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Ocular safety of sildenafil citrate when administered chronically for pulmonary arterial hypertension: results from phase III, randomised, double masked, placebo controlled trial and open label extension.

OBJECTIVE: To assess the ocular effects and safety profile of chronic sildenafil oral dosing in patients with pulmonary arterial hypertensio … vestigator was low with all doses, but a modest, dose related incidence of chromatopsia, cyanopsia, photophobia, and visual disturbance was reported with 80 mg three times daily consistent with the indicated dosing for erectile dysfunction. Retinal haemorrhages, captured on funduscopy, occurred in 2% (4/207) of sildenafil treated participants and none in the …

Sumatriptan-naproxen and butalbital: a double-blind, placebo-controlled crossover study.

OBJECTIVES: The primary objective was to compare the efficacy of a sumatriptan and naproxen combination medication (SumaRT/Nap-85mg sumatrip … hours (P≤.01); sustained pain relief 2-24 hours (P<.001); migraine free (pain free with no nausea, photophobia, or phonophobia) at 4, 6, 8, 24, 48 hours (P≤.046); and complete symptom free (migraine free with no neck/sinus pain) at 4, 6, 8, 48 hours (P≤.031). Adverse event incidence was similar for all treatments (10%, 12%, and 9% for placebo, SumaRT/Nap, an …

Ocular adverse events associated with antibody-drug conjugates for cancer: evidence and management strategies.

Antibody-drug conjugates (ADCs) are a fast-growing class of cancer drugs designed to selectively deliver cytotoxic payloads through antibody binding to cancer cells with high expression of the target antigen, thus reducing systemic exposure and minimizing off-target effects. However, ADCs are associated with various ocular adverse events (AEs) that may impact treatment administration and patient outcomes. In this review, we provide a summary of ocular AEs associated with approved and investigational ADCs, recommendations for the mitigation and management of ocular AEs, current guidelines and e

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… limiting instrumental ADL | Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self-care ADL | Best corrected visual acuity of 20/200 or worse in the affected eye | — Photophobia … High FRα subset ORR: 24% SORAYA 25 | Preservative-free lubricating artificial tears (daily) and steroid eye drops (starting 1 day predose and continuing through day 8 of each cycle) | 6 mg/kg Q3W ( n = 106) | Blurred vision: 41% (any grade); 6% (grade ≥3) Keratopathy: 29% (any grade); 9% (grade ≥3) Photophobia …

Comprehensive Review of the Ocular Toxicities Associated With Antibody-Drug Conjugates Used to Treat Gynecological Cancers.

This comprehensive literature review investigates the ocular toxicities associated with antibody-drug conjugates (ADCs) used in the treatment of gynecological cancers. Gynecological cancers, including uterine, ovarian, and cervical, pose a significant health burden with varying incidence and survival rates. Despite advancements in treatment modalities, survival rates remain moderate to relatively low for advanced or recurrent gynecologic cancers. ADCs, a targeted therapy utilizing antibody-antigen interactions, have emerged as a promising chemotherapeutic approach, delivering cytotoxic agents

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… Drug | Cancer Indication | Reported Ocular Complications | Incidence/Values Mirvetuximab soravtansine [ 9 , 10 , 15 , 16 , 17 , 29 ] | Platinum-resistant ovarian cancer | Blurred vision, keratopathy, increased lacrimation, dry eye, foreign-body sensation, photophobia, ocular pain, corneal microcysts, … Ocular toxicities in 26 patients included: photophobia (26.92%; one grade 3), dry eye (23.08%; grades 1-2), ocular pain (15.38%; one grade 3), blurred vision (11.54%; grades 1-2), conjunctivitis (7.69%; grades 1-2), lacrimation (7.69%; grades 1-2), and vitreous floaters (7.69%; grades 1-2) [ 21 ]. …

Interventions for chronic blepharitis.

BACKGROUND: Blepharitis, an inflammatory condition associated with itchiness, redness, flaking, and crusting of the eyelids, is a common eye … oms such as burning sensation, irritation, tearing, and red eyes as well as visual problems such as photophobia and blurred vision. The exact etiopathogenesis is unknown, but suspected to be multifactorial, including chronic low-grade infections of the ocular surface with bacteria, infestations with certain parasites such as demodex, and inflammatory skin con …

Pharmacological synergy: the next frontier on therapeutic advancement for migraine.

