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Fatigue, anxiety, and cognitive effects in neurosurgical patients: a prospective multicenter longitudinal study.

OBJECTIVE: Existing studies on postoperative fatigue (POF) following neurosurgery are generally small, retrospective, and lack longitudinal data. Despite frequent associations with temporary cognitive impairment and mood disorders, the precise relationship remains unclear. This study investigated POF following neurosurgery and its association with anxiety, depression, and cognitive impairment. METHODS: This prospective multicenter study enrolled patients undergoing elective or semi-elective cranial or spinal surgery at four centers. Assessments including the Fatigue Severity Scale (FSS), Chri…

Effect of foreign object damage on fatigue performance of Inconel 718 welded joints.

Foreign object damage (FOD) in Inconel 718 base metal(BM) and welded joints(WJ) was investigated using pendulum impact testing. The effects of impact energy on damage morphology, microstructure, and fatigue performance were analyzed. The results show that: 1. The fatigue life and hardness inherent in WJ are higher than those of the BM, primarily due to grain refinement and the presence of precipitated phases at grain boundaries; 2. Macroscopically, the damage notches exhibit a V-shape. Their dimensions increase with the rise in impact energy. However, under the same energy level, the damage di…

Sleep Disorders, Dysregulation of Circadian Rhythms, and Fatigue After Craniopharyngioma-A Narrative Review.

Introduction: Tumor- and/or treatment-associated hypothalamic damage results in reduced quality of life and increased morbidity due to sleep disorders in survivors of craniopharyngioma. Methods: The narrative review is based on a search of Web of Science, MEDLINE/PubMed, and Embase databases for the identification of publications. The search terms craniopharyngioma, sleep disorders, fatigue, and daytime sleepiness were used. Selected English language papers published 1970-2025 were included. Results: Circadian rhythms (wakefulness and sleep) are controlled by hypothalamic suprachiasmatic nucle…

Fatigue in intensive care unit survivors with COVID-19: An observational cohort study.

•Fatigue was highly prevalent one year after ICU admission in ICU survivors with COVID-19.•Younger age, pain/discomfort, dyspnoea, and mental health symptoms were associated with reports of fatigue.•COVID-19 ICU survivors should be assessed with comprehensive symptom screening during follow-up care.

Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis, Fatigue, and Treatment With Avacopan: A Case Series.

This report describes three patients who developed marked somnolence and fatigue during treatment with avacopan for antineutrophil cytoplasmic antibody (ANCA) vasculitis. Though fatigue is a common symptom in ANCA vasculitis, each of these patients reported noticeable worsening of fatigue after starting avacopan, with improvement shortly after stopping the medication. All of them had a good response to treatment of their underlying vasculitis, and none of them had other clear causes of worsening fatigue.

Premature Fatigue Failure Analysis of Axle in Permanent Magnet Direct-Drive Electric Locomotive.

This study investigates premature fatigue failures in three EA1N steel axles from permanent magnet direct-drive locomotives during wheel-seat bending tests. Complete fracture occurred in one axle at 3 million cycles, and in the other two axles, cracks appeared and were observed through magnetic particle detection at 3.5 million and 1.6 million cycles, respectively. A comprehensive failure analysis was conducted through metallurgical examination, fractography, mechanical testing, residual stress measurement, and finite element analysis. The fractographic results revealed fractures consistently …

Bilateral anterior acetabular-superior pubic ramus junction fatigue fractures in a marathon runner.

Fatigue fractures occur due to repetitive submaximal mechanical stress on bone and are most common in the lower extremities of endurance athletes and military recruits. This report details a rare case of bilateral anterior acetabular-superior pubic ramus junction fatigue fractures in a marathon runner presenting with low back and hip pain. MR imaging of the pelvis was initially interpreted as normal. Further review by a sports medicine physician and a musculoskeletal radiologist prompted an addendum identifying bilateral mild marrow edema of the anterior acetabula with incomplete fracture line…

Multiscale vibration response analysis and fatigue damage prediction after idiopathic scoliosis kyphosis surgery.

