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Риски гематологических обледенений у пациентов, прошедших лечение от твердых опухолей, связанных с использованием пегилизованных гранулоцитов-стимулирующих факторов: 2005.

Широкое применение пегилизованных гранулоцитов (PGCS), в частности pegfilgrastim и липегфилграстим, в целях сокращения числа случаев нейтрализации женских половых органов у пациентов, проходящих химиотерапию. Вместе с тем по-прежнему сохраняется озабоченность по поводу долгосрочной безопасности ПХГФ, в частности по поводу риска вторичных гематологических заболеваний. Цель настоящего исследования заключалась в оценке распространенности вторичных гематологических заболеваний у пациентов, которые лечились от твердых опухолей с помощью PGCSF в одном учреждении 2005 в адрес 2019. Ретроспективный ан

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… haematological malignancy, given that the existence of several genetic syndromes and specific mutations, such as mutations in the FANC genes or SBDS gene, are known to increase the risk of haematological malignancies, often through mechanisms involving bone marrow failure, such as Fanconi anaemia or Schwachman-Diamond …

Long term responders in frontline multiple myeloma-exception vs expectation of the modern era.

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… Maura F Weinhold N Diamond B Kazandjian D Rasche L Morgan G The mutagenic impact of melphalan in multiple myeloma Leukemia 2021 35 2145 50 10.1038/s41375-021-01293-3 34012133 15. …

Результаты перкутановой вертебропластики в множестве миеломы: опыт третичной нейрофизики в долгосрочной последующей деятельности.

Множественная миелома диагностируется в 5,800 ежегодно в Соединенном Королевстве (Соединенном Королевстве) 64% - иметь переломы позвоночника при диагностике. Больные переломы позвоночника могут нанести значительный ущерб качеству жизни пациентов. Перкутанная вертебропластика направлена на обеспечение долгосрочного обезболивания и стабилизацию перелома позвонков. МЕТОДЫ И МАТЕРИАЛЫ: Данные были собраны по всем случаям перкутановой вертебропластики, выполненной пациентами с множественной миеломой с ноября 2017 по январь 2019. Показатели боли измерялись по шкале Визуального Аналога (VAS) и предпр

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… Clark W, Bird P, Gonski P, Diamond TH, Smerdey P, McNeil HP, et al. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. (2016) 388:1408–16. doi: 10.1016/S0140-6736(16)31341-1 8. …

Characteristics and Outcomes of Patients with Partial Do Not Resuscitate Orders in a Large Community Hospital.

Background Formal writing of do not resuscitate (DNR) orders first appeared in the literature in the late 20th century. Recently, providers have also noticed the presence of partial DNR orders while caring for patients. We sought to determine the effect of these orders on the clinical outcomes of the patients. Methods The study was a retrospective chart review covering a period of approximately 30 months. Patients included in the study were over 18 years of age and had a partial DNR order (i.e., chemical code, do not defibrillate (DND), do not intubate (DNI), intubate only, no cardiopulmonary

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… patients' satisfaction with primary care J Gen Intern Med Tierney WM Dexter PR Gramelspacher GP Perkins AJ Zhou XH Wolinsky FD 32 40 16 2001 11251748 10.1111/j.1525-1497.2001.00215.x PMC1495157 16 Relationship of advance directives to hospital charges in a Medicare population Arch Intern Med Chambers CV Diamond …

Extraintestinal Cancers in Inflammatory Bowel Disease: A Literature Review.

BackgroundInflammatory bowel disease (IBD) is a group of chronic multifactorial inflammatory disorders including two major entities: Crohn's disease (CD) and ulcerative colitis (UC). Preliminary evidence suggests that patients with IBD may be at increased risk of developing intestinal and extraintestinal cancers (EICs). Actually, little is known about the association between IBD and EICs, and there is ever-growing concern regarding the safety of immunomodulators and biological therapy, which may represent a risk factor for carcinogenesis.AimsThe aim of this review is to summarize the evidence

Traditional and Complementary Medicine Use among Cancer Patients in Asian Countries: A Systematic Review and Meta-Analysis.

Globally, cancer patients frequently use T&CM during their treatment for various reasons. The primary concerns regarding the use of T&CM among cancer patients are the potential risks associated with interactions between pharmaceuticals and T&CM, as well as the risk of noncompliance with conventional cancer treatments. Despite the higher prevalence of T&CM use in Asia, driven by cultural, historical, and resource-related factors, no prior review has tried to estimate the prevalence and influencing factors of T&CM use and disclosure among cancer patients in this region. This study aims to examin

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… The black diamond dots represent the individual prevalence from each study, with the horizontal lines representing the 95% CI. The green rhombus and the red dashed line represent the pooled prevalence estimate and its 95% CI. … The black diamond dots represent the individual prevalence from each study, with the horizontal lines representing the 95% CI. The green rhombus and the red dashed line denote the pooled prevalence estimate and its 95% CI. …

OCT-Based Retina Assessment Reflects Visual Impairment in Multiple Sclerosis.

