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Chlamydial infection in homosexual men. Frequency of isolation of Chlamydia trachomatis from the urethra, ano-rectum, and pharynx.

Urethral, rectal, and pharyngeal material from 150 men who had had exclusively homosexual contact and who consecutively attended a sexually transmitted diseases clinic was cultured for Chlamydia trachomatis. The organism was isolated from at least one site in 15 (105) patients. The isolation rates from the urethra, rectum, and pharynx were 6 . 7%, 4%, and 1 . 3% respectively.

Prevalence of Chlamydia trachomatis infection in women, heterosexual men and MSM visiting HIV counselling institutions in North Rhine-Westphalia, Germany - should Chlamydia testing be scaled up?

BACKGROUND: Patients asking for a free anonymous HIV test may have contracted other sexually transmitted infections (STIs) such as Chlamydia trachomatis, yet Chlamydia prevalence in that population is unknown. This study aimed to assess the prevalence and factors associated with Chlamydia infection in patients seeking HIV testing at local public health authorities (LPHA) in order to evaluate whether Chlamydia testing should be routinely offered to them. METHODS: We conducted a cross-sectional study among patients (≥18 years) attending 18 LPHA in North Rhine-Westphalia from November 2012 to Se…

Field Performance and usability of a novel molecular point-of-care assay for Chlamydia trachomatis and Neisseria gonorrhoeae detection.

BackgroundFew studies have evaluated the field performance of novel point-of-care molecular assays for Chlamydia trachomatis and Neisseria gonorrhoeae. We aimed to assess the performance, feasibility and acceptability of the prototype OraSure CT/NG assay (InteliQuick, OraSure Technologies Inc., USA) among clinics in Peru.MethodsBetween May and June 2025, we recruited men and women from three clinics in Lima. Participants self-collected rectal and vaginal or penile meatal swabs and provided urine samples, while clinic staff collected pharyngeal swabs. We compared results of the prototype OraSur…

British association for sexual health and HIV UK national guideline for the management of infection with Chlamydia trachomatis, 2026.

This guideline provides details on the pathology and clinical features of Chlamydia trachomatis infection and makes recommendations for diagnostic tests, treatment regimens and the health promotion principles needed for the effective management of chlamydia, in people aged 16 years or older attending sexual health services. The guideline is primarily aimed at level 3 sexual health services in the UK, although it could also serve as a reference guide for sexually transmitted infection services at other levels. This guideline is an update of the previous one published in 2015.

HIV-1 and Chlamydia trachomatis limit their respective growth but promote their survival in co-infected human macrophages.

HIV-1 and Chlamydia trachomatis (CT) are two significant sexually transmitted pathogens that frequently co-infect individuals. However, the mechanisms by which these two obligate intracellular pathogens interact at the cellular level remain elusive, particularly in macrophages, where persistent infections can occur. In this study, we demonstrate that CT generates inclusions in macrophages of murine and human origins. We also show that both HIV-1 and CT reciprocally reduce the growth and replication of each other within co-infected human macrophages, irrespective of whether the viral or bacteri…

Genotyping and characterization of Chlamydia trachomatis and Ureaplasma parvum isolates of reproductive aged women in South Andaman Islands.

BACKGROUND: Chlamydia trachomatis is a prevalent sexually transmitted infection (STI) that often remains asymptomatic, complicating control efforts. Characterizing its serovars, particularly in isolated regions like the Andaman Islands, is crucial for understanding local epidemiology. METHODS: This study involved PCR assays to identify C. trachomatis and Ureaplasma parvum serovars in high vaginal samples from reproductive-aged women attending a gynaecology clinic in Port Blair, India, from August 2020 to July 2022. DNA sequencing of the OMP1 gene was performed to determine genotypes. RESULTS…

Distribution and viability of ocular and non-ocular Chlamydia trachomatis in households in a trachoma-endemic community in Oromia, Ethiopia.

