Результаты поиска

Single-Incision Broström-Gould Surgery with Peroneal Debridement and Calcaneal Osteotomy.

BACKGROUND: Broström-Gould surgery is the gold standard operative treatment of chronic lateral ankle instability. In cases of failed nonoper … ility. The ATFL is elevated from the talus and lateral malleolus. The lateral malleolus is freed of periosteum with use of a rongeur. Two 3.5-mm suture anchors (each with 4 needles) with number-0 FiberWire (Arthrex) are inserted through the tip of the lateral malleolus. The suture material is passed through the ATFL and calcaneofibular ligament to tighten th …

Surgical Treatment of Pediatric Seymour Fractures of the Great Toe.

BACKGROUND: Seymour fractures are open, distal phalangeal physeal fractures with an associated nail-bed injury that occur in pediatric patie … ring proper alignment of bone fragments. Any interposed soft tissue, such as the germinal matrix or periosteum, is extricated from the fracture site with use of fine instruments. If the fracture is deemed unstable, percutaneous pinning with 0.045-in or 0.062-in Kirschner wires is performed to stabilize the fracture. Kirschner wires are inserted through the s …

Total Talar Replacement: Surgical Technique.

BACKGROUND: Total talar replacement is a salvage procedure for end-stage osteonecrosis of the talus. A customized total talar implant is des … talar bone fragments is succeeded by careful dissection of the ligament and joint capsule under the periosteum. After dissecting the remaining interosseous talocalcaneal ligament, the foot is distally retracted and a customized talar implant is inserted. After testing and confirming the stability and mobility of the implant, the wound is irrigated with use o …

Could C3, 4, and 5 Nerve Root Block be a Better Alternative to Interscalene Block Plus Intermediate Cervical Plexus Block for Patients Undergoing Surgery for Midshaft and Medial Clavicle Fractures? A Randomized Controlled Trial.

BACKGROUND: Variable innervation of the clavicle is a major challenge in surgery of clavicle fractures with patients under regional anesthes … ences between the two groups regarding NRS scores after nerve blocks and NRS score for incision and periosteum separation, with the minimum clinically important difference set at a 2-point difference (of 10). There were no severe complications in this study. CONCLUSION: Based on our analysis of the data, a C3, 4, and 5 nerve root block was better than ISB c …

A Case of Syphilis with High Bone Arsenic Concentration from Early Modern Cemetery (Wroclaw, Poland).

Venereal syphilis is a sexually transmitted disease caused by Treponema pallidum - Gram-negative, slowly growing bacteria. The spread of the disease in the Old World was due to increased birth rate, urban population growth, migration and lack of knowledge concerning the epidemiology. In the past, the treatment was mainly symptomatic and included application of mercury compounds. The goal of the study was to present the case of advanced venereal syphilis found in early modern (16th-18thc) graveyard localized in Wroclaw, Poland. The object of the study is a cranium of a male whose age at death h

Совпадение в полном тексте источника
… In the course of venereal syphilis, the disease affects mainly these elements of the skeleton in which periosteum strictly adheres to the bone surface. They are mainly frontal and parietal bones of the neurocranium and proximal parts of the long bones shafts. … The lesions within neurocranium characteristic for the tertiary syphilis are usually caused by gummata production, which subsequently stimulates the periosteum to inflammatory response. Gummata can derive from the subcutaneous tissue, bone, periosteum or muscles [ 57 ]. …

Mechanisms of bone pain: Progress in research from bench to bedside.

The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuronal cells in the peripheral tissues as important targets for bone pain treatment are under extensive investigation in both pre-clinical and clinical settings. An understanding of the peripheral mechanisms underlying pain conditions associated with va

Совпадение в полном тексте источника
… Sensory and autonomic nerve fibers have been identified in both bone marrow and periosteum, and are particularly concentrated in areas with high osteogenic activity. … Bone has different compartments including bone marrow, mineralized bone and periosteum on the surface (Fig. 3 ). The density of nerve innervation is the highest in the periosteum, and the lowest in mineralized bone. …

Bone Pain in Cancer Patients: Mechanisms and Current Treatment.

