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Impact of COVID-19 on Orthopaedic and Trauma Service: An Epidemiological Study.

BACKGROUND: Coronavirus disease 2019 (COVID-19) has caused substantial disruptions to orthopaedic and trauma services. The purpose of the present study was to quantify its impact on surgical volume, hospitalizations, clinic appointments, and accident and emergency attendances to guide staffing and resource deployment for the sustenance of emergency services. METHODS: Data were retrieved from all 43 Hong Kong public hospitals and 122 outpatient clinics from a population of 7.5 million residents. The "COVID-19 cohort" of patients who received treatment from January 25 to March 27, 2020, was com…

Communal farmers' perceptions of tick-borne diseases affecting cattle and investigation of tick control methods practiced in Zimbabwe.

Tick borne diseases (TBDs) are responsible for huge economic losses in cattle production in most African countries where the majority of cattle owners are the resource poor communal farmers. Governments have initiated and co-ordinate tick control programs with farmers required to contribute funds for their sustenance. The success of these programs will hinge upon the involvement of communal farmers in their design, implementation and evaluation. To this end, 313 communal farmers (approximately 8.4% response rate) were interviewed and 3 focus group discussions were carried out in the southern l…

Regional endocardial mapping of spontaneous and induced atrial fibrillation in patients with heart disease and refractory atrial fibrillation.

We performed simultaneous catheter mapping of right and left atrial regions at onset and during sustenance of spontaneous atrial fibrillation (AF) in patients with ischemic and/or hypertensive heart disease. Seventeen patients with structural heart disease had spontaneous and electrically induced AF episodes mapped from their onset simultaneously in multiple right and left atrial regions. Atrial premature complexes (APCs) that initiated spontaneous AF had coupling intervals ranging from 260 to 400 ms (mean 332 +/- 61), most commonly arising from the lateral right atrium (31%), right atrioventr…

Energy optimization and plant comfort management in smart greenhouses using the artificial bee colony algorithm.

Agriculture is an essential component of human sustenance in this world. These days, with a growing population, we must significantly increase agricultural productivity to meet demand. Agriculture moved toward technologies as a result of the demand for higher yields with less resources. Increasing awareness of the significance and influence of agricultural practices in global climate change has made the use of energy-efficient innovations a vital aspect of the agriculture sector. The use of greenhouses to provide controlled environments that encourage effective plant growth is one of the curre…

Progress on Sustainable Development Goal indicators in 707 districts of India: a quantitative mid-line assessment using the National Family Health Surveys, 2016 and 2021.

BACKGROUND: India has committed itself to accomplishing the Sustainable Development Goals (SDGs) by 2030. Meeting these goals would require … at this time will help India ensure success with regards to meeting the SDGs. India's emergence and sustenance as a leading economic power depends on meeting some of the more basic health and social determinants of health-related SDGs in an immediate and equitable manner. FUNDING: This work was funded by the Bill and Melinda Gates Foundation, INV-002992.

Effects of health system limitations on the use of blood culture and sensitivity testing in Kenyan county hospitals: an interview-based qualitative study using causal loop diagrams.

BACKGROUND: There is evidence of rapidly growing resistance to antibiotics across Africa. We aimed to establish whether blood culture and se … hospital management, and scarcity of refresher training opportunities, hinder the availability and sustenance of BCS testing. The CLDs show that these multiple factors can create mutually reinforcing feedback loops that undermine efforts to provide BCS testing in hospitals. INTERPRETATION: The findings suggest that sustainable and routine provision of BCS …

Feasibility for evaluation of the efficacy of conventional ventilatory support in very low birth weight infants.

Morbidity and mortality analysis in prematurely born low birth weight (LBW) neonates, very low birth weight (VLBW) neonates and extremely lo … at fluctuations in OI values reflecting the breakdown in oxygenation at the high price paid for its sustenance in the nonsurvivors group whereas the mean airway pressure showed a gradual decrease in the survivors group and allowed early weaning from mechanical ventilation. (A-a)DO2 remained high in the non-survivors group thus reflecting a high-degree, pract …

Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias.

UNLABELLED: Sudden cardiac death (SCD) is a major complication of obesity, yet it remains unclear whether early metabolic stress, prior to t … celerated repolarization. Together, impaired conduction and action potential shortening promoted VT sustenance in HFD-fed AMPK-deficient hearts. CONCLUSIONS: Our findings identify AMPK as a key metabolic regulator that integrates redox balance, mitochondrial integrity, and protein homeostasis to preserve cardiac excitability during early nutrient overload. …

Evaluating the Impact of the HeartHab App on Motivation, Physical Activity, Quality of Life, and Risk Factors of Coronary Artery Disease Patients: Multidisciplinary Crossover Study.