PURPOSE: To explore the relationship between visual performance and retinal morphology as assessed by optical coherence tomography (OCT), and the ability of OCT to reflect visual impairment in people with multiple sclerosis (PwMS) compared with healthy controls (HC). METHODS: We gathered data from two neurology referral centers on PwMS and HC. Neurological and ophthalmological assessments, including OCT, high-contrast visual acuity (HCVA) and low-contrast visual acuity (LCVA), area under the log contrast sensitivity function (AULCSF), and vision-related quality of life (National Eye Institute

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… The mean is represented by a diamond symbol, with the corresponding numeric value displayed. ( A ) HCVA in logMAR. ( B ) HCVA measured with the Sloan chart at 100% contrast. ( C ) LCVA measured with the Sloan chart at 2.5% contrast. ( D ) AULCSF. …

Individual Trade-Offs Between Possible Benefits and Risks of Cancer Treatments: Results from a Stated Preference Study with Patients with Multiple Myeloma.

BACKGROUND: The objectives of this study were to elicit the preferences of patients with multiple myeloma regarding the possible benefits and risks of cancer treatments and to illustrate how such data may be used to estimate patients' acceptance of new treatments. PATIENTS AND METHODS: Patients with multiple myeloma from the cancer charity Myeloma UK were invited to participate in an online survey based on multicriteria decision analysis and swing weighting to elicit individual stated preferences for the following attributes: (a) 1-year progression-free survival (PFS, ranging from 50% to 90%)

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… The black points represent the attribute weights of the individual study participants, and the red diamond represents the average weight given to the three attributes (0.54 for PFS, 0.32 for severe or life‐threatening toxicity, and 0.14 for mild or moderate chronic toxicity). …

Efficacy and safety of acupuncture for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trial.

OBJECTIVE: Chemotherapy-induced nausea and vomiting (CINV) represents a common and debilitating side effects in cancer patients, often compromising treatment adherence and quality of life. Current management remains suboptimal, necessitating the exploration of complementary therapies. Acupuncture, as a widely used adjunctive therapy, has been attempted for the treatment of CINV. This study aims to systematically evaluate the effect and safety of acupuncture in managing CINV. METHODS: We comprehensively searched seven electronic databases (EMBASE, Cochrane Library, Web of Science, PubMed, Chin

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… Each plot includes weights, confidence intervals, and summary estimates represented by diamonds. Figure 8 Sensitivity analysis of the acupuncture-mediated nausea control for nausea severity. Forest plot for a leave-one-out meta-analysis showing the random effects model for eight studies. … Blue squares represent individual studies, and diamonds indicate pooled effect sizes. The pooled effect favors the experimental group. …

Прогнозирующее значение динамического мониторинга состояния минимальных остаточных заболеваний у пациентов с множественной миеломой: исследование реального мира.

Фон: Минимальное остаточное заболевание (МВД) является установленным прогнозным фактором в миеломе (ММ), однако значение динамических изменений MRD до и после аутологической трансплантации стволовых клеток (ASCT) остается неясным. Методы: Ретроспективный анализ 335 Недавно диагностировали пациентов MM, прошедших первичную ACCT. Общий показатель выживаемости (ОС) и выживаемости без прогрессирования (ПФС) оценивался с использованием метода Kapan-Meier и сопоставлялся с использованием теста log-rk. Для оценки коэффициентов опасности (HR) и 95% Интервал доверия (CI), коррекция с учетом клинических

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… Meseha M., Hoffman J., Kazandjian D., Landgren O., Diamond B. Minimal Residual Disease-Adapted Therapy in Multiple Myeloma: Current Evidence and Opinions. Curr. Oncol. Rep. 2024;26:679–690. doi: 10.1007/s11912-024-01537-2. 4. … Diamond B., Korde N., Lesokhin A.M., Smith E.L., Shah U., Mailankody S., Hultcrantz M., Hassoun H., Lu S.X., Tan C., et al. Dynamics of minimal residual disease in patients with multiple myeloma on continuous lenalidomide maintenance: A single-arm, single-centre, phase 2 trial. …

Risk prediction models for cancer therapy related cardiac dysfunction in patients with cancer and cancer survivors: systematic review and meta-analysis.

