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Percutaneous Balloon Kyphoplasty Vertebral Augmentation for Compression Fracture Due to Vertebral Metastasis: A 12-Month Retrospective Clinical Study in 72 Patients.

BACKGROUND Vertebral compression fracture is common in osteoporosis, but can also occur due to bone metastases, for which current treatment options are limited and include bone-strengthening with cement and supportive care. Kyphoplasty is a surgical method of bone augmentation that can reduce pain, stabilize vertebral bone, and restore some or all of the vertebral body height. The aim of this study was to investigate the clinical results of balloon kyphoplasty in the correction of vertebral deformity due to metastatic vertebral compression fracture. MATERIAL AND METHODS A retrospective clinica

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… Bed rest, analgesics, and the use of braces or corsets can be used in the conservative management of vertebral compression fractures. While non-surgical treatment may have limited effects, prolonged immobilization can also exacerbate osteoporosis and increase the risk of thromboembolic events. … rest, treatment with non-steroidal anti-inflammatory drugs (NSAIDs), or with supporting corsets or braces were included in the study. …

Individualized, Single Session Yoga Therapy to Reduce Physical and Emotional Symptoms in Hospitalized Hematological Cancer Patients.

Objective: Inpatient treatment of hematological cancer is among the most physically and mentally arduous cancer treatments, and it is associated with a number of common physical, emotional, and social symptoms that can negatively affect quality of life (QOL) for years following treatment. While treating symptoms during hospitalization holds promise for improving long-term QOL, successful approaches likely require multidisciplinary interventions. In this article, we describe a 4-year effort in program enhancement that incorporated an adjunctive single yoga therapy session during treatment for h

Design of the EXercise Intervention after Stem cell Transplantation (EXIST) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of an individualized high intensity physical exercise program on fitness and fatigue in patients with multiple myeloma or (non-) Hodgkin's lymphoma treated with high dose chemotherapy and autologous stem cell transplantation.

BACKGROUND: The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduced global quality of life, role and physical function. Physical exercise interventions may be beneficial for physical fitness, fatigue and quality of life. However, the trials conducted so far to test the effects of physical exercise interventions in this group of patients were of poor to moderate methodological quality and economic evaluations are lacking. Hence there is need

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… Cancer, its treatment and the associated bed rest can lead to poor physical fitness (a.o. impaired cardiorespiratory function and reduced muscle strength). … The muscle athrophy is likely to be even more pronounced in patients undergoing HDC and ASCT because of the nature of drugs being used (a.o. high dose glucocorticoids) [ 16 ], and because of the morbidity associated with the neutropenic phase after ASCT, which often leads to prolonged bed rest. …

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small-cell lung cancer.

BACKGROUND: The incidence of lung cancer is declining following a drop in smoking rates, but it is still the leading cause of death from cancer in England and Wales, with about 30,000 deaths a year. Survival rates for lung cancer are poor everywhere, but they appear to be better in the rest of the European Community and the USA than in the UK. Only about 5 per cent of people with lung cancer survive for 5 years, and nearly all of these are cured by surgery after fortuitously early diagnosis. At present, only a small proportion of patients (probably about 5 per cent) with non-small-cell lung ca

Balloon Kyphoplasty in the Treatment of Neoplastic Spine Lesions: A Systematic Review.

STUDY DESIGN: Systematic review. OBJECTIVES: To assess the efficacy of kyphoplasty in controlling pain and improving quality of life in oncologic patients with metastatic spinal disease and pathologic compression fractures of the spine. METHODS: A literature search through medical database was conducted (using PubMed, EMBASE, Cochrane, and LILACS) for randomized controlled trials comparing balloon kyphoplasty versus the traditional treatment for compression fractures of the spine due to metastatic disease. Two investigators independently assessed all titles and abstracts to select potential

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… However, these were observational studies and not clinical trials. 6 , 8 It seems that only one randomized controlled trial (RCT) compared balloon kyphoplasty with standard, nonsurgical management such as analgesic use, bed rest, radiation therapy, and orthoses, 9 reporting improved function and adequate … Patients with cancer and painful spine metastases will benefit from interventions that will decrease the need for pain medication and bed rest. …

Morbidity and Mortality: A Case Report of Metastatic Bone Disease.

Metastatic prostate cancer and multiple myeloma (MM) usually present with bone lesions, posing a diagnostic challenge in males presenting in late stages. In this case report, an 86-year-old male who had not seen a physician in over 30 years presented with complaints of hip pain and progressive difficulty in walking for three weeks. Outpatient X-ray of the right hip showed multiple lytic bone lesions, raising suspicion of MM. Other laboratory tests revealed elevated serum calcium and elevated prostate-specific antigen (PSA), supporting a diagnosis of prostate cancer. The patient was admitted fo

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… It was recommended by orthopedic surgeons that the patient be on bed rest indefinitely due to high fracture risk as a result of his bone frailty. The patient was given the option to proceed with bone marrow biopsy and appropriate treatment based on results. …

Audit of In-Hospital Mortality from a Medical Oncology and Hemato-Oncology Center with the Emphasis on Best Supportive Care.

