Результаты поиска

Multidisciplinary supportive care in systemic light chain amyloidosis.

The immunoglobulin light-chain amyloidosis is a multisystemic disease which manifests by damage to the vital organs by light chain-derived amyloid fibril. Traditionally, the treatment has been directed to the underlying plasma cell clone with or without high dose chemotherapy followed by autologous stem cell transplantation using melphalan based conditioning. Now with the approval of highly tolerable anti-CD38 monoclonal antibody daratumumab based anti-plasma cell therapy in 2021, high rates of hematologic complete responses are possible even in patients who are otherwise deemed not a candidat

Совпадение в полном тексте источника
… Clot stabilization for mucosal bleeds is achieved using tranexamic acid. Of note, both tranexamic acid and recombinant factor VIIa are associated with increased risk of thrombosis and therefore, the risk of thrombosis should be discussed with patients and clinical team. …

Cell salvage for the management of postpartum haemorrhage.

RATIONALE: Postpartum haemorrhage (PPH), defined as a blood loss of 500 mL or more within 24 hours of birth, is the leading global cause of … e estimated blood loss, blood loss ≥ 500 mL, blood loss ≥ 1000 mL, use of additional uterotonics or tranexamic acid, maternal death, postpartum haemoglobin concentration, change in haemoglobin, major surgery including hysterectomy, future major surgery, end-organ dysfunction or failure, amniotic fluid embolism, side effects, clotting abnormalities, maternal exper …

Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis.

BACKGROUND: Heavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the … uded medical interventions were: non-steroidal anti-inflammatory drugs (NSAIDs), antifibrinolytics (tranexamic acid), combined oral contraceptives (COC), combined vaginal ring (CVR), long-cycle and luteal oral progestogens, LNG-IUS, ethamsylate and danazol (included to provide indirect evidence), which were compared to placebo. Surgical interventions were: open ( …

FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.

In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-threatening pneumonia in the Hubei province, China, and has now spread worldwide, causing a pandemic. The urgent need to control the disease, combined with the lack of specific and effective treatment modalities, call for the use of FDA-approved agents that have shown efficacy against similar pathogens. Chloroquine, remdesivir, lopinavir/ritonavir or ribavirin have all been successful in inhibiting SARS-CoV-2 in vitro. The initial results of a number of clinical trials involving various protocols of administr

Совпадение в полном тексте источника
… combined with azithromycin + hydroxychloroquine Tocilizumab | NCT04331795 | 50 | - Tocilizumab | NCT04330638 | 342 | compared with anakinra and siltuximab; combined with anakinra and siltuximab Tocilizumab | NCT04320615 | 330 | - Tofacitinib | NCT04332042 | 50 | - Tradipitant | NCT04326426 | 300 | - Tranexamic … acid | NCT04338126 | 60 | - Tranexamic acid | NCT04338074 | 100 | - Tranilast | ChiCTR20000 30002 | 60 | compared to standard treatment Triazavirin | ChiCTR20000 30001 | 240 | compared to standard treatment Ulinastatin | ChiCTR20000 30779 | 100 | compared to standard treatment Umifenovir | ChiCTR20000 …

Non-infectious pulmonary complications after haematopoietic progenitor transplantation: a diagnostic approach.

Haematopoietic stem cell transplantation (HCT) is an established treatment for a wide variety of haematological diseases, both malignant and non-malignant. Infectious and non-infectious post-HCT pulmonary complications are a major cause of morbidity and mortality, with non-infectious complications becoming more prominent in recent decades as prophylaxis has led to a decrease in infectious complications. Globally, these complications can be divided into three phases (neutropenic, early and late phase) depending on their time of onset in relation to the graft. There is a growing awareness that t

Совпадение в полном тексте источника
… Entity | Time post-HCT | Diagnosis | Management | Prognosis DAH | <30 days post-HCT | CT infiltrates + hypoxia + >20% BAL hemosiderophages | Steroids, tranexamic acid, recombinant factor VIIa | 80–100% mortality PERDS | <30 days post-HCT (4–5 days post pmn reconstitution) | CT infiltrates + respiratory …

Women with Gaucher Disease.

Gaucher disease is an inherited disorder in which there is a deficiency of the enzyme glucocerebrosidase, which leads to the accumulation of glucosylceramide. Although much scientific evidence is now available, there is still limited data on the impact on the different life stages of women with this disease. Among other alterations, a delay in menarche has been described, although it has not been related to fertility problems. Menorrhagia is relatively frequent, being related to the presence of thrombocytopenia, thrombocytopathies or coagulation disorders. On the other hand, pregnancy planning

Совпадение в полном тексте источника
… There is little evidence on the management of hemostatic coverage in these patients, and the recommendations established for pregnant patients with congenital or acquired alterations of hemostasis are generally applied, mainly using tranexamic acid for situations of low bleeding risk and platelet transfusion …

Aspirin Versus LMWH for Thromboprophylaxis Following Hip or Knee Arthroplasty-Clinical Implications and Budget Impact.

