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:: < < Действенность и безопасность антителных препаратов > > (BCMA) в программе < < Развитие против рака: систематический обзор > > .

В качестве перспективных методов лечения повторной/охлажденной множественной миеломы (RRMM) появились антителные антигены (BCMA), ориентированные на антитела-наркотики (ADC). Цель этого исследования заключалась в обобщении имеющихся данных о безопасности и эффективности БКМА-АДЦ в процессе разработки системы RRM.MetodsA систематического поиска. six Библиографические базы данных и клинические анализы.gov до ноября 2024. Исследования имеют право на проведение таких исследований, если они являются клиническими испытаниями человека или исследованиями животных с оценкой БЦМА-АЦД, и если они содержа

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… The most common AEs [ 17 ] included photophobia (43.9%), rash (29.0%), thrombocytopenia (19.6%), and fatigue (44.9%), while Grade ≥3 AEs included thrombocytopenia (36.6%), gamma-glutamyl transferase increase (26.8%), and photophobia (17.1%). … Ocular toxicity, particularly photophobia, affected 57% of patients, leading to 14% discontinuation but without keratopathy or visual acuity loss. …

Acupuncture as a Complementary Method of Traditional Psoriasis Treatment: Myth or Reality?

Dear Editor, the practitioners of traditional Chinese medicine described psoriasis some 2000 years ago (1). Psoriasis vulgaris is a common, … headache was mainly located on the left side of head and accompanied by nausea, vomiting, and both photophobia and phonophobia, and there was a worsening of symptoms upon exertion. The headaches were occurring once a week with an average duration of 2-3 continuous days. The patient also had frequent mild headaches. Additionally, the patient was diagnosed wit …

Profile and Management of Toxicity of Selinexor and Belantamab Mafodotin for the Treatment of Triple Class Refractory Multiple Myeloma.

Treatment options are limited for multiple myeloma patients who have developed four/five drug-refractory disease. Selinexor (Sel) and belantamab mafodotin (belamaf) were recently approved by the US FDA for treatment of RRMM. The toxicity profile of these drugs is a concern since these agents are used in patients who have already undergone multiple lines of treatment. In this review, we discuss the toxicity profile and strategies for the management of toxicities of Sel and belamaf for the treatment of RRMM. We conducted a comprehensive literature search on PubMed, Embase, Cochrane, and Clinical

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… Ophthalmic steroid drops in DREAMM-1 were used to mitigate the ocular toxicity given the established side effects of MMAF. 16 However, ocular toxicity (blurring of vision, eye pain, and dryness, keratitis, and photophobia) still occurred, especially with the increasing doses of the drug. 17 Permanent … | | Photophobia | Management of Ocular toxicity: see Table 3 | | Dry Eyes | Preservative free artificial tears | | Pyrexia/headache/arthralgia | Acetaminophen/Ibuprofen | | Constipation | Laxatives | | Epistaxis | Correct underlying thrombocytopenia if severe Symptomatic management | | Acute …

Conjunctival HLA-DR and CD8 expression detected by impression cytology in ocular graft versus host disease.

PurposeTo assess the expression of human leucocyte antigen (HLA)-DR in epithelial cells and cluster of differentiation (CD8)-positive lymphocytes as possible markers of chronic ocular graft versus host disease (cGvHD) after hematological stem cell transplantation (HSCT).MethodsTwenty-seven consecutive patients with dry-eye symptoms following HSCT (24 [89%] with peripheral blood stem cell transplantation and 3 [11%] with bone marrow transplants; 17 [63%] familiar allogenic grafts) and 19 age-matched controls were included. Conjunctival impression cytology specimens were stained for HLA-DR, cyto

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… Besides strong ocular surface staining, conjunctival scarring of the tarsal plate and inflammatory changes of the lid margin, increased blinking frequencies and photophobia were the most characteristic symptoms of severe ocular cGvHD. … Patients with accentuated blinking and photophobia showed the highest OSDI scores, indicating severely impaired quality of life. Overall, the OSDI correlated well with the severity of ocular surface involvement, which is in agreement with recent publications [ 21 , 23 , 24 ]. …

Комплексный подход к дифференцированию системного лейкоцита от других аутоиммунных заболеваний, вызываемых оптическим невритом.

