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Prevalence, awareness, and treatment of anemia in Chinese patients with nondialysis chronic kidney disease: First multicenter, cross-sectional study.

This was the first multicenter, cross-sectional survey to assess the prevalence of anemia, patient awareness, and treatment status in China. Data of patients with chronic kidney disease (CKD; age, 18-75 years; both out- and inpatients) from 25 hospitals in Shanghai, seeking medical treatment at the nephrology department, were collected between July 1, 2012 and August 31, 2012. The prevalence, awareness, and treatment of anemia in patients with nondialysis CKD (ND-CKD) were assessed. Anemia was defined as serum hemoglobin (Hb) levels ≤12 g/dL in women and ≤13 g/dL in men. A total of 2420 patien

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… Because of the ever-growing population of patients with CKD, nephrologists are concerned about anemia in patients with ND-CKD and the treatment modalities to delay end-stage renal disease (ESRD) and reduce the high cardiovascular risk associated with it. [ 23 , 24 ] Furthermore, reliable prevalence data … One nephrologist in each center underwent formal training for data entry. All participants were voluntary and submitted written informed consent. Patient identity was kept anonymous. Each participating site procured approval from the institutional review board before study initiation. …

Low-dose daratumumab and bortezomib for the treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a case report.

BACKGROUND: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is an exceptionally rare glomerular disease, accounting for only 0.17-3.7% of all renal biopsies, and no consensus-based treatment algo-rithm has been established. Although daratumumab, a humanized anti-CD38 monoclonal antibody, has shown promising efficacy in PGNMID, the existing evidence is limited to small case series using standard-dose regimens (16 mg/kg). Critically, data on reduced-dose daratumumab in elderly patients with CyBorD-refractory disease and multiple comorbidities remain scarce. This

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… Acknowledgments The authors thank the nephrologists, hematologists, pathologists, and clinical researchers whose pioneering work on proliferative glomerulonephritis with mono- clonal immunoglobulin deposits (PGNMID) and monoclonal gammopathy of renal significance (MGRS) has advanced our understanding … Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective . Nephrol Dial Transplant . ( 2021 ) 36 : 208 – 15 . doi: 10.1093/ndt/gfz176 , 33494099 5. Liu M Yu X Wang S Qin A Zhou F Zhao M . …

Expanded haemodialysis: news from the field.

Expanded haemodialysis (HDx) has emerged as a promising solution to improve haemodialysis effectiveness. A medium cut-off membrane allows the removal of a wider range of uraemic toxins. However, little is known about the potential interesting applications of HDx therapy. Feedback from the first routine use of HDx therapy under real-life conditions in European facilities was excellent for priming and rinse back. There was no adverse event after 5191 HDx treatments. Patients suffering from itching, restless legs syndrome, persistent asthenia or malnourishment could benefit from HDx therapy. More

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… Nurses and nephrologists answered questionnaires about everyday use of Theranova ® in their HD centres. The satisfaction with regards to packaging, priming and the rinsing of the membrane was collected using a three-level scale (full, medium and poor satisfaction, scored, respectively, 1, 2 and 3). … Thus, to avoid these issues in HDF-using centres, strengthened prevention through training of nurses is required and nephrologists should pay particular attention to HD session prescription. More generally, the study found that HDx therapy was easy to handle in routine use. …

Clinical Presentation, Renal Histopathological Findings, and Outcome in Patients with Monoclonal Gammopathy and Kidney Disease.

Monoclonal gammopathies are associated with acute and chronic kidney injury. Nephrotoxicity of the secreted monoclonal (M)-protein is related to its biological properties and blood concentration. Little is known about epidemiology, clinical manifestations, and outcome of monoclonal gammopathies in patients with kidney disease. We retrospectively collected data about demographics, clinical manifestations, and renal histological lesions of all patients (n = 1334) who underwent kidney biopsy between January 2000 and March 2017. Monoclonal gammopathy was detected in 174 (13%) patients with a mean

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… The growing interest in this new pathological entity has spurred nephrologists and hematologists to reevaluate the pathogenicity of these small and apparently indolent clones. … Once M-protein has been identified and characterized, exclusion of a malignant disorder should remain a high priority among nephrologists, as the outcome of the patient is associated with a poor prognosis if left untreated. …

Effect of electronic patient record use on mortality in End Stage Renal Disease, a model chronic disease: retrospective analysis of 9 years of prospectively collected data.

