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Воздействие дефицита витамина D до трансплантации на иммунную реабилитацию и клинические результаты у многих пациентов с миеломой, проходящих аутологическую трансплантацию стволовых клеток.

В этом исследовании анализируется воздействие дефицита витамина D перед трансплантацией на иммунную реабилитацию и клинические результаты у многих пациентов с миэломой, проходящих аутологическую трансплантацию стволовых клеток (ASCT). Учитывая известное иммунодуляторное воздействие витамина D, исследование описывает его влияние на нейтрофиль и энграфацию тромбоцитов, восстановление лимфоцитов и общие коэффициенты реагирования после ASCT. Анализируя ретроспективную когорту, исследование показывает потенциальные связи между состоянием витамина D и восстановлением иммунной системы после трансплан

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… Anticancer Res . ( 2015 ) 35 : 6281–5 ., PMID: 26504063 12 Diamond T Golombick T Manoharan A . Vitamin D status may effect the skeletal complications of multiple myeloma . …

Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells.

Bortezomib (BTZ), a chemotherapeutic drug used to treat multiple myeloma, induces life-threatening side effects, including severe pulmonary toxicity. However, the mechanisms underlying these effects remain unclear. The objectives of this study were to (1) investigate whether BTZ influences vascular permeability and (2) clarify the effect of BTZ on the expression of molecules associated with cell-cell junctions using human pulmonary microvascular endothelial cells in vitro. Clinically relevant concentrations of BTZ induced limited cytotoxicity and increased the permeability of human pulmonary m

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… Polycrystalline Diamond as a Potential Material for the Hard-on-Hard Bearing of Total Hip Prosthesis: Von Mises Stress Analysis Biomedicines 2023 11 951 10.3390/biomedicines11030951 36979930 PMC10045939 37. Ammarullah M.I. Santoso G. Sugiharto S. Supriyono T. Wibowo D.B. Kurdi O. Tauviqirrahman M. …

Cancer Research in the Time of COVID-19: A Colombian Narrative.

Cancer research is deficient in Colombia and efforts and resources diverted due to the COVID-19 pandemic could worsen the situation. We explore the impact of the pandemic on cancer research funding, output, and conduct. We sought information at national level and used the experience of an academic reference center to contrast the impact at institutional level. We searched databases and official documents of national governmental institutions, trial registries, hospital registries, and the Web of Science. We interviewed principal investigators (PIs) to retrieve information on the conduct of can

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… Lamont EB, Diamond SS, Katriel RG, Ensign LL, Liu J, Rusli E, et al. Trends in oncology clinical trials launched before and during the COVID-19 pandemic. JAMA Netw Open. (2021) 4:e2036353. 10.1001/jamanetworkopen.2020.36353 22. Upadhaya S, Yu JX, Hodge J, Campbell J. …

Multiple Myeloma: Risk Stratification and Toxicity Management

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… 2012 120 1801 1809 22665938 10.1182/blood-2012-04-422683 PMC5162553 11 Korde Neha Roschewski Mark Zingone Adriana Kwok Mary Manasanch Elisabet E Bhutani Manisha Tageja Nishant Kazandjian Dickran Mailankody Sham Wu Peter Morrison Candis Costello Rene Zhang Yong Burton Debra Mulquin Marcia Zuchlinski Diamond …

Predictors of functional health status of end stage renal disease patients.

Potential predictors of the functional health status of 125 end stage renal disease (ESRD) patients were studied cross-sectionally. When health status was assessed by the physician with the Karnofsky Index, younger patient age, lower ESRD severity of illness, lower comorbidity severity, and higher albumin levels were predictors of better health [R-square = 0.48]. When patients self-reported their health status with the Duke Health Profile, African-American race, higher family support, lower family stress, and lower ESRD severity were positive predictors [R-square = 0.23]. The importance of mea

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… Perspective Seminars in Dialysis 8 198 200 1995 Rettig RA Sadler JH Meyer KB Assessing Health and Quality of Life Outcomes in Dialysis, A Report on an Institute of Medicine Workshop American Journal of Kidney Diseases 1997 in press 10.1016/s0272-6386(97)90578-3 9214415 Schrier RW Burrows-Hudson S Diamond …

What is the Reason That the Pharmacological Future of Chemotherapeutics in the Treatment of Lung Cancer Could Be Most Closely Related to Nanostructures? Platinum Drugs in Therapy of Non-Small and Small Cell Lung Cancer and Their Unexpected, Possible Interactions. The Review.

