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Cost analysis in thyroid cancer clinical trials: Toward value-based oncology care.

BACKGROUND: Clinical trials are crucial in advancing novel therapies for thyroid cancer. Given the increased cost of modern healthcare, cost considerations in clinical trials are important yet remain under-reported. METHODS: A search of ClinicalTrials.gov identified thyroid cancer studies including cost in the trial description or as an outcome. Data collected included trial information, cost outcomes, and cost-effectiveness analyses. RESULTS: Among 46 thyroid cancer-focused clinical trials, only 28 (60.8 ​%) mentioned cost in any capacity, of which 21 (75 ​%) included cost outcomes and 7 (2

The cost-effectiveness of treating triple coinfection with HIV, tuberculosis and hepatitis C virus.

OBJECTIVES: The objective of this study was to estimate the cost-effectiveness of treating patients infected with HIV and simultaneously coinfected with tuberculosis (TB) and hepatitis C virus (HCV). METHODS: A mathematical model for HIV coinfection with TB and HCV is introduced. The model was designed to incorporate parameters of control for the coverage of care, which makes it useful for performing cost-effectiveness analysis of public policies. A cost-effectiveness analysis of early medical care of patients with TB and HCV coinfection, with coverage of 0 (basal), 25, 50, 75 and 100%, was p…

Pharmacoeconomic analysis of ethanol and benzalkonium chloride to prevent infections in dental facilities.

BACKGROUND: This paper describes pharmacoeconomic analysis of ethanol and benzalkonium chloride disinfectants used in dental institutions to prevent infections. Pathogens can be transmitted to patients via air, items, contact or vectors. The aim of this study is to compare the efficiency and cost-effectiveness of both disinfectants. METHODS: For pharmacoeconomic assessment, cost minimization analysis, cost benefit analysis (CBA), cost effectiveness analysis and cost utility analysis were performed. The cost of disinfectants used in hand disinfection of dental professionals is estimated to be

Comparative analyses of published cost effectiveness models highlight critical considerations which are useful to inform development of new models.

Background: Comparative analyses of published cost effectiveness models provide useful insights into critical issues to inform the development of new cost effectiveness models in the same disease area.Objective: The purpose of this study was to describe a comparative analysis of cost-effectiveness models and highlight the importance of such work in informing development of new models. This research uses genotypic antiretroviral resistance testing after first line treatment failure for Human Immunodeficiency Virus (HIV) as an example.Method: A literature search was performed, and published cost

Cost-effectiveness of intradiscal injection with condoliase versus microendoscopic discectomy for lumbar disc herniation: a retrospective multicenter study.

Intradiscal condoliase injection has been described as a safe treatment with relatively favorable results. In Japan, the direct medical cost of intradiscal condoliase injection is significantly lower than that of microendoscopic discectomy (MED). The objective of this study was to assess the cost-effectiveness of condoliase injection compared to MED in patients with lumbar disc herniation (LDH). This retrospective study included patients who received either an intradiscal condoliase injection or MED for LDH at nine participating centers. Pretreatment magnetic resonance imaging revealed that th

Improvements in Quality-Adjusted Life Years and Cost-Utility After Pharmacotherapy for Premenstrual Dysphoric Disorder: A Retrospective Study.

BACKGROUND AND OBJECTIVE: To investigate the cost-effectiveness of pharmacotherapy for premenstrual dysphoric disorder (PMDD), a relatively … g mean EuroQoL-5D values. Direct costs per patient were estimated in order to conduct a preliminary cost-effectiveness analysis. RESULTS: Pharmacotherapy produced a 0.190-point increase in mean EuroQoL-5D score per menstrual cycle after 6 menstrual cycles and an improvement of approximately 0.2 QALYs. Based on direct costs of 156,000 yen per patient, the cost-effectiveness …

Cost and cost-effectiveness of treatments for rheumatic heart disease in low- and middle-income countries: a systematic review protocol.

OBJECTIVE: This review will synthesize studies on costs, the impact of these costs, and the cost-effectiveness of treatments for rheumatic h … National Health Service Economic Evaluation Databases, Pediatric Economic Database Evaluation, and Cost-Effectiveness Analysis Registry. Two independent reviewers will screen titles and abstracts, followed by a full-text review based on the inclusion criteria. Data will be extracted using a modified JBI data extraction form for economic evaluations. JBI's Dominance Ranking …

Cost-effectiveness of Diagnostic Algorithms for Tuberculosis in Children Less Than 5 Years of Age.