BackgroundIn chronic disease, health information technology promises but has yet to demonstrate improved outcomes and decreased costs. The main aim of the study was to determine the effects on mortality and cost of an electronic patient record used in daily patient care in a model chronic disease, End Stage Renal Disease, treated by chronic maintenance hemodialysis. Dialysis treatment is highly regulated, and near uniform in treatment modalities and drugs used.MethodsThe particular electronic patient record, patient-centered and extensively coded, was used first in patient care in 3 dialysis u

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… Eight full-time salaried Rogosin Institute staff nephrologists, who also care for renal and transplant patients, teach, and do clinical research, and 2 nurse practitioners care for patients in Unit A. … In Unit B, there are 1 to 2 Rogosin nephrologists, 2 to 5 in private practice, and 1 nurse practitioner. In Unit C, the 3 nephrologists are in private practice. Participants The patients were all 1790 patients treated by chronic maintenance HD from 91 days after ESRD start. …

Acute Kidney Injury in Hospitalized Cancer Patients: Single-Centre Real-Life Analysis of Incidence and Clinical Impact.

Background: Acute kidney injury (AKI) is a frequent and clinically relevant complication in cancer patients, with highly variable incidence. AKI increases morbidity and mortality, prolongs hospitalization, and may limit access to oncologic therapies. This study evaluated the incidence, risk factors, and outcomes of AKI in hospitalized cancer patients. Methods: We retrospectively analyzed patients admitted between 1 January 2016 and 31 December 2019. Individuals with cancer were identified and categorized into three groups: hematologic malignancies, solid cancers with metastases, and solid canc

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… Finally, these findings support a multidisciplinary approach involving oncologists, nephrologists, intensivists, and supportive care specialists, particularly in high-risk populations such as those with hematologic cancers or critical illness [ 37 ]. … Malignancy Diseases and Kidneys: A Nephrologist Prospect and Updated Review. Medicine. 2023;102:e33505. doi: 10.1097/MD.0000000000033505. 30. Perazella M.A. Drug-Induced Acute Kidney Injury. Curr. Opin. Crit. Care. 2019;25:550–557. doi: 10.2215/CJN.11290821. 31. …

Treatment of acute kidney injury in cancer patients.

Acute kidney injury (AKI), either of pre-renal, renal or post-renal origin, is an important complication in cancer patients, resulting in worse prognosis, withdrawal from effective oncological treatments, longer hospitalizations and increased costs. The aim of this article is to provide a literature review of general and cause-specific treatment strategies for AKI, providing a helpful guide for clinical practice. We propose to classify AKI as patient-related, cancer-related and treatment-related in order to optimize therapeutic interventions. In the setting of patient-related causes, proper as

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… This further underpins the need for frequent and thorough interactions between nephrologists and oncologists, i.e. the rational basis of the subspecialty of onco-nephrology. … According to the guidelines, the need and timing of kidney biopsy should be discussed with the nephrologist in difficult cases [ 63–65 ]. …

Бремя хронической почечной болезни по категориям KDIGO Glomerular Filtration Standard and Albuminuria: системный обзор.

ВВЕДЕНИЕ: Заболевание почек: улучшение глобальных результатов (KDIGO) 2012 Руководящие принципы рекомендуют категоризировать пациентов по гломерулярной скорости фильтрации (GFR) и альбуминурии для прогнозирования хронического заболевания почек (CKD). Цель этого систематического обзора заключалась в изучении эпидемиологического бремени ОВД, стратифицированного КДИГО 2012 категории. МЕТОДЫ: МЕДЛИНЕ и Эмбасе были найдены для наблюдения за пациентами с ККД, результаты которых были стратифицированы в соответствии с KDIGO 2012 классификация. В числе исследованных результатов можно назвать распростра

[Access for starting kidney replacement therapy: vascular and peritoneal temporal access in pre-dialysis].

