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Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseases.

Janus kinase inhibitors (JAKi) have undergone three decades of research and development, demonstrating substantial therapeutic efficacy and broad clinical applicability in autoimmune diseases, inflammatory disorders, hematopoietic malignancies, and a spectrum of rare diseases. However, their research and development are constrained by three key challenges: the difficulty in target selection and safety concerns arising from their effects on cellular signaling pathways, as well as the challenges in formulating optimal dosing regimens due to interindividual variability in pharmacokinetics. In thi

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… Y-axis lists immune mediated inflammatory disease indications using abbreviations, including LP, SSc, SjS, Pemphigoid, PBC, JIA, PsA, SLE, CSA, RA, GVHD, HS, MS, UC, VKH, IgG4 AD, AO, AA, Vitiligo, Pem, Eczema, PG, RA, SLE, AS, Myas, SS, axSpA, MPR, CD, Osteoarthritis, T1DM, MG, Hyperimmunity, KD, EGPA … Y-axis lists immune mediated inflammatory disease indications using abbreviations, including LP, SSc, SjS, Pemphigoid, PBC, JIA, PsA, SLE, CSA, RA, GVHD, HS, MS, UC, VKH, IgG4 AD, AO, AA, Vitiligo, Pem, Eczema, PG, RA, SLE, AS, Myas, SS, axSpA, MPR, CD, Osteoarthritis, T1DM, MG, Hyperimmunity, KD, EGPA …

Биоинформатический анализ взаимодействия миелинов и микробов говорит о том, что в патогенезе множественных склерозов присутствуют различные виды молекулярной имитации.

Множественный склероз (MS) — разрушительная аутоиммунная болезнь, приводящая к разрушению милиновой оболочки в центральной нервной системе человека (КНС). Было установлено, что инфекция вирусов и бактерий тесно связана с наступлением мороза или его остротой. Мы предположили, что атака иммунной системы на милиновую оболочку может быть спровоцирована вирусами и бактериальными антигенами, которые напоминают компоненты миелиновой оболочки. Для выявления вирусных и бактериальных антигенов, похожих на миелин олигодендроцит гликпротеин (МОГ) и миелинский основной протеин (МБП), был применен подход, о

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… Results obtained from the first group (EBNA1 , MAP_0106 , MBP) | HLA-DRB 1 : 15 : 01 Score Organism | Sequence information | Protein name Aspergillus fumigatus (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 818 | PGRRPRGDSLSRSPS | 832 | Pre-mRNA-splicing factor cwc22 | 97 Klebsiella pneumoniae …

Melatonin: Facts, Extrapolations and Clinical Trials.

Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, the focus has changed from investigating its natural role as a transducer of biological time for physiological systems to hypothesized roles in virtually all clinical conditions. This goes along with the appearance of extensive literature claiming the (generally) positive benefits of high doses of melatonin in animal models and various clinical situations that would not be receptor-mediated. Based on the assumption that melatonin is safe, high doses have been a

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… Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya Proc. Natl. Acad. Sci. USA 2014 111 314 319 10.1073/pnas.1312634110 24351931 PMC3890824 7. Cassone V.M. …

Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment.

Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This re

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… Laopaiboon M, Panpanich R, Swa Mya K. Azithromycin for acute lower respiratory tract infections. Cochrane Database Syst Rev. 2015;2015(3):CD001954–CD001954. doi: 10.1002/14651858.CD001954.pub4. 94. Lode H, Borner K, Koeppe P, Schaberg T. …

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy.

Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor microenvironment, dysregulation of amino acid consumption in immune cells is an important underlying mechanism leading to impaired anti-tumor immunity. Emerging studies have revealed that altered amino acid metabolism is tightly linked to tumor outgrowth, metastasis, and therapeutic resistance through governing the fate of various immune cells. During these processes, the concentration of free amino acids, their membrane bound tr

Pleuropulmonary Changes Induced by Drugs in Patients with Hematologic Diseases

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Bone Research Society 2021 Abstracts

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… The impact of adiposity and lean mass on bone health and metabolic profile in Asian women of reproductive age Mya Thway Tint 1,2 , Andrea Cremaschi 1 , Jerry Kok Yen Chan 3 , Lyenette Pei Chi Shek 2 , Peter Gluckman 4 , Yap‐Seng Chong 1,2 , Keith Godfrey 5 , David Cameron‐Smith 1 , Maria De lorio 1,2 …

2026 Приложение к резюме Международного конгресса

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Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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ISEV2020 Резюме

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Serum Mycophenolic Acid Levels and Infection Risk in Myasthenia Gravis.