Системная волчанка (SLE) представляет собой сложное аутоиммунное заболевание со значительной заболеваемостью и смертностью. Ранняя диагностика имеет решающее значение для эффективного управления. В качестве потенциальных первых признаков SLE появились окулярные проявления, в частности оптический нейрит (ON). В этом систематическом обзоре литературы анализируются 23 исследования, включая восемь ретроспективных исследований, пять межсекторальных исследований, два групповых исследования, четыре тематических доклада, один обзор описательной части и три систематического обзора литературы, в целях и

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… Rarely, MS-associated ON can manifest bilaterally, leading to severe vision loss, photophobia, vitritis, neuroretinitis, and other complications [ 20 ]. About 28% of MS-associated ON cases are recurrent [ 25 ]. The features of ON between these three conditions are summarized in Table 2 . … features May involve the optic chiasm; thrombotic ON associated with antiphospholipid antibodies [ 20 ] Coexistence with SLE reported; diagnosis confirmed with MRI, ON, TM, and elevated AQP4 antibodies [ 29 ] Mild disc swelling, diminished color vision, and afferent pupillary defect [ 20 ]; rarely: photophobia …

Ocular Toxicity of Belantamab Mafodotin, an Oncological Perspective of Management in Relapsed and Refractory Multiple Myeloma.

Belantamab mafodotin (belamaf), an antibody-drug conjugate approved for the treatment of relapsed and refractory multiple myeloma (RRMM), is an anti B-cell maturation antigen (BCMA) agent. DREAMM-1, a first in-human trial of belamaf, reported several ocular toxicities requiring dose adjustments, dose delays and treatment discontinuations. In DREAMM-1, 53% of patients in part-1 and 63% of patients in part-2 had ocular toxicity. Similarly, 73% of patients in DREAMM-2 had keratopathy (71% in 2.5 mg/kg versus 75% in 3.4 mg/kg) with the most common symptoms being blurred vision and dry eyes. Ocular

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… These adverse events (AEs) were diverse including blurred vision, dry eyes, photophobia/eye pain, abnormal visual activity, and keratitis. The majority of the events were mild but caused frequent dose adjustments in the dose-expansion part. … Keratitis and photophobia caused belamaf interruption or delays in 9% of cases for each category. Overall, corneal events in part-2 were responsible for dose reductions in 46% and dose interruptions/delays in 49% of participants ( 6 ). …

Практическое руководство по клиническому управлению окулистическими неблагоприятными событиями, связанными с Belantamab Mafodotin для пациентов с повторной/редактированной миеломой: рекомендации Группы экспертов стран Латинской Америки.

Множественная миелома является значительной причиной смертности во всем мире, и, хотя изменения в области лечения в целом улучшили результаты, многие пациенты становятся небрежными к стандартной терапии. В Латинской Америке результаты являются особенно неблагоприятными, что еще больше усугубляется препятствиями на пути доступа и равенства. Belantamab mafodotin — новый антитело-наркоманный матрос, направленный против анти-B-клеток антигена. Two недавно фазы 3 - судебные разбирательства, DREAMM-7 и DREAMM-8, продемонстрировали заметную эффективность комбинаций белантамб мафодотина у пациентов с

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… Ocular symptoms should be assessed and monitored by HCPs/patients and reported to ophthalmologists, including but not limited to eye pain, blurred vision, photophobia, eye irritation, and foreign-body sensation. Q3: How are belantamab mafodotin-associated ocular events classified? … Common OAEs include eye pain, blurred vision, photophobia, eye irritation, and foreign-body sensation. Bilateral worsening of visual acuity (20/50 or worse) was seen in 34% of patients in both studies [ 17 , 19 ]. …

The International Headache Congress - IHS and EHF joint congress 2021 : Virtual. 8-12 September 2021.

