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Stillbirths in China: a nationwide survey.

OBJECTIVE: To estimate a stillbirth rate at 24 or more gestational weeks in 2015-2016 and to explore potentially preventable causes in China … hs by 17.9% and 7.4%, respectively. Overall, 31.4% of all stillbirths were potentially preventable. Advanced maternal age, pre-pregnant obesity, chronic hypertension and diabetes mellitus were important risk factors in East China; low education and SGA were major risk factors in Northwest, Southwest, Northeast and South China; and pre-eclampsia/eclampsia and intrapartu …

Risk factors for and perinatal outcomes of major depression during pregnancy: a population-based analysis during 2002-2010 in Finland.

OBJECTIVES: To identify risk factors for and the consequences (several adverse perinatal outcomes) of physician-diagnosed major depression d … .39 to 2.89) increased prevalence. The risk profile of major depression also included adolescent or advanced maternal age, low or unspecified socioeconomic status (SES), single marital status, smoking, prior pregnancy terminations, anaemia and gestational diabetes regardless of a history of depression. Outcomes of pregnancies were worse among women with major depressio …

Modifiable risk factors for schizophrenia and autism--shared risk factors impacting on brain development.

Schizophrenia and autism are two poorly understood clinical syndromes that differ in age of onset and clinical profile. However, recent genetic and epidemiological research suggests that these two neurodevelopmental disorders share certain risk factors. The aims of this review are to describe modifiable risk factors that have been identified in both disorders, and, where available, collate salient systematic reviews and meta-analyses that have examined shared risk factors. Based on searches of Medline, Embase and PsycINFO, inspection of review articles and expert opinion, we first compiled a s

Pure partial monosomy 3p (3p25.3 → pter): prenatal diagnosis and array comparative genomic hybridization characterization.

OBJECTIVE: The purpose of this case report is to present prenatal diagnosis and molecular cytogenetic characterization of pure partial monosomy 3p (3p25.3 → pter) by array comparative genomic hybridization (aCGH) and quantitative fluorescent polymerase chain reaction (QF-PCR) on uncultured amniocytes. CASE REPORT: A 35-year-old, gravida 2, para 0, woman underwent amniocentesis at 19 weeks of gestation because of advanced maternal age. Her husband was 37 years of age. She had experienced one intrauterine fetal death. Amniocentesis during this pregnancy revealed a distal deletion of chromosome …

Mosaic trisomy 7 at amniocentesis: prenatal diagnosis and molecular genetic analyses.

OBJECTIVE: To present prenatal diagnosis and molecular genetic analyses of mosaic trisomy 7. MATERIALS, METHODS AND RESULTS: A 38-year-old primigravid woman underwent amniocentesis at 19 weeks of gestation because of her advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+7[26]/46, XY[16]. Repeated amniocentesis at 21 weeks of gestation revealed a karyotype of 47,XY,+7[20]/46,XY[17]. Simultaneous cordocentesis revealed a karyotype of 46,XY in 100/100 cultured lymphocytes. Polymorphic DNA marker analyses of uncultured amniocytes and cord blood revealed a diallelic pattern with …

Распределение детородного веса пакистанских младенцев.

ЦЕЛЬ: Определение распределения веса новорожденных и его связи с конкретными социально-демографическими и медицинскими факторами. МЕТОДЫ: Все дети, родившиеся после 24 недель беременности в период с ноября 1994 года по июнь 1996 года, были включены независимо от того, являются ли они живыми или еще рожденными. Младенцы, имеющие весы при рождении 2,5-4 кг, были названы как обычно взвешенные младенцы, менее 2,5 кг - как низкий вес при рождении и более 4 кг - как макросомики. Собранные данные включают социально-демографические и медицинские переменные. Вес новорожденных измерялся без одежды до бл

Совпадение в аннотации оригинала
OBJECTIVE: To determine the distribution of birthweights among newborns and its relationship to specific sociodemographic and medical factor … twin pregnancy, PROM and severe preeclampsia and eclampsia. Risk factors for fetal macrosomia were advanced maternal age and parity, postdatism and diabetes mellitus. CONCLUSION: In this study the relative impact of some of the factors related to birthweight in reference to our population was highlighted. Further explorations preferably in population based studies ar …

Clinical outcome of mild fetal ventriculomegaly.