Over the course of several decades, anticancer treatment with chemotherapy drugs for lung cancer has not changed significantly. Unfortunately, this treatment prolongs the patient's life only by a few months, causing many side effects in the human body. It has also been proven that drugs such as Cisplatin, Carboplatin, Oxaliplatin and others can react with other substances containing an aromatic ring in which the nitrogen atom has a free electron group in its structure. Thus, such structures may have a competitive effect on the nucleobases of DNA. Therefore, scientists are looking not only for

Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… platelets <50 × 10 9 /L), or severe BM fibrosis. d Additional high-risk gene mutations (ASXL1, RUNX1, SETBP1, N-RAS), severe cytopenia or transfusion dependency, excessive proliferative features or extramedullary involvement. e Constitutional SAA includes Fanconi anaemia, dyskeratosis congenita, Blackfan–Diamond … Patients with Blackfan–Diamond anaemia with a MSD should be transplanted if they do not respond to steroids. If a MSD is not available, allo-HCT may be performed with a MUD in experienced centres [ 296 ]. …

МСМ-ММРГ 2025 Консенсусная геномная установка предсказывает результаты с помощью четырехструнных режимов, основанных на дратумумабе, для NDMM.

Международное общество миеломы (ММО) и Международная рабочая группа по миеломе (МРГ) недавно опубликовали новый консенсусный геномический комплект (КОГ) для определения недавно диагностированного множества миеломы (НДММ) с целью обеспечения последовательности в отчетности о клинических испытаниях и для использования при разработке клинических испытаний по обогащению с уделением особого внимания подклассу ЛР. Определение HR является первым, включающим мутации TP53, и предусматривает совместное использование переносов иммуноглобулина Н с хромосомой. 1 Отклонения. С учетом ограниченного объема да

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… Landgren O, Hultcrantz M, Diamond B, et al. Safety and effectiveness of weekly carfilzomib, lenalidomide, dexamethasone, and daratumumab combination therapy for patients with newly diagnosed multiple myeloma: the MANHATTAN nonrandomized clinical trial. …

Результаты среди пациентов MM, получающих раннее вмешательство в процесс развития MRD после автономной трансплантации стволовых клеток.

Для оценки реакции нескольких пациентов, страдающих миеломой (ММ), на лечение необходимо проводить обследование на наличие минимальных остаточных заболеваний (МСД). Многие пациенты, прежде чем удовлетворять критериям клинического или биохимического прогресса (PD), сталкиваются с MRD (MRD-P), в связи с чем возникают вопросы о сроках лечения. В этом ретроспективном исследовании было исследовано воздействие раннего вмешательства (РВ) на прогнозы 42 вновь диагностированные пациенты MM, разработавшие MRD-P после первоначального лечения аутологической трансплантации стволовых клеток. В группе EI (n

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… Diamond , “ Minimal Residual Disease‐Adapted Therapy in Multiple Myeloma: Current Evidence and Opinions ,” Current Oncology Reports 26 ( 2024 ): 679 – 690 . 38676789 10.1007/s11912-024-01537-2 PMC11169024 14 O. Landgren and D. …

Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy.

Objectives: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. Methods: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (n = 10); (2) BNC/Iodine (n = 10); (3) BNC/Chlorhex (n = 10); (4) Control (n = 10). Maxillae were dissected and macro- and microscopically analyzed. Results: Oral lesion frequency on macroscopic

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… The osteotomy was performed with the aid of a 19 × 0.20 mm double-faced total diamond disk (American Burrs, Porto Alegre, RS, Brazil), at low-speed and with irrigation. …

Optimal infused CD34+ cell dose in multiple myeloma patients undergoing upfront autologous hematopoietic stem cell transplantation.