OBJECTIVES: To systematically review all prediction models developed or validated for cancer therapy related cardiac dysfunction (CTRCD) and to quantitatively analyse their performance. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Embase, Medline, and the Cochrane Central Register of Controlled Trials, from inception to 23 August 2024. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies that developed or externally validated multivariable models to predict CTRCD risk in young people (children, adolescents, and young adults (≤39 years)) or older adults (≥40 years) with cancer o

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… Blue and pink diamonds (with confidence intervals) represent the observed proportion of patients with the outcome (y axis) per study. Diamonds above the corresponding expected range indicate underestimation of risk by the model; those below indicate overestimation. …

Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study.

INTRODUCTION: Allogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation of latent herpesviruses such as CMV and EBV within the first 100 days are frequent. Small studies and case series indicated that application of herpes virus specific T cells can control and prevent disease in this patient population. METHODS: We report the results of a randomized controlled multi centre phase I/IIa study (MULTIVIR-01) using a new

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… . | Full Sequence | Protein | HLA Restriction | Reference 1 | VTE | VTEHDTLLY | pp50 | A*01:01 | Elkington et al. 2003 ( 21 ) 2 | YSE | YSEHPTFTSQY | pp65 | A*01:01 | Longmate et al. 2001 ( 22 ) 3 | NLV | NLVPMVATV | pp65 | A*02:01 | Diamond et al. 1997 ( 23 ) 4 | VLE | VLEETSVML | IE-1 | A*02:01 | Khan … Immunogenetics ( 2001 ) 52 ( 3-4 ): 165–73 . 10.1007/s002510000271 11220618 23 Diamond DJ York J Sun JY Wright CL Forman SJ . Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection . …

New Directions in the Study and Treatment of Metastatic Cancer.

Traditional cancer therapy has relied on a strictly cytotoxic approach that views non-metastatic and metastatic tumor cells as identical in terms of molecular biology and sensitivity to therapeutic intervention. Mounting evidence suggests that, in fact, non-metastatic and metastatic tumor cells differ in key characteristics that could explain the capacity of the metastatic cells to not only escape the primary organ but also to survive while in the circulation and to colonize a distant organ. Here, we lay out a framework for a new multi-pronged therapeutic approach. This approach involves modif

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… Plot of (A) % change in tumor volume and (B) average body weight for mice treated with (i) no treatment (open diamonds), (ii) ultrasound only (filled diamonds), (iii) gemcitabine (open triangles), (iv) O 2 MB-RB/O 2 MB-5FU mix − US (open circles), (v) O 2 MB-RB + US (filled squares), (vi) O 2 MB-RB/O …

Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity.

Multiple myeloma (MM) cells induce relevant angiogenic effects within the human bone marrow milieu (huBMM) by the aberrant expression of angiogenic factors. Hypoxia triggers angiogenic events within the huBMM and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is over-expressed by MM cells. Since synthetic miR-199a-5p mimics negatively regulates HIF-1α, we here investigated a miRNA-based therapeutic strategy against hypoxic MM cells. We indeed found that enforced expression of miR-199a-5p led to down-modulated expression of HIF-1α as well as of other pro-angiogenic factors such a

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… therapeutic approaches in multiple myeloma Curr Cancer Drug Targets 2012 12 7 768 775 22780844 10.2174/156800912802429346 13 Hickey MM Simon MC Regulation of angiogenesis by hypoxia and hypoxia-inducible factors Curr Top Dev Biol 2006 76 217 257 17118268 10.1016/S0070-2153(06)76007-0 14 Martin SK Diamond … P Williams SA To LB Peet DJ Fujii N Gronthos S Harris AL Zannettino AC Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells Haematologica 95 5 776 784 20015878 10.3324/haematol.2009.015628 PMC2864384 15 Martin SK Diamond P Gronthos S Peet DJ …

Balloon-assisted sacroplasty as a successful procedure for osteoporotic sacral insufficiency fractures after failure of the conservative treatment.

Osteoporotic vertebral fractures without prior adequate traumatization are frequent diagnosed in orthopedics because of the increasing life expectancy and incidence of osteoporosis. The associated high mortality is caused by reduced mobilization which leads to a higher risk of infection and a bedridden state. On the other hand the diagnosis of sacral insufficiency fractures is often prolonged because of unspecific symptoms while being associated with similar risks. This article presents an overview of the present scientific literature and a retrospective analysis of patients treated via balloo

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… Gotis-Graham I McGuigan L Diamond T Sacral insufficiency fractures in the elderly J. Bone Surg. Br. 1994 76 882 886 10.1302/0301-620X.76B6.7983111 7983111 6. Balseiro J Brower AC Ziessman HA Scintigraphic diagnosis of sacral fractures AJR Am. J. …

Establishing measurable residual disease trajectories for patients on treatment for newly diagnosed multiple myeloma as benchmark for deployment of T-cell redirection therapy.

