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Neck swelling in a patient with gout - What is the cause?

We describe the case of a 55-year-old man with underlying tophaceous gout who presented with a 6-month history of multiple joint pains and associated constitutional symptoms. Physical examination revealed firm and non-tender swelling measuring 3x4 cm adjacent to the left clavicular head. This swelling did not move with deglutition. Neck imaging showed bilateral heterogeneous soft tissue lesions at the sternoclavicular, first costochondral and acromioclavicular joints. Multiple lytic lesions with cortical destruction involving the upper manubrium and distal ends of both clavicles were seen. Fin

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… A barium swallow showed normal peristalsis of the oesophagus with a lateral oesophageal indentation attributed to cervical osteophyte, potentially contributing to his dysphagia. Further investigations ruled out malignancies. …

Case Report: Acute kidney injury due to minimal dilated obstructive nephropathy in the context of gastric cancer.

Postrenal obstruction is a rare but reversible cause of acute kidney injury (AKI), often underrecognized when hydronephrosis is mild or absent. We present a 55-year-old woman with gastric cancer who developed severe AKI requiring hemodialysis. Initial non-contrast abdominal CT revealed only mild bilateral hydronephrosis without obvious ureteral obstruction. Given these subtle radiologic findings and a history of chemotherapy and NSAID exposure. Initially, a multidisciplinary team attributed the AKI to intrinsic renal causes. Subsequent renal biopsy revealed only minimal glomerular changes, ins

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… External compression or fibrosis may impair ureteral peristalsis and disrupt urine flow, leading to renal pelvic pressure and functional decline ( 58 , 59 ). Yet, in the absence of complete obstruction, the collecting system often lacks significant dilation. … Peristalsis prevents ureteral dilation. Neurourol Urodynamics. (2024) 43:258–66. doi: 10.1002/nau.25332, PMID: 59. Chen F. Genetic and developmental basis for urinary tract obstruction. Pediatr Nephrol. (2009) 24:1621–32. doi: 10.1007/s00467-008-1072-y, PMID: 60. …

Bioengineered Humanoid-on-Chip Platforms: Tools for Evaluating the Effects of Environmental Exposure on Human Physiological Barriers.

UNLABELLED: Environmental pollutants; bioaerosols, chemicals and micro/nano-plastics (MNPs) can disrupt the mechano-biological processes of … cross the entire axis.9 By combining tissue-specific cellular architectures, mechanical cues (e.g., peristalsis, breathing motions), and physiologically relevant flow dynamics, brain-lung-liver-intestine axis OoC models represent a transformative step toward predictive environmental health assessment.5,10 These platforms not only reduce the need for animal te …

Местный гастроинский кишечник (AL) Five Годы: отчёт по делу.

Амилоидоз, характеризующийся осаждением аномальных белковых фибрилов в органах, классифицируется как системный или локальный. Нечасто встречается локальный амилоидоз типа амилоидной световой цепи (AL), особенно когда он ограничивается желудочно-кишечным трактом. Здесь мы сообщаем случай локализованного амилоидозного желудочно-кишечного типа AL, который был случайно обнаружен и оставался эндоскопическим и клиническим по сравнению с амилоидным. 5-year последующий период. Пациенту, мужчине в 40 лет, была сделана колоноскопия для выявления рака цвета, в ходе которой в толстой кишке были обнаружены

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… Systemic gastrointestinal amyloidosis is commonly diagnosed in association with multiple myeloma and presents with diverse symptoms, including diarrhea, gastrointestinal bleeding, malabsorption, and obstruction due to peristalsis failure [ 2 ]. …

Paediatric intestinal pseudo-obstruction: a scoping review.

