Результаты поиска

Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery.

BACKGROUND: This is the second update of a Cochrane Review first published in 2013 and last updated in 2017. Laparoscopic surgery is now wid … ECTIVES: To assess the safety, benefits, and harms of different gases (e.g. carbon dioxide, helium, argon, nitrogen, nitrous oxide, and room air) used for establishing pneumoperitoneum in participants undergoing laparoscopic abdominal or gynaecological pelvic surgery. SEARCH METHODS: We searched CENTRAL, Ovid MEDLINE, Ovid Embase, four other databases, …

Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization.

The primary objective of this study was to evaluate the effect of cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), in two in vivo models of VEGF-dependent corneal and choroidal angiogenesis and two in vivo models of VEGF-mediated vascular leakage. Non-selective COX inhibitors (the NSAIDs indomethacin and flunixin, p.o. or i.p.), the COX-1 selective inhibitor SC-560 (s.c. or i.p.), and the COX-2 selective inhibitor NS-398 (s.c. or i.p.) were evaluated in four experimental models. Choroidal neovascularization was induced in Brown Norway rats by argon laser photoco…

[Photodynamic therapy (PDT) for early cervical cancer].

The incidence of carcinoma in situ (CIS) and dysplasia of the uterine cervix has been increasing among young women in recent years. Most of … low pulse laser, has a considerably higher degree of tissue penetration, even compared to PDT using Argon Dye Laser (ADL). Also, PDT using EDL can manage glandular involvement of CIN, and its special feature of selective destruction of malignant cells with almost no effect on normal tissues is noteworthy. Beginning in 1995, PDT using YAG-OPO Laser with …

Risk Factors Associated with Mortality and Increased Drug Costs in Nonvariceal Upper Gastrointestinal Bleeding.

BACKGROUND/AIMS: To determine risk factors associated with mortality and increased drug costs in patients with nonvariceal upper gastrointestinal bleeding. METHODOLOGY: We retrospectively analyzed data from patients hospitalized with nonvariceal upper gastrointestinal bleeding between January 2001-December 2011. Demographic and clinical characteristics and drug costs were documented. Univariate analysis determined possible risk factors for mortality. Statistically significant variables were analyzed using a logistic regression model. Multiple linear regression analyzed factors influencing dru

Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities.

BackgroundRefractory gastrointestinal bleeding (GIB) secondary to gastrointestinal vascular malformations (GIVM) such as gastrointestinal angiodysplasia (GIAD) and gastric antral vascular ectasia (GAVE) remains challenging to treat when endoscopic therapy fails. Recently thalidomide has been suggested as a treatment option for refractory GIB.AimTo determine the outcome of patients treated with thalidomide for refractory GIB due to GIVM.MethodsIRB approved, single center, retrospective review of electronic medical records from January 2012 to November 2018. Patients age > 18 years old, who had

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… Endoscopic therapy primarily with argon plasma coagulation (APC) is the mainstay of treatment for GIVM. … Endoscopic therapy with argon plasma coagulation (APC) is the mainstay of treatment for GIVM. …

Cryotherapy for liver metastases.

BACKGROUND: Primary liver tumours and liver metastases from colorectal carcinoma are the two most common malignant tumours to affect the liver. The liver is second only to the lymph nodes as the most common site for metastatic disease. More than half of the patients with metastatic liver disease will die from metastatic complications. In cryoablation, liquid nitrogen or argon gas is delivered to the liver tumour, guided by ultrasound using a specially designed probe. Ice crystal formation during the rapid freezing process causes destruction of cellular structure and kills the tumour cells. OB…

Radiobiology with heavy charged particles: a historical review.

Radiobiological studies using heavy charged particles followed closely the development of accelerators to produce beams of ever-increasing energy, driven primarily by the aspirations of physicists and chemists interested in the structure of matter. An impressive share of this development took place at Berkeley, beginning with the invention of the cyclotron by Ernest Lawrence in 1930. There followed a series of cyclotrons, synchrotrons and linear accelerators, culminating in the BEVALAC, which provided the first source of very heavy ions (helium to argon) to be used clinically, beginning in 197…

[Clinical classification, characteristics, and prognosis of chronic radiation-induced rectal injury: a single-center analysis of 1131 cases].

