Результаты поиска

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects.

In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention. In this review, we summarized the clinica

Совпадение в полном тексте источника
… EA at CV12 has been shown to improve CADS via an increase in the secretion of ghrelin and cholecystokinin (CCK) and a decrease in the secretion of 5-hydroxytryptamine (5-HT) into the serum 9 , 78 . … Electro-Acupuncture Alleviates Cisplatin-Induced Anorexia in Rats by Modulating Ghrelin and Monoamine Neurotransmitters. Biomolecules. 2019;9(10):624. doi: 10.3390/biom9100624. …

Towards an adiposity-related disease framework for the diagnosis and management of obesities.

Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart,

Совпадение в полном тексте источника
… Finally, adiponectin, leptin and ghrelin levels are altered in PlwO [ 41 , 42 ]. Adiponectin/Leptin ratio (Adpn/Lep) is a suitable indicator of AT dysfunction, thus it may be a useful estimator of cardiometabolic risk [ 42 ]. … The ghrelin O-Acyltransferase-Ghrelin system reduces TNF-α-Induced apoptosis and autophagy in human visceral adipocytes. Diabetologia. 2012;55:3038–3050. doi: 10.1007/s00125-012-2671-5. 105. Obesity FG. Aquaporin enters the picture. Nature. 2005;438:436–437. doi: 10.1038/438436b. 106. …

Neuromuscular electrical stimulation for physical function maintenance during hematopoietic stem cell transplantation: Study protocol.

Hematopoietic stem cell transplantation is a common life-saving treatment for hematologic malignancies, though can lead to long-term functional impairment, fatigue, muscle atrophy, with decreased quality of life. Although traditional exercise has helped reduce these effects, it is inconsistently recommended and infrequently maintained, and most patients remain sedentary during and after treatment. There is need for alternative rehabilitation strategies, like neuromuscular electrical stimulation, that may be more amenable to the capabilities of hematopoietic stem cell transplant recipients. Pat

Совпадение в полном тексте источника
… Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study . … Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia . J Clin Endocrinol Metab . 2005 ; 90 ( 5 ): 2920 – 6 . doi: 10.1210/jc.2004-1788 15713718 41 Lerner L , Hayes TG , Tao N , Krieger B , Feng B , Wu Z , et al . …

Безопасность и эффективность кетогенного диета в управлении множественным склерозом: систематический обзор.

В рамках этого систематического обзора изучаются вопросы безопасности и эффективности кетогенных рационов питания (КД) при управлении множественным склерозом (МС). В соответствии с предпочтенными принципами отчетности по элементам для системных обзоров и мета-анализами (PRISMA) мы систематически искали пять основных баз данных до апреля 2025 года, идентифицировав шесть соответствующих исследований, опубликованных в период с 2017 по 2024 год. Эти исследования, в основном направленные на восстановление эмиссий MS, свидетельствуют о последовательных преимуществах кетогенного вмешательства во мног

Совпадение в полном тексте источника
… Benlloch et al. [ 14 ] | 2019 | Pilot study with quasi-experimental design (prospective, mixed) | 27 MS patients | Anthropometric measurements, satiety/hunger perception (VAS scale), beta-hydroxybutyrate (BHB) levels, paraoxonase 1 (PON1) as oxidation marker, ghrelin levels | Significant increase in … No significant change in ghrelin levels. | A Mediterranean isocaloric KD increases lean mass and decreases inflammation and oxidation, possibly as a consequence of increased satiety and decreased hunger in MS patients. …

Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects.

Although chemotherapy is the first-line treatment strategy for a variety of tumors, its side effects have limited its efficacy. This review summarizes the progress on the use of acupoint stimulation to combat chemotherapy-associated side effects, including chemotherapy-induced peripheral neuropathy (CIPN), cognitive impairment (CICI), and gastrointestinal toxicity (GI), as well as myelosuppression and immunosuppression. It was found that acupoint stimulation attenuated CIPN and GI by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the d

Совпадение в полном тексте источника
… In addition, it was ( 46 ) found that EA at CV12 not only decreased 5-TH, 5-hydroxyindoleacetic acid, dopamine, and norepinephrine but also increased appetite in rats by regulating gastrointestinal hormones and neuropeptides (ghrelin and neuropeptide Y). … Electro-Acupuncture Alleviates Cisplatin-Induced Anorexia in Rats by Modulating Ghrelin and Monoamine Neurotransmitters. Biomolecules (2019) 9(10):624. doi: 10.3390/biom9100624 47. Kang KS, Huh W, Bang Y, Choi HJ, Baek JY, Song JH, et al. …

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

Совпадение в полном тексте источника
… Various studies have found that sleep deprivation is associated with a decrease in leptin levels and an increase in ghrelin levels [ 54 – 56 ]. … Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1:e62. doi: 10.1371/journal.pmed.0010062. 57. Knutson KL, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation. …

The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study.

