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[Chinese expert consensus on diagnosis and treatment of high risk multiple myeloma (2024)].

High-risk multiple myeloma (HRMM) refers to patients with multiple myeloma whose overall survival time is less than 2-3 years under current standardized diagnosis and treatment. By combining various static and dynamic prognostic factors, risk stratification is performed to identify HRMM patients early and treat patients with personalized strategies, with the aim of significantly improving adverse survival outcomes in HRMM patients. Although the clinical value of HRMM has reached a consensus domestically in recent years, there still exist confusions and ambiguities in the definition, high-risk

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… 23 2456 2464 10.1182/blood-2018-06-858613 30249784 PMC6284215 11 Kumar S Paiva B Anderson KC International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma[J] Lancet Oncol 2016 17 8 e328 e346 10.1016/S1470-2045(16)30206-6 27511158 12 Diamond …

Ixazomib, Lenalidomide и Dexamethasone (IRD) Лечение с цитогенетическим обслуживанием на основе риска в Трансплантационной миеломе: фазы 2 Мультицентральное исследование, проведенное Исследовательской группой Северной Европы по миеломе.

Имеются скудные данные о двойном обслуживании недавно диагностированных пациентов с высокой степенью риска при пересадке (РЧ) с несколькими миеломой (НДММ). Это будущее фазы 2 зачисленные в учебные заведения 120 Пациенты NDMM, отвечающие требованиям трансплантации. Лечение состояло из: four Циклы впрыскивания ixazomib-lenalidomide-dexamethason (IRD) плюс аутологическая трансплантация стволовых клеток, за которыми следуют консолидация IRD и цитогенетическая психотерапия на основе цитогенетического риска с использованием линалидомида + ixazomib (IR) только для пациентов HR и линалидомида (R) для

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… Diamond B.T., Rustad E., Maclachlan K., Thoren K., Ho C., Roshal M., Ulaner G.A., Landgren C.O. Defining the undetectable: The current landscape of minimal residual disease assessment in multiple myeloma and goals for future clarity. Blood Rev. 2021;46:100732. doi: 10.1016/j.blre.2020.100732. 11. …

Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.

PurposeStudy purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n = 112) and determine which characteristics were associated with worse PF.MethodsBalance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. Hierarchical linear modeling was used to assess inter-individual variability in the trajectories of the three tests. Demographic, clinical, and symptom characteristics, and levels of cognitive function ass

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… Diamond A Executive functions Annu Rev Psychol 2013 64 135 168 10.1146/annurev-psych-113011-143750 23020641 PMC4084861 44. …

Cost-Effectiveness of Post-Autotransplant Lenalidomide in Persons with Multiple Myeloma.

Considerable data indicate post-transplant lenalidomide prolongs progression-free survival and probably survival after an autotransplant for multiple myeloma (MM). However, optimal therapy duration is unknown, controversial and differs in the EU and US. We compared outcomes and cost-effectiveness of 3 post-transplant lenalidomide strategies in EU and US settings: (1) none; (2) until failure; and (3) 2-year fixed duration. We used a Markov decision model, which included six health states and informed by published data. The model estimated the lenalidomide strategy given to failure achieved 1.06

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… Diamond B, Mclachlan K, Chung DJ, et al. Maintenance therapy and need for cessation studies in multiple myeloma: focus on the future. Best Pract Res Clin Hematol. 2002;33(1):101140. doi: 10.1016/j.beha.2020.101140. 9. Mian I, Milton DR, Shah N, et al. …

Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.

The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients' outcomes. We have con

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… Observed (denoted by square, diamonds and triangles points) and predicted (denoted by solid line) prognosis curves for the PDAC patients according to (a) univariate o and (b) multivariate Cox's proportional hazard model analysis. …

Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans.

Glycosphingolipids (GSLs) are composed of hydrophobic ceramide and hydrophilic sugar chains. GSLs cluster to form membrane microdomains (lipid rafts) on plasma membranes, along with several kinds of transducer molecules, including Src family kinases and small G proteins. However, GSL-mediated biological functions remain unclear. Lactosylceramide (LacCer, CDw17) is highly expressed on the plasma membranes of human phagocytes and mediates several immunological and inflammatory reactions, including phagocytosis, chemotaxis, and superoxide generation. LacCer forms membrane microdomains with the Sr

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… Guillain-Barré syndrome and anti-ganglioside antibodies: a clinician-scientist's journey Proceedings of the Japan Academy—Series B: Physical and Biological Sciences 2012 88 7 299 326 10.2183/pjab.88.299 2-s2.0-84867034919 PMC3422685 22850724 92 Diamond B. Honig G. Mader S. Brimberg L. Volpe B. T. …

The Multiple Roles of Microrna-223 in Regulating Bone Metabolism.

Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this rev

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… Diamond M.P. Azziz R. Chen Y.-H. MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue J. Diabetes Res. 2015 2015 1 8 10.1155/2015/943659 26273679 PMC4530273 31. Rangrez A.Y. Massy Z.A. Metzinger-Le Meuth V. …

Воздействие средств АИ, основанных на крупных языковых моделях, на физиологические и пациентские связи: систематический обзор и мета-анализ.

