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Бенефициарное воздействие Омега-3 Жировых кислот на ожирение и связанные с ним метаболические и хронические воспаленные заболевания.

Известно, что омега-3 полинунасыщенные жирные кислоты (N-3 PUFA) помогают решить проблему воспаления посредством создания антивоспалительных эйкосаноидов и специализированных посредников по восстановлению, включая резолвинов, защитных сооружений и мареинов. Благодаря привязке к рецептору GPR120/FFAR4 они оказывают благоприятное воздействие в результате фосфолипидной реконструкции мембраны, повреждения воспалительных сигнальных молекул, последующего ингибирования NF-ИВ и воспаления активации, а также уменьшения окислительного стресса. Ожирение, хроническое воспалительное заболевание, которое пр

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… Peroxisome proliferator-activated receptor DGLA Dihomo-gamma-linolenic acid PPRE Peroxisome proliferator-activated receptor response element EDSS Expanded Disability Status Scale PUFA Polyunsaturated fatty acid EPA Eicosapentaenoic acid RA Rheumatoid arthritis ERK Extracellular signal-regulated kinase RAGE …

Spatiotemperal Dynamics of Osteoarthritis: Преобразование значений от стенда до Бедсайда.

Остеоартрит (OA) представляет собой многогранное дегенеративное совместное расстройство, вызванное различными факторами риска, такими, как возраст, механический стресс, воспаление и метаболическое воздействие. Эти элементы способствуют его разнообразным фенотипам и эндотипам, что подчеркивает имманентную сложность болезни. Участие нескольких тканей и их взаимодействие еще больше осложняет расследование ОА. Нынешние ограничения в области технологий пространственного фенотификации в сочетании со сложной сетью многофакторных взаимодействий препятствуют обнаружению надежных ранних диагностических

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… The RAGE gene 82G/S polymorphism is also associated with an increased risk of knee OA [ 167 ]. …

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.

Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with … studies are required, the promising preclinical findings and the safe pharmacological profile encourage further studies to define a clinical usefulness of caryophyllane sesquiterpenes in primary, secondary, or tertiary chemoprevention.

Interleukin-1 Beta-A Friend or Foe in Malignancies?

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial

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… This resulted in an up-regulation of IL-1β/IL1R1 target genes such as PTGES (prostaglandin E synthase), COX2, RAGE (receptor for advanced glycation endproducts), and ABCG2 (ATP binding cassette subfamily G member 2). … Circulating hmgb1 and rage as clinical biomarkers in malignant and autoimmune diseases Diagnostics (Basel) 2015 5 219 253 10.3390/diagnostics5020219 26854151 PMC4665591 20. Mouri F. Tsukada J. Mizobe T. Higashi T. Yoshida Y. Minami Y. Izumi H. Kominato Y. Kohno K. Tanaka Y. …

Многофункциональная роль аполипопротеина Е в нейродегенеративных заболеваниях.

Генетическое разнообразие в гене аполипопротеина Е (АпоЭ) было определено в качестве основного фактора риска уязвимости в плане генетического риска для спорадического заболевания Альцгеймера (САД). В частности, аллея АпоЕ4 является важным фактором риска для SAD, в то время как аллея АпоЕ2 обеспечивает защиту по сравнению с более распространенными аллеями АпоЕ3. В настоящем обзоре рассматривается роль АпоЭ в АД и других нейродегенеративных расстройствах. ApoE — белок переноса холестерина — влияет на несколько путей нейродегенерации, особенно в AD. Помимо своей установленной роли в метаболизме и

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… The key PRRs include toll-like receptors (TLRs), inflammasome-forming nucleotide-binding oligomerization domain-like receptors (NLRs), the receptor for advanced glycation end-products (RAGE), and the triggering receptor expressed on myeloid cells 2 (TREM2) ( Kigerl et al., 2014 ; Ulland and Colonna, …

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice.