The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological skeletal fractures, compression of the spinal cord or other nervous structures, decreased mobility, and increased mortality. Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and neuropathic components. Its treatment should be

Совпадение в полном тексте источника
… All the bone compartments (marrow, mineralized bone, and the overlying periosteum) are innervated by sensory nerve fibers, which differ significantly in terms of their density. The periosteum is the most densely innervated, whereas the fewest nerve fibers are in mineralized bone. … These new pathological nerve fibers are formed within the periosteum, mineralized bone tissue, and bone marrow ( A ). …

CRLF1 and CLCF1 in Development, Health and Disease.

Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades that lead to altered gene expression in the target cell and consequent changes in its proliferation, differentiation, or activation. In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (IL)-6 cytokine CLCF1 (cardiotrophin-like cytokine fa

Совпадение в полном тексте источника
… During development, the sympathetic innervation of the periosteum switches from a catecholaminergic phenotype to a cholinergic phenotype [ 52 ]. … In particular, the number of osteogenic cells expressing RANKL was reduced in the periosteum of sympathectomized rats, along with an increase in OPG expression. Sympathectomy impairs osteoclastic resorption along the mandible periosteum. …

Bone Metastasis Pain, from the Bench to the Bedside.

Bone is the most frequent site of metastasis of the most common cancers in men and women. Bone metastasis incidence has been steadily increasing over the years, mainly because of higher life expectancy in oncologic patients. Although bone metastases are sometimes asymptomatic, their consequences are most often devastating, impairing both life quality and expectancy, due to the occurrence of the skeletal-related events, including bone fractures, hypercalcemia and spinal cord compression. Up to 75% of patients endure crippling cancer-induced bone pain (CIBP), against which we have very few weapo

Совпадение в полном тексте источника
… Historically, the periosteum has been the focus of attention for most studies on bone nociception [ 63 , 64 ] probably due to its ease of access and stimulation. These studies revealed the generation of action potentials following sufficient mechanical stimulation of the periosteum. … A member of the former family, P2X3, has been studied extensively in CIBP, since it is expressed quite specifically in small diameter nociceptive fibres throughout the bone marrow and periosteum [ 108 ]. …

Sensory nerves: A driver of the vicious cycle in bone metastasis?

Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is associated with various complications, of which bone pain is most common and debilitating. The cancer-associated bone pain (CABP) is induced as a consequence of increased neurogenesis, reprogramming and axonogenesis of sensory nerves (SNs) in harmony with sensitization and excitation of SNs in response to the tumor microenvironment created in bone. Importantly, CABP is associated with increased mortality, of which precise cellular and molecular mechanism remains poorly understood. Bone is densely innervated

Совпадение в полном тексте источника
… However, since the total area of the bone marrow is broader than that of the periosteum, the total number of SNs in the bone marrow is greater than that in the periosteum [24] , consistent with the observation that patients with cancer that evidently colonizes only within the bone marrow cavity but not … spread out on the periosteum often complain CABP. …

Calcium Signalling in Breast Cancer Associated Bone Pain.

Calcium (Ca2+) is involved as a signalling mediator in a broad variety of physiological processes. Some of the fastest responses in human body like neuronal action potential firing, to the slowest gene transcriptional regulation processes are controlled by pathways involving calcium signalling. Under pathological conditions these mechanisms are also involved in tumoral cells reprogramming, resulting in the altered expression of genes associated with cell proliferation, metastatisation and homing to the secondary metastatic site. On the other hand, calcium exerts a central function in nocicepti

Совпадение в полном тексте источника
… The density, pattern and morphology of these two main fibre populations may vary from joint and bone but also between periosteum, cortical bone and bone marrow. … In physiological conditions, the pain following bone fracture upon movement before an effective stabilisation may therefore be imputable to the normally silent mechanosensitive nerve fibres densely innervating the periosteum. …

Managing bisphosphonate-related osteonecrosis of the jaws with xenografts: a case report.

