The sharing of clinical trial data and biomarker data sets among the scientific community, whether the data originates from pharmaceutical companies or academic institutions, is of critical importance to enable the development of new and improved cancer immunotherapy modalities. Through data sharing, a better understanding of current therapies in terms of their efficacy, safety and biomarker data profiles can be achieved. However, the sharing of these data sets involves a number of stakeholder groups including patients, researchers, private industry, scientific journals and professional societ
Совпадение в полном тексте источника … This program is truly a partnership effort contributed to by the US government, industry, biotech, biopharma, and academia. … Data sharing in academia is a multidimensional effort that includes a diverse set of stakeholders, entities, and individual interests. …
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Background: Cannabinoids are studied as anticancer agents, but their effects vary across tumors, compounds, and experimental settings, underscoring the need to define consistent patterns. Our objective was to map cannabinoid efficacy across cancer preclinical models and identify tumor settings with the greatest translational promise. Methods: The protocol was registered on PROSPERO (CRD42025543744); PubMed, Embase, and CENTRAL were searched on 4 April 2024 for in vitro and in vivo studies assessing cannabinoid antitumor effects alone or with chemotherapy versus vehicle or chemotherapy only. Ra
Совпадение в полном тексте источника … This work was carried out as part of the Systems Education Program at Semmelweis University and conducted within the Translational Medicine (TM) Cycle Framework by the Academia Europaea [ 70 , 75 ].
4.2. … Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits. J. Clin. Med. 2020;9:1532. doi: 10.3390/jcm9051532.
76. Haddaway N.R., Grainger M.J., Gray C.T. …
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KEY CLINICAL MESSAGE: Plasma cell myeloma is a rare entity in the pediatric population. The peak incidence is in the seventh decade, with less than 2% of cases occurring in patients under the age of 40. It is worth noting that any destructive bony lesion in a child should be investigated.
ABSTRACT: Plasma cell myeloma (multiple myeloma) is the most common form of plasma cell neoplasm. It is a rare entity in young patients. The peak incidence is in the seventh decade, with less than 2% of cases occurring in patients under the age of 40. A male patient aged 9 years old with a progressive pain i
Совпадение в полном тексте источника … ACKNOWLEDGMENTS
I want to thank my wife Kobusingye Brendah Nyakairu and my two daughters Katrina and Ursula for Inspiring me to work so hard in my filed of academia and publications.
Ronald K, Jacinta A, Umaru S. Plasma cell myeloma in a 9‐year‐old male: Case report and literature review. …
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Immunoglobin light chain (AL) amyloidosis is a rare disease characterized by organ deposition of amyloid fibrils, most commonly in the heart and kidney. Disease heterogeneity necessitates organ-specific assessment to determine prognosis and response or progression. To facilitate development of new therapies, the Amyloidosis Forum (a public-private partnership between the US Food and Drug Administration and the nonprofit Amyloidosis Research Consortium) held a series of meetings and formed multiple working groups to identify clinical trial end points and analytic strategies. This report summari
Совпадение в полном тексте источника … amyloid disorders, a public-private partnership was formed between the nonprofit Amyloidosis Research Consortium ( www.arci.org ) and the US Food and Administration Center for Drug Evaluation and Research. 15 The Amyloidosis Forum ( https://amyloidosisforum.org ) leverages expertise of stakeholders from academia … This review summarizes the proceedings of the Renal Working Group (hereafter referred to as the “Working Group”), which comprised a patient representative, 2 statisticians, and a panel of AL amyloidosis experts representing academia, industry, and regulatory agencies (US Food and Drug Administration, …
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The treatment of chronic lymphocytic leukemia (CLL) patients with venetoclax-based regimens has demonstrated efficacy and a safety profile, but the emergence of resistant cells and disease progression is a current complication. Therapeutic target of sphingosine kinases (SPHK) 1 and 2 has opened new opportunities in the treatment combinations of cancer patients. We previously reported that the dual SPHK1/2 inhibitor, SKI-II enhanced the in vitro cell death triggered by fludarabine, bendamustine or ibrutinib and reduced the activation and proliferation of chronic lymphocytic leukemia (CLL) cells
Совпадение в полном тексте источника … All samples used in this study were obtained after informed consent in accordance with the Declaration of Helsinki and with Institutional Review Board approval from the Academia Nacional de Medicina, Buenos Aires, Argentina. CLL was diagnosed according to standard clinical and laboratory criteria. … Ethics statement
The studies involving human participants were reviewed and approved by Institutional Ethics Committee from the Institutes of the Academia Nacional de Medicina, Buenos Aires, Argentina. The patients/participants provided their written informed consent to participate in this study. …
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Veterinary nephrology is a specialized field of veterinary medicine providing a high level of care for animals with all types of kidney disease. Veterinarians complete extensive training to become board-certified in veterinary nephrology-urology. Companion animal nephrology is the most advanced field; however, all species are afflicted by a variety of renal disorders. Most naturally occurring animal kidney diseases have similar disorders found in people; where veterinary research is lacking, clinical management is often modified from standard of care in people. Veterinarians have become adept
Совпадение в полном тексте источника … Fifteen percent of veterinarians work in academia or corporate domain where they do not primarily perform patient care.
The daily activities of a veterinarian in clinical practice are quite variable. … Most work in multispecialty hospitals—in both academia and private practices. A typical workday involves providing care for hospitalized patients, seeing appointment consults, and performing procedures. …
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Italy has a well-established prominent system of national registries to support managed entry agreements (MEAs), monitoring innovative medicinal products (MPs) with clinical as well as economic uncertainties to ensure appropriate use and best value for money. The technological architecture of the registries is funded by pharmaceutical companies, but fully governed by the national medicines agency (AIFA). A desktop analysis was undertaken of data over a 15-year timeframe of all AIFA indication-based registries and associated EMA information. The characteristics of registries were evaluated, com
Совпадение в полном тексте источника … These registries generate evidence from real-world clinical practice, representing an opportunity for collaboration among patients, academia, regulators, HTAs, payers, and industry to undertake analyses that can support learning health systems and improve patient outcomes ( Russo et al., 2010 ; Facey … This document, created in 2014, could be updated and extended, inserting new rules that take into account the potential use of registries’ data and the specific needs of NHS (specially to avoid data duplication), the pharmaceutical industry, patient organizations, academia, and other scientific research …
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Repurposing Food and Drug Administration (FDA)-approved drugs for a new indication may offer an accelerated pathway for new treatments to patients but is also fraught with significant commercial, regulatory, and reimbursement challenges. The Alzheimer's Drug Discovery Foundation (ADDF) and the Michael J. Fox Foundation for Parkinson's Research (MJFF) convened an advisory panel in October 2013 to understand stakeholder perspectives related to repurposing FDA-approved drugs for neurodegenerative diseases. Here, we present opportunities on how philanthropy, industry, and government can begin to a
Совпадение в полном тексте источника … A collaboration between industry, academia, FDA, and the NIH to develop a path to make data available on failed or abandoned drugs would accelerate repurposing by helping to identify (or exclude) new repurposing opportunities. …
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