Chemotherapy is frequently accompanied by several side effects, including nausea, diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that chemotherapy can also play a major role in causing not only cachexia, but also bone loss. This complicates prognosis and survival among cancer patients, affects quality of life, and can increase morbidity and mortality rates. Recent findings suggest that soluble factors released from resorbing bone directly contribute to loss of muscle mass and function secondary to metastatic cancer. However, it remains unknown whether similar mech

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… Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice. Bone. (2019) 124:89–102. 10.1016/j.bone.2019.04.012 42. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. …

Radiotherapy plus CAR-T cell therapy to date: A note for cautions optimism?

Radiotherapy (RT) is a traditional therapeutic regime that focuses on ionizing radiation, however, RT maintains largely palliative due to radioresistance. Factors such as hypoxia, the radiosensitivity of immune cells, and cancer stem cells (CSCs) all come into play in influencing the significant impact of radioresistance in the irradiated tumor microenvironment (TME). Due to the substantial advances in the treatment of malignant tumors, a promising approach is the genetically modified T cells with chimeric antigen receptors (CARs) to eliminate solid tumors. Moreover, CAR-T cells targeting CSC-

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… Enabling car-T cells for solid tumors: Rage against the suppressive tumor microenvironment. Int Rev Cell Mol Biol (2022) 370:123–47. doi: 10.1016/bs.ircmb.2022.03.004 6. Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. …

Effects of three flavonoids from an ancient traditional Chinese medicine Radix puerariae on geriatric diseases.

As the worldwide population ages, the morbidity of neurodegenerative, cardiovascular, cerebrovascular, and endocrine diseases, such as diabetes and osteoporosis, continues to increase. The etiology of geriatric diseases is complex, involving the interaction of genes and the environment, which makes effective treatment challenging. Traditional Chinese medicine, unlike Western medicine, uses diverse bioactive ingredients to target multiple signaling pathways in geriatric diseases. Radix puerariae is one of the most widely used ancient traditional Chinese medicines and is also consumed as food. T

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… It reduced the AGE content and decreased the expression of AGE-specific cellular receptor (RAGE) mRNA in the kidneys of rats with STZ-induced diabetes.[ 53 ] Puerarin has beneficial effects on hyperlipidemia. …

The metabolic syndrome-cancer axis: global research trends and clinical landscapes.

BackgroundThe link between metabolic syndrome (MetS) and cancer has been widely studied, but overall research patterns, shared mechanisms, and applications remain unclear. A bibliometric and bioinformatics analysis is needed to identify trends and clarify the molecular pathways connecting MetS to cancer.MethodsA bibliometric analysis using Web of Science and PubMed assessed publication trends, collaboration, key authors/journals, and research topics from 2000 to 2024. Visualization and analysis used VOSviewer, CiteSpace, and Bibliometrix. Also included bioinformatics for protein interaction ne

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… The KEGG pathway analysis revealed significant enrichment of the PI3K-Akt and AGE-RAGE signaling pathways in diabetic complications ( Figure 8C ; detailed results are provided in Supplementary Table 5 ). …

European Association for the Study of Obesity Position Statement on the Diagnosis and Management of Obesity in Older Adults.

<p>Obesity is increasingly prevalent among older adults and is a major contributor to cardiometabolic diseases, functional decline, frailty, and loss of independence. The intersection between population ageing and the obesity epidemic poses major public health and clinical challenges. This European Association for the Study of Obesity (EASO) position statement represents an update of the EASO guideline from 2012, and provides a comprehensive overview of the epidemiology, pathophysiology, clinical consequences, and management of obesity in adults aged ≥65 years. It summarizes current evidence a

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… A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on . Metabolism . 2022 ; 133 : 155217 . 35584732 10.1016/j.metabol.2022.155217 PMC9107388 12. …

Ультрафиолетовое излучение и нейродегенерация: молекулярные механизмы, лежащие в основе двойного нейрозащитного и нейротоксичного воздействия.