The burden of migraine significantly impacts the individual sufferer, their families, the workplace, and society. The World Health Organizat … atistical superiority for sumatriptan over placebo in reduction or elimination of headache, nausea, photophobia, and phonophobia. Since the introduction of sumatriptan, 6 other triptan products have been released in the United States as acute treatments for migraine, all having the same mechanism of action and similar efficacy. Despite their utility as migrai …

Ocular toxicities associated with anticancer drug therapy in Asian patients: a literature review and practical management recommendations for non-ophthalmologic settings.

BACKGROUND: Ocular toxicities associated with anticancer therapies, including cytotoxic chemotherapy, hormonal agents, molecular targeted therapies, immune checkpoint inhibitors, and antibody-drug conjugates, are increasingly recognized and may substantially impair visual function and quality of life. However, ethnicity-specific data for Asian populations and practical management strategies applicable to non-ophthalmologic settings remain limited. METHODS: A literature review of publications up to December 2025 was conducted using PubMed to identify studies reporting incidence, mechanisms, pr

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… Symptoms such as blurred vision, eye pain, photophobia, and visual field disturbances can lead to dose delays, reductions, or discontinuations, potentially compromising anticancer efficacy. … Patients should be informed that ocular symptoms, such as blurred vision, visual field disturbances, eye pain, redness, tearing, or photophobia, may occur during treatment. …

Финголимод, связанный с криптококковым менингитом у пациента с множественным склерозом: доклад о деле и обзор литературы.

У 65-летней женщины с множественным склерозом появились головные боли и судороги. Культура цереброспиновой жидкости (CSF) указывает на неоформаны криптококка. Анализ литературы по 20 случаям криптококкового менингита показал, что головная боль является наиболее распространенным первоначальным симптомом, и все случаи были положительными для сыворотки и/или криптококковых антигенов CSF.

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… Huang D 2015 50 Male 3y6m headache, somnolence, nausea, ataxia thalamic and corpus callosum lesion with mass effect, diffuse meningeal enhancement 500 ND 128 108 ND ND 308 217 23 positive liposomal amphotericin B + flucytosine (8w) -> fluconazole improved (8) Achtnichts L 2015 40s Male 2y headache, photophobia … , nausea, malaise no change 530 ND ND 100 33 < 5 ND 94 3 positive amphotericin B + flucytosine (2w) -> fluconazole improved (25) Singh R 2024 44 Male 8y headache, ataxia, confusion, photophobia, dysphasia leptomeningeal enhancement 250 ND ND ND ND 780 218 367 3 positive liposomal amphotericin B + flucytosine …

Topical treatments for blepharokeratoconjunctivitis in children.

BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and…

Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis.

BACKGROUND: Seasonal/perennial allergic conjunctivitis is the most common allergic conjunctivitis, usually with acute manifestations when a … onnaire) of severity of four main ocular symptoms: itching, irritation, watering eye (tearing), and photophobia (dislike of light), both separately and, if possible, by an overall symptom score. We considered any follow-up time between one week and one year. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data and assessed risk of bi …

STUDIES ON MEASLES : I. SUSCEPTIBILITY OF MONKEYS TO THE VIRUS OF MEASLES.

By the intratracheal injection into monkeys of unfiltered nasopharyngeal washings from cases of measles in the preeruptive and early eruptiv … cocyte count, frequently constituting a true leucopenia. Other symptoms of irregular occurrence are photophobia, diarrhea, and fever. Symptoms of rhinitis and bronchitis have not been noted. Histological sections of the lesions of the skin show an exudative and proliferative lesion about the capillaries of the corium in which endothelial leucocytes are the pr …

Varicella-Zoster Virus Infection and Varicella-Zoster Virus Vaccine-Related Ocular Complications.

