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Bile Acid Profiles Define Disease-Specific Cholestatic States in Primary Sclerosing and Primary Biliary Cholangitis.

BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic cholestatic liver diseases with … between diseases. PSC was characterized by increased BA conjugation fraction and reduced glycine-to-taurine ratios, whereas PBC showed preserved overall conjugation with increased glycine predominance. In PSC, BA composition was further modulated by inflammatory bowel disease and colectomy, with depletion of secondary BA species. Across both diseases, adv …

Geroprotective Agents, Including Glucagon-Like Peptide-1 Receptor Agonists, for Ocular Health.

Aging has long been implicated in the onset and progression of major retinal diseases, including age-related macular degeneration (AMD), dia … um-glucose cotransporter-2 inhibitors, statins, cannabinoids, calcium channel blockers, spermidine, taurine, nicotinamide adenine dinucleotide precursors, rapamycin, and mifepristone.

Early proteomic and metabolomic signatures in diabetes associated with progression to diabetic retinopathy over 1-2 years.

BACKGROUND: The progression from diabetes mellitus (DM) to diabetic retinopathy (DR) represents a dynamic pathological process in which vasc … fense responses. Metabolomic profiling revealed 168 differential metabolites, primarily involved in taurine and hypotaurine metabolism, neuroactive ligand-receptor interaction, and tyrosine metabolism. Integrated proteomic-metabolomic analysis revealed significant correlations between proteins and metabolites. Eight candidate proteins were validated by EL …

Characterization of multi-stage metabolic alterations in hepatitis B virus-related acute-on-chronic liver failure using high-coverage metabolomics.

INTRODUCTION: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a serious condition characterized by acute liver decomp … n-serotonin pathway decreased. Additionally, metabolic pathways involving cysteine, methionine, and taurine displayed activation, indicating a compensatory response to oxidative stress and liver dysfunction. CONCLUSION: This study identifies distinct metabolic trajectories from normal liver function to CHB and ultimately to HBV-ACLF, contributing to unde …

Type 2 diabetes mellitus is associated with distinct post-treatment metabolic profiles in pulmonary tuberculosis.

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for pulmonary tuberculosis (PTB), exacerbates disease severity and reduce … uding changes in arginine and proline metabolism, steroid hormone biosynthesis, cAMP signaling, and taurine and hypotaurine metabolism. After 6 months of standard therapy, the PTB_6M group showed treatment-associated metabolic differences, especially in bile acid metabolism, suggesting partial normalization of several metabolic features. In contrast, pati …

[Identification of diagnostic biomarkers for metastatic lymph nodes in oral squamous cell carcinoma using spatial metabolomics].

Objective: To uncover alterations in the metabolic microenvironment of lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) an … tion modes were selected for ROC curve analysis: phenylalanine, phosphoethanolamine, histidine, and taurine. The area under the curve values were 0.861, 0.802, 0.729, and 0.722, respectively, indicating promising diagnostic performance. Metabolic pathway analysis revealed significantly heightened activity in Amino acid metabolism (P=0.469) and Glycerophos …

Dietary Supplementation of Lactobacillus reuteri Modulates Amino Acid Metabolism and Extracellular Matrix in the Gut-Liver Axis of Weaned Piglets.

Weaning stress leads to intestinal dysfunction and impaired growth performance and intestinal development in piglets. This study aims to inv … aled that LR1 elevated the serum concentrations of glycine and hydroxyproline, along with increased taurine in the liver. Masson staining indicated LR1 reduced ileum fiber deposition, with COL3A1 identified as a key component. Furthermore, untargeted metabolomic analysis identified 27 amino acid-related differential metabolites and 11 significantly up-reg …

Metabolomics based analysis reveals the therapeutic effects of Incarvillea arguta (Royle) Royle aqueous extract against alcohol-induced liver injury.

BACKGROUND: Alcohol-induced liver injury (ALI) poses a significant threat to global human health. The Chinese Yi medicine Liangtoumao (LTM), … spectively. Metabolic pathways of glyoxylate and dicarboxylate, glycerophospholipid, linoleic acid, taurine and hypotaurine, and cysteine and methionine were closely related to the hepaprotective effects of LTM. CONCLUSION: Our research confirmed significant effects of LTM on ALI prevention and treatment for the first time. Metabolomic findings revealed …

Serum neonicotinoid insecticides levels and gestational diabetes mellitus: mediation by plasma metabolomic alterations.

As the most extensively utilized pesticides worldwide, neonicotinoid insecticides (NNIs) have underestimated health effects. The link betwee … IMI being the major contributors. Further mediation analysis revealed that two metabolomic markers (taurine and 2-Hydroxypalmitic acid) significantly mediated the effect of NNIs mixture exposure on GDM, exhibiting mediation proportions of 6.9 % and 6.0 %, respectively. In conclusion, serum NNIs levels are positively associated with GDM risk, and metabolom …

Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats.

Olanzapine, an atypical antipsychotic drug, is used to treat psychological diseases. However, it's use carries common side effects. Those in … kers in a dose-dependent manner. Improvements were also noted in other homeostatic markers, such as taurine, coenzyme Q10, ascorbic acid, and vitamin E. Remarkably, in both combination groups, there was a significant improvement in all metabolic indicators of dyslipidemia (triglycerides, total cholesterol) and insulin resistance index. The biochemical stu …

Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling.

