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Recent advances in tumor immunotherapy based on NK cells.

Immunotherapy has emerged as the established fourth pillar of cancer treatment following surgery, radiotherapy, and chemotherapy, representing a cutting-edge research domain in translational medicine and clinical oncology. Natural killer (NK) cells, a type of innate cytotoxic lymphocyte, possess unique antitumor properties that are independent of major histocompatibility complex (MHC) restrictions, making them promising candidates for "off-the-shelf" therapeutic products. NK cells can eliminate tumor cells through various mechanisms. Genetic engineering of NK cells can enhance their activation

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… However, in clinical trials for refractory/relapsed acute myeloid leukemia (AML) ( NCT03050216 and NCT01898793 ), Melissa et al. observed that IL-15/N-803, compared to IL-2, might reduce NK cell clinical activity due to its stimulation of CD8+ T cell activation and proliferation ( 63 ). …

Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents.

Neurodegenerative diseases (NDDs) represent a class of incurable and progressive disorders characterized by the gradual degeneration of the structure and function of the nervous system, particularly the brain and spinal cord. A range of innovative therapeutic approaches is currently under investigation, such as stem cell-based therapies, gene-editing platforms such as CRISPR, and immunotherapies directed at pathogenic proteins. Moreover, phytochemicals such as β-caryophyllene and xanthohumol have demonstrated significant neuroprotective potential in preclinical models. These natural agents exe

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… Notable examples include Ginkgo biloba , Bacopa monnieri , Salvia officinalis , Curcuma longa , Rosmarinus officinalis , Melissa officinalis , Galanthus nivalis , Lepidium meyenii , and Centella asiatica . …

2026 Приложение к резюме Международного конгресса

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Регулирование заразительных осложнений в создании химической антигенной приемной клетки (CAR-T)

Химерическая антигенная рецепторная T-клетка (CAR T-клетка) изменила парадигму управления лимфомой не Ходжкина (NHL) и множественной миеломой. Осложнения, связанные с инфекцией, стали предметом озабоченности, которая может возникнуть в процессе лечения и привести к заболеваемости и смертности. В ходе этого обзора мы классифицировали осложнения, связанные с инфекцией, в three Категория, этап предварительного вливания с момента предварительного лимфодерации (LD) до дня zero, ранний этап от дня вливания до дня 30 после введения в эксплуатацию и с запозданием изо дня в день 30 и дальше. Инфекции,

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… Alsina Melissa Sidana Surbhi Hansen Doris K. …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

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… sibiricus (Motherwort) | 120 | [ 35 ] Phyllanthus emblica (Gooseberry) | 290 | [ 35 ] | Salvia officinalis (Sage) | 1660 ** 74.2 * | [ 35 ] [ 39 ] Physalis angulata (Poppers) | 120 | [ 35 ] | Perilla frutescens (Purple mint) | 1890 870 | [ 35 ] [ 40 ] Physalis peruviana (Goldenberry) | 860 | [ 35 ] | Melissa …

Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance.

Bone repair and regeneration is a complex spatiotemporal process recruiting a variety of cell types, which need to precisely mediated for effective healing post-damage. The concept of osteoimmunology emphasizes the extensive and intricate crosstalk between the bone and the immune system. Despite the significant advancements in understanding osteoimmunology, the precise role of dendritic cells (DCs) in this field remains under investigation. As key antigen-presenting cells, DCs are critical in orchestrating adaptive immune responses and maintaining tissue homeostasis. Recent researches have fur

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… Swiecki, Melissa & Colonna, M. The multifaceted biology of plasmacytoid dendritic cells. Nat. Rev. Immunol. 15 , 471–485 (2015). 28. Musumeci, A., Lutz, K., Winheim, E. & Krug, A. B. What makes a pDC: recent advances in understanding plasmacytoid DC development and heterogeneity. Front. …

Abstracts From JADPRO Live 2019: Washington State Convention Center • Seattle • October 24-27.

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… JL701 Adapting to an Evolving Environment: The Role of the Inpatient Oncology Advanced Practitioner Team Kimberlee Gold, PA-C, MPAS, University of Washington; Leah Roess, PA-C, MSPAS, University of Washington; Justin Speyer, ARNP, University of Washington Medical Center/Seattle Cancer Care Alliance; Melissa …

34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 2 : National Harbor, MD, USA. 10 November 2019.

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… P504 Arginase therapy combines effectively with checkpoint blockade or agonist anti-OX40 immunotherapy to control tumor growth Annah Rolig, Ph D 1 , Scott Rowlinson, PhD 2 , Melissa Kasiewicz, BS 1 , Mark Badeaux, PhD 2 , William Redmond, PhD 1 , Giulia Agnello, PhD 2 , Leslie Priddy, BS 2 , Danlee …

Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives.

Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly aggressive malignant tumor. Traditional therapeutic approaches have limited efficacy in locally advanced HNSCC patients, and neoadjuvant immunotherapy has emerged as a new hope. However, the current outcomes of neoadjuvant immunotherapy for HNSCC are not yet optimal and urgently need improvement. This article comprehensively reviews the clinical research progress of neoadjuvant immunotherapy in the field of HNSCC treatment. By integrating perspectives from the regulatory mechanisms of the immune microenvironment, we propose future resea

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… Others | NCT06223568 | Melissa L,et al.(2021) | Docetaxel+Cisplatin+PRGN-2009 | 28% | 9% | 15% | 4% | Low-toxicity regimens are suitable for elderly patients with comorbidities. …

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

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… Goes, Louise Thurman, Stephen Strakowski, Tracy Greer, Andrew Nierenberg, Giacomo Salvadore, Melissa DelBello Johnson and Johnson, Titusville, New Jersey, United States Background: Bipolar disorder (BD) is highly familial. …

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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Clinical Posters From JADPRO Live 2022

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… for Pancreatic Cancer in a Multilocation Practice Lauren Kiley, MSN, APN-BC, AOCNP, Rachel Carroll, MSN, FNP-BC, AOCNP, Victoria Barnes, MSN, FNP-BC, Kristen Benson, MSN, APRN, AGPCNP-BC, OCN, Darria Lloyd, MSN, APRN, AGNP-C, OCN, PCCN, Salma Haj-Ibrahim, PA-C, Shannon Woerner, ANP-BC, AOCNP, MBA, Melissa …

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders.

Molecular glue degraders (MGDs) constitute a class of innovative therapeutic agents within the field of targeted protein degradation (TPD). In contrast to proteolysis-targeting chimeras (PROTACs), MGDs induce protein degradation by stabilizing the interaction between an E3 ubiquitin ligase and a target protein. They typically exhibit favorable drug-like characteristics, including lower molecular weight and enhanced bioavailability. Although their discovery was historically serendipitous, recent advances in high-throughput screening, bioinformatics, and artificial intelligence are enabling more

The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy.

In this review, we carefully describe the composition and operation of cryptochrome-1 (CRY1). We introduce four related signaling pathways, namely cAMP/PKA/CREB signaling way, HIFα signaling way, NF-κB signaling way, STAT3 signaling way, FOXO signaling pathway and Hedgehog (HH) signaling pathway. We also emphasize the current understanding of the complex roles CRY1 plays in the progression of various solid tumors. We propose that its function represents a novel therapeutic target that could pave the way for new cancer treatments. Additionally, we summarize three emerging therapeutic strategies

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… Melissa H. Madden and colleages evaluated the relationship between glioma risk and genetic variations in the circadian gene pathway [ 225 ]. Using TCGA data, this clinic-based investigation demonstrated how CRY1 expression differs in glioblastoma multiform compared to normal brain. …

Emerging agents and regimens for multiple myeloma.

The outcomes of multiple myeloma (MM) have been improved significantly with the therapies incorporating proteasome inhibitors (PI), immunomodulatory drugs, monoclonal antibodies (MoAb) and stem cell transplantation. However, relapsed and refractory MM (RRMM) remains a major challenge. Novel agents and regimens are under active clinical development. These include new PIs such as ixazomib, marizomib, and oprozomib; new MoAbs such as isatuximab and MOR202; novel epigenetic agent ricolinostat and novel cytokines such as siltuximab. Recently, the first XPO-1 inhibitor, selinexor, was approved for R

ЭПОС/ПОНСА Резюме

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… Lullo Lurie Children’s Hospital of Chicago, Chicago, IL, USA OP-117 11:13 AM–11:17 AM Greater obstetric barriers for female orthopedic surgeons compared to the general population and peer physicians Emily Reeson, Gwen Grimsby, Melissa Esparza, Heather Menzer Phoenix Children’s Hospital, Phoenix … for Children, Dallas, TX, USA OP-199 4:47 PM–4:51 PM Septic arthritis after anterior cruciate ligament reconstruction in pediatric and adolescent vs young adult patients: the 20-year experience at a regional referral center Deepak Chona , Jeffrey Kay, Ata M Kiapour, Dennis Kramer, Yi-Meng Yen, Melissa …

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018.

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Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Melissa Alsina, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 12. Kenneth Anderson, Dana-Farber Cancer Institute, Boston, MA 13. Larry D. Anderson Jr., UT Southwestern Medical Center, Dallas, TX 14. Frida Askeland, Oslo University Hospital, Oslo, Norway 15. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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