Ультрафиолетовое излучение имеет сложную, зачастую противоречивую связь с риском/прогрессом нейродегенерации, охватывающую клинически диагностированные заболевания [Заболевания Паркинсона (PD), болезни Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS)] или промежуточные фенотипы (уменьшенный нейрогенесис, потеря гиппокампального объема). Цель этого обзора заключается в выявлении двойного воздействия УФ-излучения путем сбора и обобщения экспериментальных (доклинических и переводческих) данных, а также эпидемиологических данных. Нынешняя литература демонстрируе

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Ultraviolet radiation exhibits a complex, often contradictory link to neurodegeneration risk/progression, spanning clinically diagnosed dise … of neurodegenerative diseases in the general population, these pathways and mechanisms must be leveraged in future research to develop novel therapeutic and preventive strategies. Investigation of biomarkers linked to certain genetic and environmental factors that could provide a link to predisposition toward neurodegeneration and standardization of U …

Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential.

Neutrophil extracellular traps (NETs) are complex, web-like structures consisting of DNA intertwined with antimicrobial proteins, which neutrophils release upon immune activation. These structures play a crucial role in pathogen elimination, particularly in infectious diseases. However, their involvement in various pathological conditions is multifaceted and context-dependent, while NETs contribute to host defense against infections, they can also exacerbate sterile inflammation, autoimmune disorders, and tumor progression. This review provides a comprehensive analysis of the molecular mechani

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… Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma. Cancer Commun (Lond). 2022;43:225–45. 10.1002/cac2.12388. 31. Veras FP, et al. …

Нейтрофильная активация и повторное расширение CAR-T, лежащее в основе синдрома высвобождения цитокина, во время цилакабтагенской автолексельной терапии в множестве миеломы.

Синдром цитокина (CRS) является наиболее распространенным осложнением химерика антигенного рецептора, перенаправления Т клеток (CAR-T). Существенно улучшено регулирование токсичности CAR-T, однако ДУС по-прежнему является одной из главных проблем в области безопасности. Здесь мы следим уровням сыворотки цитокина и циркулируем транскриптомы иммунных клеток в продольном направлении. 26 для понимания иммунологической кинетики CRS. Мы видим, что, хотя T лимфоциты и моноциты/макропаты являются основным общим источником цитокина в виде ДУС, нейтрофильная активация достигла пиков ранее, до появления

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… IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 p70, IL-13, IL-15, IL-17A, IL-17E, IL-33, EGF, FGF basic, VEGF, PDGF-AA, PDGF-AB/BB, TGF-α, G-CSF, GM-CSF, sPD-L1, sCD40 Ligand, sFLT-3Ligand, IFN-α, IFN-β, IFN-γ, TNF-α, TRAIL, Granzyme B, sIL-2Rα, CXCL9, gp130, sIL-1R II, sIL-6Rα, sTNF RI, sTNF RII, RAGE …

Osteocytes: New Kids on the Block for Cancer in Bone Therapy.

The tumor microenvironment plays a central role in the onset and progression of cancer in the bone. Cancer cells, either from tumors originating in the bone or from metastatic cancer cells from other body systems, are located in specialized niches where they interact with different cells of the bone marrow. These interactions transform the bone into an ideal niche for cancer cell migration, proliferation, and survival and cause an imbalance in bone homeostasis that severely affects the integrity of the skeleton. During the last decade, preclinical studies have identified new cellular mechanism

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… High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4. Biochem. Biophys. Res. Commun. 2020;531:422–430. doi: 10.1016/j.bbrc.2020.07.120. 82. Pin F., Prideaux M., Huot J.R., Essex A.L., Plotkin L.I., Bonetto A., Bonewald L.F. …

Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis.

