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CYP17A1 gene polymorphisms and environmental exposure to organochlorine pesticides contribute to the risk of small for gestational age.

OBJECTIVES: The cytochrome P-450c17α enzyme encoded by the cytochrome P-450c17α (CYP17A1) gene plays a role in oestrogen synthesis. Genetic … d OCP levels were considered, a significant (p=0.004) association was found between a high level of endosulfan in cord blood and the A1A1 (wild-type) genotype of CYP17A1, leading to an estimated reduction in birth weight of 315g. CONCLUSIONS: Higher OCP levels and the A1A1 genotype of CYP17A1 in pregnant women may be considered as important aetiological fac …

Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils.

As a free-living nematode, C. elegans is exposed to various pesticides used in agriculture, as well as to persistent organic residues which … ese, like dichlorvos, induced multiple stress genes in a concentration-dependent manner. Unusually, endosulfan induced only one gene (cyp-34A9) to very high levels (8-10-fold) even at the lowest test concentration, with a clear plateau at higher doses. Other pesticides, like diuron, did not alter reporter gene expression detectably even at the highest test c …

Widespread occurrence of pesticides in low-income housing.

BACKGROUND: Low socioeconomic status (SES) residents living in social housing, which is subsidized by government or government-funded agenci … ed maximum total air (particle plus gas phase) concentration of 443,000 pg/m3. Heptachlor, lindane, endosulfan I, chlorothalonil, allethrin, and permethrin (except in one study) had higher concentrations than those measured in low-income residences reported elsewhere. In addition to the intentional use of pesticides to control pests and their use in building …

Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization.

Environmental chemicals are thought to adversely affect human reproductive function, however there are no studies that have explored the ass … amples of follicular fluid whereas cotinine was detected in 18 (85.7%). Residue levels of p,p'-DDE, endosulfan I, PCB 99, PCB 138, PCB 153, PCB 180 were quantified in more than 50% of the sera samples examined. Seminal plasma was relatively free of pollutants with mirex being the most frequently detected contaminant found in seven of 21 (33.3%) samples. Mire …

Pesticide usage pattern in tea ecosystem, their retrospects and alternative measures.

Tea is a perennial plantation crop grown under monoculture providing favorable conditions for a variety of pests. The concept of pest contro … ase. Thus, over reliance on pesticides end up with pesticide residue in made tea (DDT - 10.4-47.1%; endosulfan - 41.1-98.0%; dicofol- 0.0-82.4%; ethion - 0.0-36.2%; cypermethrin - 6.0- 45.1%). The growing concern about the pesticide residue in made tea, its toxicity hazards to consumers, the spiraling cost of pesticides and their application have necessitate …

Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium.

The human population in the industrialized world is ubiquitously exposed to complex mixtures of persistent pollutants that contaminate food, … obenzene [HCB], tetrachlorodibenzo-p-dioxin [TCDD], polychlorinated biphenyls [PCBs], methoxychlor, endosulfan, heptachlor, hexachlorocyclohexane, dieldrin, aldrin, mirex, and several chlorinated benzenes, and metal contaminants [lead, cadmium]). The doses of the mixture that were administered were related to minimum risk levels or tolerable daily intakes of …

Influence of pollen feeding and physiological condition on pesticide sensitivity of the honey bee Apis mellifera carnica.

In two consecutive years heavy bee mortality at end April/early May followed the use of pesticides classed as harmless for bees along road v … ur tests raised doubts however about the registration as harmless for bees of insecticides based on Endosulfan and Phosalon. Of interest in practice and for the official testing of pesticides are also the high pesticide sensitivity of old winter bees, the decrease in sensitivity of bees on a stable feed from early to late summer, and the sensitivity-reducing …

Determination of pesticide residues in foods by acetonitrile extraction and partitioning with magnesium sulfate: collaborative study.

A collaborative study was conducted to determine multiple pesticide residues in fruits and vegetables using a quick, simple, inexpensive, an … lonil, 70 (34); chlorpyrifos, 89 (25); cyprodinil, 89 (19); o,p'-DDD, 89 (18); dichlorvos, 82 (21); endosulfan sulfate, 80 (27); imazalil, 77 (33); imidacloprid, 96 (16); linuron, 89 (19); methamidophos, 87 (17); methomyl, 96 (17); procymidone, 91 (20); pymetrozine, 69 (19); tebuconazole, 89 (15); tolylfluanid (in grapes and oranges), 68 (33); and triflurali …

Persistent organic pollutants and metals in the freshwater biota of the Canadian Subarctic and Arctic: an overview.

Over 1999-2002, an extensive series of contaminant studies was conducted on freshwater biota of Canada's Arctic and Subarctic regions. The m … icularly SigmaHCH and Sigmachlordane, which may reflect a response to declining atmospheric inputs. Endosulfan concentrations increased, as in the atmosphere. There also was evidence of declining OC concentrations in burbot in the Slave and Mackenzie rivers but not in Great Slave Lake and Yukon lakes. OC concentrations decreased in lake trout in Yukon lakes …

Persistent organic pollutants and mercury in marine biota of the Canadian Arctic: an overview of spatial and temporal trends.

This review summarizes and synthesizes the significant amount of data which was generated on mercury (Hg) and persistent organic pollutants … ss than half the levels of the 1970s, particularly in seabirds and ringed seals. Chlorobenzenes and endosulfan were among the few OCs to show increases during this period while summation operatorHCH remained relatively constant in most species. A suite of new-use chemicals previously unreported in Arctic biota (e.g., polybrominated diphenyl ethers (PBDEs), s …

Chemical contaminants, health indicators, and reproductive biomarker responses in fish from the Colorado River and its tributaries.

Common carp (Cyprinus carpio), black bass (Micropterus spp.), and channel catfish (Ictalurus punctatus) were collected from 14 sites in the … these two sites but did not exceed toxicity thresholds. Currently used pesticides such as Dacthal, endosulfan, gamma-HCH, and methoxychlor were also greatest in fish from the Gila River downstream of Phoenix. Total polychlorinated biphenyls (PCBs; >0.11 microg/g ww) and TCDD-EQs (>5 pg/g ww) exceeded wildlife guidelines in fish from the Gila River at Phoeni …

Study of Liposomes Containing Extract from the Leaves of Protium heptaphyllum (Aubl.) March in Animals Submitted to a Mutagenic Model Induced by Cyclophosphamide.

Cyclophosphamide (CPA) is an alkylating agent used as a chemotherapy agent in the treatment of cancer, but it has immunosuppressive effects. Protium heptaphyllum (P. heptaphyllum) is a plant rich in triterpenes and flavonoids, with some bioactive and therapeutic properties presented in the literature. Thus, the present study aimed to investigate the chemoprotective potential of P. heptaphyllum extract inserted into liposomes against oxidative damage chemically induced by CPA. Male Swiss mice received 1.5 mg/kg of P. heptaphyllum liposomes as a pre-treatment for 14 consecutive days (via gavage)

Совпадение в полном тексте источника
… DNA damage and oxidative stress induced by endosulfan exposure in zebrafish (Danio rerio) Ecotoxicology. 2012;21:1533–1540. doi: 10.1007/s10646-012-0907-2. 60. Abbas K., Batool U., Abdul S.M., Sana S. Estresse oxidativo: Uma espada de dois gumes. …

Diseases of the Nervous System

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Emergency Care

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