It is possible to manage large bone destruction induced by BRONJ using xenograft grafting to promote a bone formation.

Совпадение в полном тексте источника
… The flap obtained from the palatal incisions helped to prevent detachment of the periosteum of the palate, thus preserving the palatal mucosa (Fig. 5 B and C). … Maintenance of the soft tissues was paramount for preservation of the local vascular supply, as all vascularization was captured from the local connective tissues and, for this reason, a variation of the palatal flap technique was selected to preserve the position of the periosteum. …

Acupuncture for cancer-induced bone pain?

Bone pain is the most common type of pain in cancer. Bony metastases are common in advanced cancers, particularly in multiple myeloma, breast, prostate or lung cancer. Current pain-relieving strategies include the use of opioid-based analgesia, bisphosphonates and radiotherapy. Although patients experience some pain relief, these interventions may produce unacceptable side-effects which inevitably affect the quality of life. Acupuncture may represent a potentially valuable adjunct to existing strategies for pain relief and it is known to be relatively free of harmful side-effects. Although acu

Совпадение в полном тексте источника
… Peripheral Mechanisms periosteum is well innervated and the sensory free nerve endings present are thought to be involved in the mediation of pain. … Sensory neurons in the periosteum are also affected by increased mechanical stress within the bone which may lead to pain and increased sensitization [ 19 ]. …

The Neuro-Bone Axis in Metastatic Progression: Innervation, Neuro-Immune-Osteoclast Crosstalk, and Therapeutic Opportunities.

Bone metastases represent a major cause of morbidity in advanced cancers, yet the neural regulation of metastatic growth within bone remains largely unexplored. The skeletal system is richly innervated by sensory and sympathetic nerve fibers that influence bone remodeling, hematopoiesis, and immune surveillance. Emerging evidence suggests that disseminated tumor cells exploit these neural circuits to create a growth-permissive microenvironment. Tumor-secreted neurotrophic factors can induce nerve sprouting, while sympathetic activation via β-adrenergic receptors promotes osteoclastogenesis, im

Совпадение в полном тексте источника
… The periosteum, the outer layer of the bone, along with other regions such as the bone marrow cavity, is highly innervated by peripheral nerves that primarily contain sensory and autonomic fibers. … Rodent models revealed pathological sprouting and neuroma formation by sensory and sympathetic nerve fibers in the periosteum and bone marrow of the metastatic tumor-invaded bone [ 209 , 210 ]. …

Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla.

BACKGROUND: The management of bisphosphonate related necrosis of the jaw has become clinical routine. While approximately two thirds of the lesions are in the mandible, one third is located in the maxilla. In 40-50 % of maxillary necrosis the maxillary sinus is involved, leading to maxillary sinusitis and oro-antral communications. METHODS: This retrospective single center study includes all patients with diagnosis of BP-ONJ of the maxilla and concomitant maxillary sinusitis. The information collected includes age, gender, primary disease, bisphosphonate intake, involving type of bisphosphona

Совпадение в полном тексте источника
… In this technique, after slitting of the vestibular periosteum, its mobile part is quilted under the palatinal mucosa with absorbable backstitches. A second layer of absorbable backstitches is used to align the wound edges to one level and tighten the closure. … While the buccal fat pad provides a mechanic protection and a rich vascularization in the BRONJ site, in the technique used, the periosteum that is quilted under the palatal mucosa serves as a second layer for a reliable wound closure and helps to develop a thick scar that seals off the bone from the …

Case Report: Surgical treatment of stage 3 medication-related osteonecrosis of the maxilla using the "FTT Split" surgical protocol: a report of 14 cases.