Objective: To analyze the clinical characteristics and endoscopic manifestations of patients with chronic radiation-induced rectal injury (R … giectatic RLRI (17.0%, 93/547) versus 168 patients with mixed-type RLRI (30.1%,168/559). Endoscopic argon plasma coagulation (APC) was administered to 172 patients with telangiectatic RLRI (31.4%) and 96 patients with mixed-type RLRI (17.2%). Thirty-five patients (3.1%) received transanal formalin therapy, predominantly telangiectatic RLRI (29 cases), w …

Коррозионное поведение Incoloy_800H, Hasteloy ¶G35> и 316L бесшовной стали в смеси фтористых молотков FLINAK и ее паров

Данная статья рассматривает результаты эксперимента по коррозии, который исследует переходную зону между нижней и верхней областями образца. В этом эксперименте нижняя половина поверхности образца подвергается воздействию расплавленной соли, а верхняя половина поверхности образца подвергается воздействию паров, генерируемых расплавленной солью FLiNak. Для коррозионного эксперимента были выбраны сплавы Incoloy®800H и Hastelloy®G35® и нержавеющая сталь 316L на основе их содержания хрома. Эксперимент был проведен при температуре 600 °C в течение 100 часов. Результаты эксперимента показывают, что

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… The crucible and its contents were then heated to 600 °C for a period of 100 h in an argon atmosphere. After the stipulated time of 100 h, the furnace was turned off and allowed to cool spontaneously to room temperature. … Corrosion of Hastelloy-N and Hastelloy-G35 from vapors generated from FLiNaK salt with addition of 5% oxygen in argon atmosphere Mater. Corros. 2022 10.1002/maco.202213412 22. Riley B. DelCul J.M.G. Vienna J. Contescu C. Hay L. Savino A. Adkins H. …

Необоснованные конкретные подписи на структурные воды, выявленные в результате динамической ядерной поляризации с помощью УФ-почитаемых радикалов.

Содержимые молекулы структурной воды стабилизируют белковые сгибы и модернизируют свою функцию, однако по-прежнему трудно наблюдать в растворе, поскольку рецензии на основе обмена благоприятствуют местам, в которых используется растворитель. Здесь мы введем протокол для обнаружения структурных молекул воды в местных условиях с использованием долгоживущей гиперполяризованной воды (HyperW), срабатывающей с помощью ультрафиолетовых, нетерпимых радикалов. В модели белкового ингибитора химотрипсина 2, ГиперВ-усилен two- размерная корреляция NMR-спектра через PD 5.5-8.4 :: выявлять значительные улуч

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… The 60 μ L DNP sample was rapidly dissolved by automatic injection of 4.5 mL deoxygenated (argon‐purged), deuterated buffer (99.9% D 2 O) heated to 170 ∘ C to produce radical‐free, hyperpolarized water containing 0.7% HDO (360 mM protons). … Throughout the whole workflow, particular emphasis was therefore placed on avoiding molecular oxygen by purging all collection, transfer, and detection vessels with argon. …

Case report: Cryoablation as a novel bridging strategy prior to CAR-T cell therapy for B cell malignancies with bulky disease.

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a powerful immunotherapy in relapsed/refractory (R/R) hematological malignancies, especially in R/R B-cell acute lymphocytic leukemia (B-ALL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM). To prevent disease progression and reduce tumor burden during CAR-T cell manufacturing, bridging therapies prior to CAR-T cell infusion are crucial. At present, it has been demonstrated that targeted therapy, radiotherapy and autologous stem cell transplantation (ASCT) could serve as effective bridging strategies. However, whether cryoabl

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… Cryoablation usually utilizes liquefied gases, such as argon and helium. … The rapid expansion of high-pressure argon results in the temperature of the distal end of cryoprobes as low as -170 °C, while the expansion of high-pressure helium makes the temperature of the distal end of cryoprobes rapidly rise to 40 °C. …

Preoperative Denosumab With Curettage and Cryotherapy in Giant Cell Tumor of Bone: Is There an Increased Risk of Local Recurrence?

BACKGROUND: Denosumab is a monoclonal RANKL antibody, which was originally introduced for the treatment of osteoporosis and bone metastases … ressive-looking lesions. After curettage, cryotherapy of the residual bone walls was performed with argon cryoprobes to -150° C after pouring gel into the cavity, and we then used cement (17 patients) or morcellized allograft (four patients). Tumors were Campanacci Grade 3 in eight of 12 patients in the denosumab group and in two of nine patients in the …

Theatrical fire pursuant exploratory laparotomy.

Fire in the operating theater is a rare but potentially fatal complication. We report igniting an intraperitoneal fire while preforming an exploratory laparotomy for perforated viscus. Fortunately, the patient suffered no injuries as a result.

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… Ignition usually occurs secondary to electrocautery, argon beam coagulators, lasers and other sources of electrical current. …

[New examination methods for macular disorders--application of diagnosis and treatment].