UNLABELLED: PATIENT EVALUATION AND PREPARATION PRIOR TO VASCULAR ACCESS (VA) PLACEMENT: 1. Early referral of patients with advanced chronic kidney disease (ACKD: GFR <or= 30 ml/min: CKD stage 4) is necessary so that they are educated about the different modalities of kidney replacement therapy (KRT) and there is sufficient time to perform a permanent functioning VA before the initiation of HD (Strength of Recommendation C). 2. Preservation of the venous network of the upper extremities (UE): - Venipuntures and catheterizations in the UE should be avoided to reduce the incidence of venous occlu

Acute kidney injury in critically ill cancer patients: an update.

Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients frequently develop acute kidney injury (AKI). A wide variety of definitions for AKI are still used in the cancer literature, despite existing guidelines on definitions and staging of AKI. Alternative diagnostic investigations such as Cystatin C and urinary biomarkers are discussed briefly. This review summarizes the literature between 2010 and 2015 on

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… Given the increasing number of novel therapeutics and the complexity of cancer treatment protocols, nephrologists and intensivists face the difficult task to stay updated on the advances in onco-nephrology. … A specific cause of potentially dramatic AKI – acute TLS – requires the attention of all stakeholders; the hemato-oncologist, the nephrologist, and the intensivist. …

Short term outcome of patients attending a renal-immunology clinic in central India.

BACKGROUND: : Glomerular diseases (GDs) and other renal immunologic diseases are an important cause of morbidity and mortality. Providing a single point of service in collaboration with various specialists at a renal immunology clinic for such patients is not novel, but outcomes have not been reported. Here, we report the short-term outcome of Indian patients attending our clinic. METHODS: : This single-center prospective cohort study enrolled biopsy-proven immunologically-mediated adults with renal diseases between April 2018 and December 2019, and followed them for six months. The primary e

Uremic Paralytic Ileus in a 70 Years Old Female: A Diagnostic Dilemma.

Uremia has been associated with slowed intestinal motility, resulting in loss of peristalsis and the development of paralytic ileus. We present a case of uremia-induced paralytic ileus in a 70-year-old woman. The patient was admitted with a 7-day history of abdominal pain, vomiting, and constipation. Initial evaluation revealed a soft non-tender abdomen with decreased bowel sounds. Urgent ultrasonography showed dilated gut loops and sluggish gut motility, while atrophic kidneys with hydronephrosis were also appreciated. Routine biochemistry labs revealed elevated creatinine and potassium level

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… CONCLUSION: There are several advantages of TDC insertion by nephrologists. With an active role and responsibility of vascular access creation, nephrologists get better idea about the vascular access needs of their patients. Care will not compartmentalised across various disciplines. … Tunnelled dialysis catheter insertion by nephrologists has a good success rate and safety profile with lesser cost. …

Variation in Kidney Transplant Referral, Living Donor Contacts, Waitlisting, and Kidney Transplant Across Regional Renal Programs in Ontario, Canada: A Population-Based Cohort Study.

BackgroundPrevious studies conducted in publicly and privately funded health care systems suggest that access to kidney transplants may vary depending on where a patient receives their kidney care. It is poorly understood whether variability exists across the key steps required to receive a kidney transplant in a publicly funded health care system.ObjectiveTo determine whether there is variation across Ontario's regional renal programs (RRPs) in key steps completed toward receiving a kidney transplant.DesignPopulation-based cohort study from November 1, 2017, to December 31, 2021, using linked

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… One potential barrier may be that nephrologist and RRP remuneration in Ontario for transplant-related activity is lower than that for dialysis-related activities. … Modifying financial incentives for nephrologists to manage kidney transplant recipients and providing incentives to RPPs for getting their patients transplanted may improve access to kidney transplants. Once barriers are identified, patients and providers can co-design solutions to target them. …

Clinical characteristics and outcomes of patients on haemodialysis at Jimma medical center, Ethiopia: a 7-Year review.

BACKGROUND: Haemodialysis is the primary kidney replacement therapy modality in Africa. In Ethiopia, the number of patients undergoing Haemodialysis is increasing, yet data on their outcomes is scarce. This study assesses the clinical characteristics and outcomes of Haemodialysis patients at Jimma Medical Center. METHODS: A retrospective cross-sectional study was conducted from April 08 to 12, 2024, involving patients who underwent Haemodialysis at Jimma Medical Center from June 2017 to March 2024. The data were coded and entered into EpiData version 3.1, then exported to the Statistical Pack

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… The HD unit at JMC was established in June 2017 and is staffed by one nephrologist and four nurses. It is equipped with two dialysis machines, both utilizing low-flux membranes. … The substantial percentage of AKI patients requiring dialysis in our cohort likely reflects delayed presentation to nephrologists, which can be attributed to late referrals and health-seeking behaviors. …

Multidisciplinary Approach to Older Adults with Hematologic Malignancies-a Paradigm Shift.

