT, Dihydrotestosterone …

Testosterone addition to estrogen therapy - effects on inflammatory markers for cardiovascular disease.

OBJECTIVE: To analyze the effects of testosterone addition to estrogen therapy in comparison with estrogen alone on cardiovascular risk factors in postmenopausal women. METHODS: Fifty surgically postmenopausal women were included in this double-blind, placebo-controlled and randomized study to receive daily oral treatment with estradiol valerate 2 mg + placebo (E/P) or estradiol valerate 2 mg + testosterone undecanoate 40 mg (E/T) for 24 weeks and then switched to the other regimen for another 24 weeks. Sex hormones, High sensitivity CRP (hsCRP), Interleukin-6 (IL-6), Tissue necrosis factor (

Tissue-specific androgen-inhibited gene expression of a submaxillary gland protein, a rodent homolog of the human prolactin-inducible protein/GCDFP-15 gene.

The human PRL-inducible protein (PIP)/gross cystic disease fluid protein-15 is expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands. In human breast cancer cells, the expression of PIP/gross cystic disease fluid protein-15 is stimulated by androgen and PRL, and inhibited by estrogen. However, it is not known whether the expression of PIP in other tissues is under similar hormonal regulation. In the present study we employed reverse transcriptase-polymerase chain reaction followed by rapid amplification of co

Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials.

BACKGROUND: The Physical Function Trial (PFT) was one of seven Testosterone Trials (TTrials), the aim of which was to assess the effect of t … ges in 6MWT distance were significantly associated with changes in testosterone, free testosterone, dihydrotestosterone, and haemoglobin concentrations. Fall frequency during the intervention period was identical in the two treatment groups of the TTrials (103 [27%] of 380 analysed in both groups had at least one fall). INTERPRETATION: Testosterone therapy consisten …

Proceedings of the British Association For Cancer Research, 19th Annual General Meeting St. Edmund Hall, University of Oxford 4--6 April, 1978.

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… Serum testosterone and dihydrotestosterone changes with age in rat. Steroids. 1975 Jun;25(6):753–762. doi: 10.1016/0039-128x(75)90039-2. Hagmar B. Experimental tumour metastases and blood coagulability. Acta Pathol Microbiol Scand Suppl. 1970;211(Suppl):5+–5+. Ho D. H. …

Association of gender with outcomes in critically ill patients.

IntroductionThe influence of gender on mortality and other outcomes of critically ill patients is not clear. Different studies have been performed in various settings and patient populations often yielding conflicting results. We wanted to assess the relationship of gender and intensive care unit (ICU) outcomes in the patients included in the Acute Physiology and Chronic Health Evaluation (APACHE) IV database (Cerner Corporation, USA).MethodsWe performed a retrospective review of the data available in the APACHE IV database. A total of 261,255 consecutive patients admitted to adult ICUs in Uni

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… Estrogen preserves the cardiovascular and immunological function [ 30 , 31 ] and tolerance to severe hypoxia, while 5 α-dihydrotestosterone (DHT) suppresses these functions. … Abbreviations APACHE: Acute Physiology and Chronic Health Evaluation; APS: Acute Physiology Score; CABG: coronary artery bypass graft; CI: confidence interval; COPD: chronic obstructive pulmonary disease; DHT: 5 α-dihydrotestosterone; COTH: Council of Teaching Hospitals; LTAC: long term acute care facility …

Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis.

STUDY QUESTION: Do circadian genes exhibit an altered profile in peripheral blood mononuclear cells (PBMCs) of polycystic ovary syndrome (PC … a significant reduction in estradiol production, by reducing CYP19A1 and a significant increase in dihydrotestosterone production, by upregulating SRD5A1 and SRD5A2 in PBMCs. Our data also showed that CYP17A1 as a direct CLOCK-BMAL1 target in PBMCs. Phenotypic classification of PCOS subgroups showed a higher variation in expression of clock genes and steroidogenesis …

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.

Polycystic Ovary Syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This docum … inhibition of 5α-reductase (finasteride) to prevent the conversion of T to its more potent form, 5α-dihydrotestosterone. The choice of antiandrogen therapy is guided by symptoms. The diagnosis of PCOS in adolescents is particularly challenging given significant age and developmental issues in this group. Management of infertility in women with PCOS requires an unders …

Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications.

Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiology and clinical implications, the impact of sex is typically overlooked in obesity research. Worldwide, women have a higher likelihood to become obese compared to men. Although women are offered weight loss interventions more often and at earlier stages than men, they are more vulnerable to psychopathology. Men, on the other hand, are less likely to pursue wei

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… Testosterone can act on the AR or can also be converted to dihydrotestosterone (DHT) or oestradiol by 5α-reductase and aromatase, respectively. Dihydrotestosterone is a more potent androgen that cannot be aromatized to oestradiol [ 45 ]. … A recent study by Sebo and Rodeheffer assessed the effect of testosterone deficiency and the individual contributions of testosterone, oestradiol, and dihydrotestosterone to body composition, total adiposity, and fat distribution by using mouse models with castration-induced hypogonadism that were fed …

Identification of novel androgen receptor target genes in prostate cancer.

BACKGROUND: The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression. RESULTS: Using Chromatin Immunoprecipitation (ChIP) Display, we discovered 19 novel loci occupied by the AR in castrate resistant C4-2B PCa cells. Only four of the 19 AR-occupied regions were within 10-kb 5'-flanking regulatory sequences. Three were located up to 4-kb 3' of the nearest gene, eight were intragenic and four were in gene deserts. Whereas the AR

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

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… Also, testosterone is metabolized into dihydrotestosterone (DHT) by local enzyme 5-reductase (SRD5A; type I and II) in target tissues like skin, hair follicles, and the prostate gland [ 68 ]. … DHT: dihydrotestosterone; BMD: bone mineral density; RANKL: receptor activator of nuclear factor kappa-B ligand; AR: androgen receptor. Table 3 A summary of impacts on bone in different diseases associated with androgen deficiency. …

Ядерное изображение костных метастазов в раке простаты: появление современных методов с использованием новых радиотрацеров

Точная установка рака простаты (ПХА) при начальной диагностике и при биохимических рецидивах имеет важное значение для определения прогноза … T). Включают новые радиопередатчики 18F-sodium фторид (NaF), 11C-/18F-fluorocholine (FCH), 18F-fluordihydrotestosterone (ДНТ), 68 Галлий и 18F-radiolabeled антиген мембраны с конкретным простатом (например, 68Ga-PSMA-11, 18F-DCFPyL). PET/CT с этими индикаторами превосходят обычные изображения. В результате этого, хотя в соответствующих клинических испытаниях необходи …

Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia.

Prostate cancer (PCa) remains both a global health burden and a scientific challenge. We present a review of the molecular targets driving current drug discovery to fight this disease. Moreover, the preventable nature of most PCa cases represents an opportunity for phytochemicals as chemopreventive when adequately integrated into nutritional interventions. With a renovated interest in natural remedies as a commodity and their essential role in cancer drug discovery, Malaysia is looking towards capitalizing on its mega biodiversity, which includes the oldest rainforest in the world and an estim

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… AR activity is regulated by two major ligands, testosterone, and dihydrotestosterone (DHT). DHT, which has a ten times higher binding affinity to the AR, is the primary androgen bound to the AR. … Inhibition of 5-α-reductase will decrease dihydrotestosterone (DHT) levels in prostate cancer tissues, thus lowering the androgenic stimulation to the prostate [ 95 ]. …

Osteoid cell-derived chemokines drive bone-metastatic prostate cancer.

One of the greatest challenges in improving prostate cancer (PCa) survival is in designing new therapies to effectively target bone metastases. PCa regulation of the bone environment has been well characterized; however, bone-targeted therapies have little impact on patient survival, demonstrating a need for understanding the complexities of the tumor-bone environment. Many factors contribute to creating a favorable microenvironment for prostate tumors in bone, including cell signaling proteins produced by osteoid cells. Specifically, there has been extensive evidence from both past and recent

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… Levels of soluble CX3CL1 in the bone marrow were found to be androgen regulated, with the potent androgen dihydrotestosterone upregulating cleavage of CX3CL1 from the plasma membrane of bone cells ( 160 ). … The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. Mol Cell Endocrinol (2000) 167:11–21. doi: 10.1016/S0303-7207(00)00305-1 171. Shulby SA, Dolloff NG, Stearns ME, Meucci O, Fatatis A. …

Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness.