BACKGROUND: The objective of this analysis was to assess the cost-effectiveness of TB diagnosis using microscopic observation drug susceptibility (MODS), Xpert MTB/RIF (Xpert) and empiric treatment for all patients, in addition to current clinical diagnostic practices in children less than 5 years of age in a national tuberculosis (TB) referral hospital in Uganda. METHODS: A decision analysis was conducted from the healthcare perspective, with a primary outcome of incremental cost-effectiveness expressed as cost per year of life gained (YLG). RESULTS: Cost-effectiveness of the algorithms dep

The cost-effectiveness of immediate treatment or watch and wait with deferred chemotherapy for advanced asymptomatic follicular lymphoma.

Recent evidence has shown that immediate treatment with rituximab induction, with and without maintenance, substantially reduces the need for further treatment in patients with advanced asymptomatic follicular lymphoma. This analysis estimates the cost-effectiveness of immediate treatment approaches in comparison to a watch and wait approach from the perspective of the UK National Health Service. A Markov decision model was developed to estimate the cost-effectiveness of treatment strategies in patients with asymptomatic follicular lymphoma. The model was populated using effectiveness data fro

Cost-effectiveness of yoga vs. strengthening exercise for treating knee OA: Evidence from a randomized controlled trial.

OBJECTIVE: This study aims to evaluate the cost-effectiveness of yoga vs. strengthening exercise for people with knee OA. METHODS: A cost-utility analysis was conducted alongside a randomized controlled trial. Participants with symptomatic knee OA were randomized to 12 weeks of yoga or strengthening exercise. Costs were assessed from both societal and healthcare perspectives, including healthcare utilization, intervention delivery, medications, equipment, transport, and productivity losses. Health-related quality of life was measured using the EQ-5D-5L to calculate quality-adjusted life years

Impact of an expanded male catch-up HPV vaccination program on the clinical and economic burden of HPV-associated diseases in Denmark: a modeling study.

BACKGROUND: Denmark's publicly funded routine HPV vaccination program has included boys born from 2005 onward, leaving earlier birth cohorts of young men potentially unprotected. METHODS: A published deterministic dynamic transmission metapopulation model was adapted to evaluate the impacts of a 3-year male catch-up vaccination program on the cases, deaths, and costs of HPV-associated diseases in Denmark over a 100-year time horizon. Routine gender-neutral HPV vaccination of adolescents with a nonavalent vaccine was modeled with and without a male catch-up program, at 4 catch-up vaccination c

Cost Effectiveness of Cognitive Behavioral Therapy for the Treatment of Subjective Tinnitus in Australia.

OBJECTIVES: The aim of this study was to conduct an economic evaluation for the treatment of subjective tinnitus using different modalities of cognitive behavioral therapy (CBT) in Australia. DESIGN: A decision tree model was used to conduct a cost-utility analysis for CBT to determine the cost effectiveness for tinnitus treatments, in terms of cost per responder and cost per quality-adjusted life-year (QALY), from a health system perspective using a 2-year time horizon. Meta-analysis was used to differentiate the levels of effectiveness between three delivery methods for CBT: individual face

Cost-Effectiveness of Colchicine Prophylaxis for Gout Flares When Commencing Allopurinol.

OBJECTIVE: Colchicine prophylaxis to prevent gout flares when commencing urate-lowering therapy is recommended by international rheumatology society guidelines. Whether this is a cost-effective intervention is currently unknown. Our objective was to perform a cost-effectiveness analysis using both a US cost input model and an Australian cost input model. METHODS: This cost-effectiveness analysis was completed from the point of view of the third-party payer. We used a 2-arm decision tree with 1 arm commencing allopurinol with no colchicine prophylaxis and the other with colchicine prophylaxis.…

Экономическая оценка развертывания Волбачии для борьбы с денге во Вьетнаме.

ВВЕДЕНИЕ: " Денге " является одной из основных проблем в области здравоохранения и растущей проблемой, обусловленной изменением климата. Выпуск комаров Aedes aegypti, инфицированных внутриклеточной бактерией Wolbachia, является новой формой борьбы с переносчиками денге. Вместе с тем по-прежнему существует необходимость в широкомасштабной оценке преимуществ такого вмешательства. В настоящем документе мы оцениваем потенциальные экономические последствия и экономическую эффективность масштабного развертывания вулбачии в качестве одной из форм контроля за денге во Вьетнаме в наиболее тяж

Cost-Effectiveness of Midazolam Versus Haloperidol Versus Olanzapine for the Management of Acute Agitation in the Accident and Emergency Department.

