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A practical approach to joint pain in primary care.

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… For example, focal tenderness at the radial aspect of the wrist may suggest De Quervain’s tenosynovitis, whereas generalised tenderness on light palpation may suggest fibromyalgia. … A young woman who often carries her newborn and complains of focal tenderness over the radial wrist likely has De Quervain’s tenosynovitis. 5. …

How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… OR "Arthropathy" OR "Dermatomyositis" OR "Eosinophilia myalgia syndrome"OR "Fibromyalgia"OR "Myositis ossificans" OR "Osteoarthrosis" OR "Osteochondritis" OR "Osteomyelitis" OR "Osteoporosis" OR "Polymyalgia rheumatica" OR "Polymyositis" OR "Rhabdomyolysis" OR "Sjögren's disease" OR "Synovitis" OR "tenosynovitis … " OR "Boutonniere deformity" OR "de Quervain's disease" OR "Dupuytren's contracture" OR "Lateral epicondylitis" OR "Mallet finger" OR "Medial epicondylitis" OR "Olecranon bursitis" OR "Swan-neck deformity" OR "Tenosynovitis" OR "Rheumatoid arthritis" OR "Osteoarthritis" OR "Gout" OR "Back pain" OR "neck …

Разоблачение множественных миеломы: важность подозрения в совершении злодеяний при атипичной хронической болезни, имитирующей дегенеративные условия.

Для пациентов с атипичной хронической болью необходима повышенная клиническая бдительность в отношении множественной миеломы. Симптомы могут перекликаться с дегенеративными мускулоскелетными условиями, что часто приводит к неправильному диагностике. Это подчеркивает необходимость проведения тщательной оценки в тех случаях, когда симптомы отклоняются от традиционных методов лечения, с тем чтобы содействовать своевременному диагностированию и эффективному регулированию злоумышленничества.

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… Additionally, an interstitial tear and tenosynovitis of the biceps tendon were identified. (A) Sagittal T1. (B) Sagittal T2 FS. (C) Axial T1 FS Post‐contrast. (D) Axial T1 FS Pre‐contrast. …

[Relationship between wrist bone mineral density and synovitis, erosion by ultrasonography in female rheumatoid arthritis patients].

OBJECTIVE: To find the correlation of wrist bone mineral density (BMD) to wrist synovitis and erosion, by comparing wrist BMD and ultrasonography. METHODS: A number of 80 female RA patients were examined by BMD measurement of the femoral neck, spine and non-dominant wrist using dual-energy X-ray absorptiometry (DXA). Synovitis of the wrist was examined by ultrasonography. The wrist joint (radiocarpal joint, dorsal midline, and carpoulnar joint) was assessed in the same side of DXA, with transverse and longitudinal scans for USGS synovial hypertrophy and proliferation, tenosynovitis,tendinitis…

Evaluating the Impact of Insurer-Sponsored Health Coaching on Hospitalization and Costs in India: A Retrospective Cohort Study.

Health coaching programs are emerging as a promising intervention to improve disease management and reduce healthcare costs, particularly in the context of insurer-sponsored wellness initiatives. While such programs have shown positive outcomes in Western healthcare settings, their effectiveness in India remains underexplored. This study examines the impact of a health coaching program implemented by a prominent Indian health insurer (Aditya Birla Health Insurance), focusing on hospitalization rates and claims paid among high-risk policyholders. To assess the intervention's effectiveness, a re

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… | Non-preventable M65-M67 - Disorders of synovium and tendon | Non-preventable M65311 - Trigger thumb, right thumb | Non-preventable M654 - Radial styloid tenosynovitis [de Quervain] | Non-preventable M66 - Spontaneous rupture of synovium and tendon | Non-preventable M67 - Other disorders of synovium … injury of ankle, foot and toes (S90) | Non-preventable Superficial injury of head (S00) | Non-preventable Superficial injury of wrist, hand and fingers (S60) | Non-preventable Suppurative and unspecified otitis media (H66) | Non-preventable Syncope and collapse (R55) | Non-preventable Synovitis and tenosynovitis …

Is a Steroid Injection in Both Compartments More Effective than an Injection in the Extensor Pollicis Brevis Subcompartment Alone in Patients with de Quervain Disease? A Randomized, Controlled Trial.

BACKGROUND: Ultrasonography (US)-guided steroid injections can improve the accuracy of injection in patients with de Quervain disease, especially in those with an intracompartmental septum. Although the main lesion of de Quervain disease in patients with a septum is a stenosing tenosynovitis of the extensor pollicis brevis (EPB), no report we know of has compared injection into the EPB subcompartment with an injection into both the abductor pollicis longus (APL) and EPB subcompartments. In this randomized trial, we compared the results of US-guided steroid injections targeting both subcompartm…

Mixed-Methods to Define Meaningful Change using Exit Interviewand Clinical Trial Data in Patients with Tenosynovial Giant Cell Tumor (TGCT).

BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm associated with limited range of motion (ROM), stiffness, joint damage, pain, and reduced physical functioning (PF). The MOTION Phase 3 trial (NCT05059262) was a randomized, placebo-controlled, double-blind study of vimseltinib among patients with TGCT. The objective of the current study was to define meaningful changes in clinical outcome assessments (COAs) measuring active ROM, PF, and stiffness using qualitative and quantitative data from patients in the MOTION trial. METHODS: Embedded exit interviews with pa

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… International Agency for Research on Cancer. 2. van der Heijden L Gibbons CL Dijkstra PD Kroep JR van Rijswijk CS Nout RA Bradley KM Athanasou NA Hogendoorn PC van de Sande MA The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis … The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). Journal of Bone and Joint Surgery. British Volume, 94 (7), 882–888. 10.1302/0301-620X.94B7.28927 22733940 10.1302/0301-620X.94B7.28927 3. …

Каталоги оценок показателей качества жизни, связанных с здоровьем, по шкале EQ-5D-3L для 199 хронических заболеваний и рисков здоровья для использования в Великобритании и США.

СВОДНАЯ ИНФОРМАЦИЯ: В экономической оценке важное значение имеют связанные со здоровьем показатели качества жизни (HRQOL), однако в некоторых случаях отсутствуют первичные источники и требуется информация из вторичных источников. Существующие каталоги HRQOL Соединенного Королевства/США основаны, в частности, на предыдущих системах классификации диагнозов. Недавно опубликованный датский каталог объединился EQ-5D-3L Данные национальных обследований в области здравоохранения с использованием национальных регистров, содержащих информацию о пациентах ICD-10 - диагностика, медицинское обслуживание и

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… 0.0394 0.264 0.691 0.76 0.693 0.0268 0.467 0.777 0.816 151 Dorsalgia M54 621 50.6 5.3 0.1649 0.528 0.0159 0.197 0.689 0.76 0.662 0.0105 0.446 0.767 0.816 152 Soft tissue disorders M60–M63, except M60.0 133 48.2 5.2 0.3852 0.663 0.0333 0.656 0.760 0.796 0.753 0.0224 0.748 0.816 0.827 153 Synovitis and tenosynovitis …

Insights Into Late-Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets.

Late-onset rheumatoid arthritis (LORA) is defined as rheumatoid arthritis (RA) manifesting after the age of 65 years, although the terminology remains somewhat ambiguous. With the advent of a super-aging society and extended life expectancies, a significant increase in the incidence of LORA is anticipated. In comparison to young-onset RA (YORA), LORA is predominantly characterized by a higher incidence of acute onset, augmented disease activity and constitutional symptoms, a propensity for systemic manifestations, increased erythrocyte sedimentation rate at disease onset, reduced seropositivit

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… Characteristics | LORA | PMR | RS3PE Involvement of the shoulder and pelvic girdles | + | +++ | − Peripheral joint symptoms | +++ | + | +++ Tenosynovitis/peritendinitis | ++ | +/− | +++ Pitting edema on the back of the hands | + | + | +++ Rheumatoid factor presence | +/− | − | − Anti‐citrullinated protein … Transverse ultrasound (US) (A, right and B, left) and axial T2‐weighted gradient echo magnetic resonance images (MRI) (C, right and D, left) sequences of shoulders showing a representative example of bilateral long head of the biceps tenosynovitis. …

What Is the Financial Impact of Orthopaedic Sequelae of Intravenous Drug Use on Urban Tertiary-care Centers?

BACKGROUND: Orthopaedic sequelae such as skin and soft-tissue abscesses are frequent complications of intravenous drug use (IVDU) and compri … e included in the study. These sequelae included cellulitis, cutaneous abscess, bursitis, myositis, tenosynovitis, septic arthritis, osteomyelitis, and epidural abscess. Patients were included if they were older than 18 years of age, presented to the emergency department for management of a musculoskeletal infection secondary to IVDU, and required inpatient ort …

Multicenter investigation of lifestyle-related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age.

BACKGROUND: In utero exposure to thalidomide causes a wide range of birth defects, including phocomelia, hearing loss and visceral disorders, known as thalidomide embryopathy (TE). Fifty years after the first report of TE, we conducted the first cross-sectional multicenter study to investigate the development of lifestyle-related diseases and identify risk factors for visceral disorders in subjects with TE. METHODS: Seventy-six cases with TE (31 men, 45 women) underwent medical examinations between 2011 and 2014 to determine the types of TE-related anomalies (limbs, auditory organs, or viscer

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… Malformations in TE cause a gradual loss of muscle mass and strength leading to pain due to overuse syndrome, which includes stenosing tenosynovitis, carpal tunnel syndrome, coxarthrosis, shoulder pain, poor posture, and backache. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021) : Virtual. 19-21 September 2021

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… Subclinical tenosynovitis was present in 20/135 (14.8%) patients. 58.6% of patients showed persistent subclinical synovitis at 6 month follow up MSUS examination. During the 3-year follow up 45/135 (33.3%) patients experienced a disease flare (median survival time 2.2 y). … Subclinical tenosynovitis was the best predictor of disease flare, with important therapeutic implications. To date, the role of tenosynovitis in the diagnosis and prognosis of JIA has been poorly investigated. …

Burning Issues/Hot Topics: The Charcot Foot.