Autologous stem cell transplantation (ASCT) has been the prime consolidative strategy to increase the depth and duration of response in newly diagnosed multiple myeloma (NDMM), albeit with short- and long-term toxicities. Minimal residual disease (MRD) is an important early response endpoint correlating with clinically meaningful outcomes and may be used to isolate the effect of ASCT. We report the impact of ASCT on MRD burden and generate a benchmark for evaluation of novel treatments as consolidation. We collected MRD by next generation sequencing (NGS; clonoSEQ®) post induction and post-ASC

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… Maura F, Weinhold N, Diamond B, Kazandjian D, Rasche L, Morgan G, et al. The mutagenic impact of melphalan in multiple myeloma. Leukemia. 2021;35:2145–50. 20. Bal S, Godby K, Chhabra S, Medvedova E, Cornell RF, Hall AC, et al. …

Параллельные клинические испытания селинксора у пациентов с продвинутой тимомой и тимической карциномой.

ВВЕДЕНИЕ: ТИМИЧЕСКИЕ эпителиальные опухоли (ТЕТ) редки и включают тимомы (Т) и тимические карциномы (ТК). Для пациентов с прогрессивными заболеваниями после платиновой химиотерапии необходимы эффективные варианты лечения. Доклинические исследования показали антитумбурную активность селинксора, ингибитора ядерного рецептора exportin-1 (XPO1/CRM1), поддержка клинического развития XPO1-targeted - лечение ТЭТ. Для дальнейшей оценки безопасности и эффективности селинксора в ТЭЦ мы провели two - скоординированные параллельные клинические испытания второго этапа.МЕТОДЫ: В настоящий доклад включена ин

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… Kim reports receiving research funding (to institution) from Karyopharm , 10.13039/100004325 AstraZeneca , 10.13039/100004336 Novartis , Regeneron, Janssen, Genentech, Lyell, Daiichi Sankyo, Gilead, Macrogenics, Boehringer Ingelheim, Black Diamond Therapeutics, and ORIC Pharmaceuticals; providing consulting …

Risk of rehospitalization due to Clostridioides difficile infection among hospitalized patients with Clostridioides difficile: a cohort study.

BackgroundReducing rehospitalization has been a primary focus of hospitals and payors. Recurrence of Clostridioides difficile infection (CDI) is common and often results in rehospitalization. Factors that influence rehospitalization for CDI are not well understood.ObjectiveTo determine the risk factors that influence rehospitalization caused by CDI.DesignA retrospective cohort study from January 1, 2018, to December 31, 2018, of patients aged ≥18 who tested positive for C. difficile while hospitalized.SettingAcademic hospital.MethodsThe risk of rehospitalization was assessed across exposures d

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… Diamonds represent time point in which the patient is censored. The dashed line represents the median rehospitalization time (50 th percentile). Table 2. …

Трабковая кость как дополнительный инструмент для оценки плотности костных минералов у пациентов с асимптоматической моноклонной гаммопатией.

Фон/цели: Моноклональные гаммопатии, такие, как Моноклональная Гаммопатия Неопределенной Значимости (MGUS) и Смолдинг Мильома (SMM), являются условиями, характеризующимися перепроизводством конкретных моноклонных белков. Известно, что больные, страдающие этими заболеваниями, подвержены более высокому риску переломов по сравнению с населением в целом, однако не существует каких-либо руководящих принципов оценки или регулирования состояния их здоровья. Скорость кости (TBS), которая может быть рассчитана на основе изображений поясничного позвоночника DXA, позволяет получить дополнительную информа

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… Diamond T. Prevalence of monoclonal gammopathy of undetermined significance/myeloma in patients with acute osteoporotic vertebral fractures Acta Haematol. 2008 120 87 90 10.1159/000162282 18852483 14. Bida J.P. Kyle R.A. Therneau T.M. Melton L.J. 3rd Plevak M.F. Larson D.R. Dispenzieri A. …

Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma.

Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of pati

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… Diamond EL , Corner GW , De Rosa A , Breitbart W , Applebaum AJ . Prognostic awareness and communication of prognostic information in malignant glioma: a systematic review . J Neurooncol. 2014 ; 119 ( 2 ): 227 - 234 . 24874468 10.1007/s11060-014-1487-1 PMC5116439 15. …