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ERN ReCONNET-SLICC-SLEuro consensus on the therapeutic management of rare systemic lupus erythematosus manifestations (part 2).

Systemic lupus erythematosus (SLE) guidelines predominantly focus on common major organ involvement. An international taskforce from three S … ulmonary haemorrhage, rare cutaneous manifestations (bullous lupus, chilblain lupus, lupus tumidus, erythema multiforme, and toxic epidermal necrolysis-like lupus erythematosus), renal manifestations (interstitial nephritis and lupus podocytopathy), rare neurological manifestations (chorea, small fibre neuropathy, catatonia, and intracranial hypertension), rare gastr …

Positive Direct Immunofluorescence in Rowell Syndrome: Further Support for a Subtype of Cutaneous Lupus Erythematosus.

Rowell syndrome (RS) is a rare clinical entity characterized by erythema multiforme (EM)-like lesions and lupus erythematosus (LE). Immunologic findings associated with RS include a speckled antinuclear antibody (ANA) pattern, positive rheumatoid factor (RF), and anti-Ro (SS-A)/anti-La (SS-B) antibodies. While direct immunofluorescence (DIF) positivity is a hallmark of cutaneous LE (CLE), recent diagnostic criteria for RS suggest DIF should be negative, raising debate over whether RS is a distinct disease or a CLE variant. We present the case of a 42-year-old woman with systemic lupus erythema…

Severe Skin Disorders Due to Sorafenib Use After Nivolumab Treatment in Renal Cell Carcinoma Patients.

BACKGROUND: We report two cases in which severe skin disorders developed during sorafenib treatment in patients with renal cell carcinoma (RCC) who had previously received nivolumab. CASE REPORT: Case 1: A 50-year-old man with RCC received nivolumab as the fifth-line therapy followed by sorafenib as the sixth-line therapy. On day 15 of sorafenib administration, the patient was hospitalized with systemic erythema multiforme, acne-like skin rash, and hand-foot syndrome. Case 2: A 40-year-old man with RCC received nivolumab as the second-line therapy followed by sorafenib as the fifth-line treat…

дерматологические проявления заболевания коронавируса 2019 года у детей: системный обзор.

ВВЕДЕНИЕ: Все большее число публикаций, описывающих дерматозы, связанные с болезнью коронавируса 2019 года (COVID-19), свидетельствует о различиях в морфологии и распространенности дерматоза среди детей по сравнению с населением в целом. МАТЕРИАЛ И МЕТОДЫ: Из 22 отобранных полнотекстовых статей дерматозы, связанные с COVID-19, были описаны у 196 детей (средний возраст: 12,57 года). Единственным симптомом для большинства пациентов (n = 134; 68,4%) были дерматозные заболевания. Анализы Nasopharyngeal мазков показали, что инфекция SARS-COV-2 имела место только в 18 случаях (n = 18/69; 26,1%).РЕЗУ

Совпадение в аннотации оригинала
INTRODUCTION: An increasing number of publications describing dermatoses associated with Coronavirus disease 2019 (COVID-19) have shown diff … toses described include chilblain-like lesions (n = 173; 88.3%), maculopapular rash (n = 16; 8.2%), erythema multiforme-like lesions (n = 12; 6.1%), varicella-like exanthema (n = 1; 0.5%), and urticaria (n = 1; 0.5%). CONCLUSIONS: This publication aims to summarise existing data on dermatoses and to draw attention to how identification of dermatological symptoms in …

Allopurinol-Induced Stevens-Johnson Syndrome.

Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA. …

Non-haemorrhagic, bilateral adrenal infarction in a patient with antiphospholipid syndrome along with lupus myocarditis.

A 40-year-old woman with antiphospholipid syndrome presented with a 5-day history of right upper quadrant (RUQ) pain, radiating posteriorly, associated with fever and vomiting. She was admitted 1-week prior with an upper respiratory infection and erythema multiforme. Clinical assessment revealed sepsis with RUQ tenderness and positive Murphy's sign. Laboratory results showed raised inflammatory markers, along with renal and liver impairment. CT showed bilateral adrenal infarction and inferior vena cava thrombus. The patient was managed for sepsis and started on heparin. Further immunological i…

Rapid clinical change in lesions of atypical cutaneous lymphoproliferative disorder in an HIV patient: a case report and review of the literature.

BACKGROUND: HIV associated atypical cutaneous lymphoproliferative disorder (ACLD) is a rare condition characterized by a pruritic, often gen … ts that this condition should be considered in the differential diagnosis with syphilis or atypical erythema multiforme in HIV patients.

Oral mucosal lesions in children from 0 to 12 years old: ten years' experience.

OBJECTIVE: The exact prevalence of oral lesions in childhood is not well known. We sought to define the prevalence of oral mucosal lesions i … (17.8%), recurrent aphthous ulcerations (14.8%), herpes simplex virus type 1 infections (9.3%), and erythema multiforme (0.9%). Children suffering from chronic diseases had a higher frequency of oral lesions compared with healthy children (chi-square: P < .01). CONCLUSION: Mucosal alterations in children are relatively common, and several oral disorders are associat …

Non-infectious ulcerating oral mucous membrane diseases.

Non-infectious ulcerative oral mucous membrane diseases are difficult to separate at first glance: they can appear as aphthous, bullous, lic … with intraepidermal or subepidermal formation of blisters including pemphigus, bullous pemphigoid, erythema multiforme and variants as well as allergic or toxic contact stomatitis.

Clinicopathological analysis of oral mucous autoimmune disease: A 27-year study.

OBJECTIVES: The aim of the present study was to analyze the main clinical and histopathological features of autoimmune diseases with oral manifestations such as oral lichen planus (OLP); mucous membrane pemphigoid (MMP); pemphigus vulgaris (PV) and erythema multiforme (EM). STUDY DESIGN: Retrospective review of 5770 files from the Oral Pathology Laboratory of São José dos Campos Dental School, São Paulo State University (UNESP) comprising a 27-year period from 1974 to 2000. RESULTS: The cases accounted for 64 (1.10%) of 5770 anatomopathological examinations performed over the study period. A…