BACKGROUND: Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward. METHODS: In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signa

Совпадение в полном тексте источника
… Active ghrelin levels and active to total ghrelin ratio in cancer‐induced cachexia. J Clin Endocrinol Metab 2005;90:2920–2926. 32. Ashburner J, Friston KJ. Nonlinear spatial normalization using basis functions. Hum Brain Mapp 1999;7:254–266. 33. …

Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome.

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the process of muscle loss. Muscle atrophy in adult tissue occurs when protein degradation rates exceed protein synthesis. Two major protein degradation pathways, the ubiquitin-proteasome and the autophagy-lysosome systems, are activated during muscle atrophy and variably contribute to the loss of muscle mass. These degradation systems are controlled by a transcription dependent program that modulates the expression of rate-lim

Совпадение в полном тексте источника
… Recently the hormone ghrelin was found to prevent muscle wasting ( Porporato et al., 2013 ). Ghrelin is a peptide hormone that stimulates growth hormone (GH) release and positive energy balance through binding to the receptor GHSR-1a. … Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice Journal of Clinical Investigations 123 2013 611 622 10.1172/JCI39920 PMC3561827 23281394 Puigserver P. Rhee J. Donovan J. Walkey C.J. Yoon J.C. Oriente F. …

Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.

BackgroundGenetic studies have found that a germline BRCA1 gene mutation is the origin of highly increased cancer risk. Clinical studies have suggested that increased cancer risk in type-2 diabetes may be attributed to unhealthy lifestyle factors and bad habits.PurposePatients with either BRCA1 gene mutation or type-2 diabetes similarly exhibit increased cancer risk, insulin resistance, and fertility disorders. It was suggested that these three alterations derive from a common genomic failure, and its recognition may shed light on the unsolved secret of cancer.Results(1) Germline mutations on

Совпадение в полном тексте источника
… Ghrelin is a multifaceted hormone secreted by gastric and intestinal cells showing endocrine function. Ghrelin is known as the hunger hormone, increasing growth hormone release, food intake, and fat storage when the stomach is empty [ 164 ]. … Estrogen regulates ghrelin secretion and ghrelin receptor activation, controlling the ghrelin effect on appetite, energy balance, and metabolic changes [ 165 ]. In conclusion, estrogen signaling controls all hormones regulating appetite, hunger, food intake, and fat deposition. …

The Effects of Artificial Sweeteners on Intestinal Nutrient-Sensing Receptors: Dr. Jekyll or Mr. Hyde?

The consumption of artificial and low-calorie sweeteners (ASs, LCSs) is an important component of the Western diet. ASs play a role in the pathogenesis of metabolic syndrome, dysbiosis, inflammatory bowel diseases (IBDs), and various inflammatory conditions. Intestinal nutrient-sensing receptors act as a crosstalk between dietary components, the gut microbiota, and the regulation of immune, endocrinological, and neurological responses. This narrative review aimed to summarize the possible effects of ASs and LCSs on intestinal nutrient-sensing receptors and their related functions. Based on the

Совпадение в полном тексте источника
… Evaluation of the relationship between serum ghrelin, C-reactive protein and interleukin-6 levels, and disease activity in inflammatory bowel diseases Hepatogastroenterology 2014 61 1196 1200 25436282 36. Bendet N. Scapa E. Cohen O. Bloch O. Aharoni D. Ramot Y. Weiss M. Halevi A. Rapoport M.J. … Serum ghrelin levels in inflammatory bowel disease with relation to disease activity and nutritional status Dig. Dis. Sci. 2008 53 2215 2221 10.1007/s10620-007-0113-x 18080768 38. Kreuch D. Keating D.J. Wu T. Horowitz M. Rayner C.K. Young R.L. …

Assessing Cachexia Acutely after Autologous Stem Cell Transplant.

