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Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature.

BackgroundPrecision medicine is based on molecular and genotypic patient characterization to define specific target treatment. BRAF mutation is an oncogenic driver, and the Cancer Genome Atlas has identified BRAF mutations in different cancer types. Tumor type agnostic therapy is based on targeting genomic alterations, regardless of tumor origin. In this context, novel therapeutic agents including BRAF and MEK inhibitors based on the molecular landscape in solid tumors have been investigated. Case presentation, Case 1: The first case is chemotherapy-refractory, BRAF V600E mutated intrahepaticc

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… Hyman D.M., Puzanov I., Subbiah V., Faris J.E., Chau I., Blay J.Y., Wolf J., Raje N.S., Diamond E.L., Hollebecque A., et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N. Engl. J. Med. 2015;373:726–736. doi: 10.1056/NEJMoa1502309. 30. …

Воздействие окисляющего стресса Gene Protein, экспрессии и метилирования ДНК на множественный склероз: многомерное исследование менделий.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Окисляющий стресс (ОС) связан с развитием множественного склероза (MS), однако причинно-следственная связь с точки зрения генетической патофизиологии остается неясной. Мы использовали менделианскую случайность (MR) и анализ совместной локализации для изучения взаимосвязи между генами ОС и MS с использованием комплексного подхода, основанного на мультиомике. МЕТОДЫ: Мы получили данные по результатам исследования, проведенного в рамках всей ассоциации по геному (GWAS) MS, из Международного консорциума по многоразовым склерозовым генетикам (этап обнаружения) и исследования

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… (A) Chromosome Loci Map: The top plot displays the p values for SNPs from GWAS and SMR tests, with solid diamonds indicating SNPs that pass the HEIDI test. The middle plot illustrates the eQTL results for STAT3 . …

Coronary lesions in patients with COPD (Global Initiative for Obstructive Lung Disease stages I-III) and suspected or confirmed coronary arterial disease.

BackgroundSystemic inflammation is the pathophysiological link between coronary artery disease (CAD) and COPD. However, the influence of subclinical COPD on patients with suspected or diagnosed CAD is largely unknown. Thus, this study was designed to evaluate the degree of coronary involvement in patients with COPD and suspected or confirmed CAD.MethodsIn this cross-sectional study, carried out between March 2015 and June 2017, 210 outpatients with suspected or confirmed CAD were examined by both spirometry and coronary angiography or multidetector computed tomography. These patients were divi

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… University Hospital of the Federal University of Sergipe (FUS), in addition to the Echocardiography Laboratory (ECOLAB) of the Clínica e Hospital São Lucas, Aracaju, Sergipe, Brazil, a cardiology referral center, with Accreditation with Excellence (Instituto Qualisa de Gestão) and Qmentum International Diamond …

Bone-Specific Alkaline Phosphatase Levels among Patients with Multiple Myeloma Receiving Various Therapy Options.

ObjectiveThis study aimed to investigate the impact of the different therapy regimens used in multiple myeloma (MM) on bone-specific alkaline phosphatase (BALP) levels.Materials and methodsOne hundred and thirteen patients with MM were included in the study. Patients were grouped according to the regimens they received, as follows: group 1, melphalan and prednisolone (MP); group 2, vincristine, adriablastin, and dexamethasone (VAD); group 3, thalidomide plus dexamethasone; and group 4, bortezomib plus dexamethasone. BALP levels were measured before treatment and at the third and sixth months o

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… Diamond T, Levy S, Day P, Barbagallo S, Manoharan A, Kwan YK. Biochemical, histomorphometric and densitometric changes in patients with multiple myeloma: effects of glucocorticoid therapy and disease activity. Br J Haematol. 1997;97:641–648. doi: 10.1046/j.1365-2141.1997.1042920.x. 23. …

Навигация Прогнозного диалога во время серьёзных болезнетворных споров.