BACKGROUND AND AIM: Electroejaculation (EE) is widely used for semen collection in bulls but raises concerns about animal welfare due to pot … nociception. Metabolomic analysis revealed distinct biochemical shifts, with variations in glucose, taurine, and norepinephrine profiles across baseline, stimulation, and recovery phases. Behavioral observations corroborated physiological findings, with bulls exhibiting signs of discomfort, such as struggling, arched back posture, and excessive salivation …

Metabolome analyses of mouse uteri two to four days post coitum.

To elucidate the temporal and dynamic changes in uterine metabolites in mice, uterine samples were collected on Day 2 (D2; n = 8), Day 3 (D3 … cids (linoleic acid, arachidonic acid, and α-linolenic acid) and amino acid metabolism (vitamin B6, taurine, and hypotaurine). Cluster 3 mainly comprised prostaglandins and related compounds, whereas Cluster 5 consisted largely of long-chain fatty acids. Notably, most lipid and lipid-like metabolites in these clusters were associated with embryonic develo …

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

Совпадение в аннотации оригинала
Over the years, the global disease burden of neurological disorders (NDs) and mental disorders (MDs) has significantly increased, making the … l natural sources of the sulfur-rich substances such as isothiocyanates, sulforaphane, glutathione, taurine, sulfated polysaccharides, allyl sulfides, and sulfur-containing amino acids, all of which have neuroprotective properties. A multitude of studies have documented that consuming foods that are high in sulfur enhances brain function by improving cogn …

Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease.

AIMS: Serum, liver and urinary bile acids are increased, and hepatic transport protein levels are decreased in a non-clinical model of polyc … MS). RESULTS: Patients with ADPKD exhibited increased serum concentrations of total (1.3-fold) and taurine-conjugated (2.8-fold) bile acids compared to healthy volunteers. Specifically, serum concentrations of six bile acids known to be more hydrophobic/hepatotoxic (glycochenodeoxycholate, taurochenodeoxycholate, taurodeoxycholate, lithocholate, glycolit …

An untargeted comparative metabolomics analysis of infants with and without late-onset breast milk jaundice.

BACKGROUND: Late-onset breast milk jaundice (LBMJ) is a common form of hyperbilirubinemia, which can result in serious complications for new … s of the two groups were mainly annotated and enriched in Biotin metabolism, N-Glycan biosynthesis, Taurine and hypotaurine metabolism, Pyrimidine metabolism, and Pentose and glucuronate interconversions. CONCLUSION: Significant differences exist in fecal metabolites between LBMJ infants and healthy controls. The study of differential metabolic pathways …

Maternal exposure to polystyrene nanoplastics causes defective retinal development and function in progeny mice by disturbing metabolic profiles.

Microplastics (MPs) and nanoplastics (NPs) are widely spreading in our living environment, accumulating in the human body and potentially th … otal to neuron retinal function, such as glutamate, aspartate, alanine, glycine, serine, threonine, taurine, and serotonin. Transcriptomics identified significantly dysregulated genes, which were enriched in processes of angiogenesis, visual system development and lens development. Regulatory analysis showed that Fos gene mediated pathways could be a pote …

Salvia miltiorrhiza Alleviates Memory Deficit Induced by Ischemic Brain Injury in a Transient MCAO Mouse Model by Inhibiting Ferroptosis.

Salvia miltiorrhiza (SM) has been used in oriental medicine for its neuroprotective effects against cardiovascular diseases and ischemic str … onance spectroscopy (MRS) study, which demonstrated the restoration of brain metabolites, including taurine, total creatine, and glutamate. The neuroprotective effects of SM were associated with the reduction in gliosis and upregulation of inflammatory cytokines, such as interleukin-6 (IL-6) and Tumor necrosis factor-α (TNF-α), along with the upregulation …

Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study.

BACKGROUND: Seronegative elderly-onset rheumatoid arthritis (EORA)neg and polymyalgia rheumatica (PMR) have similar clinical characteristics … s in PMR and EORAneg suggesting different inflammatory activated pathways. Finally, lactate, o-ACh, taurine, and sex (female) were identified as distinguishable factors of PMR from EORAneg with a sensitivity of 90%, specificity of 92.3%, and an AUC of 0.925 (p < 0.001). CONCLUSION: These results suggest that EORAneg and PMR have different serum metabolom …

Serum metabolomic profiles in BALB/c mice induced by Babesia microti infection.

INTRODUCTION: The protozoan parasite Babesia microti is the primary cause of human babesiosis. This parasite invades and multiplies inside r … bation of metabolites. Acutely infected mice displayed perturbations in metabolites associated with taurine and hypotaurine metabolism, histidine metabolism, and arachidonic acid metabolism. Taurocholic acid, anserine, and arachidonic acid may be potential candidates as serological biomarkers for diagnosing B. microti infection at the acute stage. These m …

Metabolomics study on liver of db/db mice treated with curcumin using UPLC-Q-TOF-MS.

A metabolomics method based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was appli … biosynthesis of unsaturated fatty acids, arachidonic acid metabolism, phospholipid metabolism, and taurine and hypotaurine metabolism. The effects of curcumin on type 2 diabetes mellitus (T2DM) include antioxidant, delaying development of T2DM, preventing β-cell death, decreasing insulin resistance, alleviating hepatic damage, and improving metabolic dis …