Autologous hematopoietic stem cell transplantation (AHCT) is an accepted strategy for various hematologic malignancies that can lead to functional impairment, fatigue, muscle wasting, and reduced quality of life (QOL). In cancer cachexia, these symptoms are associated with inflammation, hypermetabolism, and decreased anabolic hormones. The relative significance of these factors soon after AHCT setting is unclear. The purpose of this study was to characterize the acute effects of AHCT on physical function, body composition, QOL, energy expenditure, cytokines, and testosterone. Outcomes were ass

Совпадение в полном тексте источника
… Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J. Clin. Endocrinol. Metab. 2005;90:2920–2926. doi: 10.1210/jc.2004-1788. 11. Gagnon B., Murphy J., Jelowicki M., Morris D.V. …

Predicting survival in cancer patients: the role of cachexia and hormonal, nutritional and inflammatory markers.

BACKGROUND: Cancer can lead to weight loss, anorexia, and poor nutritional status, which are associated with decreased survival in cancer patients. METHODS: Male cancer patients (n = 136) were followed for a mean time of 4.5 years. Variables were obtained at baseline: cancer stage, albumin, hemoglobin, tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, bioavailable testosterone, appetite questionnaire, and weight change from baseline to 18 months. Primary statistical tests included Kaplan-Meier survival analysis and Cox proportional hazard regression (PHREG). RESULTS: Univariate PHREG

Совпадение в полном тексте источника
… Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J Clin Endocrinol Metab. 2005;90:2920–6. doi: 10.1210/jc.2004-1788. 10. Tisdale MJ. Cachexia in cancer patients. Nat Rev Cancer. 2002;2:862–71. doi: 10.1038/nrc927. 11. …

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

BACKGROUND: Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexia disease. Amiloride, a diuretic drug, is clinically used for treatments of hypertension and edema due to heart failure. Here, we explored the effects of the amiloride treatment for ameliorating muscle wasting in murine models of cancer cachexia. METHODS: The CT26 and LLC tumor cells were subcutaneously in

Совпадение в полном тексте источника
… In the past decades, strategies for cachexia therapy mainly focused on the development of new drugs, including ghrelin and ghrelin receptor agonists, myostatin antagonists, inflammatory cytokine neutralizing antibodies, and natural product extracts [ 28 – 37 ]. … Chen JA Splenser A Guillory B Luo J Mendiratta M Belinova B Halder T Zhang G Li YP Garcia JM Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved J Cachexia Sarcopenia Muscle. 2015 6 2 132 143 10.1002/jcsm.12023 26136189 PMC4458079 31. …

Plasma микроRNA Подпись как предсказательный знак клинической реакции на терапию во время множественного склероза.

ЦЕЛЬ: Несмотря на наличие эффективных методов лечения множественного склероза (MS), непредсказуемый характер развития заболеваний и изменчивость результатов индивидуального лечения требуют надежных биомаркеров. Цель этого экспериментального исследования заключается в изучении потенциала плазмы, циркулирующей микроРНК (миРНК), в качестве биомаркеров-метилфумаратов для клинической реакции на диметил-фумарат (ДМП), широко применяемой пероральной обработки НР. МЕТОДЫ: Образцы периферальной крови были взяты из nineteen лиц с повторными выбросами MS (PwRRMS) до и после 3, 6, 12, и 24 месяцев управле

Совпадение в полном тексте источника
… Cytokine and Soluble Factors Measurement Plasma levels of Ghrelin, Leptin, Resistin, Adiponectin, Serpin E1, and Adipsin were evaluated using Human Magnetic Luminex Assays kits (R&D systems); plasma levels of GM‐CSF, IFNγ, IL1β, IL2, IL4, IL5, IL6, IL8 (CXCL8), IL10, IL12p70, IL17A (CTLA8), MCP1 (CCL2 … Disease Onset Correlates With the Levels of Relevant Soluble Factors Upon DMF Treatment In healthy controls and pwRRMS before and after DMF treatment, we also evaluated plasma levels of several cytokines (GM‐CSF, IFNγ, IL1β, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL17A, MCP1, TNFα), metabolic factors (ghrelin …

Влияние изменений, флуктуации или изменчивости веса на риск неалкогольной толстой болезни печени в общей численности населения: систематический обзор и мета-анализ.