Male pattern baldness (MPB) is a highly prevalent condition with a complex, poorly understood molecular basis that limits therapeutic innovation. This study aimed to bridge the gap between statistical genetic associations and biological function by identifying and prioritizing causal proteins and pathways involved in MPB. Using data from 24,069 men in the UK Biobank, we performed a proteome-wide association study of 2911 plasma proteins with self-reported MPB severity via multivariable ordinal logistic regression, adjusting for age, Body Mass Index (BMI), ethnicity, lifestyle, socioeconomic fa

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… While this process is multifactorial, the principal androgen implicated in genetically susceptible individuals is dihydrotestosterone (DHT). … Effects of dihydrotestosterone on rat dermal papilla cells in vitro Eur. J. Pharmacol. 2015 757 74 83 10.1016/j.ejphar.2015.03.055 25838072 12. Im S.T. Mun H. Kang N. Heo S.-J. Lee S.-H. …

The Roles of EDA2R in Ageing and Disease.

Ageing is a complex biological process driven, in part, by inflammaging. Recent research identifies the ectodysplasin A2 receptor (EDA2R) as a key regulator of inflammaging and a novel biomarker of ageing, with its expression increasing with age across diverse tissues in humans and animal models. Elevated EDA2R gene expression is associated with accelerated ageing, cellular senescence, frailty, obesity, acne, radiation response and increased levels of inflammatory, renal, cardiac and vascular biomarkers. Similarly, elevated EDA2R protein levels, a critical component of the proteomic ageing clo

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… Mutations in the androgen receptor ( AR ) gene increase sensitivity to dihydrotestosterone (DHT), promoting progressive hair loss (Fu et al. 2021 ; Wang et al. 2023 ). … “Dihydrotestosterone‐Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia.” Biomedicine & Pharmacotherapy 137: 111247. Gao, Y. , Jiang X., Wei Z., Long H., and Lai W.. 2023. …

Воздействие лечения на стероидом у женщин с множественным склерозом.

Множественный склероз (MS) — хроническое воспалительное нейродегенеративное заболевание центральной нервной системы. Происхождение MS связано с стероидными изменениями во время менструального цикла и беременности. Поскольку данных о воздействии лечения противомоскитных препаратов на стероидом недостаточно, мы провели оценку стерейдомичных изменений (79 стероидов) у 61 женщины-психолога репродуктивного возраста 39 лет (29, 47 лет) после лечения с помощью антимиосных препаратов на платформе GC-MS/MS и иммуномассы (кортизол и эстрадиол). Эти изменения были оценены с использованием уровней стероид

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… Active Androgens and Estrogens From active androgens, testosterone after treatment significantly increased in LP but not in FP, conjugated 5α-dihydrotestosterone significantly decreased ( Figure 4 ), and unconjugated 5α-dihydrotestosterone (5α-DHT) was not significantly influenced by anti-MS treatment …

Нейростероиды и неврологические расстройства.

Нейростероиды играют важную роль в качестве эндогенных нейромодуляторов, которые производятся на местном уровне в центральной нервной системе и быстро изменяют взрываемость нейронов и активацию микроглиальных клеток и астроцитов. Здесь мы рассматриваем механизмы синтеза, метаболизма и действия нейростероидов в центральной нервной системе. Нейростероиды могут играть различные роли в центральной нервной системе в физиологических условиях, связывая их с мембранными ионными каналами и рецепторами, такими, как рецепторы гамма-аминобутирной кислоты типа А, рецепторы Nметил-D-асортатных рецепторов, к

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… DHP, dihydroprogesterone; DHT, dihydrotestosterone; 17-OH-PREG, 17-OH-pregnenolone; 17-OH-PROG, 17-OH-progesterone. The conversion of pregnenolone to progesterone is catalyzed by 3β-hydroxysteroid dehydrogenase (3β-HSD). 3β-HSD exists in two isoforms: 3β-HSD1 and 3β-HSD2 [ 21 ]. …

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research

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… Mice are given slow-release implants of androgen (testosterone or dihydrotestosterone) in combination with slow-release implants of estrogen (17beta-estradiol or diethylstilbesterol). … Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate. J. Clin. Endocrinol. Metab. 1993;77:375–381. doi: 10.1210/jcem.77.2.7688377. 124. …

Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: a protocol for a cohort study from Scotland and Wales.

BackgroundHormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is unclear. There are particular concerns that HRT could accelerate cancer progression in women with cancer, and also that HRT could increase the risk of cardiovascular disease in such women. Therefore, our primary aim is to determine whether HRT use alters the risk of cancer-specific mortality in women with a range of common cancers. Our secondary objectives

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… Kanda N, Watanabe S. 17Β-estradiol, progesterone, and Dihydrotestosterone suppress the growth of human melanoma by inhibiting Interleukin-8 production. J Invest Dermatol. 2001;117(2):274–283. doi: 10.1046/j.1523-1747.2001.01422.x. 21. …