BACKGROUND: Telerehabilitation approaches have been successful in supporting coronary artery disease (CAD) patients to rehabilitate at home after hospital-based rehabilitation. However, on completing a telerehabilitation program, the effects are not sustained beyond the intervention period because of the lack of lifestyle adaptations. Furthermore, decline in patients' motivation lead to recurrence of disease and increased rehospitalization rates. We developed HeartHab, using persuasive design principles and personalization, to enable sustenance of rehabilitation effects beyond the intervention…

Is There a Relationship Between Social Health and Musculoskeletal Discomfort and Incapability? A Systematic Review.

BACKGROUND: The notable and consistent evidence that musculoskeletal symptom intensity varies according to thoughts and feelings as much or more so than pathophysiologic factors has firmly established the importance of comprehensive, biopsychosocial, whole-person health strategies in orthopaedic surgery. A systematic review of existing knowledge of the role of social health factors (defined as security in relationships, roles, finances, housing, and sustenance) as sources of variation in levels of musculoskeletal discomfort and incapability could further inform the development and disseminatio…

A single-center 7-year experience with end-stage renal disease care in Nigeria-a surrogate for the poor state of ESRD care in Nigeria and other sub-saharan african countries: advocacy for a global fund for ESRD care program in sub-saharan african countries.

Background. A single-center ESRD care experience in a Nigerian teaching hospital is presented as a surrogate case to demonstrate the prevailing ESRD care situation in Nigeria and most SSA countries. Methods. The data of 320 consecutive ESRD patients undergoing maintenance haemodialysis treatment during a seven-year period were retrospectively analyzed. Results. Over 80% of the subjects funded dialysis treatments from direct out of pocket payment. The mean duration on dialysis before dropout was 5.2 ± 7.6 weeks, with majority 314 (98.1%) of the patients unable to sustain dialysis above 12 weeks

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… The annual estimate of government expenditure for ESRD care in developed countries also justifies this as the “US government spent about $12.04 billion in annual Medicare spending on ESRD in 1998, not including an additional out-of Medicare $4.7 billion spending by employer group health plan for the sustenance …

Алекситимия и привязанность к психическому здоровью людей с множественным склерозом: посредническая роль воспринимаемой социальной поддержки и одиночества.

Множественный склероз и его прогрессивный релапсирующий характер для пациентов с НР сопряжены с трудностями и оказывают значительное воздействие на психическое здоровье людей с НР. Мы изучили прямое воздействие алекситимии и привязанности на психическое здоровье и косвенное воздействие привязанности, алекситимии, одиночества и воспринимаемой социальной поддержки на психическое здоровье людей с MS. МАТЕРИАЛЫ И МЕТОДЫ: Триста сорок пять диагностированных множественных склерозов (MS) были признаны приемлемыми для включения в исследование и отобраны через Иранскую ассоциацию MS. К числу таких мер

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… identify emotions like happiness, sadness, anger, and fear.[ 15 ] Interpersonal difficulties associated with alexithymia can be reflected in underlying attachment issues, and during the stage of adulthood, alexithymic individuals exhibit an insecure attachment approach that hinders the establishment and sustenance …

Serum stromal cell-derived factor 1α as a prognostic indicator in elderly patients with acute myeloid leukemia receiving CAG-based chemotherapy.

BackgroundStromal-cell-derived factor 1 (SDF-1) plays a crucial role in hematopoiesis and has been implicated in acute myeloid leukemia (AML) pathogenesis. Understanding its relationship with chemotherapy outcomes could lead to improved therapeutic approaches for elderly AML patients.MethodsThis study retrospectively analyzed the medical records of elderly AML patients (n = 187) and compared serum SDF-1α levels with age-matched controls (n = 120). Patients received CAG (cytarabine, aclarubicin, and G-CSF)-based chemotherapy, and serum SDF-1α levels were assessed using ELISA.ResultsSerum SDF-1α

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… CXCR4 and its ligand, SDF-1, constitute a critical axis in AML, involved in the navigation and maintenance of leukemia cells within the bone marrow niche, a sanctuary that offers protection and sustenance to both malignant and healthy hematopoietic stem cells. …

The contributions of family care-givers at end of life: A national post-bereavement census survey of cancer carers' hours of care and expenditures.

BackgroundFamily members provide vital care at end of life, enabling patients to remain at home. Such informal care contributes significantly to the economy while supporting patients' preferences and government policy. However, the value of care-givers' contributions is often underestimated or overlooked in evaluations. Without information on the activities and expenditures involved in informal care-giving, it is impossible to provide an accurate assessment of carers' contribution to end-of-life care.AimThe aim of this study was to investigate the contributions and expenditure of informal, fam

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… For example, to provide care 50.6% incurred costs travelling, 44.6% spent money on sustenance while they were doing this and 25.1% spent money on medical equipment and care supplies in addition to those supplied by the National Health Service. …

Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer.

Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising molecular target in gastric cancer. We demonstrate significant overexpression of XPO1 in a cohort of histologically diverse gastric cancer patients with primary and metastatic disease. XPO1 RNA interference suppressed gastric cancer cell growth. Anti-tumor activity was observed with specific inhibitor of nuclear export (SINE) compounds (selinexor/XPOVIO), second-generation comp

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… In this report, we demonstrate the critical role of XPO1 in gastric cancer sustenance using diverse sub-types of patient tissues, in in vitro cellular models, 3D models as well as an in vivo xenograft model. …

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising fibroblasts, cells of the immune system, and endothelial cells, besides various soluble secretory factors from all cellular components (including tumor cells). The TME forms a pro-tumorigenic cocoon around the tumor cells where reprogramming of the metabolism occurs in tumor and non-tumor cells that underlies the nature of interactions as well as competitions ensuring steady supply of nutrients and anapleoretic molecules for the tumor cells that fuels its growth even under hypoxic conditions. This metabolic reprogram

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… The M1 macrophages, providing protection against bacterial infection, depends principally on glycolysis for ATP generation but the M2 macrophages, populating the sites of healing wounds, utilize the FAO and oxidative phosphorylation for their sustenance ( 138 ) and does not compete with the tumor cells … Thus, lipid biogenesis not only ensures the sustenance of the ETC/ATP production but also maintains the high glycolytic flux in the TME. …

Sp3 улучшила экспериментальный аутоиммунный энцефаломиэлит, спровоцировав Socs3 в клетках Th17.

ВВЕДЕНИЕ: Хотя считается, что хронические подстрекательские и дегенеративные заболевания центральной нервной системы поддерживаются аутоиммунными клетками ТТ17, основополагающие механизмы остаются в основном неисследованными. Недавние исследования и наши исследования показали, что Sp3 был заблокирован в нескольких склерозах (MS) и экспериментальном аутоиммунном энцефаломиелите (EAE). Вместе с тем остается неясным, почему в нем ничего не говорится и как он регулирует дифференциацию клеток TH17 в MS. ЦЕЛИ: Данное исследование было направлено на изучение воздействия Сп3 на ТХ17 в клетках EAE и ле

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… Accommodated and provided sustenance in a controlled environment free of specific pathogens at either the animal facility of Guangdong Pharmaceutical University (Guangzhou, China) or the Experimental Animal Center of Tianjin Medical University (Tianjin, China). …

Targeting KRAS in NSCLC: Old Failures and New Options for "Non-G12c" Patients.

Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) gene mutations are among the most common driver alterations in non-small cell lung cancer (NSCLC). Despite their high frequency, valid treatment options are still lacking, mainly due to an intrinsic complexity of both the protein structure and the downstream pathway. The increasing knowledge about different mutation subtypes and co-mutations has paved the way to several promising therapeutic strategies. Despite the best results so far having been obtained in patients harbouring KRAS exon 2 p.G12C mutation, even the treatment landscape of non-p.

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… This high glycolytic phenotype is responsible of increased autophagy that enables KRAS-mutated cells to obtain metabolites for cellular sustenance and proliferation. …

Воспаление меняет миэлоидную клетку и олигодендроглиевую железную погрузку при множественном склерозе.

Изменения в уровнях мозгового железа являются последовательной особенностью множественного склероза (MS) на протяжении его курса болезни. Они включают в себя потерю железа в олигодендроцитах в милинных областях мозга и накопление железа в миелиоидных клетках на так называемых парамагнитных ободах хронических активных повреждений. Здесь мы исследуем механизмы, лежащие в основе этого общего перехода железа от олигодендроцитов (ОИ) к миэлоидным клеткам (МК) и потери полного ирона мозга в MS. Мы провели расследование в отношении различных импортеров и экспортеров железа, применив иммунохистохимию

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… Thus, we suggest that iron rim sustenance is a sign of ongoing BBB-disturbance, with IFN-γ induced, heme-ingesting MCs facilitating blood iron scavenging [ 87 , 88 ]. The transcriptional response of MG to iron loading is highly context dependent. …

The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease.

The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid metabolism in providing the fuel necessary for the proper functioning of OBs. Among the amino acids, it has been reported that OBs are largely dependent on glutamine (Gln) for their differentiation and activity. In this review, we describe the main metabolic pathways governing OBs' fate and functio

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… Its function is to ensure the shape, protection, and sustenance of body structures and to facilitate locomotion [ 4 ]. …