OBJECTIVES: A multicenter randomized clinical trial in Hong Kong Accident and Emergency (A&E) departments concluded that intramuscular (IM) … ial conducted in Hong Kong A&E departments between December 2014 and September 2019. A within-trial cost-effectiveness analysis comparing the 3 sedatives was conducted, from the A&E perspective and a within-trial time horizon, using a decision-analytic model. Sensitivity analyses were also undertaken. RESULTS: In the base-case analysis, median total management costs associa …

The Economic Model of Retinopathy of Prematurity (EcROP) Screening and Treatment: Mexico and the United States.

PURPOSE: To describe an economic (Ec) model for estimating the impact of screening and treatment for retinopathy of prematurity (ROP). DESIGN: EcROP is a cost-effectiveness, cost-utility, and cost-benefit analysis. METHODS: We surveyed caregivers of 52 children at schools for the blind or pediatric eye clinics in Atlanta, Georgia and 43 in Mexico City. A decision analytic model with sensitivity analysis determined the incremental cost-effectiveness (primary outcome) and incremental monetary benefit (secondary outcome) of an ideal (100% screening) national ROP program as compared to estimates

Исследование экономической эффективности, рентабельности и рентабельности в области ревматологии: обзор литературы, 2001-2002 годы.

Экономический анализ мероприятий по профилактике и лечению в области ревматологии является потенциально мощным инструментом для оценки многих сложных решений, с которыми сталкиваются клинические и государственные директивные органы. Анализ эффективности затрат, рентабельности и затрат и выгод позволяет оценить компромиссы между расходуемыми ресурсами и ожидаемыми выгодами для здоровья. В настоящем обзоре содержится описание 12 анализов эффективности затрат, проведенных в прошлом году. Каждый из них связан с различными видами рематологических заболеваний, включая остеопороз, ревматоидный артрит

Совпадение в аннотации оригинала
Economic analyses of prevention and treatment interventions in rheumatology are potentially powerful tools for evaluating many complex decis … d arthritis have been presented at national meetings, these have yet to be published. Proper use of cost-effectiveness analysis could provide valuable evidence about treatment decisions for clinical and public policy makers in rheumatology.

Protons in head-and-neck cancer: bridging the gap of evidence.

PURPOSE: To use Normal Tissue Complication Probability (NTCP) models and comparative planning studies to explore the (cost-)effectiveness of … ve (0.967 QALYs) and less expensive (€8218) and thus dominated IMPT for all patients. CONCLUSIONS: Cost-effectiveness analysis based on normal tissue complication probability models and planning studies proved feasible and informative and enables the analysis of individualized strategies. The increased effectiveness of IMPT does not seem to outweigh the higher costs for all …

Subcutaneous methotrexate for treating rheumatoid arthritis in Portugal: a cost-utility analysis versus current practice.

AIMS: This study evaluated the cost-utility of subcutaneous versus oral methotrexate for rheumatoid arthritis (RA) management in Portugal. METHODS: A cost-utility analysis (CUA) was conducted over a lifetime horizon from the Portuguese National Health Service perspective, adapting a model previously published for the United Kingdom. Patients were modelled to transition through lines of therapy including conventional synthetic, followed by biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs). In the base case, first-line subcutaneous methotrexate was compared with fi

Cost-effectiveness of concurrently available oral and long-acting injectable pre-exposure prophylaxis for preventing HIV infections among men who have sex with men in eastern China: A modelling study.

BACKGROUND: China faces a growing HIV burden among men who have sex with men (MSM), yet uptake of pre-exposure prophylaxis (PrEP) remains low. Long-acting injectable cabotegravir (CAB-LA) may improve prevention effectiveness, but its economic value in China remains uncertain. METHODS: We developed a risk-stratified dynamic compartmental model incorporating HIV natural history, diagnosis, ART, and both transmitted and acquired drug resistance. Model parameters were calibrated to published surveillance data in Zhejiang and Jiangsu Province from 2009 to 2019. Assuming zero PrEP coverage in 2025,