OBJECTIVE: Our purpose was to evaluate the outcome of fetuses with mild cerebral ventriculomegaly. STUDY DESIGN: We prospectively collected … present in two cases of isolated mild cerebral ventriculomegaly, both of which were associated with advanced maternal age, and in seven cases associated with other anomalies. CONCLUSIONS: Mild cerebral ventriculomegaly should prompt targeted ultrasonographic examination, inclusive of markers of aneuploidies, visualization of the corpus callosum, and echocardiogram as …

Gestational age-related reference values for Apgar score and umbilical cord arterial and venous pH in preterm and term newborns.

INTRODUCTION: Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are as yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar scores for term and preterm infants has not yet been determined. MATERIAL AND METHODS: Data were obtained from the maternity units of Skåne University Hospital, Malmö and Lund, Sweden, from 2001 to 2010. Validated paired arterial and venous cord pH values were obtained from 27 175 ne

The changing situation about maternal age, risk factors and pregnancy outcomes after the two-child policy: a retrospective cohort study.

BACKGROUND: To evaluate the relationship between gestational age, risk factors, pregnancy outcomes, and the causes and trends of the changes in the incidence of pregnancy in different years after the two-child policy. METHODS: The study enrolled all of the childbirth women (n=7,016) from January 1st, 2015 to December 31th, 2017 in the Zhujiang Hospital. According to the age of all childbirth women, they were divided into four groups: ≤24, 25-29, 30-34 and ≥35 years old. While 20-29 years old group regarded as the control group (OR =1). Pregnancy complications and outcomes data of 4 groups wer

Risk Factors Associated With Placenta Previa: A Matched Case-Control Study.

Introduction Placenta praevia is a recognized pregnancy complication characterized by the placenta implanting partially or completely within … = 0.0001).  Conclusion Our study highlights several key risk factors for placenta previa, including advanced maternal age, previous cesarean section, history of dilatation and curettage, ARTs, and prior placenta previa. Identifying these factors early can help clinicians recognize women at higher risk and implement careful monitoring to prevent complications. While our …

Assessment of the Level of Knowledge About Risk Factors, Prevention, and Treatment of Gestational Diabetes Mellitus in a Community Sample From Saudi Arabia.

Introduction Gestational diabetes mellitus (GDM) is a common disease affecting pregnant females, and it carries a major risk of short and long-term health problems for both mothers and their offspring. Multiple factors like advanced maternal age, obesity, and unhealthy lifestyle can increase the risk of GDM. The current guidelines recommend screening all pregnant females for risk factors during the first trimester with subsequent testing of the blood glucose level at 24 weeks gestation. Lack of awareness about GDM is a main contributing factor in the delay in screening and diagnosis of GDM wit…

Advancing Personalized Medicine in Gestational Diabetes Mellitus Management Through Gut Microbiota Insights.

Gestational diabetes mellitus (GDM) is a metabolic disorder that is characterized by hyperglycemia developed or first diagnosed during pregnancy, affecting up to 15% of pregnant women worldwide. Although risk factors for GDM such as a family history of diabetes, obesity, and advanced maternal age are well recognized, the underlying pathophysiological mechanisms are complex and remain incompletely understood. Multiple studies indicate that GDM arises from a combination of peripheral insulin resistance and pancreatic β-cell dysfunction, in which insulin secretion fails to compensate for the prog…

Prevalence and associated factors of anemia during pregnancy at a tertiary hospital in Zambia.

BACKGROUND: Anemia during pregnancy is among the leading causes of poor outcomes among mothers and neonates in low-resource settings like Zambia. This study aimed to determine the prevalence and factors associated with anemia among pregnant women attending antenatal care (ANC) at Livingstone University Teaching Hospital (LUTH). METHODS: A retrospective cross-sectional study was conducted of which 307 records using a systemic random sampling method were abstracted among pregnant women attending ANC from 12th October 2023-12th January 2024. Demographic and clinical factors were collected from m

Evaluating the Effectiveness of Spousal Testing Among Syphilis-Infected Pregnant Women in the Context of Mother-to-Child Transmission Elimination: A Multicenter Study in Southeastern China.

PURPOSE: Syphilis during pregnancy poses significant risks to maternal and neonatal health. Spousal testing is crucial for preventing congenital syphilis transmission. This study assessed spousal testing rates among syphilis-positive pregnant women to guide public health interventions. METHODS: This multicenter effectiveness study was conducted in Southeast China, utilizing data from the Chinese HIV/AIDS, Syphilis, and Hepatitis B Prevention Information System between 2018 to 2024. Proportions were used to describe the sociodemographic characteristics of pregnant women with syphilis. Univaria

Заболеваемая беременностью гипертензия и связь с будущими аутоиммунными заболеваниями.