The varicella-zoster virus is a human herpesvirus that causes varicella as the primary infection and HZ as the reactivation of a latent infection. Ten to twenty percent of cases of herpes zoster ophthalmicus (HZO) involve the ophthalmic branch of the fifth cranial nerve. Any area of the eye may be affected by the condition. HZ has a lifetime risk of more than 30%. Complications from herpes zoster can significantly lower quality of life. The goal of HZ vaccinations is to stop HZ activation and PHN formation. Despite the uncommon possibility of side effects such as eye problems, the majority of

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… In 12–25% of cases, a moderate acute anterior uveitis may develop, resulting in discomfort, perilimbal injection, swelling of the lids, irritation, photophobia, and reduced visual acuity [ 23 ]. … Type | Age | Gender | Signs | Symptoms | Lab Tests | Medical History | Interval Post-Vaccination ^ | Treatment | Outcome Esmaeli-Gutstein et al. [ 47 ] | Anterior and intermediate uveitis (left eye) | varicella vaccine | Live attenuated | 16 | F | generalized vesicular rash on her face and trunk | photophobia …

Assessing the performances of a chatbot to collect real-life data of patients suffering from primary headache disorders.

BackgroundThere are many scales for screening the impact of a disease. These scales are generally used to diagnose or assess the type and severity of a disease and are carried out by doctors. The chatbot helps patients suffering from primary headache disorders through personalized text messages. It could be used to collect patient-reported outcomes.ObjectiveThe aims of this study were (1) to study whether the collection and analysis of remote scores, without prior medical intervention, are possible by a chatbot, (2) to perform suggested diagnosis and define the type of headaches, and (3) to as

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… It can sometimes be accompanied by phonophobia or photophobia, but not at the same time. 4 Despite its high prevalence, migraine remains an under-diagnosed and under-treated condition in the general population, as many patients are often outside the care pathway (extensive use of over-the-counter drugs … D During headaches, at least one of the following characteristics: nausea and/or vomiting; photophobia and phonophobia. E Clinical examination should be normal between attacks. In case of doubt, the secondary headache should be ruled out by appropriate further investigation. …

Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered® Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan.

OBJECTIVE: To further characterize the clinical utility of AVP-825 based on additional prespecified outcomes and post hoc analyses of COMPAS … graine freedom (defined as no pain and no migraine-associated symptoms, including nausea, vomiting, photophobia, and phonophobia), time to pain freedom, time to meaningful pain relief, and local (occurring at the site of administration in the nose) vs systemic treatment-emergent adverse events (TEAEs). RESULTS: A total of 185 patients completed both treatmen …

Острый некроз сетчатки, связанный с диметилфумаратом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Предстоит определить весь спектр побочных эффектов корректирующего заболевания лечения множественным склерозом (MS). К настоящему времени в связи с диметилфумаратом (ДМФ) поступили сообщения о четырех серьезных заболеваниях вирусом варицелла-зостр (VZV). Доклад: 44-летний мужчина на DMF за повторный перевод MS с монокулярной болью и нарушением зрения. Офтальмологический осмотр выявил панувеит с артеритом, ретинитом и витритом. ПЦР был положительным для VZV, что подтверждает клиническое впечатление острого некроза сетчатки (ARN). ДИСКУССИЯ: ARN из-за VZV может имитировать

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… He represented 1 week later with worsening symptoms of photophobia, ocular discomfort and deteriorating vision. Visual acuity was 47 letters (Early Treatment of Diabetic Retinopathy Study; 0.76 LogMAR; approximately 6/36 Snellen) in the left eye and 85 letters (0 LogMAR; 6/6 Snellen) in the right. … While an episode of ON typically features pain on eye movement, ocular pain associated with anterior uveitis is usually accompanied by conjunctival injection and photophobia, and these features should highlight the likelihood of an alternative diagnosis. …

Практическое руководство по клиническому лечению окулярных неблагоприятных явлений, связанных с белантамбовым мафодотином у пациентов с повторной/редактированной множественной миеломой: рекомендации группы экспертов Японии.

Существенной причиной смертности является множественная миелома, а лечение пациентов с множественными миеломами с рецидивом/перестройкой имеет ограниченную эффективность. Режимы лечения с использованием белантамаба мафодотина свидетельствуют о значительном улучшении положения в плане обеспечения бесперебойного выживания по сравнению с нынешними стандартными режимами ухода, однако они связаны с повышенным риском возникновения окулярных неблагоприятных явлений (ОАЭ). Цель этих практических руководящих принципов состоит в том, чтобы дать рекомендации для оказания помощи японским врачам в управлен

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… However, dry eye and photophobia are commonly occurring subjective symptoms that are not measured with the KVA scale and should be kept in mind when it is used. … In cases of progressive symptoms, close attention should be paid to patients experiencing photophobia, foreign body sensation, and other severe pains. …

Практическое руководство по клиническому управлению белантамбом мафодотином-ассоциированными окулярными событиями.