ВАЖНОСТЬ: Двойное осознание, способность жить конструктивно, готовясь к концу жизни, имеет ключевое значение для разговоров о серьезных заболеваниях. В гематологии прогнозируемая неопределенность и ожидания новых методов лечения часто задерживают прогнозируемый диалог, ограничивая возможности для развития у пациентов и лиц, обеспечивающих уход, двойного понимания. ЦЕЛЬ: Изучение вопроса о том, каким образом пациенты, те, кто ухаживает за больными, и гематологические врачи, обученные разговорам о серьезных заболеваниях, ведут перспективный диалог и как это может способствовать двойному осознани

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… But we hope to reach the diamond wedding anniversary by the end of this year. …

A Cost-Effectiveness Analysis of Mosunetuzumab vs Tisagenlecleucel for Treatment of Third- or Higher-Line (3L+) Relapsed or Refractory (R/R) Follicular Lymphoma (FL) in Italy.

PURPOSE: To compare the cost-effectiveness of mosunetuzumab with tisagenlecleucel for treating patients with relapsed or refractory follicular lymphoma (R/R FL 3L+) from the perspective of the Italian National Health Service (NHS). PATIENTS AND METHODS: The analysis employs a weekly cycle partitioned survival model (PSM) with a lifetime horizon. The PSM model tracks patient outcomes based on time-to-event data, including progression-free survival (PFS) and post-progression survival (PPS). A matching-adjusted indirect treatment comparison (MAIC) approach was used to account for differences in

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… Notes : The yellow diamond represents the deterministic case (base case). …

Factors influencing further vertebral height loss following percutaneous vertebroplasty in osteoporotic vertebral compression fractures: A 1-year follow-up study.

BackgroundOsteoporotic vertebral compression fractures (OVCFs) contribute to back pain and functional limitations in older individuals, with percutaneous vertebroplasty (PVP) emerging as a minimally invasive treatment. However, further height loss post-PVP prompts investigation into contributing factors.AimTo investigate the factors associated with further height loss following PVP with cement augmentation in OVCF patients.MethodsA total of 200 OVCF patients who underwent successful PVP between January 2021 and December 2022 were included in this study. "Further height loss" during 1 year of f

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… Clark W, Bird P, Gonski P, Diamond TH, Smerdely P, McNeil HP, Schlaphoff G, Bryant C, Barnes E, Gebski V. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. …

Clonal Myeloid Dysplasia Following CAR T-Cell Therapy: Chicken or the Egg?

Multiple myeloma (MM) is characterized by recurrent relapses. Consequently, patients receive multiple therapy lines, including alkylating agents and immune modulators, which have been associated with secondary malignancies such as myelodysplastic syndrome (MDS). Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T cell (CART) therapy is efficacious in patients with relapsed/refractory (R/R) MM. However, the long-term complications, particularly MDS, are not well understood. Whether CART therapy causes or promotes MDS has not been thoroughly investigated. In this study, we explored

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… Jonsdottir G., Björkholm M., Turesson I., Hultcrantz M., Diamond B., Porwit A., Landgren O., Kristinsson S.Y. Cumulative Exposure to Melphalan Chemotherapy and Subsequent Risk of Developing Acute Myeloid Leukemia and Myelodysplastic Syndromes in Patients with Multiple Myeloma. Eur. J. …

Sexual Function in Women Survivors of Hematologic Malignancy after Autologous Hematopoietic Stem Cell Transplantation.

A multicenter, cross-sectional study was conducted to assess the sexual function of women survivors of hematologic malignancy after autologous hematopoietic stem cell transplantation (AHSCT), and to compare it with that of healthy women controls. Fifty-six sexually active women survivors of hematologic malignancy who underwent AHSCT were recruited through convenience sampling, as well as 60 healthy women. Demographic and clinical data questionnaires and the Female Sexual Function Index (FSFI) were completed. Survivors had a median age of 44 years and a median time since transplant of 3 years,

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… Diamond M.P. Sexual function in elderly women: A review of current literature Rev. Obstet. Gynecol. 2012 5 16 27 22582123 PMC3349920 35. Nappi R.E. Lachowsky M. …

Geriatric assessments and frailty scores in multiple myeloma patients: a needed tool for individualized treatment?

