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Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID-19-A common clinical feature between a rare disorder and a new, common infection.

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Prevalence and risk factors for postpartum depression 2 months after cesarean delivery: a prospective multicenter study.

BACKGROUND: The prevalence and risk factors of postpartum depression after cesarean delivery remain unclear. OBJECTIVE: To assess the prevalence of postpartum depression and its risk factors 2 months after cesarean delivery. STUDY DESIGN: Prospective ancillary cohort study of the Tranexamic Acid for Preventing Postpartum Hemorrhage after Cesarean Delivery trial, conducted in 27 French hospitals in 2018 to 2020 and enrolling women undergoing cesarean delivery before or during labor at 34 or more weeks of gestation. After randomization, characteristics of the cesarean delivery, postpartum bloo…

Self-applied topical interventions for melasma: a systematic review and meta-analysis of data from randomized, investigator-blinded clinical trials.

BACKGROUND: Melasma is a common dermatological condition. Although its relevance as a skin condition is primarily of a cosmetic nature, it m … reams covering different light spectra. Pooling data was possible for only two comparisons, topical tranexamic acid (TXA) vs. hydroquinone (HQ) and cysteamine vs. placebo. Direct comparisons were available for a variety of interventions; however, the reported outcomes varied greatly. Overall, our confidence in the effect estimates ranged from very low to high. C …

Coagulation changes and thromboembolic risk in COVID-19 obstetric patients.

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[Clinical application of distal femoral patient-specific cutting guide based on knee CT and full-length X-ray film of lower extremities].

OBJECTIVE: To discuss the feasibility and accuracy of distal femoral patient-specific cutting guide in total knee arthroplasty (TKA) based o … as periarticular infection and deep vein thrombosis. Except for 1 patient who was not treated with tranexamic acid, the intraoperative blood loss of the rest 19 patients ranged from 30 to 150 mL, with an average of 73.2 mL; the postoperative drainage loss ranged from 20 to 500 mL, with an average of 154.5 mL; and the hidden blood loss ranged from 169.2 to 1 400. …

Acute subdural hematoma in patients on oral anticoagulant therapy: management and outcome.

OBJECTIVE Isolated acute subdural hematoma (aSDH) is increasing in older populations and so is the use of oral anticoagulant therapy (OAT). … oagulation, patients who were taking a thrombocyte inhibitor received desmopressin 0.4 μg/kg, 1-2 g tranexamic acid, and preoperative transfusion with 2 units of platelets. Patients following other oral anticoagulant regimens received 50 IU/kg of prothrombin complex concentrates and 10 mg of vitamin K. There was no significant difference in the rebleeding rate be …

Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.

The diagnosis of disseminated intravascular coagulation (DIC) should encompass both clinical and laboratory information. The International S … inolytic state and who present with severe bleeding could be treated with lysine analogues, such as tranexamic acid (e.g. 1 g every 8 h).

Intraoperative coagulopathy during cesarean section as an unsuspected initial presentation of COVID-19: a case report.

BACKGROUND: The world's understanding of COVID-19 continues to evolve as the scientific community discovers unique presentations of this disease. This case report depicts an unexpected intraoperative coagulopathy during a cesarean section in an otherwise asymptomatic patient who was later found to have COVID-19. This case suggests that there may be a higher risk for intrapartum bleeding in the pregnant, largely asymptomatic COVID-positive patient with more abnormal COVID laboratory values. CASE: The case patient displayed D-Dimer elevations beyond what is typically observed among this hospita

Critical Care Transport: Blunt Polytrauma in Pregnancy.

AUDIENCE: This simulation is designed for critical care transport nurses and attending physicians. It can also be adapted for critical care … rstanding of appropriate imaging evaluation/interpretation, blood product resuscitation, and use of tranexamic acid (TXA) in the pregnant trauma patient. Improvement in interpretation of fetal heart rate as well as use/application of a pelvic binder in the setting of pregnancy were seen as a result of this simulation training. TOPICS: Pregnant trauma, fetal hear …

Diagnosis and treatment of peripartum haemorrhage, consensus of the interdisciplinary working group by the modified ACCORD method.

of recommendations Preventive measures and procedures We recommend monitoring of blood loss in women with risk factors for PPH during labor … women at increased risk of PPH. (Weak recommendation) We recommend a single-dose administration of tranexamic acid (TXA) in women at increased risk of PPH undergoing a caesarean section. Clinical note: The use of TXA prior to the caesarean section is not explicitly stated in the product's SPC. A recent meta-analysis states the most common dosage to be 1 g i.v. ( …

Challenges and Advances in Managing Thrombocytopenic Cancer Patients.

Cancer patients have varying incidence, depth and duration of thrombocytopenia. The mainstay of managing severe chemotherapy-induced thrombocytopenia (CIT) in cancer is the use of platelet transfusions. While prophylactic platelet transfusions reduce the bleeding rate, multiple unmet needs remain, such as high residual rates of bleeding, and anticancer treatment dose reductions/delays. Accordingly, the following promising results in other settings, antifibrinolytic drugs have been evaluated for prevention and treatment of bleeding in patients with hematological malignancies and solid tumors. I

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… EACA, epsilon aminocaproic acid; IV , intravenous; PLT , platelet count (×10 9 /L); TXA , tranexamic acid. … The TREATT Trial (TRial to EvaluAte Tranexamic acid therapy in Thrombocytopenia): Safety and efficacy of tranexamic acid in patients with haematological malignancies with severe thrombocytopenia: Study protocol for a double-blind randomised controlled tr. …

Acquired von Willebrand syndrome and lymphoproliferative disorders: A case report.