Purpose: The aim of this study was an exploration of the multiscale vibratory response of the spine following orthopedic surgery in patients with idiopathic scoliosis and postoperative traumatic fatigue injury. Methods: In this paper, the postoperative macroscopic spine model in the modal, time and frequency domains to obtain the vibration response of the patient's entire spine were analyzed. Subsequently, the stresses in the cortical bone mesoscopic bone units around the surgically damaged interface were calculated using submodeling algorithms. The pore stresses and pore flow velocities of th…

Peripheral Levels of Selected Biomarkers in Patients with Post-Sarcoidosis Chronic Fatigue Syndrome.

INTRODUCTION: Chronic fatigue syndrome (CFS) is characterized by persistent fatigue and multiple symptoms such as cognitive impairment and muscle pain, often linked to immune-inflammatory dysfunction. Sarcoidosis, a granulomatous disease with systemic inflammation, commonly causes fatigue, even during remission. This study examined whether fatigue and depressive symptoms in sarcoidosis remission relate to residual inflammation or oxidative stress. Recent studies highlight parallels between post-infectious fatigue syndromes, including Long COVID, and sarcoidosis-related fatigue, emphasizing IL-…

The Various Mechanisms by Which Exercise-Induced Fatigue (EIF) Affects Spermatogenesis Through Testosterone.

Currently, a great number of researches have proven that the EIF triggered by inappropriate and excessive exercise will affect normal function of the male reproductive system, resulting in various disorders or increasing disease risks. Reproductive system and motor system are highly correlated. Now, it is mainly considered that the testicular cell is modulated via hypothalamus-hypophysis-gonad(HPG) axis in the process of exercise, which involves the whole male reproductive system and affects spermatogenesis. However, there are many mechanisms leading to EIF, including hormonal levels, lactic a

[Irritable cough, fatigue, weight loss in a patient who has undergone cardiac surgery].

We report the diagnosis and clinical course of a 62-year-old patient with non-specific symptoms, such as dry cough, weight loss, increased fatigue, and a long-standing previously operated aortic graft prosthesis. Extensive investigations led to the diagnosis of a chronic infection of the aortic graft caused by Coxiella burnetii (Q-fever), following which an antibiotic therapy with Doxycycline and Hydroxychloroquine was established.

Fatigue relief in multiple sclerosis by personalized neuromodulation: A multicenter pilot study [FaremusGE].

BACKGROUND: A recent application of the GRADE guidelines indicated Faremus, a 5-day neuromodulation for 15 min per day via transcranial direct current stimulation (tDCS), as medium to highly recommendable for alleviating fatigue in multiple sclerosis (MS). METHODS: With this pilot study we aimed to evaluate the feasibility, acceptance, safety, and effectiveness of the Faremus treatment carried out in a multicenter context. The Rome unit prepared the intervention, supplied the personalized electrodes to the San Martino Hospital in Genova, where the neurological team enrolled the population of …

Оценка степени усталости пациента при множественном склерозе с использованием финского регистра MS.

ЦЕЛИ: Охарактеризовать усталость пациента с помощью финских данных о множественном склерозе (MS). МАТЕРИАЛЫ И МЕТОДЫ: Усталость оценивалась по шкале утомления (FSS), шкале утомления моторных и когнитивных функций (FSMC) и шкале Визуального аналога (Visual Analogue). Острота заболеваний оценивалась с помощью расширенной шкалы инвалидности и симптомов с помощью шкалы Визуального Аналога. К числу результатов, о которых сообщили пациенты (ПРО), относятся неевропсихологический вопросник по множественным склерозам, Евро Качество жизни - 5 измерений, 15 D и шкала воздействия множественных склерозов.