PURPOSE OF REVIEW: Multiple myeloma is a disease of elderly adults. Improvement in survival has occurred because of biological insights and novel agents. Therapeutic options involve choices today, thus have become more complex. Demographics have led to an increased number of elderly patients and age may be associated with a poorer outcome but is not the only prognostic predictor today. RECENT FINDINGS: To evaluate patients' health status rather than their chronological age alone, frailty scores and functional geriatric assessments are used to identify prognostic groups, avoid adverse events,

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… Br J Haematol 2014 ; 165 : 824 – 831 . 24684252 10.1111/bjh.12837 9 Diamond E Lahoud OB Landau H . Managing multiple myeloma in elderly patients . Leuk Lymphoma 2018 ; 59 : 1300 – 1311 . 28847191 10.1080/10428194.2017.1365859 PMC7494002 10 Jackson GH Pawlyn C Cairns DA . …

Leptomeningeal Metastasis: The Role of Cerebrospinal Fluid Diagnostics.

Background: Metastatic spread into the cerebrospinal fluid (CSF) represents a severe complication of malignant disease with poor prognosis. Although early diagnosis is crucial, broad spectrums of clinical manifestations, and pitfalls of magnetic resonance imaging (MRI) and CSF diagnostics can be challenging. Data are limited how CSF parameters and MRI findings relate to each other in patients with leptomeningeal metastasis. Methods: Patients with malignant cells in CSF cytology examination diagnosed between 1998 and 2016 at the Department of Neurology in the Hannover Medical School were includ

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… Hatzoglou V Karimi S Diamond EL Lis E Krol G Holodny AI . Nonenhancing leptomeningeal metastases: imaging characteristics and potential causative factors . Neurohospitalist. ( 2016 ) 6 : 24 – 8 . 10.1177/1941874415591702 26753054 PMC4680901 27. …

Bone-targeted agents in multiple myeloma.

Osteolytic bone disease, characterized by bone pain, increased risk of pathologic fractures, tumor-induced hypercalcemia known as skeletal-related events (SREs), is a frequent complication of patients with multiple myeloma (MM) and persists even in the absence of active disease, resulting in a major cause of morbidity and mortality. The interaction between myeloma cells and their surrounding cells in the bone marrow (BM) microenvironment promotes both myeloma cell growth and bone destruction and forms the vicious cycle of MM bone disease. Therefore, therapeutic strategies targeting the interac

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… Vandyke K, Dewar AL, Diamond P. The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclast in vivo. J Bone Miner Res 2010;25:1759-70. 58. Lee Y. …

Second-Generation Antimitotics in Cancer Clinical Trials.

Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics, mainly microtubule-targeting agents (MTAs), such as taxanes and vinca alkaloids, are amongst the most successful anticancer drugs. By disrupting microtubules, they activate the spindle assembly checkpoint (SAC), which induces a prolonged delay in mitosis, expected to induce cell death. However, resistance, toxicity, and slippage limit the MTA's effectiveness. With the desire to overcome some of the MTA's limitations, mitotic and SAC components have attracted great interest as promising microtubule

Глубинные пространственные омики MLADI-MS, управляемые квантовой каскадной лазерной микроскопией среднего инфракрасного изображения.