BACKGROUND: We aimed to determine the household distribution and viability of Chlamydia trachomatis (Ct) from the eyes, face, and hands during the initial two visits of a year-long fortnightly cohort study in geographically defined adjacent households. METHODS/FINDINGS: We enrolled 298 individuals from 68 neighbouring households in Shashemene Woreda, Oromia, Ethiopia. All individuals above 2 years of age residing in these households were examined for signs of trachoma. Swab samples were taken from the conjunctiva, faces, and hands and analysed for the presence and viability of Ct. Ct viabilit…

Распространение хламидии трахоматиса в очках пациентов, подозреваемых в наличии вирусного кератита: перекрестное исследование.

ТРАХОМАТИС (C. trachomatis) является одной из основных глобальных проблем в области здравоохранения, которая признана среди основных бактериальных причин заболеваний, передаваемых половым путем, и связана с окулярными заболеваниями. Его связь с хроническим фолликулярным конъюнктивитом и тяжелым папиллярным воспалением подчеркивает важность точной идентификации при диагностике трахомы. В ходе этого исследования была проведена оценка распространенности C. trachomatis у пациентов, подозреваемых в вирусном кератите, в лаборатории и были сопоставлены четыре различных типа образцов глаз.МЕТОДЫ: Это

Совпадение в аннотации оригинала
BACKGROUND: Chlamydia trachomatis (C. trachomatis) is a major global health concern, recognized among the leading bacterial causes of sexually transmitted infections and implicated in ocular diseases. Its association with chronic follicular conjunctivitis and severe papillary inflammation underscores the importance of accurate identification in diagnosing tr…

Cost-effectiveness of adding measurement of Chlamydia trachomatis infection and serology to trachoma prevalence surveys in Tanzania and Mozambique.

BACKGROUND: Accurate methods to measure trachoma prevalence are critical to monitor progress and guide mass drug administration as countries near elimination. Currently, countries conduct trachoma prevalence surveys via clinical examination using the simplified trachoma grading system. Grading can have reduced accuracy in low prevalence settings, potentially resulting in errors. Adding ocular swabbing and Chlamydia trachomatis (Ct) infection testing and dried blood spot (DBS) collection and testing can be more sensitive and specific methods for trachoma identification, with potential cost-savi…

Improving the quality of self-collected swab specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in a clinical setting.

BACKGROUND: The practice of patient self-collected swab specimens for Neisseria g onorrhoeae and Chlamydia trachomatis is supported in the literature. LOCAL PROBLEM: Health care providers observed that patients sometimes performed their self-swabs incorrectly resulting in cancelled or invalid specimens. METHODS: The clinic's outdated visual aids were replaced with new visual aids. The goal was to improve health care provider proficiency in providing the health teaching and to reduce the clinic's number of cancelled or invalid swab specimens. Staff evaluated the visual aids using an online pr…

Clinical Validation of Loop-Mediated Isothermal Amplification Assays for the Rapid Detection of Neisseria gonorrhoeae and Chlamydia trachomatis.

Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) are the predominant causes of bacterial sexually transmitted diseases. While nucleic acid amplification testing (NAATs), primarily polymerase chain reaction (PCR), is regarded as the gold standard for identifying these two pathogens, it usually takes a prolonged turnaround time and requires sophisticated equipment with considerable expense. In this study, we developed novel loop-mediated isothermal amplification (LAMP) assays for rapid detection (< 30 min) of GC and CT in clinical urine and swab specimens. We analysed 208 clinical sampl…

Histopathology of peritonitis due to infectious mononucleosis with background Chlamydia trachomatis infection: A case report and literature review.

Epstein-Barr virus (EBV) is a major cause of infectious mononucleosis (IM), characterized by fever, fatigue, sore throat, lymphadenopathy, a … polymorphous B-cell lymphoproliferative disorder. Furthermore, intracytoplasmic inclusion bodies of Chlamydia trachomatis were observed by immunohistochemistry. Real-time polymerase chain reaction detected C. trachomatis in cervical secretions. Two months after laparoscopy, ascites decreased, and the diagnosis was IM-associated peritonitis with C. trachomatis infection …

Chlamydia Trachomatis Prevalence in Asymptomatic Women in Madrid: Study Findings and Their Association with Risk Factors and Mental Health.

