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Exploring osteosarcopenia from the gut microbiota perspective: mechanistic insights and therapeutic potentials based on the gut-muscle-bone Axis.

The aging society presents a growing challenge in the form of osteosarcopenia (OS). This syndrome is marked by the concomitant deterioration … ing GM modulation-such as dietary optimization (plant-based proteins, high-fiber diets), probiotics/prebiotics, exercise, and fecal microbiota transplantation (FMT)-suggest a potential capacity to modulate gut-muscle-bone interactions, which may be relevant to osteosarcopenia-related pathophysiological processes. This review proposes an integrative conceptua …

Роль микробиотики в гематологических заболеваниях: описательный обзор механизмов и терапевтического потенциала.

Микробиота человека, в частности кишечный микробиом, играет центральную роль в поддержании иммунного гомеостаза, регулировании гематопоисиса и модуляции хост-метаболизма с помощью биоактивных метаболитов, таких, как короткоцепные жирные кислоты (СКФА), желчные кислоты и соединения триптофана. Разрушение этой микробной экосистемы (дисбиоз) стало одним из ключевых факторов развития и развития гематологических магнатов (ГМ), включая острые и хронические лейкемии, лимфомы и множественные миеломы. В настоящем обзоре описательной части обобщаются последние данные (см.2022-2025) о сложных двухнаправл

Совпадение в аннотации оригинала
The human microbiota, particularly the gut microbiome, plays a central role in maintaining immune homeostasis, regulating hematopoiesis, and … nsplantation. Emerging microbiota-targeted interventions, including dietary modulation, probiotics, prebiotics, and fecal microbiota transplantation, show promise for restoring microbial homeostasis and improving therapeutic outcomes. Furthermore, microbiome-derived biomarkers are increasingly being investigated for predicting treatment response, relapse ris …

Effects of High-Altitude Environments on Gut Microbiota and Their Mechanisms in Immune Regulation and High-Altitude Adaptation.

High-altitude environments, characterized by hypoxia, low temperature, and intense ultraviolet radiation, profoundly disrupt host intestinal … heterogeneity remain incompletely defined, microbiota-targeted interventions, including probiotics, prebiotics, and fecal microbiota transplantation, have shown promise for promoting acclimatization and preventing high-altitude-related disorders. Overall, this review provides an integrated framework linking environmental stress, gut microbial ecology, and ho …

Microbiome-Targeted Interventions for Early Cardiometabolic Prevention: A Systematic Review and Meta-Analysis in Children and Adolescents.

BACKGROUND: Cardiometabolic disease develops across the life course, making childhood critical for cardiovascular prevention. Although micro … conducted. Randomised controlled trials assessing dietary interventions, fecal microbiome transfer, prebiotics, probiotics, or synbiotics in participants aged 1 month-19 years were included. Cardiometabolic outcomes were grouped as: adiposity, lipids, liver function, inflammation, glycaemic regulation, and blood pressure. Inverse-variance weighted random-eff …

Improvement effect of synbiotics intake on stool frequency in constipation-prone healthy participants: placebo-controlled, randomised, double-blind, parallel-group comparison.

Synbiotics exert various physiological effects by complementing the physiological functions of both probiotics and prebiotics. Chronic constipation is a prevalent global health concern, and despite several clinical studies utilising synbiotics, definitive conclusions regarding its efficacy remain elusive. This study aimed to investigate the effect of a synbiotic combination of Lacticaseibacillus paracasei strain Shirota (LcS: formerly known as Lactobacillus casei strain Shirota) and galactooligosaccharides (GOS), both of which independently improve defecation symptoms, on defecation frequency …

The Gut Microbiome in HIV Pathogenesis: Interconnections Between Dysbiosis, Immune Dysfunction, and Viral Persistence.

The human gut microbiome is essential for immune regulation and mucosal homeostasis, functions that are profoundly disrupted during HIV infe … ractions. Furthermore, we evaluate emerging microbiome-targeted interventions-including probiotics, prebiotics, fecal microbiota transplantation, and engineered bacterial therapeutics-and consider their potential role as adjunctive strategies in HIV treatment and cure research. By integrating microbiological, immunological, and clinical perspectives, this re …

The gut microbiota in Salmonella Typhi infection and translocation: Mechanisms of colonization resistance, pathogen subversion, and prospects for microecological intervention.

The systemic establishment of the strictly human-adapted pathogen Salmonella Typhi critically depends on functional interplay between its vi … strength of evidence and applicability of microbiota-targeted interventions, including probiotics, prebiotics, synthetic microbial consortia, and fecal microbiota transplantation (FMT), and address the limitations of extrapolating from Salmonella Typhimurium mouse models to human Salmonella Typhi, typhoid toxin infection. Furthermore, we emphasize the need …

The Gut-Endometrium Axis: Exploring the Role of Microbiome in the Pathogenesis and Treatment of Endometrial Cancer-A Narrative Review.

Background/Objectives: Endometrial cancer (EC) is a prevalent gynecological malignancy with an increasing incidence, particularly in develop … mechanisms involving local immune modulation and the production of harmful metabolites. Probiotics, prebiotics, fecal microbiota transplantation (FMT), and personalized microbiota-based therapies can be used as clinical interventions for EC management. This review emphasizes the need for further research to explore the gut-endometrium axis and its potential …

Therapeutic strategies for hypertension: exploring the role of microbiota-derived short-chain fatty acids in kidney physiology and development.