Hematologic malignancies are most likely to present in the seventh and eighth decades of life. Continued population growth will lead to increasing numbers of older adults with hematologic malignancies. Oncology care for older adults is complex and must account for the effect of aging on disease biology and treatment tolerance. Multidisciplinary oncology care has been utilized in solid tumor oncology for decades, initially driven by the need for multi-modality treatment. In this review, we make the case for multidisciplinary oncogeriatric care for older adults with hematologic malignancies in o

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… Our CAC team is comprised of nephrologists, neurologists, cardiologists, hematologists, and physical therapists. The CAC runs biweekly with up to six patients scheduled on a half-day clinic. … Table 2 Comparison of existing multidisciplinary oncology clinics at The James Cancer Hospital | Comprehensive amyloidosis clinic | Cancer and aging resiliency clinic Team members | Hematologist Cardiologist Nephrologist Neurologist Physical therapist Nurse case manager Clinical nurse Pharmacist | Audiologist …

Множественная миелома с психической нефропатией и негативом Бенса-Джонса Протеинурии: Редкое клиническое представление.

Множественная миелома (MM) — злокачественное расстройство плазменных клеток, которое обычно вызывает анемию, боль в костях, гиперкальцемию и почечную недостаточность. Мы сообщаем о случае 55-year-old Мужчина, у которого были в основном острые повреждения почек (АКИ), пинентопенция и системное воспаление без классических особенностей гиперкальцемии или литических повреждений костей. В частности, мочевые белки Бенса-Джонса были отрицательными, несмотря на заметно повышенную сыворотку каппа и аномальный белковый электрофорез (SPEP). Биопсия костного мозга выявила скромный плазмоцитоз, в то время

Atrial Fibrillation With Decompensated Heart Failure Complicated With Non-ST Elevation Myocardial Infarction.

Non-ST-elevation myocardial infarction (NSTEMI) has a less severe ratio of acute coronary syndromes compared with ST-segment elevation myocardial infarction (STEMI), arising from complete occlusion of a major coronary artery. The name implies a syndrome that does not exhibit the dramatic ST-elevation seen in the traditional 12-lead ECG in chest pain patients with a confirmed diagnosis of STEMI. The crucial clinical significance of NSTEMI is that delay in diagnosis can lead to increased morbidity, risk of arrhythmia, and death. It was recently reported that atrial fibrillation (AF) correlates w

The Coexistence of Multiple Myeloma-associated Amyloid Light-chain Amyloidosis and Fabry Disease in a Hemodialysis Patient.

Fabry disease (FD) is an inherited lysosomal disorder caused by an X-linked α-galactosidase A deficiency. We report the case of a 50-year-old male FD patient on hemodialysis who presented with macroglossia-related speaking difficulty and gastrointestinal symptoms. An endoscopic analysis revealed multiple gastric ulcers, and a histological examination led to a diagnosis of amyloid light-chain amyloidosis. Serum free light-chain and bone marrow analyses detected multiple myeloma (MM). Treatment with bortezomib and dexamethasone significantly improved the patient's symptoms. This is the first cas

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… Accordingly, FD patients, who present with various clinical features and multi-organ dysfunction, tend to pose a diagnostic challenge for nephrologists, and this tendency is expected to increase in the future. …

Towards an adiposity-related disease framework for the diagnosis and management of obesities.

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart,

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… Renal stone disease and obesity: What is important for urologists and nephrologists? Ren Fail. 2012;34:1348–1354. doi: 10.3109/0886022X.2012.723777. 47. Sinha MK, Collazo-Clavell ML, Rule A, et al. Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery. … A nephrologist perspective on obesity: from kidney injury to clinical management. Front Med. 2021;8:655871. doi: 10.3389/fmed.2021.655871. 51. Foster MC, Hwang SJ, Massaro JM, et al. Association of subcutaneous and visceral adiposity with albuminuria: The framingham heart study. …