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Natural oils based nanoform of chlorantraniliprole for sustainable management of Helicoverpa armigera in tomato.

Chlorantraniliprole is an anthranilic diamide insecticide that has both contact and systemic action and is commonly used to manage lepidopteran pests. However, its natural hydrophobicity and poor solubility limit the creation of effective and eco-friendly formulations. In the current study, high energy ultra-sonication power was used to create natural oil-based and dimethyl sulfoxide (DMSO) based nanoemulsions, which were then compared to commercial suspension concentrate (SC) formulation of chlorantraniliprole. The natural oil-based nanoemulsion had a particle size of 98 nm and indicated high

Cardiovascular outcomes following intrauterine and lactational exposure to cyantraniliprole in male Wistar rats.

Cyantraniliprole, a systemic insecticide that modulates ryanodine receptors, may impact mammalian physiological systems. Due to its ability … d. These findings also, contribute to developmental risk assessment of ryanodine receptor-targeting insecticides.

Regulation of venom composition by the Australian funnel-web spider Hadronyche infensa is achieved via compartmentalised toxin production and venom metering.

The ability to regulate the composition of secreted venom has been demonstrated in an increasing number of taxa, including scorpions, centipedes, and assassin bugs. However, the extent to which this regulation occurs across venomous lineages, and how it is achieved remains largely unknown. Here, we investigate the ability of the lethal Australian funnel-web spider Hadronyche infensa to regulate the biochemical composition of its venom. Using a combination of transcriptome-guided mass spectrometry-based proteomic and peptidomic analyses of serial defensive venom secretions from multiple spiders

The role of CYP4Gs involved in hydrocarbon formation in the survival, reproduction, and pyrethroid resistance of Triatoma infestans, a major Chagas disease vector.

Very long-chain normal and branched hydrocarbons are essential for insect physiology and ecology. The final metabolic step of hydrocarbon formation involves an oxidative decarbonylation carried out by cytochrome P450 from family 4, subfamily G (CYP4G). Triatoma infestans Klug (Hemiptera: Reduviidae: Triatominae) has two CYP4G genes, named CYP4G106 and CYP4G107. In this study, we have silenced in T. infestans the expression of both genes by RNA interference in order to assess the relevance of hydrocarbons to survival, reproductive physiology, and insecticide susceptibility. Gene knockdown led t

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment.

Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging. A promising new strategy is drug-based vector control where drugs are administered to vector hosts (human/animal), which renders the host blood toxic to mosquitoes-thereby reducing mosquito lifespan, fecundity and onward transmission of pathogens. Afoxolaner, fluralaner, and lotilaner are isoxazoline derivatives widely used as systemic insecticides for ectoparasite…

Exploring the metabolic and cuticular mechanisms of increased pyrethroid resistance in Anopheles gambiae S.l populations from Ghana.

Increasing insecticide resistance in malaria vectors threatens the efficacy of current control tools, however knowledge of metabolic and cut … ites. Piperonyl butoxide significantly increased susceptibility to pyrethroids across all sites and insecticides, implicating P450s. Gene expression analysis revealed overexpression of metabolic and cuticular resistance genes in field An. gambiae populations compared to the susceptible Kisumu strain. CYP6M2 and CYP6P3 were the most overexpressed metabolic gene …

Identification and validation of ABCB transporter genes involved in chlorantraniliprole and emamectin benzoate tolerance in Spodoptera exigua.

Spodoptera exigua is a significant invasive pest that has developed resistance to various commonly applied insecticides. The detoxification of insecticides in insects may partially depend on ATP-binding cassette (ABC) transporters. Although the functions of ABCB subfamily genes are diverse in insects, the specific roles of ABCBs in S. exigua remain largely unexplored. This research focused on identifying ten SeABCB genes and characterizing their expression profiles across various developmental stages and tissues, as well as in response to different insecticide treatments. Our findings indicate…

Novel Meta-Diamide Derivatives Bearing Triazole: Design, Synthesis, and Bioactivity.

In searching for novel insecticide lead, 20 new meta-diamide compounds containing triazole were designed and synthesized regarding cyproflanilide as lead compound. All the compounds were characterized by 1H NMR, 13C NMR, and High-resolution mass spectra (HR MS). In preliminary bioassay, we found that one of the compounds: N-(cyclopropylmethyl)-N-(5-((2,6-dibromo-4-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)phenyl)carbamoyl)-2-(1H-1,2,4-triazol-1-yl)phenyl)-6-(trifluoromethyl) nicotinamide (16a) had high activity against the target organism Plutella xylostella at 1 mg/L and against the targe

Assessment of the efficacy of Piper methysticum (Micrembryeae: Piperaceae) as a bioinsecticide, and/or spinosad combined with attractive plant volatiles for a novel lure and kill strategy against Bactrocera tryoni (Diptera: Tephritidae) in laboratory.

The Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae), is a crop pest of global economic importance because of its wide range of hosts and its invasiveness capacities. To develop a novel integrated and sustainable crop protection, we have investigated the insecticidal properties of different varieties of kava (Piper methysticum [Frost]) extracted by two methods and the attractive effects of six plant volatiles identified from B. tryoni host plants to female, mated or not. We did not identify any significant insecticidal effect of the traditional Pacific kava plant at th

Plant-Derived Natural Products and Their Nano Transformation: A Sustainable Option Towards Desert Locust Infestations.