Autologous transplantation remains the standard of care for eligible multiple myeloma (MM) patients, yet optimal CD34+ cell dose remains unclear. We conducted a retrospective study on MM patients undergoing upfront transplant between 2005 and 2021 and divided them into low (≤2.5 × 106 cells/kg) and high (>2.5 × 106 cells/kg) CD34+ dose groups. We included 2479 patients, 95 in the low CD34+ group and 2384 in the high CD34+ group. Patients in the low CD34+ group were older (63.2 vs 61.1 years, p = 0.013), more often had R-ISS III (19% vs 9%, p = 0.014), received plerixafor (60% vs 35%, p + group

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… Tan CR, Derkach A, Nemirovsky D, Ciardiello A, Diamond B, Hultcrantz M, et al. Bortezomib, lenalidomide and dexamethasone (VRd) vs carfilzomib, lenalidomide and dexamethasone (KRd) as induction therapy in newly diagnosed multiple myeloma. Blood Cancer J. 2023;13:112. 30. …

Percutaneous vertebroplasty/kyphoplasty contributes to the improved outcome in patients with newly diagnosed multiple myeloma: A single center cohort study.

ObjectiveTo evaluate the efficacy and prognosis of percutaneous vertebroplasty/kyphoplasty (PVP/PKP) in patients with newly diagnosed multiple myeloma (NDMM).MethodsClinical data of NDMM patients who underwent PVP/PKP during front-line regimen at Peking Union Medical College Hospital from January 1, 2003, to June 30, 2023, were analyzed. Patients with comparable bone diseases not receiving orthopedic surgery were selected as controls. Visual analogue scale (VAS) score, progression-free survival (PFS), and overall survival (OS) were compared.ResultsBaseline characteristics were matched between

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… Clark W., Bird P., Gonski P., Diamond T.H., Smerdely P., Mcneil H.P., Schlaphoff G., Bryant C., Barnes E., Gebski V. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. …

Patient-reported patterns of follow-up care in the 'Aftercare in Blood Cancer Survivors' (ABC) study.

BACKGROUND: Follow-up care provides long-term support for cancer survivors. Little is known about follow-up care in hematologic malignancies. METHODS: Our questionnaire-based study included blood cancer survivors diagnosed at the University Hospital of Essen before 2010, with a ≥ 3-year interval since the last intense treatment. The primary goal of the retrospective study was the identification and characterization of follow-up institutions. RESULTS: Of 2386 survivors meeting the inclusion criteria, 1551 (65.0%) consented to participate, with a follow-up duration > 10 years in 731. The unive

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… They are compared using the Kruskal–Wallis test and graphically displayed as box whisker plots, diamonds representing means. All analyses are exploratory assuming statistical significance at p ≤ 0.05. …

Efficacy and safety of oncolytic virus combined with chemotherapy or immune checkpoint inhibitors in solid tumor patients: A meta-analysis.

Background: In recent years, several clinical trials have focused on oncolytic virus (OVs) combined with chemotherapy or immune checkpoint inhibitors (ICIs) in solid tumor patients, which showed encouraging effects. However, few studies have concentrated on the summary on the safety and efficacy of the combined treatments. Therefore, we conducted this meta-analysis to explore the safety and curative effect of the combined therapy. Methods: We searched the PubMed, Cochrane Library, Embase, and Clinicaltrials.gov databases to comprehensively select articles on OVs combined with chemotherapy or I

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… In the all forest plots that we presented, the square represents effect sizes from a single study and the side represent weight; the diamond represents the pooled result of single study; the red dotted line represents the mean of the pooled data; the horizontal line represents a single study; the horizontal …

Использование нефротоксичных препаратов у взрослых, страдающих хроническим заболеванием почек, в рамках обычного лечения в Швеции и США.

Характеристика применения нефротоксичных препаратов у пациентов с хроническим заболеванием почек (CKD) G3-5 в обычном уходе. Мы изучали когорты взрослых с подтвержденным ККД G3-5 :: рутинная медицинская помощь 1 Январь 2016 до конца 31 декабрь 2018 В two [Stockholm CREAM, Стокгольм, Швеция (N = 57 880) и Geininger, PA, USA (N = 16 255] Мы оценили долю пациентов, получающих нефротоксичные препараты внутри 1 Год в целом и по базовой функции почек, ранжировали основных плательщиков и изучили связь между получением нефротоксичных лекарств и возрастом, сексом, СКД G-стадиями коморбиды и осведомленн

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… Shaded polygons are proportional to the total area within each diamond for the indicated percentage. …

Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry.