Myeloproliferative neoplasm (MPN)-associated myelofibrosis (MF) is characterized by cytopenias, marrow fibrosis, constitutional symptoms, extramedullary hematopoiesis, splenomegaly, and shortened survival. Constitutive activation of the janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in MF leads to cell proliferation, inhibition of cell death, and clonal expansion of myeloproliferative malignant cells. Fedratinib is a selective oral JAK2 inhibitor recently approved in the United States for treatment of adult patients with intermediate-2 or high-risk M

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… The highest level of upregulation occurred in erythropoietin, ferritin, adiponectin, and leptin; the greatest downregulation occurred in C-reactive protein, the T-cell-specific protein RANTES (regulated upon activation normal T-cell expressed), and the EN-RAGE (extracellular newly identified receptor …

A review on how to do hematology consults during COVID-19 pandemic.

The ongoing COVID-19 pandemic is the most trending and talked topic across the World. From its point of origin in Wuhan, China to clinical laboratory at NIH, a mere six-month-old SARS-CoV-2 virus is keeping the clinicians, and scientists busy at various fronts. However, COVID-19 is an emerging and evolving disease and each day brings in more data, new figures, and findings from the field of clinical practice. The role of hematologists has been increasingly recognized during the current pandemic because of several reasons. Most important of them are the characteristic hematological findings of

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… HLH, a fulminant cytokine storm syndrome is often an under-recognized entity and report by Karakike et al. suggested it to be in the rage of 3.7–4.3% of sepsis cases [ 96 ]. …

Integrative analysis of bulk and single-cell gene expression profiles to identify bone marrow mesenchymal cell heterogeneity and prognostic significance in multiple myeloma.

BackgroundMultiple myeloma is a hematologic malignancy characterized by complex interactions within the tumor microenvironment, where mesenchymal stem cells (MSCs) contribute significantly to disease progression, immune suppression, and drug resistance.MethodsThis study investigated the heterogeneity of MSCs in multiple myeloma using single-cell RNA sequencing (10X) and bulk transcriptomic data. Further analysis was performed by Seurat, SCENIC, CellChat. GSE4581 and GSE136337 were used as training set and validation set to construct a newly described prognostic model through COX and LASSO.Resu

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… HMGB1, a classic inflammatory damage molecule, is released by dying tumor cells, and DAMPs, which bind to TLR4 or RAGE innate immune receptors on DC cells, mediate innate immune recognition of cancer. …

2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery.

MAJOR UPDATES TO 1991 NATIONAL INSTITUTES OF HEALTH GUIDELINES FOR BARIATRIC SURGERY: Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) >35 kg/m2, regardless of presence, absence, or severity of co-morbidities.MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2.BMI thresholds should be adjusted in the Asian population such that a BMI >25 kg/m2 suggests clinical obesity, and individuals with BMI >27.5 kg/m2 should be offered MBS.Long-term results of MBS consistently demonstrate safety and efficacy.Appropriately

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… Chung M Sheth S McMacken M Zahra T Saunders JK Ude-Welcome A Dunn V Ogedegbe G Schmidt AM Pachter HL Randomized pilot trial of bariatric surgery versus intensive medical weight management on diabetes remission in type 2 diabetes patients who do NOT meet NIH criteria for surgery and the role of soluble RAGE …

Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease.

Diabetic kidney disease is one of the most frequent complications in patients with diabetes and constitutes a major cause of end-stage kidney disease. The prevalence of diabetic kidney disease continues to increase as a result of the growing epidemic of diabetes and obesity. Therefore, there is mounting urgency to design and optimize novel strategies and drugs that delay the progression of this pathology and contain this trend. The new approaches should go beyond the current therapy focussed on the control of traditional risk factors such as hyperglycaemia and hypertension. In this scenario, d

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… Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE)-Receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes. Diabetes Metab Res Rev 2013; 29: 624–663 50. …

Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential.

BACKGROUND: Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle wasting, systemic inflammation, reduced quality of life, and poor clinical outcomes. Interleukin-6 (IL-6) is a central mediator in cachexia pathophysiology, driving inflammatory signaling, catabolic metabolism, and muscle atrophy. However, IL-6 also rises transiently during exercise, where it exerts beneficial metabolic and anti-inflammatory effects, highlighting the context-dependent nature of IL-6 signaling. MAIN BODY: This review summarizes current knowledge on the regulation and functio