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The Development of Human Genetics at the National Research Centre, Cairo, Egypt: A Story of 50 Years.

This article describes my experiences over more than 50 years in initiating and maintaining research on human genetics and genomics at the National Research Centre in Cairo, Egypt, from its beginnings in a small unit of human genetics to the creation of the Center of Excellence for Human Genetics. This was also the subject of a lecture I gave at the 10th Conference of the African Society of Human Genetics, held in Cairo in November 2017, after which Professor Michèle Ramsay, president of the society, suggested that I write an autobiographical article for the Annual Review of Genomics and Human

[Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) - Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and the Management of Preterm Premature Rupture of Membranes].

AIMS: This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obst … a formal consensus process (structured consensus conference with neutral moderation, voting done in writing using the Delphi method to achieve consensus). RECOMMENDATIONS: Part 2 of this short version of the guideline presents Statements and Recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of mem …

Granuloma formation secondary to silicone injection for soft-tissue augmentation in facial cosmetics: Mechanisms and literature review.

The use of injectable fillers is increasingly popular as an alternative to surgery for facial cosmetic applications. In this regard, silicone is a versatile biomaterial filler that has been used for these purposes, but its use warrants further investigation, especially since it is not clinically approved for such uses. We describe the use of silicone as a facial injectable filler through a scholarly review of the literature for cases of silicone granuloma formation published from September 2007 through September 2017, and we present various contexts in which this complication has been observed

Ring Shuttling Controls Macroscopic Motion in a Three-Dimensional Printed Polyrotaxane Monolith.

Amplification of molecular motions into the macroscopic world has great potential in the development of smart materials. Demonstrated here is an approach that integrates mechanically interlocked molecules into complex three-dimensional (3D) architectures by direct-write 3D printing. The design and synthesis of polypseudorotaxane hydrogels, which are composed of α-cyclodextrins and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, and their subsequent fabrication into polyrotaxane-based lattice cubes by 3D printing followed by post-printing polym

History of clubfoot treatment, part I: From manipulation in antiquity to splint and plaster in Renaissance before tenotomy.

Idiopathic clubfoot is one of the most common problems in paediatric orthopaedics. The treatment is controversial and continues to be one of the challenges in paediatric orthopaedics. The aim of this review is to assess the different methods of clubfoot treatment used over the years in light of the documentation present in the literature and art paintings from the antiquity to the end of the 19th century. The aim of this paper is to review all treatment methods of the clubfoot over the years that were proposed to provide patients a functional, pain-free, normal-looking foot, with good mobility

Офицеры, тропическая медицина и расовые мысли в формировании полков Западной Индии, 1793 - 1802 годы.

В этой статье рассматривается вопрос о создании и росте в период с 1793 по 1802 год западноиндийских полков, британских армейских корпусов, укомплектованных рабами африканского происхождения и возглавляемых европейскими офицерами. Сосредоточив внимание на медицинской истории британских военных операций в Вест-Индии, статья показывает, что в основе полков лежали медицинские причины, но что их мотивация исходила от старших военных командиров, а не от практикующих врачей, чьи работы, как правило, имеют преимущество в гисториографии. Старшие офицеры, которые руководили экспедициями в Западной Инди

Совпадение в аннотации оригинала
The article examines the establishment and growth between 1793 and 1802 of the West India Regiments, British army corps manned by slaves of … etus for them came from senior military commanders rather than from the medical practitioners whose writings are usually privileged in the historiography. The senior officers who commanded the West Indian expeditions in the French Revolutionary Wars mobilized their own particular brand of medical theory, based explicitly on their experience of the region' …

Speaking of That: Terms to Avoid or Reconsider in the Eating Disorders Field.

Inspired by an article on 50 terms that, in the interest of clarity in scientific reasoning and communication in psychology, psychiatry, and allied fields, "should be avoided or at most be used sparingly and only with explicit caveats,"(1) we propose a list of terms to avoid or think twice about before using when writing for the International Journal of Eating Disorders (IJED). Drawing upon our experience as reviewers or editors for the IJED, we generated an abridged list of such terms. For each term, we explain why it made our list and what alternatives we recommend. We hope that our list wil…

'The child's past in the adult's present': The trauma of the Siege of Leningrad (1941-1944).

This study deals with the individual and collective memory of Leningrad Siege survivors who experienced mass and prolonged wartime trauma du … erpretative Phenomenological Analysis (IPA) and content analysis are utilized. Unpublished archival writings by children caught in the Siege have been analysed. The principal method of interpretation is based on a psychoanalytic understanding of child development, mourning and the metabolizing of traumatic experience. The subjective meaning of the Siege e …

Garcinia Cambogia-Induced Acute Hepatitis; Varenicline-Induced Parkinsonism; Resistant Hypocalcemia After Zoledronic Acid Administration; Zonisamide-Induced Acute Kidney Injury; Psychosis Associated with Guanfacine.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) Med Watch program (800-FDA-1088). If you have reported an interesting, preventable ADR to Med Watch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Instit

The 2016 Hughes Lecture: What's new in maternal morbidity and mortality?