The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures to IARC carcinogenic agents in work settings unknown to be associated with SNC risk were collected and analyzed. Out of 2,208 SNC cases recorded in the ReNaTuNS database, 216 cases and their worked exposure periods were analyzed. Unsuspected jobs with exposure to wood

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… Zheng W., Blot W.J., Shu X.O., Diamond E.L., Gao Y.T., Ji B.T., Fraumeni J.F., Jr. A population-based case-control study of cancers of the nasal cavity and paranasal sinuses in Shanghai. Int. J. Cancer. 1992;52:557–561. doi: 10.1002/ijc.2910520410. 14. …

The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction-An Animal Experimental Study.

The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM I

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… The jaws were then separated in the area of the extracted teeth using a diamond band saw (EXAKT, Norderstedt, Germany). The removed jaw segments with a thickness of 4 mm were processed into decalcified thin section preparations [ 55 ]. …

Autologous Stem Cell Transplantation in Multiple Myeloma: Where Are We and Where Do We Want to Go?

The introduction of high-dose therapy in the 1990s as well as the development of drugs such as thalidomide, lenalidomide, and bortezomib in the 2000s led to an impressive improvement in outcome of patients with multiple myeloma (MM) eligible for autologous stem cell transplantation (ASCT). Clinical trials conducted in the first ten years of the twenty-first century established as standard therapy for these patients a therapeutic approach including induction, single or double ASCT, consolidation, and maintenance therapy. More recently, incorporating second-generation proteasome inhibitors carfi

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… Landgren O., Hultcrantz M., Diamond B., Lesokhin A.M., Mailankody S., Hassoun H., Tan C., Shah U.A., Lu S.X., Salcedo M., et al. … Diamond B., Korde N., Lesokhin A.M., Smith E.L., Shah U., Mailankody S., Hultcrantz M., Hassoun H., Lu S.X., Tan C., et al. Dynamics of minimal residual disease in patients with multiple myeloma on continuous lenalidomide maintenance: A single-arm, single-centre, phase 2 trial. …

Osteoporosis in Men: A Review of an Underestimated Bone Condition.

Osteoporosis is called the 'silent disease' because, although it does not give significant symptoms when it is not complicated, can cause fragility fractures, with serious consequences and death. Furthermore, the consequences of osteoporosis have been calculated to weigh heavily on the costs of health systems in all the countries. Osteoporosis is considered a female disease. Actually, the hormonal changes that occur after menopause certainly determine a significant increase in osteoporosis and the risk of fractures in women. However, while there is no doubt that women are more exposed to osteo

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… Diamond et al., 1997 [ 36 ] | Cohort study: 51 men aged ≥60 years and 51 age-matched women presenting to St George Hospital (a 650-bed tertiary care centre) with hip fractures, recruited retrospectively in 1995 from medical records and evaluated prospectively at 6 and 12 months after fracture. | 14% … Diamond T.H., Thornley S.W., Sekel R., Smerdely P. Hip fracture in elderly men: Prognostic factors and outcomes. Med. J. Aust. 1997;167:412–418. doi: 10.5694/j.1326-5377.1997.tb126646.x. 37. Melton L., Riggs B. Epidemiology of age-related fractures. In: Avioli L., editor. …

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.

Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of B-cell malignancies, but its success in acute myeloid leukemia (AML) remains limited. Durable responses depend on the formation of long-lived memory T cells, whereas T cell exhaustion contributes to non-response and relapse. In patients with AML who achieved remission after cord blood transplantation, we here first observe enrichment of memory T cells with high expression of the chemokine receptor CXCR4. Next, we show that engineering CAR-T cells to co-express CXCR4 enhances their persistence and anti-leukemic acti

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… Diamonds indicate mean values; whiskers represent 95% confidence intervals. Statistical analysis was performed using a two-tailed T test. … Diamonds indicate mean; whiskers represent 95% confidence intervals. Statistical comparisons were made using two-tailed t-tests. Non-adjusted p-values are reported. See also Figure. S7e . d Dot plot showing expression of representative marker genes across T-cell subtypes and treatment conditions. …