Paediatric intestinal pseudo-obstruction (PIPO) encompasses a group of rare disorders in which patients present with the clinical features of bowel obstruction in the absence of mechanical occlusion. The management of PIPO presents a challenge as evidence remains limited on available medical and surgical therapy. Parenteral nutrition is often the mainstay of therapy. Long-term therapy may culminate in life-threatening complications including intestinal failure-related liver disease, central line thrombosis and sepsis. Intestinal transplantation remains the only definitive cure in PIPO but is a

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… In the muscular propria, which consists of the perpendicularly-aligned externa (longitudinal) and interna (circular) layers, the synchronised contraction and relaxation of each layer promote effective peristalsis of GIT contents. … Studies have reported improvements in oesophageal peristalsis and gastric emptying. However, these have not been well-studied with concerns for pseudo-Parkinsonism and tardive dyskinesia with chronic use of metoclopramide, and cardiac dysrhythmias with domperidone [ 49 , 67 ]. …

[Conservative treatment of hypertrophic pyloric stenosis in children].

INTRODUCTION: Hypertrophy of the pylorus causing obstruction of the gastric outlet, or infantile hypertrophic pyloric stenosis (IHPS), is th … etitive inhibitor of the muscarinic effects of acetylcholine, leading to decreased gastrointestinal peristalsis. This action is believed to be important in IHPS cases. AIM: The aim of this paper is to provide further information on potential role of atropine in the management of patients with IHPS. METHODS: From April 2000 to October 2002, 22 patients (16 b …

Integrated chemometric and pharmacological evaluation of processing-induced attenuation of hepatotoxicity in Polygonum multiflorum.

ETHNOPHARMACOLOGICAL RELEVANCE: Polygonum multiflorum (P. multiflorum) is the dried root tuber of P. multiflorum Thunb., a perennial herbace … ic changes in chemical constituents during processing. Zebrafish models of liver injury, intestinal peristalsis, anemia, and immunosuppression were used to systematically compare the hepatotoxicity and efficacy of samples with different processing cycles, with a focus on the toxicity-efficacy shift between raw P. multiflorum (0 cycles) and 9x-P. multiflorum. …

Laparoscopic excision of a noncommunicating rudimentary horn containing an ongoing pregnancy with cardiac activity: a structured minimally invasive approach.

OBJECTIVE: To describe the diagnostic process and a structured, stepwise laparoscopic excision of a noncommunicating rudimentary uterine hor … tents and minimize intra-abdominal spillage). The left ureter was reidentified with clearly visible peristalsis, confirming intact function and anatomy. The defect in the uterine myometrium at the horn-to-uterus junction was closed in a single layer using a 2-0 absorbable barbed running suture. The specimen was retrieved through the umbilical trocar. MAIN OU …

Пьезо1 в микроглиальных клетках: последствия для нейроинфламмации и опухоли.

Микроглия, центральная нервная система (ЦНС), постоянно проживающие иммунные клетки, играет ключевую роль в регулировании нейроразвития, поддержании нейронного гомеостаза и посредничающей нейро-воспалительной реакции. Недавние исследования высветили важность механотрансдукции, процесса, посредством которого клетки преобразуют механические стимуляторы в биохимические сигналы, для регулирования микроглиальной активности. Среди различных механочувствительных каналов Piezo1 стал ключевым игроком в микроглии, оказывая влияние на их поведение как в физиологических, так и патологических условиях. В н

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… evoked Ca 2 + influx through Piezo1 regulates diverse physiological processes in humans: (1) shear stress-induced vasodilation (vasculature) [ 29 ]; (2) controlling volume adaptation of erythrocytes [ 30 ]; (3) modulating osmosensing in renal tubules [ 31 ]; (4) coordinating stem cell proliferation and peristalsis …

Functional magnetic resonance imaging in oncology: state of the art.

In the investigation of tumors with conventional magnetic resonance imaging, both quantitative characteristics, such as size, edema, necrosis, and presence of metastases, and qualitative characteristics, such as contrast enhancement degree, are taken into consideration. However, changes in cell metabolism and tissue physiology which precede morphological changes cannot be detected by the conventional technique. The development of new magnetic resonance imaging techniques has enabled the functional assessment of the structures in order to obtain information on the different physiological proces

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… During the acquisition phase, the reduction of motion artifacts such as those related to heartbeats, breathing and intestinal peristalsis, is aimed to improve the images quality and the analysis of the findings ( 9 ) . …

Микроэкология и тренировка: целевое воздействие на ось микробиота-Гут-Брэйна для лечения заболеваний центральной нервной системы.