В пространственной "omics " высокоуверенные молекулярные идентификации необходимы для исследования сложной биологии и для пространственной биомаркировки. Однако нынешняя масс-спектрометрическая съемка (MSI) на основе пространственной "омики" должна скомпрометировать скорость получения данных и глубину биохимического профилирования. Здесь мы введём быструю, без этикеток квантовую каскадную лазерную микроскопию среднего инфракрасного изображения (QCL-MIR), чтобы направить MSI в высокоинтересные области тканей, такие маленькие, как гломерули почки, культурные многоклеточные сфероидные я

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… Conductive indium tin oxide (ITO)-coated glass slides were purchased from Diamond Coatings (West Midlands, UK) or Bruker Daltonics ([ITO slides and MALDI IntelliSlides], Bremen, Germany). … Sections were thaw-mounted onto ITO-coated glass slides from Diamond Coating or IntelliSlides and either stored at −80 °C until further use or dried for a minimum of 15 min in a desiccator. …

Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer.

Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a poor prognosis. Initial responses to standard-of-care chemo-immunotherapy are, unfortunately, followed by rapid disease recurrence in most patients. Current treatment options are limited, with no therapies specifically approved as third-line or beyond. Delta-like ligand 3 (DLL3), a Notch inhibitory ligand, is an attractive therapeutic target because it is overexpressed on the surface of SCLC cells with minimal to no expression on normal cells. Several DLL3-targeted therapies are being developed for the treatment of

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… MLJ has received research funding (institutional) from AbbVie, Acerta, Adaptimmune, Amgen, Apexigen, Arcus Biosciences, Array BioPharma, Artios Pharma, AstraZeneca, Atreca, BeiGene, BerGenBio, BioAtla, Black Diamond, Boehringer Ingelheim, Calithera Biosciences, Carisma Therapeutics, Corvus Pharmaceuticals … Therapeutics, Tizona Therapeutics, Tmunity Therapeutics, Turning Point Therapeutics, University of Michigan, Vyriad, and Y-mAbs Therapeutics; and payments to the institution for consulting/advisory roles from AbbVie, Amgen, Arcus Biosciences, ArriVent, Astellas, AstraZeneca, Axelia Oncology, Black Diamond …

Revisiting potential value of antitumor drugs in the treatment of COVID-19.

Since an outbreak started in China in 2019, coronavirus disease 2019 (COVID-19) has rapidly become a worldwide epidemic with high contagiousness and caused mass mortalities of infected cases around the world. Currently, available treatments for COVID-19, including supportive care, respiratory support and antiviral therapy, have shown limited efficacy. Thus, more effective therapeutic modalities are highly warranted. Drug repurposing, as an efficient strategy to explore a potential broader scope of the application of approved drugs beyond their original indications, accelerates the process of d

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… Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci USA. 2005;102:11876–11881. doi: 10.1073/pnas.0505577102. 19. Ou T, Mou H, Zhang L, Ojha A, Choe H, Farzan M. … Diamond DL, Syder AJ, Jacobs JM, Sorensen CM, Walters KA, Proll SC, et al. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog. 2010;6(1):e1000719. doi: 10.1371/journal.ppat.1000719. 66. …

Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review).

Radiotherapy (RT) is increasingly recognized as a system‑level immunomodulator capable of reshaping cytokine networks across spatial, temporal and dosimetric dimensions. This review synthesizes existing evidence on RT parameters, key signaling axes, major effector cells, organ‑specific contexts and clinical translation. It describes how the cyclic GMP‑AMP synthase/stimulator of interferon genes (STING)/IFN‑I, NF‑κB and TGF‑β pathways coordinate immune activation and immune suppression after irradiation. It then summarizes macrophage‑centered regulatory circuits and chemokine axes, including C‑

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… Cancer 23 268 2024 10.1186/s12943-024-02183-9 39614288 PMC11607834 15 Aggarwal BB Gupta SC Kim JH Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey Blood 119 651 665 2012 10.1182/blood-2011-04-325225 22053109 PMC3265196 16 Lazear HM Schoggins JW Diamond … /j.ijrobp.2010.09.034 21093169 PMC3117954 51 Arina A Beckett M Fernandez C Zheng W Pitroda S Chmura SJ Luke JJ Forde M Hou Y Burnette B Tumor-reprogrammed resident T cells resist radiation to control tumors Nat Commun 10 3959 2019 10.1038/s41467-019-11906-2 31477729 PMC6718618 52 Vanpouille-Box C Diamond …

Characteristics and outcomes of Bahraini pediatric patients sent abroad for bone marrow transplantation: A ten-year retrospective cohort study.