INTRODUCTION/AIMS: Evidence linking serum mycophenolic acid (MPA) concentrations with safety outcomes in myasthenia gravis (MG) is limited. We evaluated whether single serum MPA concentrations were associated with clinically documented infection. METHODS: This retrospective study included acetylcholine receptor antibody-positive MG patients treated with mycophenolate mofetil (MMF) for at least 1 year who had MPA and mycophenolic acid glucuronide (MPAG) measurement with same-day complete blood count testing. Exact sampling time relative to MMF dosing was not uniformly documented; therefore, va…

When Weakness Persists Beyond Its Apparent Cause: A Case Report of Myasthenia Gravis.

Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterised by fluctuating, fatigable skeletal muscle weakness. Its overlap with reversible causes of weakness such as hypokalemia can easily delay recognition. We report the case of a 40-year-old man who presented with one week of profuse diarrhea and vomiting, along with two days of generalized limb weakness. Investigations revealed hypokalemia and hypomagnesemia, and his limb weakness partially improved after fluid and electrolyte correction, which raised suspicion of an additional underlying cause contributing…

Spectrum, management, and outcomes of non-obstetric neurological disorders in pregnancy: a descriptive case series from a tertiary centre in India.

BACKGROUND: Neurological disorders unrelated to obstetric pathology are an under-recognised cause of maternal morbidity in pregnancy, partic … le short-term outcomes, although preterm birth was common. One neonate developed transient neonatal myasthenia gravis. CONCLUSIONS: This case series "Spectrum, management, and outcomes of non-obstetric neurological disorders in pregnancy: a descriptive case series from a tertiary centre in India"describes non-obstetric neurological disorders in pregn …

Therapeutic Plasma Exchange in Pediatric Patients: A Multi-Institutional Landscape Analysis.

Pediatric evidence for therapeutic plasma exchange (TPE) is largely small, single-center cohorts; there is no prior large-scale age-stratifi … splant rejection (6%), acute disseminated encephalomyelitis (5%), Guillain-Barré syndrome (5%), and myasthenia gravis (4%); nonspecific diagnosis codes were each individually more prevalent than any single ASFA-mapped indication. This is the first large-scale, age-stratified, multi-institutional characterization of pediatric TPE. We identified an inve …

Clinical study of eculizumab with or with not tacrolimus in the treatment of generalized myasthenia gravis.

INTRODUCTION: Eculizumab, an antibody that inhibits the complement system, and the immunosuppressant Tacrolimus are both authorized for treating patients with generalized myasthenia gravis (GMG). This study seeks to evaluate and compare the clinical effectiveness of Eculizumab with or with not Tacrolimus in the treatment of generalized myasthenia gravis. METHODS: A retrospective study was performed involving 95 patients with GMG treated with Eculizumab at three hospitals in China. Among them, 80 patients were included in the analysis: 57 received Eculizumab alone, while 23 were treated with a…

The effect of FcRn inhibition on overlapping autoimmune comorbidity in AChR-seropositive generalized myasthenia gravis.

INTRODUCTION: Generalized Myasthenia gravis (gMG) is a rare autoimmune disorder of the neuromuscular junction caused by IgG autoantibodies against antigens in the postsynaptic cleft. This study aimed to assess the real-world effectiveness and safety of Efgartigimod (EFG) in AChR-positive gMG with overlapping autoimmune comorbidity. METHODS: EFG was administered as 4 consecutive weekly infusions or injections. Myasthenia Gravis Activity of Daily Living (MG-ADL) and Myasthenia Gravis quantitative (QMG) scales were administered at baseline and after 4 weeks. Clinical data on autoimmune comorbidi…