Deepak SundriyalBackground and Objectives The newly established medical oncology and hemato-oncology center at the All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India, provided us an opportunity to audit in-hospital mortalities with a vision that the audit will serve as a standard for ceaseless improvement. Aim of the study was to initiate a vigorous process for the evaluation of all-cause mortality in patients suffering from cancer. Methods An audit of all in-hospital deaths that occurred during the year 2019 was performed, and comprehensive scrutiny of various para

Удобство, последовательность и эффективность одежды с текстильными электродами по сравнению с гидрогелевыми электродами для нейромускульной электрической стимуляции в ходе случайного перекрестного испытания.

Эффективность и комфортность нейромускульной электрической стимуляции (NMES) в значительной степени зависят от типа используемых электродов. Традиционные самоклеющиеся гидрогельные электроды, хотя и являются эффективными, создают ограничения с точки зрения износа, совместимости кожи и воспроизводимости. В ходе этого случайного перекрестного испытания изучается эффективность конкретного текстильного электрода, встроенного в одежду NMES нижних конечностей, с уделением особого внимания их потенциальному применению для реабилитации пациентов с неврологическими расстройствами, такими, как инсульт,

Patient Perceptions of CAR-T Therapy in the USA: Findings from In-Depth Interviews.

INTRODUCTION: Chimeric antigen receptor-T cell (CAR-T) therapy has revolutionized advanced blood cancer treatment. However, preparation, administration, and recovery from these therapies can be complex and burdensome to patients and their care partners. Utilization of an outpatient setting for CAR-T therapy administration could help improve convenience and quality of life. METHODS: In-depth qualitative interviews were conducted with 18 patients in the USA with relapsed/refractory multiple myeloma or relapsed/refractory diffuse large B-cell lymphoma, 10 of whom had completed investigational or

Outcomes of different minimally invasive surgical treatments for vertebral compression fractures: An observational study.

BackgroundOsteoporosis with vertebral compression fractures is increasingly common in the elderly population. Cement augmentation is one of the effective surgical treatments for these patients. Currently, there are several different types of cement augmentation treatments. No studies have compared the safety and efficacy of different cement augmentation types for the treatment of such fractures; thus, we retrospectively compared vertebroplasty, balloon kyphoplasty, and kyphoplasty with SpineJack or an intravertebral expandable pillar.AimTo compare the postoperative safety and efficacy of each

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… Conservative treatments include bed rest or activity modification, analgesics, and bracing; however, for most patients, conservative treatment is ineffective and unsatisfactory[ 5 ]. … The kyphotic change in spine alignment reduces the lung cavity and shifts the center of gravity forward; thus, for elderly patients, bed rest for long periods is associated with complications, such as pneumonia, urinary infections, and deep vein thrombosis[ 6 , 7 ]. …

Measuring Frailty Using Patient-Reported Outcomes (PRO) Data: A Feasibility Study in Patients with Multiple Myeloma.

PURPOSE: The objective of this retrospective study was to determine the feasibility of measuring frailty using patient responses to relevant EORTC QLQ-C30 items as proxy criteria for the Fried Frailty Phenotype, in a cohort of patients with Relapsed/Refractory Multiple Myeloma (RRMM). METHODS: Data were pooled from nine Phase III randomized clinical trials submitted to the FDA for regulatory review between 2010 and 2021, for the treatment of RRMM. Baseline EORTC QLQ-C30 responses were used to derive a patient-reported frailty phenotype (PRFP), based on the Fried definition of frailty. PRFP wa

The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges.

The frequency of chronic cutaneous wounds are sharply increasing in aging populations. Patients with age-related diseases, such as diabetes, tumors, renal failure and stroke are prone to soft tissue and skin injury, compounded by slowed healing in aging. Imbalance of wound inflammation, loss of growth factor secretion, and impairment of tissue repair abilities are all possible reasons for failed healing. Therefore, it is vital to explore novel approaches to accelerate wound healing. Platelet-rich plasma (PRP) as a cell therapy has been widely applied for tissue repair and regeneration. PRP pro

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… Patients with diabetes mellitus (DM), tumors and surgeries can experience soft tissue injury because of long-term bed rest and mobility problems ( Armstrong et al., 2017 ; Xu et al., 2022 ). … In 2010, Scevola et al. (2010) recruited 13 patients who suffered pressure sores because of prolonged bed rest secondary to spinal injuries. …

Множественная миелома: многострановое исследование по смешанным методам, касающимся восприятия заболеваний и предпочтений лечения пациентов.