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This art

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… Key pathological findings include soft tissue swelling and fascial oedema, joint effusion and tenosynovitis, bone marrow oedema ± cortical bone erosions or ±subchondral fractures, bone fragments, subluxations/dislocations. …

The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.

Musculoskeletal disorders are characterized by several impairments, including pain, affecting muscles, bones, joints and adjacent connective tissue, resulting in temporary or permanent functional limitations and disability. Musculoskeletal pain is particularly prevalent worldwide and greatly impacts the quality of life, social participation and economic burden. To date, several issues persist about the classification of musculoskeletal pain and its management strategies and resources. The treatment of musculoskeletal pain conditions is complex and often requires a multimodal approach, includin

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… OA and tenosynovitis). 44 , 108 These drugs should not be used for more than four injections per site for year to avoid serious side effects. …

Carpal tunnel syndrome.

Carpal tunnel syndrome is one of the most common peripheral neuropathies. It affects mainly middle aged women. In the majority of patients the exact cause and pathogenesis of CTS is unclear. Although several occupations have been linked to increased incidence and prevalence of CTS the evidence is not clear. Occupational CTS is uncommon and it is essential to exclude all other causes particularly the intrinsic factors such as obesity before attributing it to occupation. The risk of CTS is high in occupations involving exposure to high pressure, high force, repetitive work, and vibrating tools.

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… Local causes Inflammatory: e.g. tenosynovitis, histoplasma fungal infection, hypertrophic synovium Trauma: e.g. Colles' fracture, dislocation of one of the carpal bones Tumours: e.g. Haemangioma, cyst, ganglion, lipoma, neuroma etc. …

Joint manifestations revealing inborn metabolic diseases in adults: a narrative review.

Inborn metabolic diseases (IMD) are rare conditions that can be diagnosed during adulthood. Patients with IMD may have joint symptoms and the challenge is to establish an early diagnosis in order to institute appropriate treatment and prevent irreversible damage. This review describes the joint manifestations of IMD that may be encountered in adults. The clinical settings considered were arthralgia and joint stiffness as well as arthritis. Unspecific arthralgias are often the first symptoms of hereditary hemochromatosis, chronic low back pain may reveal an intervertebral disc calcification in

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… From a joint perspective, primary hyperoxaluria is responsible for microcrystalline arthropathy which is expressed as arthralgias, acute or chronic predominantly distal symmetric polyarthritis (proximal interphalangeal and metacarpophalangeal joints, knees, elbows and ankles), tenosynovitis, bursitis …

Overview of Ankle Arthropathy in Hereditary Hemochromatosis.

Hereditary hemochromatosis (HH) is an autosomal recessive bleeding disorder characterized by tissue overload of iron. Clinical systemic manifestations in HH include liver disease, cardiomyopathy, skin pigmentation, diabetes mellitus, erectile dysfunction, hypothyroidism, and arthropathy. Arthropathy with joint pain is frequently reported at diagnosis and mainly involves the metacarpophalangeal and ankle joints, and more rarely, the hip and knee. Symptoms in ankle joints are in most cases non-specific, and they can range from pain and swelling of the ankle to deformities and joint destruction.

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… In these cases, signs of synovitis, tenosynovitis, and CPP crystal deposition are prominent, often even earlier than the clinical symptoms, underscoring a role of US in predicting deterioration and future clinical evolution [ 45 ]. …

Ongoing clinical trials and treatment options for patients with systemic sclerosis-associated interstitial lung disease.

SSc is a rare CTD that affects multiple organ systems, resulting in substantial morbidity and mortality. Evidence of interstitial lung disease (ILD) is seen in ∼80% of patients with SSc. Currently there is no approved disease-modifying treatment for ILD and few effective treatment options are available. CYC is included in treatment guidelines, but it has limited efficacy and is associated with toxicity. MMF is becoming the most commonly used medication in clinical practice in North America and the UK, but its use is not universal. Newer agents targeting the pathogenic mechanisms underlying SSc

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… Musculoskeletal manifestations affect joints (arthralgia, synovitis, contractures), tendons (tendon friction rubs, tenosynovitis) and muscles (myalgia, muscle weakness, myositis), while skin manifestations include skin fibrosis and thickening, as well as RP, digital ulcers and calcinosis [ 1 ]. …

A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy.

Transthyretin amyloid cardiomyopathy, an often unrecognized cause of heart failure, is now treatable with a transthyretin stabilizer. It is therefore important to identify at-risk patients who can undergo targeted testing for earlier diagnosis and treatment, prior to the development of irreversible heart failure. Here we show that a random forest machine learning model can identify potential wild-type transthyretin amyloid cardiomyopathy using medical claims data. We derive a machine learning model in 1071 cases and 1071 non-amyloid heart failure controls and validate the model in three nation

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… Besides HF and cardiomyopathy-related phenotypes, the strongest cardiac predictors included pericardial effusion/pericarditis, atrial flutter, cardiac conduction disorders, and abnormal serum enzymes, whereas the strongest non-cardiac predictors included carpal tunnel syndrome, synovitis/tenosynovitis …