Недавний прогресс в крупных языковых моделях (МЖЛ), таких, как GPT-3/4 :: стимулировали развитие болтовн искусственного интеллекта (AI) и консультативных инструментов в области медицины. Эти системы предназначены для оказания помощи или расширения коммуникации между врачом и пациентом, что может способствовать улучшению сочувствия, ясности и реагирования. Однако их фактическое воздействие на результаты коммуникационной деятельности остается неопределенным.2020-2025) оценка того, каким образом принимаемые на базе ЛЛД меры влияют на общение между врачом и пациентом, включая сочувствие, ясность,

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… Squares denote study-specific SMDs with 95% CIs (size proportional to inverse-variance weight); the diamond shows the pooled effect. LLM: large language model; SMD: standardized mean difference [ 10 , 14 , 15 , 18 ]. …

Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis.

BackgroundExercise has been shown to facilitate cognitive function; however, data on changes in cognitive function in response to exercise interventions among breast cancer patients and survivors, who frequently experience cognitive impairment, have not been comprehensively synthesized. Therefore, this study aims to examine the impact of exercise interventions on cognitive function among breast cancer patients and survivors.MethodsElectronic databases including PubMed, Scopus, and Web of Science were searched from inception to December 25, 2024. A three-level meta-analysis was performed in R u

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… Diamond A. Executive functions. Annu Rev Psychol. 2013;64:135–68. 38. Levine MD. Differences in learning and neurodevelopmental function in school-age children. Developmental-behavioral pediatrics. Elsevier; 2009. p. 535–46. 39. …

Сексуальные и гендерные аспекты в миелоиде и лимфоболическом лейкемии и множественной миеломе: от молекулярных механизмов к клиническим результатам.

Биологические и гендерные факторы оказывают значительное влияние на патогенез, прогресс и реакцию на гематологическое заболевание. В настоящем всеобъемлющем обзоре рассматриваются различия по признаку пола в острой миелоидной лейкемии, острой лимфоболической лейкемии, хронической миэлоидной лейкемии и множественной миеломе на основе систематического анализа рецензируемой литературы, опубликованной между 2014-2024 и идентифицировался с помощью структурированного поиска баз данных PubMed, Web of Science и MedLINE. Эпидемиологические данные свидетельствуют о более высокой частотности заболеваний

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… Genetic predisposition to hematopoietic malignancies is associated with various inherited mutations [ 22 ], like the X-linked GATA1 gene, which is essential for proper development of erythrocytes and megakaryocytes: it can harbor mutations that lead to diseases such as Diamond–Blackfan anemia and transient …

Оценка раннего вмешательства в клинические испытания миеломы: систематический обзор.

КОЛИЧЕСТВО: Множественная миелома (ШМ), асимптоматическая прекурсорка множественной миеломы (ММ), сопряжена с различным риском продвижения к ММ. Существует мало консенсуса в отношении эффективности или оптимального времени лечения в рамках SMM. Мы систематически анализировали ландшафт всех клинических испытаний в ШММ. Мы сравнили эффективность методов лечения, изученных в рамках SMM, с результатами этих режимов, когда они использовались в недавно диагностированных миеломах (NDMM), с тем чтобы определить, свидетельствуют ли данные о более глубоких реакциях в рамках SMM и NDMM.МЕТОДЫ: Все возмож

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… Landgren O , Hultcrantz M , Diamond B , et al . Safety and effectiveness of weekly carfilzomib, lenalidomide, dexamethasone, and daratumumab combination therapy for patients with newly diagnosed multiple myeloma . …

Ось MLKLOPTN регулирует вызванные герпесвирусом неврологические сиквелы.

КОЛИЧЕСТВО: герпес просторексовый вирус-1 (HSV-1) носит пожизненный характер и связан с неврологическими заболеваниями, такими, как множественный склероз (MS), однако основные механизмы в хосте остаются недостаточно понятными. МЕТОДЫ И РЕЗУЛЬТАТЫ: В настоящем исследовании изучается новая молекулярная динамика после заражения HSV-1, выявляется ключевая роль смешанного киназа-домена (MLKL). Помимо известной функции в некроптозе, было установлено, что MLKL контролирует перенос HSV-1 в ядро, жестко регулируемый Оптинёрином (Optineurin). Мы продемонстрировали существенное нормативное взаимодействие

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… Slides were washed three more times in PBST then mounted with ProLong Diamond Antifade Mountant (Invitrogen), sealed with clear nail polish, then visualised by fluorescence microscopy. For immunohistochemistry, the anti‐goat HRP‐DAB Cell and Tissue Staining Kit (R&D systems) was used. …

Rice Bran Arabinoxylan Compound and Quality of Life (RBAC-QoL) of Cancer Patients: An Interim Analysis of the RBAC-QoL Study.