Acquired von Willebrand syndrome is a rare bleeding disorder often secondary to an underlying lymphoproliferative disorder. We report a case in whom response of both the acquired von Willebrand syndrome and smoldering multiple myeloma persist 14 months after daratumumab treatment discontinuation.

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… Prophylactic treatment of bleeding consisted of tranexamic acid, somatuline, and human plasmatic VWF concentrate started at 80 IU/kg thrice a day. … acid, somatuline and human plasmatic VWF concentrate. …

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial.

BACKGROUND: Time to treatment matters in traumatic haemorrhage but the optimal prehospital use of blood in major trauma remains uncertain. W … 25 to 50). Before randomisation, participants had received on average 430 mL crystalloid fluids and tranexamic acid (90%). The composite primary outcome occurred in 128 (64%) of 199 participants randomly assigned to PRBC-LyoPlas and 136 (65%) of 210 randomly assigned to 0·9% sodium chloride (adjusted risk difference -0·025% [95% CI -9·0 to 9·0], p=0·996). The rat …

Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH).

Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression to myelofibrosis and acute leukemia. Major bleeding represents a common and important complication in MPN, and the incidence of such bleeding events will become even more relevant in the future due to the increasing disease prevalence and survival of MPN patients. This review discu

Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders.

BACKGROUND: People with haematological disorders are frequently at risk of severe or life-threatening bleeding as a result of thrombocytopenia (reduced platelet count). This is despite the routine use of prophylactic platelet transfusions to prevent bleeding once the platelet count falls below a certain threshold. Platelet transfusions are not without risk and adverse events may be life-threatening. A possible adjunct to prophylactic platelet transfusions is the use of antifibrinolytics, specifically the lysine analogues tranexamic acid (TXA) and epsilon aminocaproic acid (EACA). This is an up…

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective.

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is an autosomal dominant disorder that causes abnormal blood vessel formation. The diagnosis of hereditary hemorrhagic telangiectasia is clinical, based on the Curaçao criteria. Genetic mutations that have been identified include ENG, ACVRL1/ALK1, and MADH4/SMAD4, among others. Patients with HHT may have telangiectasias and arteriovenous malformations in various organs and suffer from many complications including bleeding, anemia, iron deficiency, and high-output heart failure. Families with the same mutatio

Совпадение в полном тексте источника
… Epsilon-aminocaproic acid and tranexamic acid can be considered in the care of patients with moderate or severe epistaxis. 61 In a randomized, double-blind, placebo-controlled, crossover study of 22 patients, tranexamic acid 1 g 3 times daily resulted in a 54% reduction in nosebleeds while on tranexamic … on the endothelium, selectively stimulating the TGF-β pathway. 63 Tranexamic acid may have a higher potency and longer half-life than aminocaproic acid in these patients. 63 Dosing can be titrated upward if tolerable to tranexamic acid 650-1300 mg orally 3 times daily or aminocaproic acid 500-2000 mg …

A real-world study of immune thrombocytopenia management during the COVID-19 pandemic in the UK.

The COVID-19 pandemic has created many challenges in the management of immune thrombocytopenic purpura (ITP). The recommendation for avoidance of steroids by WHO led to the off-licence use, supported by NHS England, of thrombopoietin mimetics (TPO-RA) for newly diagnosed or relapsed ITP. This is a real-world prospective study which investigated the treatment patterns and outcomes in this setting. Twenty-four hospitals across the UK submitted 343 cases. Corticosteroids remain the mainstay of ITP treatment, but TPO-RAs were more effective. Incidental COVID-19 infection was identified in a signif

Acute Abdominal Pain as the Initial Presentation of an Acquired C1 Inhibitor Deficiency.

INTRODUCTION: Acquired angioedema (AAE), a rare cause of adult-onset non-urticarial mucocutaneous angioedema, can present as acute abdomen, a frequent complaint in the emergency room (ER), often leading to unnecessary and potentially harmful procedures. CASE PRESENTATION: We report a 47-year-old hypertense male, controlled with an angiotensin converting enzyme inhibitor (ACEI), who presented in the ER with progressively worsening abdominal pain, nausea, and vomiting, and a radiologic workup revealing small intestine thickening, initially diagnosed with ACEI-induced angioedema. However, furthe

Совпадение в полном тексте источника
… plan with tranexamic acid was provided and explained to the patient. … Currently, there is no consensus or approved drugs for short- or long-term prophylaxis, although antifibrinolytic agents, such as tranexamic acid, and attenuated androgens have been reported to be effective treatments [ 2 , 4 ]. …

Comparative effect of different surgical treatments for ovarian endometrioma on anti-Müllerian hormone levels: a systematic review and network meta-analysis.

STUDY QUESTION: Which surgical technique for endometrioma has the least detrimental effect on ovarian reserves? SUMMARY ANSWER: Drainage wi … techniques (cystectomy with ovarian suturing, cystectomy with hemostatic sealants, cystectomy with tranexamic acid, cystectomy alone, drainage with hemostatic sealants, drainage alone, laser ablation, and transvaginal sclerotherapy) were included in the systematic review and 17 studies in the NMA. Regarding AMH at 3-6 months after surgery, drainage with hemostat …

Tibial Lengthening with a Motorized Intramedullary Lengthening Nail.

BACKGROUND: Tibial lengthening with use of a motorized intramedullary lengthening nail (MILN) provides precise deformity correction and dist … the MILN insertion surgery.Prioritize safety (i.e., with a percutaneous technique, fasciotomy, and tranexamic acid) to optimize outcomes (i.e., avoidance of complications and achievement of the desired length).Ensure patient compliance with weight-bearing limitations and stretching exercises.Limit weight-bearing until at least 3 cortices have full bridging.MILN …