AIMS: Уяснить представления о заболеваниях и предпочтениях лечения пациентов с высокой степенью риска, страдающих множественным миэломой (HR-SMM) или множественной миэломой (MM), которая недавно прошла через HR-SMM, и оценить минимальный уровень выживаемости (мин-PFS), необходимый для того, чтобы принять лечение. МЕТОДЫ: Опрошенное исследование по смешанным методам 50 пациентов (HR-SMM и MM) 1::1) от США, Франции, Италии и Испании. Качественные полуструктурированные собеседования были посвящены изучению симптомов, качества жизни, а также осведомленности и ожиданий в отношении лечения SMM. Коли

Pulmonary Hypertension in an Oncologic Intensive Care Unit

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Unmasking orthostatic hypotension after cellular therapy: risk factors, implications, and clinical significance.

PURPOSE: Orthostatic hypotension (OH) is a common complication in cancer care, increasing the risk of falls. However, in hematopoietic cell transplantation (HCT) and cellular therapy, few studies have focused on OH, and its incidence and risk factors remain unclear. METHODS: This single-center retrospective study included 297 (autologous, 153; allogeneic, 127; and CAR-T, 17) patients. Blood pressure and heart rate were measured with the patient supine, and again at 1 min and at 3 min after standing. Data were collected to calculate OH incidence by day 30 post-infusion. RESULTS: The cumulativ

Kyphoplasty for Elderly Patients With Vertebral Compression Fractures-Do We Save Lives? Mortality Rates Analysis Comparison in a Long-Term Follow-Up Cohort.

Study designRetrospective cohort.ObjectivesWe aimed to compare a large cohort of patients with vertebral compression fractures (VCF) treated in 2 centers using different protocols (conservative vs BKP) and compare mortality rates on a long-term follow-up.MethodsRetrospective cohort held in 2 medical centers (W and AH). All patients admitted with VCF from November 2008 to January 2015 were enrolled in the study. Exclusion criteria were patients admitted with non-osteoporotic pathological fractures (such as metastatic or MM).ResultsOur study included 208 patients treated for VCF, 127 were treate

Regenerative rehabilitation: a novel multidisciplinary field to maximize patient outcomes.

Regenerative rehabilitation is a novel and rapidly developing multidisciplinary field that converges regenerative medicine and rehabilitation science, aiming to maximize the functions of disabled patients and their independence. While regenerative medicine provides state-of-the-art technologies that shed light on difficult-to-treated diseases, regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative medicine. However, regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each

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… The risk factors for such outcomes may be pre-existing cardiovascular disease risk factors and functional disability, prolonged bed rest, organ damage from chemotherapy/radiation therapy, and graft-versus-host disease (GVHD) [ 173 ]. … HSCT patients typically have an average hospitalization period of ≥ 4 weeks, which may negatively affect their cardiorespiratory health due to long-term bed rest, such as decreased muscle mass and exercise capacity [ 173 , 178 , 179 ]. …

Magnetic Resonance Imaging Findings in 13 Neurologic Pot-Bellied Pigs.

This study reports the magnetic resonance imaging (MRI) findings in 13 pot-bellied pigs presented to our institution with neurological deficits. Nine pigs had abnormal MRI findings (7 with spinal cord localization and 2 with brain localization), with three of them having histopathological confirmation of the diagnoses. MRI diagnoses included a myopathy suspected to be secondary to Erysipelothrix rhusiopathiae, a round cell neoplasia involving the vertebral canal, myelomalacia, a cervical cyst like extradural lesion, pelvic fracture with secondary cauda equina involvement, two cases of fibrocar

Outcome after Surgery for Metastases to the Pelvic Bone: A Single Institutional Experience.

BackgroundThe pelvic bone is the most common site of bone metastases following the axial skeleton. Surgery on the pelvic bone is a demanding procedure. Few studies have been published on the surgical outcomes of metastasis to the pelvic bone with only small numbers of patients involved. This study sought to analyze the complications, local progression and survival after surgery for metastasis to the pelvic bone on a larger cohort of patients.MethodsWe analyzed 83 patients who underwent surgery for metastases to the pelvic bone between the years 2000 and 2015. There were 41 men and 42 women wit

Factors influencing further vertebral height loss following percutaneous vertebroplasty in osteoporotic vertebral compression fractures: A 1-year follow-up study.

BackgroundOsteoporotic vertebral compression fractures (OVCFs) contribute to back pain and functional limitations in older individuals, with percutaneous vertebroplasty (PVP) emerging as a minimally invasive treatment. However, further height loss post-PVP prompts investigation into contributing factors.AimTo investigate the factors associated with further height loss following PVP with cement augmentation in OVCF patients.MethodsA total of 200 OVCF patients who underwent successful PVP between January 2021 and December 2022 were included in this study. "Further height loss" during 1 year of f

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… Nonsurgical treatment methods for OVCFs encompass a range of conservative approaches including bed rest, calcium and vitamin D supplementation, physical therapy, analgesic medications, hormone replacement therapy, and the use of orthopedic supports[ 7 - 9 ]. … However, these conventional strategies often fail to effectively alleviate the pain linked with vertebral compression fractures, while subjecting patients to extended bed rest, thereby elevating the susceptibility to complications such as aspiration pneumonia, urinary tract infections, and pressure sores …