В настоящее время проводятся фоновые и целенаправленные исследования воздействия изменений веса на неалкогольное заболевание жировой печени; поэтому цель этого систематического обзора заключается в критическом обсуждении воздействия изменений, колебаний или колебаний веса на риск заболевания неалкогольной жировой печени у населения в целом. three базы данных, PubMed/Medline, Google Scientist и Scopus, которые были доступны до июня 2024, были использованы для составления материалов для наших исследований. Для этого исследования были представлены только публикации на английском языке, и их оценк

Совпадение в полном тексте источника
… In addition to the above‐mentioned pathway, increased levels of gut‐derived hormones that stimulate hunger, including ghrelin, are related to an increase in circulating triglycerides [ 40 ]. Furthermore, leptin primarily reduces food intake and increases energy levels [ 37 ]. … Tschöp , et al., “ Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women ,” Journal of Clinical Endocrinology and Metabolism 89 , no. 6 ( 2004 ): 2963 – 2972 . 15181085 10.1210/jc.2003-031855 41 L. Miele , V. …

Publisher Correction: Effects of effective antithyroid therapy on adiposity and skeletal muscle in patients with hyperthyroidism across gender and age groups.

Eur Rev Med Pharmacol Sci 2023; 27 (13): 6170-6175 DOI: 10.26355/eurrev_202307_32973D-PMID: 37458673, published online on July 13, 2023. Fol … ls. Mol Cell Endocrinol 2017; 459: 79-83. Braclik M, Marcisz C, Giebel S, Orzeł A. Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. Thyroid 2008; 18: 545-550. Zhou J, Parker DC, White JP, Lim A, Huffman KM, Ho JP, Yen PM, Kraus WE. Thyroid Hormone Status Regulates Skeletal Muscle R …

Obesity, inflammation, and cancer in dogs: Review and perspectives.

Obesity is the most common nutritional disease in dogs, and its prevalence has increased in recent decades. Several countries have demonstrated a prevalence of obesity in dogs similar to that observed in humans. Chronic low-grade inflammation is a prominent basis used to explain how obesity results in numerous negative health consequences. This is well known and understood, and recent studies have pointed to the association between obesity and predisposition to specific types of cancers and their complications. Such elucidations are important because, like obesity, the prevalence of cancer in

Совпадение в полном тексте источника
… During weight loss, an increase in ghrelin concentration and a decrease in leptin and plasma insulin were observed. 2007 | Gayet et al. ( 80 ) | 13 | Induced | The plasma concentration and expression of leptin was increased, while the plasma concentration and expression of adiponectin decreased with … Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res Vet Sci. (2005) 79:169–75. 10.1016/j.rvsc.2004.11.012 80. Gayet C, Leray V, Saito M, Siliart B, Nguyen P. …

Keyword Index for Volume 98

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… expression profiling 1023, 1264, 1403, 1425 gene signature 1662 general population 708 genetic alteration 749 genetic predisposition 728, 1443, 1723 genetic testing 1457 genistein 1485 genomic imbalances 434 genomics 756 geography 1944 geriatric oncology 517 germline mutation 474 GGH 1555 ghrelin …

Obesity Pillars roundtable: Excessive weight reduction with highly effective anti-obesity medications (heAOMs).

BackgroundHistorically, many anti-obesity medications (AOMs) were withdrawn from development and/or the market due to safety concerns. Another challenge was that, with some exceptions, most of these AOMs had limited weight reducing efficacy. Approved AOMs often did not meet the weight reduction expectations of either clinicians, or their patients. Currently, newer approved and investigational AOMs achieve greater weight reduction than older AOMs. This has prompted an emerging new challenge of "too much weight loss" with some of these highly effective anti-obesity medications (heAOM) - somethin

Совпадение в полном тексте источника
… Research supports that emotional stress may plan into secretion of both GLP1 and ghrelin which helps account for the mixed phenotype of food response [ 23 ]. … Plasma levels of ghrelin and GLP-1, but not leptin or amylin, respond to a psychosocial stressor in women and men. Horm Behav. 2021;134 doi: 10.1016/j.yhbeh.2021.105017. …

Recent Articles-Skeletal Muscle and Other Topics in Diabetes.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Potential sarcopenia treatment approaches include selective androgen receptor modulators (SARMS) [ 8 ], growth hormone secretagogues [ 9 ], ghrelin agonists, and fast‐twitch skeletal muscle troponin inhibitors [ 10 ], but at present none of these appear satisfactory. …