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Mucormycosis during Imatinib treatment: case report.

UnlabelledPhiladelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a redu

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… On day 14 of salvage regimen, the patient presented abrupt onset of right side headache followed by chemosis, photophobia and right ptosis. …

Safety, pharmacokinetics, and efficacy of belantamab mafodotin monotherapy in Japanese patients with relapsed or refractory multiple myeloma: DREAMM-11.

Belantamab mafodotin, a B-cell maturation antigen-targeting antibody-drug conjugate (ADC), was investigated in Japanese patients with relapsed/refractory multiple myeloma in Part 1 of the phase I DREAMM-11 study. Patients who had received ≥ 2 prior lines of therapy including a proteasome inhibitor and immunomodulatory agent were eligible. Eight patients received belantamab mafodotin monotherapy at 2.5 mg/kg (n = 4) or 3.4 mg/kg (n = 4) by intravenous infusion every 3 weeks on day 1 of each cycle until disease progression or unacceptable toxicity. Primary objectives were tolerability and safety

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… 0 Blood alkaline phosphatase increased 1 (25) 0 1 (25) 0 2 (25) 0 Bursitis 1 (25) 0 0 0 1 (13) 0 Cardiac failure 1 (25) 0 0 0 1 (13) 0 Dyspnea 1 (25) 0 0 0 1 (13) 0 Epistaxis 1 (25) 0 0 0 1 (13) 0 Fatigue 1 (25) 0 0 0 1 (13) 0 Nasopharyngitis 1 (25) 0 0 0 1 (13) 0 Nausea 1 (25) 0 1 (25) 0 2 (25) 0 Photophobia … Ocular events by CTCAE included corneal edema in 1 (25%) patient in each cohort (Grade 2) and photophobia in 1 (25%) patient in the 2.5 mg/kg cohort (Grade 1). …

Treatment of Patients with Monoclonal Gammopathy of Clinical Significance.

Monoclonal gammopathy of undetermined significance (MGUS) is defined as the presence of a monoclonal protein (M-protein) produced by a small amount of plasma cells. The majority of patients remain asymptomatic; however, a fraction of them develop clinical manifestations related to the monoclonal gammopathy despite not fulfilling criteria of multiple myeloma or other lymphoproliferative disorder. These patients constitute an emerging clinical issue coined as monoclonal gammopathy of clinical significance (MGCS). The mechanisms involved are poorly understood, and literature is scarce regarding m

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… Eight years later, the patient complained of mild photophobia and ocular pain. The ocular examination revealed corneal deposits in both eyes; visual acuity was otherwise normal. The corneal biopsy demonstrated kappa free light chain deposits by immunohistochemistry. … Three years later, the photophobia increased with ocular pain. At that time, she had a serum M-protein of 22 g/L, serum kappa free light chain increased up to 238 mg/L, serum involved/uninvolved free light chain was 35.7, and the bone marrow aspirate had 4% of plasma cells. …

Идиопатический цервициальный трансверсальный миелит, преобладающий с нижним Лимбом слабая и автономная дисфункция: доклад о реалистическом случае.

Трансверсный миелит (TM) — это редкое нервно-воспалительное расстройство, которое может привести к значительной заболеваемости, если не диагностировать и не лечить. Мы сообщаем о случае 40-летней женщины, которая в течение двух месяцев испытывала постепенную двустороннюю слабость нижних конечностей и недержание мочеиспускания. Неврологическая экспертиза выявила верхние моторные нейроны и определенный уровень сенсорности, что вызывает подозрения в патологии спинного мозга. МРТ шейного отдела позвоночника выявила гиперинтенсивные повреждения, взвешенные на Т2 и Коротком тау инверсионном восстано

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… The patient denied any history of trauma, fever, recent infection, headache, photophobia, vomiting, seizures, or bowel disturbances. There were no complaints suggestive of upper limb weakness or cranial nerve involvement. …

Bilateral Proptosis in a Case of Recurring Multiple Myeloma: Uncommon Orbital Presentation of Plasmacytoma.