Совпадение в аннотации оригинала
OBJECTIVES: To characterize patient-perceived fatigue by using the Finnish Multiple Sclerosis (MS) registry data. MATERIALS & METHODS: Fatigue was assessed with the Fatigue Severity Scale (FSS), the Fatigue Scale for Motor and Cognitive Functions (FSMC), and the Visual Analogue Scale-Fatigue. Disease severity was evaluated with the Expanded Disability Statu…

Клинические и параклинические характеристики отличают усталость от депрессивных фенотипов при множественном склерозе.

В клинической практике, возможно, трудно провести различие между усталостью и депрессией при мультипликационном склерозе (MS). Мы провели два независимых исследования когортных наблюдений, в ходе которых клинические и параклинические особенности отличают пациентов, сообщающих об усталости, но никаких депрессивных симптомов от лиц, страдающих депрессивными симптомами, но не имеющих соответствующей усталости. В исследовании 1 n = 156 пациентов, страдающих от усталости, депрессии, когнитивного обследования и цитометрических измерений потока. В исследовании 2, n = 54 пациента MS провели всеобъемлю

Совпадение в аннотации оригинала
In clinical routine, it might be difficult to distinguish between fatigue and depression in Multiple sclerosis (MS). We investigated in two independent observational cohort studies which clinical and paraclinical features distinguish patients reporting fatigue but no depressive symptoms from those suffering from depressive symptoms but having no relevant fat…

Lacticaseibacillus rhamnosus Strains for Alleviation of Irritable Bowel Disease and Chronic Fatigue Syndrome.

Lacticaseibacillus rhamnosus is applied as a probiotic to alleviate various metabolic, gastrointestinal, and psychological symptoms and dise … rgeted as potential probiotics and were applied in mouse model tests for the alleviation of chronic fatigue syndrome (CFS) and irritable bowel syndrome (IBS). The results showed that WL11 and WL17 effectively alleviated slow body weight gain, anxiety, poor memory, and cognitive impairment in CFS mouse models. They also reduced the expression of pro-inflam …

Burden from Study Questionnaire on Patient Fatigue in Qualitative Congestive Heart Failure Research.

Mixed methods research forms the backbone of translational research methodologies. Qualitative research and subjective data lead to hypothes … ary and post hoc use. This paper discusses the issue of the burden of subjective data collected and fatigue in the context of congestive heart failure (CHF) research. The CHF population has a high baseline morbidity, so no doubt the focus should be on the content; however, the lengths of the instruments are a product of their vigorous validation processes …

Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19.

OBJECTIVES: Persistent skeletal muscle dysfunction in survivors of critical illness due to acute respiratory failure is common, but biological data elucidating underlying mechanisms are limited. The objective of this study was to elucidate the prevalence of skeletal muscle weakness and fatigue in survivors of critical illness due to COVID-19 and determine if cellular changes associate with persistent skeletal muscle dysfunction. DESIGN: A prospective observational study in two phases: 1) survivors of critical COVID-19 participating in physical outcome measures while attending an ICU Recovery …

Characterizing sEMG changes with muscle fatigue for lower-extremity prostheses and exoskeletons control.

In powered lower limb prostheses and exoskeleton control, sEMG based methods have been widely explored and utilized due to non-invasive nature and ability to directly reflect user intentions. However, in practical use, neuromuscular fatigue (NMF) caused by long-term use can cause significant changes in sEMG signals. These issues are constraining sEMG's active prosthetics from the laboratory to real life. In this study, the changes in sEMG signals with muscle fatigue was investigated. sEMG data from one healthy subject and a below-knee amputee were logged and analyzed when they walked on a trea…

Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndrome.

Reduced natural killer (NK) cell cytotoxicity is the most consistent immune finding in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Meta-analysis of the published literature determined the effect size of the decrement in ME/CFS. Databases were screened for papers comparing NK cell cytotoxicity in ME/CFS and healthy controls. A total of 28 papers and 55 effector:target cell ratio (E:T) data points were collected. Cytotoxicity in ME/CFS was significantly reduced to about half of healthy control levels, with an overall Hedges' g of 0.96 (0.75-1.18). Heterogeneity was high but was …