Важная бентанамб-мафодотин (беламаф) - это эффективные методы лечения пациентов с рецидивной и/или рефрактной множественной миеломой. Цель заключается в разработке клинических рекомендаций по выявлению, мониторингу и регулированию окулярных явлений, связанных с терапией беналама, и рекомендаций по любой требуемой модификации дозы. Был проведен систематический обзор литературы, и международная группа гематологов и офтальмологи проанализировала данные клинических испытаний, реальные данные и опубликованную литературу о о окулярных событиях, связанных с беламафом. Этот обзор литературы и коллекти

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… These ocular events are reversible in almost all patients and range from dry eye and photophobia to more serious issues impacting vision [ 5 , 6 , 7 ]. … Key ocular symptoms that may develop in response to belamaf treatment include visual acuity reduction, dry eye, photophobia, and foreign body sensation [ 7 ]. …

Повсеместность коморбидной мигрени в множестве склерозов: сосуществуют ли множественный склероз и мигрень?

Множественный склероз (MS) является хроническим воспалительным заболеванием, вызывающим многофукаловое демиэлирование и повреждение аксона в центральной нервной системе. Последние исследования свидетельствуют о том, что среди пациентов, страдающих НР, наблюдается более высокий уровень заболеваемости мигренью, чем среди населения в целом. В ходе этого перекрестного исследования, проведенного в одном центре, была проведена оценка распространенности мигрени среди пациентов, проходящих курс лечения с целью изменения болезней (ДМТ). МЕТОДЫ: Всего 205 Включены пациенты с сенсорным синдромом. Все уча

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… Typical characteristics of migraine headache are unilateral location, pulsating quality, moderate-to-severe intensity, aggravation by routine physical activity, and association with nausea and/or photophobia and phonophobia. … For each headache episode, we assessed: location, pain character, intensity (1–10 scale), duration, triggering and alleviating factors, and presence of accompanying symptoms (nausea, vomiting, photophobia, phonophobia). …

Ocular toxicity associated with antibody-drug conjugates in cancer therapy: a comprehensive review.

Ocular toxicity from anti-cancer drugs is frequently overlooked, largely because it is non-life-threatening, whereas clinical priorities often center on adverse events that pose immediate risks to survival. Antibody-drug conjugates (ADCs) have emerged as an important therapeutic modality in oncology, offering potent cytotoxicity against tumor cells through the targeted delivery of payloads. However, this potency also introduces a spectrum of toxicities, among which ocular toxicity has gained increasing attention. ADC-induced ocular toxicity can impair visual function and significantly compromi

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… The most commonly reported ocular AEs were corneal events included but were not limited to blurred vision, dry eye, photophobia, and others. … In the event of sudden vision loss or eye pain accompanied by photophobia, immediate ophthalmologic evaluation is warranted. …

The Antibody Drug Conjugate, Belantamab-Mafodotin, in the Treatment of Multiple Myeloma: A Comprehensive Review.

Despite recent advancements in treatments, including proteasome inhibitors, immunomodulators, and anti-CD38 monoclonal antibodies, multiple myeloma (MM) remains mostly incurable with patients frequently experiencing disease relapses due to therapy resistance. Hence there is an urgent need for innovative treatments for patients with relapsed and/or refractory MM (RRMM). This review examines Belantamab mafodotin, the first antibody-drug conjugate (ADC) targeting B-cell maturation antigen (BCMA), which has shown efficacy in pre-clinical and clinical settings for RRMM. BCMA, a type III transmembra

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… : 60% sCR : 6% CR : 9% VGPR : 40% PR : 6% | N/A | Part 1: Thrombocytopenia : 34% Anemia : 16% Part 2: Any AE ≥3 : 83% Thrombocytopenia : 34% Anemia : 17% Serious AE : 49% | Part 1: Corneal events : 53% Part 2: Corneal events : 69% Grade 1 or 2 : 54% Grade 3 : 14% Blurred vision : 51% Dry eyes : 37% Photophobia … Corneal events were reported in 69% of patients, with 51% experiencing blurred vision, 37% reporting dry eyes, and 29% reporting photophobia. Thrombocytopenia, anemia, and neutropenia of any grade occurred in 63%, 29%, and 6% of patients, respectively. …