Multiple myeloma is a malignant plasma cell dyscrasia that may invade the orbits in extramedullary presentations. Common manifestations of orbital involvement include unilateral proptosis, injection, chemosis, diplopia, and occasionally pain. Additionally, the soft-tissue tumors associated with multiple myeloma typically cause bony destruction of adjacent structures. However, in certain patients, bilateral proptosis and a lack of bony destruction may occur. In these instances, it is important for physicians to consider patient history, presentation, and progression in order to ensure that a po

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… Case Report A 45-year-old-male presented to the ophthalmology consult service for bilateral, severe orbital proptosis associated with pain and photophobia. His past medical history was significant for prior diagnosis of multiple myeloma. …

Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) : Immunologic Reactions

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… Approximately 80% of cases with have ocular involvement which is characterized by erythema, discharge, lacrimation, tenderness, and photophobia [ 62 ]. Severity of initial symptoms correlate with the development of subsequent complications [ 56 ]. … A retrospective review of patients with ocular complications of SJS and TEN who were fitted with scleral lens noted reduction in photophobia and tenderness [ 49 ]. Suction to prevent aspiration pneumonitis may be indicated in cases with oropharyngeal involvement [ 5 ]. …

Austrian Syndrome - A Devastating Osler's Triad: Case Report and Literature Review.

Austrian syndrome is a rare triad of meningitis, pneumonia, and endocarditis caused by Streptococcus pneumoniae. We present a case of the Austrian syndrome in the oldest patient in the reviewed literature, with no other classically described risk factors. She had an unusual initial presentation and microorganism portal of entry. Her hospital course was complicated by the diagnosis of monoclonal gammopathy, septic knee joint, septic brain emboli and respiratory failure. We also provide an extensive review of available literature of this commonly unrecognized entity.

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… On physical exam three hours afterwards, she was completely disoriented with Glasgow Coma Scale score of nine (E2M5V2) and significant photophobia, was febrile to 103.2F but otherwise hemodynamically stable. Kernig’s and Brudzinski’s signs were equivocal. …

Характеристики реального мира и результаты лечения пациентов с множественной миэломой белантамбом мафодотином: исследование немецких данных.

В DREAMM-2 belantamab mafodotin (беламаф) продемонстрировала клиническую активность и приемлемый профиль безопасности у пациентов, прошедших предварительное лечение, с множественными миеломами (RRMMM). Реальные данные об этой терпеливой популяции скудны. В настоящем исследовании описываются реальные базовые характеристики, окулярные явления и временные результаты лечения пациентов с RRMM до, во время и после лечения бенамафа в период с августа 1, 2020, и март 31, 2023, в Германии на основе анонимных данных о медицинском страховании. В общей группе (N = 31), средний возраст 66 В течение многих

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… Other adverse events reported in DREAMM-2 were eye pruritus, ulcerative keratitis, infective keratitis, ocular discomfort, visual impairment, photophobia, and blepharitis [ 6 ]. … In a US observational study of 30 adult patients with MM treated with belamaf monotherapy at the Duke Cancer Institute between 2020 and 2022, 53%, 17%, and 14% of patients experienced blurry vision, dry eye, and photophobia, respectively [ 13 ]. …

Isolated oculomotor nerve palsy as a manifestation of diffuse large B cell lymphoma: A case report.

An isolated third nerve palsy presenting as the primary manifestation of a lymphoma is rare, with only few cases having been described. The present study reports an unusual case of a healthy 67-year old male diagnosed with isolated right oculomotor nerve palsy (ONP), who was found to have an underlying B cell lymphoma. The patient's medical records were accessed upon consent. A thorough physical examination, including stroke and infections work-ups were performed. A chest computerized tomography (CT), brain magnetic resonance imaging and positron emission tomography (PET) scans and a mediastin

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… He denied having photophobia, phonophobia, blurry vision, nausea or vomiting. …

"Пожалуйста, встаньте?" - "Настоящее демилилиническое расстройство, пожалуйста, встаньте?" - из материалов Национальной конференции общества с множественным склерозом.

