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Some recent advances in the clinical aspects of multiple sclerosis.

UNLABELLED: Recent work on the clinical aspects of multiple sclerosis is reviewed with particular regard to symptomatology: New approaches to clinical symptoms and the identification of more subtle impairments are illustrated by recent studies of visual function in M.S. patients; pathophysiology: It is now widely appreciated that the dysfunction observed in patients is not determined solely by histologically demonstrable demyelination. The function of the demyelinated neuron is highly variable, being dependent upon factors which may change from day to day. Recent ideas about 'neuro-electric bl…

The syndrome of inappropriate antidiuretic hormone secretion in multiple sclerosis.

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS). Rapid symptomatic improvement occurred with correction of the hyponatremia. Although the pathophysiology responsible for development of the SIADH in this patient is unknown, CNS involvement by MS is a likely explanation.

Is multiple sclerosis an age-dependent host response to measles?

Several lines of evidence support the possibility that multiple sclerosis (M.S.) may be an age-dependent host response to measles. In animals, measles evokes different responses depending upon age at inoculation. In man, measles is already known to produce at least two age-dependent responses: risk of subacute sclerosing panencephalitis is increased among those who have had measles before 2 years of age and risk of measles encephalitis increases with age, at least during adolescence. Studies of immigrant populations indicate that an event at or before adolescence but not infancy affects risk o…

Measurement of cerebrospinal fluid IgG in the diagnosis of multiple sclerosis.

CSF IgG was measured in 190 patients by Single Radial Immunodiffusion, A high value for the ratio CSF IgG/total protein (normal values being up to 14%) was obtained in 13 of 22 patients (54%) with definite or probable multiple sclerosis and in 16 of 137 patients (12%) with other neurological disorders excluding acute infections, subarachnoid haemorrhage and neurosyphilis. In 56 patients IgG and albumin were measured in CSF and serum using Rocket Immunoelectrophoresis (Electroimmunodiffusion) and results assessed by dividing the radio IgG/albumin in the CSF by the same ratio in the serum to obt…

Multiple sclerosis in the Faroe Islands. 7. Results of a case control questionnaire with multiple controls.

Detailed questionnaires were completed in 1978-79 by 23 of the 28 then known resident Faroese multiple sclerosis (MS) patients and 127 controls. These controls were divided into 69 Group A (patient sibs and other relatives), 37 Group B (matched neighbor controls, their spouses and sibs, plus patient's spouse), and 21 Group C (distant matched controls, spouses, relatives living where MS patients never resided and British troops were not encamped during the war). No differences between cases and controls were found for education, occupation, types of residence, bathing, sanitary or drinking faci…

Management of Urinary Symptoms in Multiple Sclerosis: An Umbrella Review.

BACKGROUND: Lower urinary tract dysfunctions (LUTDs) are prevalent among patients with multiple sclerosis (MS), which is the most common immune-mediated neurologic disease among the juvenile population. This study aims to evaluate the efficacy and safety of different methods in the management of MS-related LUTD. METHODS: This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and Joanna Briggs Institute (JBI) methods. Systematic review studies that reported the efficacy of any management method for LUTD in MS are considered …

Sleep in caregivers of people with multiple sclerosis: A scoping review.

BACKGROUND: Informal caregivers of people with multiple sclerosis (MS) frequently provide long-term support, which can adversely affect their sleep. The extent, characteristics, and determinants of sleep problems in caregivers of people with MS remain poorly characterized. OBJECTIVES: The objective of this scoping review was to map the existing literature examining sleep issues among caregivers of people with MS. METHODS: A systematic search was conducted on PubMed, Cochrane, Embase/Ovid, PsycINFO, CINHAL, and Web of Science to find relevant studies. RESULTS: Of the 5036 studies screened, e…

Resident T cells in the healthy and multiple sclerosis brain.

Insights into T-cell biology in the central nervous system (CNS) have evolved from early neuroinflammatory models demonstrating the pathogen … rstanding of CNS immune surveillance and provide a framework for dissecting T-cell contributions to multiple sclerosis.

Degree and pattern of atrophy in multiple sclerosis - a systematic review.

INTRODUCTION: Prior research regarding multiple sclerosis (MS) has extensively examined the inflammatory processes, while the mechanisms of neurodegeneration, particularly cerebral atrophy, remain less understood. The purpose of this systematic review was to summarize the current knowledge about the degree and pattern of atrophy in various types of MS, and its relationship with the clinical progression of the disease and the impact of treatment on brain volume loss. MATERIAL AND METHODS: A systematic review was performed in accordance with the PRISMA guidelines. Relevant articles published be…

Discontinuation of ocrelizumab in multiple sclerosis: reoccurrence of disease activity.

BACKGROUND: The optimal strategy after discontinuation of B-cell depleting therapies like ocrelizumab in people with multiple sclerosis (pwMS) remains uncertain, particularly regarding delayed disease reactivation, disability progression and required treatment duration before cessation. METHODS: In this prospective two-centre observational cohort study with propensity score-matched (PSM) analysis, we evaluated recurrence of disease activity and disability worsening after ocrelizumab discontinuation. PwMS fulfilling the 2017 McDonald criteria were enrolled between January 2018 and December 202…

Реальный опыт использования озанимода у взрослых с множественной скlerозом.

AIM: Ozanimod — фингозин второго поколения. 1-phosphate Модулятор рецептора (S1PR), утвержденный для лечения повторного склероза (MS). Данные об использовании озанимодов в реальной клинической практике отсутствуют. Цель этого исследования состоит в том, чтобы определить характеристики людей, у которых MS (PwMS) предписан озанимод, а также стойкость, терпимость, безопасность и эффективность по отношению к ним. one Год. МЕТОДЫ: Ретроспективно собирались данные по взрослым с синдромом MS или клинически изолированным синдромом, которые получали озанимод two Высшие центры MS. Результаты: Мы определ

Совпадение в аннотации оригинала
AIM: Ozanimod is a second-generation sphingosine 1-phosphate receptor (S1PR) modulator approved for treatment of relapsing multiple sclerosis (MS). Data are lacking for ozanimod use in real-world clinical practice. This study aims to determine characteristics of people with MS (pwMS) prescribed ozanimod as well as ozanimod persistence, tolerability, safety, …

Mobile Health for Monitoring and Supporting Mobility in Multiple Sclerosis.

This review addresses the use of mHealth for monitoring and supporting mobility in people with multiple sclerosis (MS). We discuss its use for assessing free-living movement behaviors and identifying relevant physical activity metrics for monitoring decrements in real-world mobility in MS. We then provide a rationale for using these metrics to monitor MS progression and severity in the clinical setting.