Venous thromboembolism (VTE) remains a significant concern for patients undergoing hip or knee arthroplasty, with a need to balance effective thromboprophylaxis and bleeding risk. We aimed to compare the efficacy, safety, and budget impact of aspirin versus low-molecular-weight heparin (LMWH) as sole thromboprophylactic agents initiated immediately postoperatively in this population. First, we conducted a systematic review of randomized controlled trials (RCTs) from Ovid MEDLINE, Embase, and Cochrane CENTRAL databases, assessing clinical outcomes and healthcare costs. Subsequently, a simplifie

Совпадение в полном тексте источника
… acid. … Q., “Effectiveness of Different Antithrombotic Agents in Combination With Tranexamic Acid for Venous Thromboembolism Prophylaxis and Blood Management After Total Knee Replacement: A Prospective Randomized Study,” BMC Musculoskeletal Disorders 24, no. 1 (2023): 5. 22. Westrich G. …

Pre-clinical Research on Bladder Toxicity After Radiotherapy for Pelvic Cancers: State-of-the Art and Challenges.

Despite the dramatic advancements in pelvic radiotherapy, urinary toxicity remains a significant side-effect. The assessment of clinico-dosimetric predictors of radiation cystitis (RC) based on clinical data has improved substantially over the last decade; however, a thorough understanding of the physiopathogenetic mechanisms underlying the onset of RC, with its variegated acute and late urinary symptoms, is still largely lacking, and data from pre-clinical research is still limited. The aim of this review is to provide an overview of the main open issues and, ideally, to help investigators in

Совпадение в полном тексте источника
… acid, used to inhibit fibrinolysis and prevent clot urinary retention in patients with hemorragic cystitis ( 95 ). … Radioprotective agents Clinical management of RC : • Systemic treatments (e.g., anticholinergic agents and β3-adrenergic receptor agonists, TCDO, SPP, tranexamic acid): non-invasive and circumvent inpatient hospital admission; these therapies suffer from a very low efficacy, often accompanied by dose-dependent …

Corticosteroid Therapy for Diffuse Alveolar Hemorrhage with Respiratory Failure in Hematologic Malignancies: A Retrospective Cohort Study.

BackgroundAlthough DAH in hematopoietic stem cell transplantation recipients is commonly treated with systemic corticosteroids, the efficacy of steroid therapy on DAH with respiratory failure in hematologic malignancy patients has not been studied. We aimed to investigate the effectiveness of steroid therapy in hematologic malignancy patients who developed DAH with respiratory failure and required treatment in the intensive care unit (ICU).MethodsAmong DAH patients with leukemia, lymphoma, or multiple myeloma, those who were not admitted to the ICU were excluded. Included patients were classif

Effects of combinations of diagnostic and treatment strategies for postpartum haemorrhage: a network meta-analysis.

RATIONALE: Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide. The combination of accurate diagnosis and effectiv … mL plus abnormal observations, or 3. blood loss ≥ 500 mL) plus MOTIVE (uterine Massage, Oxytocics, Tranexamic acid, IntraVenous fluids, and Examination and Escalation of care) treatment bundle; 2-option trigger PPH diagnosis with calibrated drape (1. clinical concern, or 2. blood loss ≥ 500 mL) plus MOTIVE treatment bundle; calibrated drape-based diagnosis plus …

Assessing Pain and Functional Outcomes of Percutaneous Stabilization of Metastatic Pelvic Lesions via Photodynamic Nails: A Bi-Institutional Investigation of Orthopaedic Outcomes.

BackgroundMinimally invasive surgical interventions for metastatic invasion of the pelvis have become more prevalent and varied. Our group hypothesized that the use of percutaneous photodynamic nails (PDNs) would result in decreased pain, improved functional outcomes and level of ambulation, and decreased use of opioid pain medication.MethodsWe performed a retrospective chart review of patients with metastatic pelvic bone disease undergoing stabilization with PDNs (IlluminOss Medical) at 2 institutions. Functional outcome measures assessed include the Combined Pain and Ambulatory Function (CPA

Совпадение в полном тексте источника
… Additional measures. such as preoperative embolization and the use of tranexamic acid, can help to further mitigate blood loss. Finally, the surgeons involved in the cases experienced a learning curve when performing the procedure. …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

Совпадение в полном тексте источника
… Under phase 1 and 2 of clinical trials [ 13 ] Dexamethasone Steroid Anti-inflammatory action Under phase 4 of clinical trials [ 13 ] Piclidenoson A3 adenosine receptor agonist Inhibit cytokine storm Under phase 2 of clinical trials [ 13 ] Tranexamic acid Antifibrinolytics Inhibit conversion of plasminogen … acid | Antifibrinolytics | Inhibit conversion of plasminogen to plasmin | Under phase 2 of clinical trials | [ 13 ] BLD-2660 | Antiviral | Targets IL6 | Under phase 2 of clinical trials | [ 13 ] Sildenafil citrate | Phospho-diesterase inhibitor | Dilates blood vessles | Under phase 3 of clinical trials …

Is There a Role for Bismuth in Diarrhea Management?