The desert locust has been recognized as the most devastating migratory pest in the world. Swarms of this pest have been threatening vast regions of pastures and crops in Africa, Middle East, and South Asia. The biological management of expanding swarms has become a strategy of particular interest due to environmental awareness and economic issues associated with chemical pesticides. The present review aims to explore the latest updates and information about pesticidal plants that are distributed across Africa. Searches on Web of Science, Google Scholar, PubMed, and Scopus databases from 2013-

Evaluation of diffuse reflectance spectroscopy for predicting age, species, and cuticular resistance of Anopheles gambiae s.l under laboratory conditions.

Mid-infrared spectroscopy (MIRS) combined with machine learning analysis has shown potential for quick and efficient identification of mosquito species and age groups. However, current technology to collect spectra is destructive to the sample and does not allow targeting specific tissues of the mosquito, limiting the identification of other important biological traits such as insecticide resistance. Here, we assessed the use of a non-destructive approach of MIRS for vector surveillance, micro diffuse reflectance spectroscopy (µDRIFT) using mosquito legs to identify species, age and cuticular

Model-based risk assessment of dengue fever transmission in Xiamen City, China.

BACKGROUND: Quantitative assessment of the risk of local transmission from imported dengue cases makes a great challenge to the development of public health in China. The purpose of this study is to observe the risk of mosquito-borne transmission in Xiamen City through ecological and insecticide resistance monitoring. Quantitative evaluation of mosquito insecticide resistance, community population and the number of imported cases affecting the transmission of dengue fever (DF) in Xiamen was carried out based on transmission dynamics model, so as to reveal the correlation between key risk facto

Fipronil impairs the GABAergic brain responses of Nile Tilapia during the transition from normoxia to acute hypoxia.

γ-aminobutyric acid (GABA) is one of the main neurotransmitters involved in the adaptation processes against the damage that hypoxia can cause to the brain. Due to its antagonist action on GABA receptors, the insecticide fipronil can turn the fish more susceptible to the negative effects of hypoxia. This study aimed to understand better if fipronil affects these GABAergic responses of Tilapia ahead to hypoxia. Oreochromis Niloticus (Nile Tilapia) were exposed for 3 and 8 h to fipronil (0.0, 0.1, and 0.5 µg.L-1 ) under normoxia (dissolved O2  > 6 mg.L-1 ) and moderate hypoxia (dissolved O2  < 2

Delivery and effectiveness of entomopathogenic fungi for mosquito and tick control: Current knowledge and research challenges.

Insects, ticks, and mites represent a threat to animal health globally, mainly due to their role as vectors of pathogens. Among the most important diseases, those transmitted by mosquitoes (e.g., malaria and arboviral infections) and ticks (e.g., Lyme borreliosis, babesiosis, and viral haemorrhagic fever) have a huge impact on human health. The principal methods available for reducing the public health burden of most vector-borne diseases are vector-based intervention relying to insecticides and acaricides. However, the use of these products is challenged by the introduction of invasive specie…

Control of Aedes albopictus Mosquito Larvae with Carpesium abrotanoides L.

As a vital vector of dengue fever, yellow fever, and other mosquito-borne diseases, Aedes albopictus (Diptera: Culicidae) can be broadly distributed worldwide and cause a severe threat to public health. To date, considering the fast-emerging insecticide resistance in the mosquito, the development of new botanical insecticides to control and reduce Ae. albopictus is urgent and crucial. Therefore, to investigate the decoction effect of the plant C. abrotanoides L. on mosquito larvae killing, we detected the mortality of larvae after treatment with different concentrations (60 mg/mL, 120 mg/mL, a…

Биохимическая характеристика Aedes aegypti (Linnaeus) (Diptera: Culicidae) резистентности к дельтаметрину, фипронилу и имидаклоприду.

Aedes aegypti — важный вектор лихорадки денге, геморрагической лихорадки денге и желтой лихорадки, чикунгунии и вируса Зика. Цель заключалась в оценке устойчивости А. аегипти к инсектицидам с различными режимами воздействия (дельтеметрин, имидаклоприд и фипронил) под интенсивным давлением отбора в течение 10 поколений в лаборатории. По данным Всемирной организации здравоохранения, биомассы проводились. Биохимический анализ, проведенный после отбора с помощью дельтаметрина (Delta-SEL), фипронила (Fipro-SEL) и имидаклоприда (Imida-SEL) от G1 до G10, использовался для оценки детоксикационных ферм

Совпадение в аннотации оригинала
Aedes aegypti is an important vector of dengue fever, dengue hemorrhagic fever and yellow fever, chikungunya, and Zika virus. The objective was to evaluate the resistance of A. aegypti exposed to insecticides with different action modes (deltamethrin, imidacloprid, and fipronil) under intense selection pressure for 10 generations in laboratory. Bioassays wer…

Cellular and molecular basis of IR3535 perception in Drosophila.

BACKGROUND: IR3535 is among the most widely used synthetic insect repellents, particularly for the mitigation of mosquito-borne diseases suc … the molecular sensors elucidated herein could be used as targets for the development of alternative insecticides. © 2021 Society of Chemical Industry.

Cytotoxic effects on the midgut, hypopharyngeal, glands and brain of Apis mellifera honey bee workers exposed to chronic concentrations of lambda-cyhalothrin.

The honeybee, Apis mellifera is economically important for its products (honey, wax, and propolis) and for its role in pollination. This insect is threated due to high population losses in both agriculture and beekeeping. Within causes involved in the loss of honeybees is the increased pesticide use on agriculture. Although current testing for the regularization of insecticide use considers its acute toxic effects on pollinators, little is known about the effects of chronic exposure to sublethal concentrations that may persist in the environment. This study investigated the effect of chronic e