To establish a diagnosis or evaluate the efficacy of treatment for macular disorders, we need methods to evaluate the anatomical and functio … layer at the macular area using a scanning laser ophthalmoscope (SLO). The SLO examination with an argon laser and a large confocal aperture was useful for conducting kinetic examination of the vitreous opacity above the macula. With a diode laser and a ring aperture (dark-field mode), it was possible to examine the retina from the deeper retinal layer …

Successful Treatment of Recurrent Gastrointestinal Bleeding Due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide: Two Birds with One Stone

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… Several attempts at endoscopic argon-plasma coagulation in the following years were not able to control the disease and the patient required regular blood transfusions (every 3-4 weeks) and parenteral iron supplementation. The patient was referred to a hematologist in 2016 for further assessment. …

Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT.

BACKGROUND: The National Institute for Health and Care Excellence recommends macular laser to treat diabetic macular oedema with a central r … sed 1 : 1 to receive 577 nm subthreshold micropulse laser or standard threshold macular laser (e.g. argon laser, frequency-doubled neodymium-doped yttrium aluminium garnet 532 nm laser); laser treatments could be repeated as needed. Rescue therapy with intravitreal anti-vascular endothelial growth factor therapies or steroids was allowed if a loss of ≥ …

Case Report: Abblation как новая х терапия в режиме слабого гематологического расстройства с внематологическими повреждениями.

Гематологические заболевания как категория злокачественных опухолей, происходящих из гематопоиетической системы, давно полагаются на такие виды лечения, как химиотерапия, радиотерапия и трансплантация стволовых клеток. Вместе с тем по-прежнему сохраняются проблемы, связанные с устранением местных прогрессивных повреждений, рецидивов/обезболивающих повреждений и участием специальных анатомических объектов, особенно в недееспособности. Технология абляции, которая представляет собой минимально инвазивный метод лечения на местном уровне, непосредственно уничтожает поврежденные ткани с помощью физи

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… Cryoablation was performed using an Argon-Helium Cryosurgical System (AH-22, Beijing Sunlight Yi Bang Medical Science and Technology Co., Ltd.). … Under CT guidance, a 24G cryoprobe was inserted into the mass, and two freeze-thaw cycles were conducted using Argon-Helium Cryosurgical System—each cycle consisting of 15 minutes of freezing followed by 3 minutes of thawing. …

Efficacy of Invariant Natural Killer T Cell Infusion Plus Transarterial Embolization vs Transarterial Embolization Alone for Hepatocellular Carcinoma Patients: A Phase 2 Randomized Clinical Trial.

PurposeInvariant NKT cells (iNKT) are CD1d-restricted T cells with the capacity of antitumor immunity. The safety of autologous iNKT cell treatment in hepatocellular carcinoma (HCC) has been verified. This study aimed to investigate its efficacy in advanced HCC after transarterial chemoembolization (TACE) failure.Patients and methodsThis open-label, randomized, controlled, trial enrolled 60 patients with unresectable HCC after TACE failure at three centers. Transarterial embolization (TAE) was used instead of TACE to protect iNKT cell function. Patients were randomly assigned (1:1) to receive

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… Cirrhosis, N (%) Yes 19 (70) 17 (63) No 8 (30) 10 (37) History of treatment TACE (≥2 consecutive procedures), N (%) 27 (100) 27 (100) TACE times 2~12 2~6 Systemic treatment, N (%) 2 (7) 1 (4) Radiofrequency ablation, N (%) 9 (33) 12 (44) Radiotherapy, N (%) 2 (7) 0 (0) Resection, N (%) 7 (26) 1 (4) Argon-helium … 63) No | 8 (30) | 10 (37) History of treatment | | TACE (≥2 consecutive procedures), N (%) | 27 (100) | 27 (100) TACE times | 2~12 | 2~6 Systemic treatment, N (%) | 2 (7) | 1 (4) Radiofrequency ablation, N (%) | 9 (33) | 12 (44) Radiotherapy, N (%) | 2 (7) | 0 (0) Resection, N (%) | 7 (26) | 1 (4) Argon-helium …

Cryotherapy for liver metastases.

BACKGROUND: The liver is affected by two of the most common groups of malignant tumours: primary liver tumours and liver metastases from colorectal carcinoma. Liver metastases are significantly more common than primary liver cancer and long-term survival rates reported for patients after radical surgical treatment is approximately 50%. However, R0 resection (resection for cure) is not feasible in the majority of patients. Cryotherapy is performed with the use of an image-guided cryoprobe which delivers liquid nitrogen or argon gas to the tumour tissue. The subsequent process of freezing is ass…

Acute pulmonary effects of ultrafine particles in rats and mice.

Ambient fine particles consist of ultrafine particles (< 100 nm) and accumulation-mode particles (approximately 100 to 1,000 nm). Our hypoth … d for only 15 minutes. We found that neither the ultrafine Teflon particles alone when generated in argon nor the Teflon fume gas-phase constituents when generated in air were toxic after 25 minutes of exposure. Only the combination of both phases when generated in air caused high toxicity, suggesting the existence of either radicals on the particle sur …