Diarrhea, an illness of both the developed and developing world, involves the burdensome characteristics of frequent bowel movements, loose stools, and abdominal discomfort. Diarrhea is a long-standing challenge in palliative care and can have a myriad of causes, making symptomatic treatment pertinent when illness evaluation is ongoing, when there is no definitive treatment approach, or when effective treatment cannot be attained. Symptomatic therapy is a common approach in palliative care settings. Bismuth is a suitable agent for symptomatic therapy and can be effectively employed for managem

Совпадение в полном тексте источника
… Her medications included ferrous fumarate, proton pump inhibitors, hydromorphone, and tranexamic acid. The patient’s behavior shifted daily with restlessness and agitation frequently observed, which appeared to be related to BM frequency. …

Haematological Diseases in the Tropics

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems.

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. The tumor microenvironment plays a crucial role in multiple myeloma pathogenesis, progression, and drug resistance. Traditional two-dimensional cell culture models have been instrumental in multiple myeloma research. However, they fail to recapitulate the complex in vivo bone marrow microenvironment, leading to limited predictive value for clinical outcomes. Three-dimensional cell culture models emerged as more physiologically relevant systems, offering enhanced insigh

Совпадение в полном тексте источника
… Fibrin gels were created from plasma obtained from fresh or frozen peripheral venous blood in the presence of calcium chloride and tranexamic acid for the culture of U266 cells in 3D structures [ 53 , 54 ]. … In fact, researchers achieved optimal gel formation by using 1 mg/mL of calcium chloride and 5 mg/mL of tranexamic acid, thus producing stable and consistent fibrin matrices. …

Гематологические маньяки маскируются как ревматологические заболевания: серия дел и обзор.

RATALE: Гематологическая недостаточность может имитировать ревматологические заболевания, создавая серьезную диагностическую проблему из-за перекрывающихся клинических особенностей. В настоящем исследовании подчеркивается 5 - случаи гематологических маньяков, представляющих собой ревматологические расстройства, и обсуждаются связанные с этим диагностические сложности. БОЛЕЕ ТРУДЯЩИЕСЯ: 64 в адрес 78, с различными рематологическими симптомами, включая полиартрит, васкулит, явление Рейно, и такими систематическими симптомами, как потеря веса, усталость и ночной пот. В ходе первоначальной эксперт

Совпадение в полном тексте источника
… Initial treatment included intravenous (IV) methylprednisolone (1 g daily for 3 days), IV immunoglobulin (2 g/kg), tranexamic acid 10mg/kg, and 16 platelet transfusions. …

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Options include antifibrinolytic agents (tranexamic acid), 5 days nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., mefenamic acid and celecoxib), 5–7 days, hormonal treatment (20–30 µg EE COCs or estrogen), short course. …

Preoperative embolization versus local hemostatic agents in surgery of hypervascular spinal tumors.

BackgroundCurrently, there is no consensus about how to reduce the intraoperative risk of hemorrhage in spinal decompression surgery of hypervascular spinal tumors, such as aggressive hemangioma, multiple myeloma, plasmacytoma, metastasis of renal cell carcinoma.MethodsA retrospective study of 110 patients, operated in our institute was held in the period between 2003 and 2013. There were 69 male and 41 female patients with extradural hypervascular spinal tumor. The study included 61 patients with metastasis of renal cell carcinoma, 27 with multiple myeloma, 15 with plasmacytoma and 7 with agg

Совпадение в полном тексте источника
… Measures routinely used to minimise blood loss include the assessment and correction of coagulopathy; the use of antifibrinolytic drugs, such as tranexamic acid; prevention of hypothermia; intraoperative ligation of feeding vessels; the use of bipolar electrocautery. 1 , 5 The diagnosis of spinal tumors …

Периоперативные соображения для пациентов с множественной миеломой.

Множественная миелома — неизлечимый рак, характеризующийся распространением клональных плазменных клеток, в основном в костном мозге, но вызывающий широкомасштабные системные осложнения. Кроме того, этот рак обычно встречается у пожилых пациентов, которые часто являются слабыми и страдают от многочисленных коморбидов. Общемировая распространенность множественной миеломы неуклонно возрастает, а терапевтические достижения способствуют повышению уровня выживания. Существует несколько осложнений миеломы, о которых анестезиолог должен знать в связи с самим заболеванием, конкретными и подкрепляющими

Разнообразие по признаку пола 90-Day Послеоперационные осложнения у пациентов с анемической атропластикой.

Первичная анемия представляет собой фактор риска для неблагоприятных последствий после полной артропопластики (THA), что в непропорционально большой степени сказывается на женщинах и способствует заболеваемости. Хотя как анемия, так и пол независимо связаны с постоперационными осложнениями, лишь в немногих исследованиях анализировались результаты у анемических пациентов, стратифицированных по признаку пола. По сравнению с этим исследованием 90-day Коэффициент осложнений послеоперационного периода между анемическими пациентами мужского пола и анемическими пациентами женского пола, проходящими п

Совпадение в полном тексте источника
… Surgical approach, implant type, operative time, anesthesia type, perioperative blood management (including tranexamic acid use), thromboprophylaxis, and discharge disposition are not captured within TriNetX, limiting adjustment for perioperative management differences. …