BACKGROUND: Chlamydia trachomatis (CT) is a sexually transmitted infection that requires early detection to prevent complications. This study aimed to evaluate the prevalence of CT among asymptomatic women in Spain and investigate the relationship between CT and risk factors associated with sexual practices, as well as factors such as stress and depression. RESULTS: We found that 3.8% of asymptomatic women tested positive for CT. Our findings suggested that having more than five sexual partners increases the risk of sexually transmitted infections (STIs) by 3.87 times when compared with havin…

Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico.

Chlamydia trachomatis (C. trachomatis) screening and treatment in pregnancy allows the opportunity to reduce adverse pregnancy and neonatal outcomes worldwide. Although C. trachomatis infection is easily treated and cured with antibiotics, only some countries have routine pregnancy screening and treatment programs. We therefore evaluated whether just one maternal screening for C. trachomatis is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4087 first-time gynecological-obstetric consultations granted at the National Institute of Perinatology in 2018, we selected…

Derivation and Internal Validation of a Risk Score for Predicting Chlamydia trachomatis Infection in Kenyan Women Planning Conception.

BACKGROUND: Availability of laboratory confirmation of sexually transmitted infections is increasing in low- and middle-income countries, but costs continue to limit their access. Chlamydia trachomatis (CT) is a sexually transmitted infection of significant clinical importance, particularly among women. This study aimed to develop a risk score to identify women with a higher likelihood of CT infection, who could then be prioritized for laboratory testing, in a population of Kenyan women planning pregnancies. METHODS: Women with fertility intentions were included in this cross-sectional analys…

The effects of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum loads on semen quality: Detection and quantitative analysis.

BACKGROUND: The loads of Chlamydia trachomatis (CT), Mycoplasma hominis (MH), and Ureaplasma urealyticum (UU) may impact infertility, as well as cause risk of transmission. The quality and quantity of semen demonstrate male reproductive health. This study aimed to investigate the semen quality affected by CT, MH, and UU loads. MATERIALS AND METHODS: 130 semen samples, including infertile and fertile cases, were collected and analyzed. The whole genomic DNA was extracted, and the desired genes' plasmids were constructed. The CT, MH, and UU loads were quantified by real-time PCR. The data were …

Performance of a rapid molecular test to detect Chlamydia trachomatis and Neisseria gonorrhoeae in women with pelvic inflammatory disease.

OBJECTIVE: The aim of this study was to investigate the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in women with pelvic inflammatory disease (PID) and the usefulness and cost-effectiveness of a rapid molecular test for the diagnosis and clinical management of PID. METHODS: This observational study included 75 patients with mild-to-moderate PID (n=33), severe PID (n=29) and non-specific lower abdominal pain (NSAP) (n=13). CT/NG infections were analyzed using a standard and a rapid test. A cost analysis was carried out. RESULTS: Samples of 19 patients (25.3%) were …

[Accuracy of pooling specimens from different individuals in the detection of genital Chlamydia trachomatis infection: a Meta analysis].

Objective: To determine the accuracy of pooled specimens from multiple individuals for detection of infection with Chlamydia trachomatis. Methods: By April 2022, PubMed and Embase searched relevant studies published in peer-reviewed journals. The QUADAS-2 scale of a quality assessment tool was used to assess the quality of the studies. A curve of summary receiver operating characteristic was applied as a comprehensive assessment of diagnosed accuracy. A bivariate mixed-effects model was used for overall value merging in sensitivity and specificity. In addition, the subgroup analyses regarding …

Seroprevalence of Chlamydia trachomatis Among Female Adults in the United States: The National Health and Nutrition Examination Surveys.

BACKGROUND: Chlamydia trachomatis is the most common nationally notifiable sexually transmitted infection in the United States; however, the seroprevalence of C. trachomatis infection is unknown. METHODS: This cross-sectional study was conducted among 1725 females aged 18 to 39 years who provided serum and urine samples in the 2013 through 2016 National Health and Nutrition Examination Surveys. Presence of anti-C. trachomatis Pgp3 immunoglobulin G (IgG) was determined using both an enzyme-linked immunosorbent assay (ELISA) and multiplex bead array (MBA). Weighted seroprevalence estimates were…