Each year, the Board of Directors of the Society for Obstetric Anesthesia and Perinatology selects an individual to review a given year's published obstetric anesthesiology literature. This individual then produces a syllabus of the year's most influential publications, delivers the Ostheimer Lecture at the Society's annual meeting, the Hughes Lecture at the following year's Sol Shnider meeting, and writes corresponding review articles. This 2016 Hughes Lecture review article focuses specifically on the 2014 publications that relate to maternal morbidity and mortality. It begins by discussing

Ranolazine-Induced Reversible T-Wave Inversions with Prolonged QTc Interval; Progressive Multifocal Leukoencephalopathy Linked to Fingolimod; Losartan-Induced Sprue-like Enteropathy; Nivolumab-Induced Psoriasiform Skin Eruption; Hepatitis B Reactivation with Hepatitis C Treatment with Simeprevir and Sofosbuvir.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MED WATCH program (800-FDA-1088). If you have reported an interesting, preventable ADR to MED WATCH, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Instit

Adenomatoid tumors of the testis: A report of two cases and review of the literature.

Adenomatoid tumors are rare benign neoplasms that normally occur in the scrotum. The clinical symptoms and routine examinations mean that it … on pathological examination. The patients were followed up and exhibit no recurrence at the time of writing. The present report also summarizes the morphological and immunohistochemical features of paratesticular tumors and reviews the literature to improve understanding of these rare lesions and assist in accurate diagnosis.

Ambroise Paré (1510 to 1590): a surgeon centuries ahead of his time.

In their extensive writings, Hippocrates and Celsus counseled physicians to be knowledgeable in both the medical and surgical management of patient recovery. However, their words fell by the wayside because cutting of the body was forbidden by the Roman Catholic Church. Furthermore, the contemporaneous Arabic medical teachings emphasized tradition and authority over observation and personal experience. This created an ever-growing rift between the schools of surgical and pharmacologic medicine with both groups denying their involvement in the other domain. Surgeons had been plagued by postoper…

Discussion of Berta Bornstein's "The Analysis of a Phobic Child".

Bornstein's paper is a true psychoanalytic study of a child, if ever there was one. The fine tracing and discussion of the technical detail, together with the clarity and exposition of the theoretical underpinning make it a truly deep and thorough study and a model for those of us doing this work and trying to understand what indeed we do and why. I should say that although I have read the writings of the (then) Hampstead Clinic's borderline workshop (Kut Rosenfeld and Sprince, 1965), I had not read this outstanding paper by Berta Bornstein, and I wish I had done so long ago. I shall begin wit…

Developmental dyscalculia in children and adolescents with idiopathic epilepsies in a Brazilian sample.

Epilepsy is one of the most prevalent chronic disorders of childhood which can threaten child development and mental health. Among cognitive disorders, dyscalculia is one of the most important. In this study, 39 children and adolescents with idiopathic epilepsy underwent clinical and neuropsychological assessment to determine the intellectual level, math skills, reading and writing performance and neuropsychological profile. It was observed that the mathematical ability was below schooling expectations in a higher frequency than expected. There were no significant differences in mathematical p…

A history of depressed skull fractures from ancient times to 1800.

The story of managing depressed fractures illustrates how knowledge of proven value does not always get handed down. Celsus was the first to describe sensible management for depressed fractures. As he wrote in Latin this was forgotten. Galen's Greek writings survived forming the basis of management until the sixteenth century. In 1517, Hans von Gersdorff published a formidable illustrated surgical text. One illustration depicts an instrument for elevating depressed bone fragments. It looked dramatic but could not work and its defects were finally defined in the eighteenth century. Ambroise Par…

Methimazole-induced chronic arthritis; bilateral gynecomastia associated with the combination of methylphenidate and paroxetine; adrenal suppression and cushingoid features with inhaled fluticasone; pulmonary thromboembolism due to paliperidone.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) Med Watch program (800-FDA-1088). If you have reported an interesting, preventable ADR to Med Watch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Instit

How low can you go: spatial frequency sensitivity in a patient with pure alexia.

Pure alexia is a selective deficit in reading, following lesions to the posterior left hemisphere. Writing and other language functions remain intact in these patients. Whether pure alexia is caused by a primary problem in visual perception is highly debated. A recent hypothesis suggests that a low level deficit - reduced sensitivity to particular spatial frequencies - is the underlying cause. We tested this hypothesis in a pure alexic patient (LK), using a sensitive psychophysical paradigm to examine her performance with simple patterns of different spatial frequency. We find that both in a d…

Mineralocorticoid receptor modulators: a patent review (2007 - 2012).

INTRODUCTION: Considered for years as a 'renal hormone' leading to the control of renal excretion of minerals (explaining the term 'mineralocorticoid' used to describe this hormone), aldosterone is now recognized as a key factor in several diseases including hypertension, heart failure, arrhythmia, metabolic and kidney diseases, to cite only a few of them. AREAS COVERED: In this review article, the authors aim to cover information provided by patents of the years 2007 through 2012. The rationale of writing this article is to cover the most important patents that can progress the field with ne…

Sickness certification.

This article forms part of our 'Paperwork' series for 2011, providing information about a range of paperwork that general practitioners comp … e disciplinary action, or even a charge of fraud. This article provides some guidance for GPs about writing certificates certifying illness, and discusses common medicolegal issues associated with sickness certificates.