BackgroundBone marrow transplantation (BMT) is a breakthrough procedure for patients with hematological and oncological conditions, particularly when all other treatments fail. Its indications vary between patients and settings, and its outcomes depend on the donor type, transplantation facility, and center expertise. In countries where transplantation facilities are lacking, sending patients abroad for transplantation might be a safe and effective alternative to leaving the patient to face eventual disease morbidity or even mortality if the procedure is not performed locally. However, studies

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… indications included the following: (1) Oncological conditions: AML, ALL, neuroblastoma, Hodgkin's lymphoma, Wilms’ tumor, mixed germ cell tumor, and hemophagocytic lymphohistiocytosis; (2) Hematological conditions: Aplastic anemia, beta-thalassemia major, Fanconi anemia, myelodysplastic syndrome, Diamond-Blackfan … Hematological indications | 21 (33.9) | 19 (39.6) | 0 (0.0) | 0.006 Aplastic anemia | 9 (42.3) | 8 (16.7) | 0 (0.0) | 0.184 Beta thalassemia major | 5 (23.8) | 5 (10.4) | 0 (0.0) | 0.575 Myelodysplastic syndrome | 2 (9.5) | 2 (4.2) | 0 (0.0) | 1.000 Fanconi anemia | 2 (9.5) | 1 (2.1) | 0 (0.0) | 1.000 Diamond …

A comprehensive update of extracutaneous involvement of mycosis fungoides: A narrative review of literature.

Mycosis fungoides, the most prevalent subtype of cutaneous T-cell lymphoma, primarily targets areas of the skin that of not exposed to sunlight. Nevertheless, it can involve extracutaneous tissues at any disease stage, especially during its advanced phases. Research suggests that all extracutaneous organs might be susceptible, though such cases are more commonly reported in autopsy studies and less so in clinical setting. The most recent comprehensive review of such extracutaneous manifestations in mycosis fungoides occurred almost a decade ago. With the aim of enhancing clinicians' understand

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… [24] Vonderheid EC, Diamond LW, Lai SM, Au F, Dellavecchia MA. Lymph node histopathologic findings in cutaneous T-cell lymphoma. A prognostic classification system based on morphologic assessment. Am J Clin Pathol. 1992;97:121–9. [25] Sausville EA, Eddy JL, Makuch RW, et al. … [96] Stokar LM, Vonderheid EC, Abell E, Diamond LW, Rosen SE, Goldwein MI. Clinical manifestations of intrathoracic cutaneous T-cell lymphoma. Cancer. 1985;56:2694–702. [97] Gomez-De La Fuente E, Ortiz PL, Vanaclocha F, Rodriguez-Peralto JL, Iglesias L. …

Global prevalence of intestinal parasites in cancer patients: a systematic review and meta-analysis.

BACKGROUND: Intestinal parasite infections (IPIs) are a major cause of diarrhea and serve as a critical factor in infections affecting both immunocompetent and immunocompromised individuals. Opportunistic infections, in particular, present substantial challenges for those who are immunocompromised, such as cancer patients undergoing treatment. Therefore, this review aimed to assess the overall prevalence of these parasites in this vulnerable population worldwide. METHODS: We conducted a search across several databases, including PubMed, Medline, EMBASE, Web of Science, African Journals Online

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… The diamond shape at the bottom illustrates this pooled prevalence, with its width representing the 95% confidence interval for the estimate. … The diamond shape at the bottom represents this overall prevalence, with its width indicating the 95% confidence interval for the estimate. The heterogeneity analysis revealed a high level of significant heterogeneity in our meta-analysis concerning cancer patients (I² = 98.2%, p = 0.000). …