Кишечная микробиота (ГМ) может играть решающую роль в развитии и развитии заболеваний центральной нервной системы (ЦНС). Микроэкология и упражнение могут влиять на состав и функции ГМ, оказывая тем самым позитивное воздействие на НКЦ. Ожидается, что комбинированные физические упражнения и микроэкология позволят более комплексно и эффективно решать проблемы, связанные с заболеваниями CNS, через ось микробиота-гут-мозгов (MMBA), потенциально превысив результаты отдельных мероприятий. Однако в настоящее время по этой теме не проводится соответствующих обзоров. В этом обзоре мы изучаем взаимосвязь

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… Butyrate has the ability to inhibit histone deacetylases, and has an impact on gene regulation, immune regulation, cell differentiation, intestinal barrier regulation, oxidative stress reduction and intestinal peristalsis regulation, which in turn can have a positive effect on the CNS [ 257 ]. … Furthermore, exercise may also reduce the potential harm of pathogenic bacterial communities by increasing the frequency of intestinal peristalsis, reducing the retention time of contents and decreasing the contact between pathogens and the gastrointestinal mucus layer and the circulatory system. …

Role of physical activity in cancer prevention: An update.

Cancer prevention via regular physical activity has been studied across the world. This minireview aimed to present the latest updates in research in the context of the role of physical activity in the cancer prevention. The various mechanisms at the molecular level were studied in depth. The essential processes at play involving hormonal balance, weight reduction, adiposity, inflammation, immunity, sunlight exposure and vitamin D levels and insulin resistance were critically analyzed here. The dose response of exercise with respect to cancer prevention was appraised. Strong evidence supports

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… Also aiding in peristalsis, clearing the bowels more frequently thus removing harmful toxins from the body. This minireview aims to present the latest updates in research in the context of the role of physical activity in the cancer prevention. …

Peripheral Nervous, Hepatic, and Gastrointestinal Endpoints for AL Amyloidosis Clinical Trials: Report from the Amyloidosis Forum Multi-organ System Working Group.

Systemic immunoglobulin light chain (AL) amyloidosis is a heterogeneous rare disease driven by a destructive monoclonal gammopathy and typified by misfolded immunoglobulin light and/or heavy chains which aggregate and deposit in organs as insoluble amyloid fibrils. Disease heterogeneity is driven by the degree of multi-systemic involvement; cardiac, renal, neurological, and gastrointestinal (GI) systems are affected to varying degrees in different patients. While prognosis is primarily driven by hematologic response to treatment and outcomes associated with cardiac events and overall survival,

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… Deposition can also occur in the neuromuscular layer of the GI tract, leading to abnormal peristalsis, abnormal GI transit times, and dysmotility [ 37 , 38 ]. GI symptoms are multifactorial and can be affected by other organ involvement and medications and therefore may not reflect GI involvement. …

Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study.

Complete blood count (CBC)-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte (ELR) ratio, and platelet-to-lymphocyte ratio (PLR) are sensitive markers of occult inflammation and disease activity for systemic lupus erythematosus, rheumatoid arthritis, psoriasis, esophageal cancer, etc. We assessed NLR, PLR, MLR, and ELR as indicators of inflammation in achalasia patients.This cross-sectional study included 103 achalasia patients and 500 healthy blood donor volunteers (HD). Demographic, clinical and laboratory informatio

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… of the lower esophageal sphincter (LES). [ 1 ] There are three distinct subtypes of achalasia which are defined with high-resolution manometry (HRM) parameters and are subclassified according to the Chicago Classification of esophageal motility disorders into: type I (classic achalasia with failed peristalsis …

Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging.

Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo scale) was completed. The LCI of the duodenal bulb was subjectively evaluated on whether redness was present and objectively evaluated based on L* a* b* color values. The clinical characteristics of the 302 study participants were: male/female, 120/182; mean age, 70.9 years.

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… Excessive alcohol intake leads to increased gastric acid secretion and decreased gastric peristalsis [ 38 ]. A history of alcohol use was excluded from this study in the multiple regression analysis, which may have been influenced by its low prevalence of 6.5% in the study participants. …

Acute Kidney Injury in the Patient with Cancer.

Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related complications. Acute kidney injury (AKI) and chronic kidney disease (CKD) are highly prevalent in patients with cancer, and they are associated with an increased risk of all-cause mortality. This bidirectional interplay between cancer and kidney, termed "the kidney-cancer connection" has become a very active area of research. This review aims to provide

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… The possible causes for the non-dilatation of ureters are the encasement of the ureter with a tumor or fibrous tissue [ 85 ], abnormal ureteral peristalsis [ 86 ], ureteral edema [ 87 , 88 ] or simultaneous severe volume depletion. …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Dilution of the microbial load is achieved by sneezing and coughing of microbes trapped in mucus, flushing of the mouth and esophagus by saliva, micturition, and peristalsis of the intestines. … The integrity of the mucosa, the production of saliva and mucus, peristalsis, gastric pH, bile acids, digestive enzymes, and the levels of secretory IgA also play an important role in maintaining colonization resistance [ 27 ]. …

Клинические эффекты пробиотических добавок на метаболический синдром: систематический обзор и мета-анализ.

Пробиотики привлекли к себе большое внимание в силу их способности модифицировать метаболизм питательных веществ или иммуноводство. Цель этого исследования заключается в оценке эффективности биотического дополнения при лечении метаболического синдрома. МЕТОДЫ: В период с момента создания базы данных по июль проводились систематические обыски в библиотеке < < Пубмед > > , < < Web of Science > > , < < Эмбаза > > и < < Кохрейн > > . 2024. СТАТА/СЕ 14.0 Программное обеспечение использовалось для статистического анализа. РЕЗУЛЬТАТЫ: Всего 12 клиническ

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… comorbidities), while the elderly have long disease courses, multiple comorbidities, and age-related metabolic decline, blunting probiotic effects. (3) Intervention scheme mismatch: Fixed probiotic doses/durations ignore age-related differences in intestinal absorption; elderly patients have reduced intestinal peristalsis …

Rhythmic Foot Embrocation According to Wegman/Hauschka for Alleviating Symptoms of Chemotherapy-Induced Peripheral Neuropathy: A Randomized Controlled Trial.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) in patients treated with platinum-, taxane- or vinca alkaloid-based chemotherapy may cause symptoms such as tingling, numbness, pain, and paresthesia, particularly in patients' hands and feet. This study aimed to evaluate rhythmic embrocation (RE) of the feet according to Wegman/Hauschka in addition to an exercise program (EP) as a complementary treatment for CIPN symptoms.MethodsThis study was a prospective, randomized controlled, 2-center trial. A total of 57 patients with CIPN symptoms were randomly allocated into 2 groups, with 52

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… widespread in clinics and home care from the 1980s onward. 11 , 12 The application of rhythmic massage has positive effects on reducing pain and symptoms of illness as well as on the quality of life of chronically ill patients. 10 , 13 RE relaxes muscles; supports vital processes such as breathing, peristalsis …

Interventional radiology in the elderly.

Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities. They may serve either as alternative primary minimally invasive therapies or adjuncts to traditional surgical treatments. The present report provides a concise review of the most important interventional radiological procedures with a special focus on the treatment of the primary debilitating pathologies of the elderly population. The authors elaborate on the scientific evidence and latest developments

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… The technical success of gastroduodenal stent insertion approaches 100%, but clinical success to relieve symptoms and restore oral feeding is nearer 90% because of either progressive distal disease or lack of functional stomach peristalsis (chronically obstructed stomach or tumor infiltration of coeliac …