Gut microbiota have emerged as a key regulator of systemic health, influencing various physiological processes, including kidney development … en with kidney disease. Therapeutically, interventions targeting SCFA pathways, such as probiotics, prebiotics, dietary fiber diet, and receptor agonists, may help restore gut-kidney axis balance and improve kidney and cardiovascular outcomes. This review illustrates the critical role of SCFAs as mediators linking the gut microbiota to kidney and vascular he …

Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

Rheumatoid arthritis (RA) is a systemic autoimmune disease shaped by complex interactions between genetics and environmental factors, among … sicatenibacter. Therapeutically, we reviewed microbiota-targeted interventions, such as probiotics, prebiotics, antibiotics, fecal microbiota transplantation, diet, and herbal medicines, highlighting the emerging field of pharmacomicrobiomics. Gut microbial signatures have shown promise in predicting treatment responses, including methotrexate efficacy via t …

Brain Fog in Gastrointestinal Disorders: Small Intestinal Bacterial Overgrowth, Gastroparesis, Irritable Bowel Syndrome.

INTRODUCTION: Brain fog (BF) is a term used to describe difficulties with concentration, memory, and overall mental clarity. Links of BF to … those without BF ( P =0.04). There was no major difference in the use of narcotics, prokinetics, or prebiotics. Gastroparesis and IBS were more common in patients who reported BF ( P =0.01 and 0.05, respectively), but not SIBO or IMO by breath testing. CONCLUSIONS: BF was observed in over one-half of patients with common GI disorders. The prevalence of BF w …

The interplay of gut microbiota and intestinal motility in gastrointestinal function.

The relationship between gut microbiota and intestinal motility is crucial for maintaining gastrointestinal health. Intestinal motility refe … ulation, highlighting both neural and non-neural factors. Various therapeutic approaches, including prebiotics, probiotics, and fecal microbiota transplantation, have been explored to improve intestinal motility, although their effectiveness has been limited. Advancements in gene-related research and innovative diagnostic methods are vital for a deeper under …

An updated review on advantages, disadvantages and uncertainties associated with probiotics.

Probiotics, defined as live microorganisms that confer health benefits when administrated in adequate amounts, including genera such as Lact … tential alternatives to live probiotics. The International Scientific Association of Probiotics and Prebiotics defines postbiotics as 'a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host'. Unlike probiotics, postbiotics do not require viability to exert their effects and include bioactive compounds such …

Citrus pectins impact the function of chicken macrophages.

The restrictions on excessive use of antimicrobials in the poultry industry have led to the search for alternative strategies including nutritional interventions to enhance gut health with the ultimate aim to prevent gut infections. Pectins as prebiotics have shown beneficial effects on gut health in humans and mice by improving the gut barrier function, altering the gut microbiota, and by modulating the gut immune response. However, little is known about immunomodulatory properties of pectins in chickens. The present in vitro study assessed the effect of three pectins (SPE6, SPE7, SPE8) diffe…

Study of the Gut Microbiome in Patients with Psoriatic Arthritis.

BACKGROUND: Gut dysbiosis may play a role in immune-mediated diseases, such as psoriasis. There is a growing interest in understanding micro … es our attention, especially since it brings different opportunities for intervention through diet, prebiotics and probiotics, pretreatment analysis, prognosis, and even microbiome modulation and transplantation.

In vitro, in vivo, and in silico analysis of synbiotics as preventive interventions for lipid metabolism in ethanol-induced adipose tissue injury.

The risk of alcoholic liver disease (ALD) is increased by excessive ethanol drinking. For the prevention of ALD, the effects of ethanol on the liver, adipose tissue, and gut are crucial. Interestingly, garlic and a few probiotic strains can protect against ethanol-induced hepatotoxicity. However, the relationship between adipose tissue inflammation, Kyolic aged garlic extract (AGE), and Lactobacillus rhamnosus MTCC1423 in developing ALD is unknown. Therefore, the present study explored the effect of synbiotics (a combination of prebiotics and probiotics) on adipose tissue to prevent ALD. To in…

Gut Microbiota: Target for Modulation of Gut-Liver-Adipose Tissue Axis in Ethanol-Induced Liver Disease.

Consumption of alcohol (ethanol) in various forms has been an integral part of human civilization. Since ages, it also has been an important … ed on the gut-liver-adipose tissue network modification with the use of probiotics, synbiotics, and prebiotics. This review is aimed at the effect of ethanol on gut and adipose tissue in both rodent and human alcoholic models.

Gut microbiome in non-alcoholic fatty liver disease associated hepatocellular carcinoma: Current knowledge and potential for therapeutics.

Metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) are rising in incidence and are an increasingly common cause of cirrhosi … xperimental studies showing the potential of diet, probiotics, fecal microbiota transplantation and prebiotics in improving liver disease in experimental models. Clinical studies are ongoing with preliminary evidence showing improvement in liver enzymes and steatosis. The microbial profile is different in responders to cancer immunotherapy including liver ca …

Epilepsy and the gut: Perpetrator or victim?

The brain and the gut are linked together with a complex, bi-path link known as the gut-brain axis through the central and enteric nervous s … e some gastrointestinal diseases. Many gut manipulations were used successfully to manage epilepsy. Prebiotics, probiotics, synbiotics, postbiotics, a ketogenic diet, fecal microbiota transplantation, and vagus nerve stimulation were used successfully to treat some patients with epilepsy. Other manipulations, such as omental transposition, still need more st …

pH-Triggered, Synbiotic Hydrogel Beads for In Vivo Therapy of Iron Deficiency Anemia and Reduced Inflammatory Response.

Iron deficiency anemia (IDA) is the most common nutritional disorder worldwide nearly affecting two billion people. The efficacies of conventional oral iron supplements are mixed, intravenous iron administration acquaintances with finite but crucial risks. Usually, only 5-20% iron is absorbed in the duodenum while the remaining fraction reaches the colon, affecting the gut microbes and can significantly impact intestinal inflammatory responses. Therefore, administration of gut bacterial modulators such as probiotics, prebiotics, and any other dietary molecules that can stimulate healthy gut ba…