Background The effect of rice bran arabinoxylan compound (RBAC), a plant-based immunomodulator, on the quality of life (QoL) in cancer patients and underlying physiological pathways remains unclear. Trial design The RBAC-QoL study, a double-blind, randomised, controlled pilot feasibility study, aimed to determine RBAC's effects on QoL and the associated action mechanisms. Primary outcomes were the EORTC QLQ-C30 functional, symptom, and global QoL scores with inflammatory, nutritional, and cytokine parameters as secondary and exploratory outcomes. Methods Participants were adults diagnosed with

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… Golombick T, Diamond TH, Manoharan A, Ramakrishna R. Integr Cancer Ther. 2016;15:183–189. doi: 10.1177/1534735416635742. 22. Effect of long-term administration of immunomodulatory food on cancer patients completing conventional treatments. …

Design and Rationale of Prolonged Nightly Fasting for Multiple Myeloma Prevention (PROFAST): Protocol for a Randomized Controlled Pilot Trial.

BACKGROUND: Obesity is an established, modifiable risk factor of multiple myeloma (MM); yet, no lifestyle interventions are routinely recommended for patients with overweight or obesity with MM precursor conditions. Prolonged nightly fasting is a simple, practical dietary regimen supported by research, suggesting that the synchronization of feeding-fasting timing with sleep-wake cycles favorably affects metabolic pathways implicated in MM. We describe the design and rationale of a randomized controlled pilot trial evaluating the efficacy of a regular, prolonged nighttime fasting schedule among

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… Golombick T, Diamond TH, Manoharan A, Ramakrishna R. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled cross-over 4g study and an open-label 8g extension study. …

The Health-Promoting Properties and Clinical Applications of Rice Bran Arabinoxylan Modified with Shiitake Mushroom Enzyme-A Narrative Review.

Rice bran arabinoxylan compound (RBAC) is derived from defatted rice bran hydrolyzed with Lentinus edodes mycelial enzyme. It has been marketed as a functional food and a nutraceutical with health-promoting properties. Some research has demonstrated this rice bran derivative to be a potent immunomodulator, which also possesses anti-inflammatory, antioxidant, and anti-angiogenic properties. To date, research on RBAC has predominantly focused on its immunomodulatory action and application as a complementary therapy for cancer. Nonetheless, the clinical applications of RBAC can extend beyond canc

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… Golombick T., Diamond T.H., Manoharan A., Ramakrishna R. …

Basket Trials for Intractable Cancer.

Currently, genomic characterization has become standard of care for tumor types such as non-small cell lung cancer, breast cancer, melanoma, and colorectal cancer. A deep understanding of genomic alterations in different tumor types would help identify potentially actionable genomic changes which occur across a wide variety of tumor types. A basket trial is a new type of clinical trial for which eligibility is based on the presence of a specific genomic alteration, irrespective of histology. Basket trials are phase II screening trials for the off-label use of a targeted drug in patients with t

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… Diamond EL, Subbiah V, Lockhart AC, Blay JY, Puzanov I, Chau I, et al. Vemurafenib for BRAF V600-mutant erdheim-chester disease and langerhans cell histiocytosis: analysis of data from the histology-independent, Phase 2, Open-label VE-BASKET Study. …

New agents in the Treatment of Myeloma Bone Disease.

Patients with multiple myeloma develop a devastating bone disease driven by the uncoupling of bone remodelling, excess osteoclastic bone resorption and diminished osteoblastic bone formation. The bone phenotype is typified by focal osteolytic lesions leading to pathological fractures, hypercalcaemia and other catastrophic bone events such as spinal cord compression. This causes bone pain, impaired functional status, decreased quality of life and increased mortality. Early in the disease, malignant plasma cells occupy a niche environment that encompasses their interaction with other key cellula

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… Diamond T, Levy S, Day P, Barbagallo S, Manoharan A, Kwan YK. Biochemical, histomorphometric and densitometric changes in patients with multiple myeloma: effects of glucocorticoid therapy and disease activity. Br J Haematol. 1997;97:641–648. doi: 10.1046/j.1365-2141.1997.1042920.x. 41. Tosi P. …

Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

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… A coarse diamond 3-mm bur is used to drill the medial pterygoid plate toward the middle cranial fossa. Drilling can proceed circumferentially around the vidian canal to reach the foramen lacerum; here, the vidian artery will be visualized as a branch from the anterior genu of the petrous ICA. …

Targeting FGFR for cancer therapy.

The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as a prominent therapeutic target. Here, we conduct a comprehensive review of the function, signaling pathways and abnormal alterations of FGFR, as well as its role in tumorigenesis and development. Additionally, we provide an in-depth analysis of pivotal phase 2 and 3 clinical trials evaluating the performance and safety of FGFR inhibitors in oncology, thereby shedding light on the current

Systemic lupus erythematosus: pathogenesis and targeted therapy.

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder characterized by dysregulated immune responses and autoantibody production, which affects multiple organs and varies in clinical presentation and disease severity. The development of SLE is intricate, encompassing dysregulation within the immune system, a collapse of immunological tolerance, genetic susceptibilities to the disease, and a variety of environmental factors that can act as triggers. This review provides a comprehensive discussion of the pathogenesis and treatment strategies of SLE and focuses on the progress