ЦЕЛЬ: изучение связей между гипертоническими расстройствами беременности и последующим развитием аутоиммунных заболеваний. МЕТОДЫ: В этом ретроспективном когортном исследовании использовался TriNetX - федеративная сеть данных реального мира. Используя данные Глобальной сети сотрудничества, мы собрали электронные медицинские записи 102 организаций здравоохранения, 131 million записи пациентов из 2006 в адрес 2020. Исследование позволило оценить риск аутоиммунных заболеваний у женщин пожилого возраста. 16-45 Годы. Two Были сопоставлены следующие категории: обусловленная беременностью когорта гип

Совпадение в аннотации оригинала
OBJECTIVE: To explore the associations between hypertensive disorders of pregnancy and the subsequent development of autoimmune diseases. M … mixed connective tissue disease, and rheumatoid arthritis. Subgroup analysis revealed that women of advanced maternal age with pregnancy-induced hypertension had a similar risk of developing autoimmune diseases compared with younger women. In addition, the risk of these autoimmune diseases increased with the severity of pregnancy-induced hypertension. CONCLUSION: Wome …

Low-level mosaic trisomy 14 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, positive non-invasive prenatal testing for trisomy 14, perinatal progressive decrease of the trisomy 14 cell line and a favorable fetal outcome.

OBJECTIVE: We present low-level mosaic trisomy 14 at amniocentesis. CASE REPORT: A 37-year-old, gravida 2, para 1, woman underwent amniocentesis at 18 weeks of gestation because of advanced maternal age. This pregnancy was conceived by in vitro fertilization and embryo transfer (IVF-ET). Amniocentesis revealed a karyotype of 47,XX,+14 [4]/46,XX [27], consistent with 12.9% mosaicism for trisomy 14. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (1-22, X) × 2 with no genomic imbalance. Prenatal ultr…

Low-level mosaic trisomy 7 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome.

OBJECTIVE: We present low-level mosaic trisomy at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome. CASE REPORT: A 40-year-old, primigravid woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 46,XY in cultured amniocytes. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of…

Low-level mosaic trisomy 21 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 21 cell line and a favorable fetal outcome.

OBJECTIVE: We present low-level mosaic trisomy 21 at amniocentesis in a pregnancy with a favorable fetal outcome. CASE REPORT: A 38-year-old, gravida 2, para 1, woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+21[4]/46,XY[34]. Prenatal ultrasound findings were normal. At 27 weeks of gestation, she was referred for genetic counseling, and the cultured amniocytes had a karyotype of 47,XY,+21[2]/46,XY[26]. Quantitative fluorescent polymerase chain reaction (QF-PCR) analysis on the DNA extracted from uncultured a…

Association between acceptance of routine pregnancy vaccinations and COVID-19 vaccine uptake in pregnant patients.

OBJECTIVE: COVID-19 vaccination is a key approach to reduce morbidity and mortality in pregnant patients and their newborns. Anti-vaccine se … Tdap vaccines, respectively. Patients were more likely to receive the COVID-19 vaccine if they had advanced maternal age, obesity, Asian race, and private insurance. After adjustment for baseline differences, COVID vaccine acceptance was associated with receipt of Tdap (aOR 2.10, 95% CI 1.90-2.33) and influenza vaccines (aOR 2.83, 95% CI 2.55-3.14). There were no diff …

Pregnancy-Associated Spontaneous Coronary Artery Dissection: Clinical Characteristics, Outcomes, and Risk During Subsequent Pregnancy.

OBJECTIVES: Spontaneous coronary artery dissection (SCAD) is a common cause of pregnancy-associated myocardial infarction. METHODS: This st … 50.7%; P=.03). The P-SCAD group had higher multigravidity (54.6% vs 31.4%; P=.03) and 68.2% were of advanced maternal age. The rates of ST-elevation myocardial infarction, ventricular tachycardia/fibrillation, and left main coronary dissection were similar. Proximal vessel dissection (31.8% vs 7.7%; P<.01), multiple vessel dissection (31.8% vs 9.5%; P<.01), and reduced …