46-летний мужчина с постепенной болезненной монокулярной потерей зрения и левой ногой парестезией. Workup продемонстрировал многофукаловые демиелионирующие повреждения и олиголональные полосы с ограничением CSF. У него был диагностирован множественный склероз (MS), но последующие тесты были заметны для положительного миэлина олигодендроцита гликопротеина-иммуноглобулина G (MOG-IgG). Мы обсуждаем последствия и клинические соображения в отношении позитива MOG-IgG в MS.

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… Case Report A 46-year-old White man presented with 2 weeks of progressive left-sided vision loss with associated pain with extraocular movement (EOM), headache, and photophobia. He further reported several weeks of circumferential numbness and tingling in his distal left lower extremity (LLE). …

Belantamab mafodotin, carfilzomib, lenalidomide и дексаметазон для рецидива или рефракта множественной миеломы.

Резюме Belantamab mafodotin (Belamaf), антитела-наркотики, направленные против антигена ячеек B-клеток, продемонстрировало активность одного агента в повторной/охлажденной миеломе (RRMM), но связано с окулярной токсичностью. Это фазы 1/2 в ходе исследования была проведена оценка безопасности и предварительной эффективности использования беналафа 8 Недели в сочетании с карфилзомидом, линалидомидом и дексаметасоном (KRd-b) у пациентов с RRMM. Пациенты, имеющие право на получение помощи, по крайней мере, 1 :: предыдущая терапия и не продвинулась по полной дозе леналидомида. На стадии " доза-

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… 50.0) 0 (0.0) 5 (83.3) 4 (30.8) 3 (23.1) 1 (7.7) 8 (61.5) Eye disorders, other ∗ 1 (16.7) 1 (16.7) 0 (0.0) 2 (33.3) 2 (15.4) 4 (30.8) 0 (0.0) 6 (46.2) Dry eye 1 (16.7) 1 (16.7) 0 (0.0) 2 (33.3) 5 (38.5) 1 (7.7) 0 (0.0) 6 (46.2) Cataract 0 (0.0) 4 (66.7) 0 (0.0) 4 (66.7) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) Photophobia … (61.5) Eye disorders, other ∗ | 1 (16.7) | 1 (16.7) | 0 (0.0) | 2 (33.3) | 2 (15.4) | 4 (30.8) | 0 (0.0) | 6 (46.2) Dry eye | 1 (16.7) | 1 (16.7) | 0 (0.0) | 2 (33.3) | 5 (38.5) | 1 (7.7) | 0 (0.0) | 6 (46.2) Cataract | 0 (0.0) | 4 (66.7) | 0 (0.0) | 4 (66.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) Photophobia …

Case report: Single infusion of combined anti-CD20 and anti-CD38 monoclonal antibodies in pediatric refractory lupus nephritis.

Lupus nephritis (LN), present in 30%-50% of systemic lupus erythematosus (SLE) patients, often necessitates standard immunosuppressive therapy (glucocorticoids, MMF, CYC) as suggested by the European League Against Rheumatism/European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) and Kidney Disease Improving Global Outcomes (KDIGO) guidelines. However, a subset of subjects remains refractory. Recent findings suggested the efficacy of targeting CD38-long-lived plasma cells in LN and SLE refractory to standard treatment. However, previous experiences were limite

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… However, over the following 2 years, the patient continued to exhibit signs and symptoms consistent with refractory SLE, including headache, photophobia, low complement levels (C3 49-70 mg/dL, C4 6-15 mg/dL), and elevated anti-dsDNA antibodies (169-240 IU/mL) with SLEDAI-2K scores between 10 and 12 ( …