Most severe presentation of medication-related osteonecrosis of the jaw (MRONJ) is classified as stage 3 for which there are still no standard surgical therapy guideline. Our aim was to describe "Five Times Three (FTT) Split" protocol as surgical treatment of stage 3 maxillary MRONJ. The present case series included a total of 14 patients diagnosed with stage 3 MRONJ of the upper jaw who were treated from February 2022 to September 2024 with mucoperiosteal flap and "FTT Split" protocol. The patients were followed up both clinically and radiologically for a period ranging from 9 months to 3 yea

Совпадение в полном тексте источника
… The Nowak-Peter flap was then converted into a Wasmund flap by incising the periosteum high in the vestibular fornix. The mucosa of the hard palate was split to a maximum thickness of 3 mm to allow eversion of the edges of the vestibular and palatal mucosa during suturing. … The key difference in this modification is that the sutures do not end on the vestibular side of the flap, but on the palatal side, with only the periosteum on the vestibular side being sutured. …

The use of cortical heterologous sheets for sinus lift bone grafting: a modification of Tulasne's technique with 7-year follow-up.

PLAIN ENGLISH SUMMARY: (Please see www.Toolsfortalking.co.uk for an easy read summary of the project.) The Tools for Talking are a set of resources that were developed through collaboration between Black, Asian and minority ethnic people with learning disabilities and researchers at the University of Birmingham. The resources were designed to be used by people with learning disabilities and service providers to facilitate culturally-sensitive communication and information sharing, service planning and delivery. They comprise illustrative videos and exploratory activities relating to five topic

Совпадение в полном тексте источника
… Macroscopically, it could be observed that a thin membrane similar to the periosteum had formed above the Carbulat™, and we consider this to be a sign of tissular integration. … It should be mentioned that we have observed a similar “periosteum” on the removal of alumina oxide or titanium implants, the difference being that the membrane adhered better to the Carbulat™ and was found clininally to be better integrated to it. …

Pain in blood cancers.

Patients with blood-related cancers (BRC) suffer from a substantial symptom burden, including several pain syndromes sustained by different causes and pathogenetic mechanisms. So, with regard to pain, a multifaceted clinical scenario may be observed in this setting. Indeed, pain may be correlated to disease itself, to disease-associated complications, to iatrogenic causes or may be due to unrelated clinical conditions. A close diagnostic procedure for the assessment of the underlying causes of the pain and of its pathogenetic mechanisms may direct the treatment approach which should be based o

Совпадение в полном тексте источника
… by bone pain [ Table 1 ] which is essentially related to two pathological processes: osteolytic lesions and the infiltration of bone marrow (BM) by malignant cells.[ 8 ] In these circumstances, pain is originated by the activation of sensory and sympathetic nerve fibers that extensively supply the periosteum … In the absence of skeletal lesions, BM hypertension, ischemia, and the strength of the periosteum due to the BM involvement by malignant cells are the traditionally supposed mechanisms of pain.[ 8 ] However, recently, some experimental data from animal models have changed these hypotheses, which demonstrate …

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

BACKGROUND: Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a μ-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain. OBJECTIVE: To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor. DESIGN: Retrospective cohort study. SETTING/SUBJECTS: A total of 274 patients were enrolled, who started a tapentadol extended-relea

Совпадение в полном тексте источника
… Periosteum being a densely innervated tissue, activation of periosteal sensory nerves by mechanical stretching of the periosteum results in more intense pain. …

Minimally Invasive Surgical Techniques for Management of Painful Metastatic and Primary Spinal Tumors.

Patients with metastatic spinal disease are affected by disabling pain. The treatment of spinal metastases is focused on pain reduction and improvement in quality of life. Until recently, many patients with metastatic spinal disease did not qualify as surgical candidates due to the risks of surgery and length of recovery period. However, recent advances in minimally invasive surgery such as kyphoplasty and vertebroplasty allow patients to safely undergo surgery for pain relief with a short recovery period. The studies reviewed here suggest that vertebral augmentation is successful in reducing

Совпадение в полном тексте источника
… Local pain is caused by inflammation and stretching of the periosteum where nociceptors are located [ 14 ]. … Similarly, multiple myeloma patients experience pain secondary to invasion of the periosteum which causes local pain and weakening of the vertebral body. The multiplicity of pain sites due to the diffuse involvement of numerous vertebrae is the rule with multiple myeloma. …