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The Role of Lifestyle Factors in Multiple Sclerosis: An Integrative Perspective.

Multiple sclerosis (MS) is a chronic, immune-mediated neurological disorder characterized by inflammation, demyelination, and progressive neurodegeneration. While genetic susceptibility contributes to disease risk, a growing body of evidence highlights the crucial role of modifiable lifestyle factors in influencing MS onset, disease activity, progression, and overall quality of life. In this narrative review, we explored the relevant literature from commonly used datasets (PubMed, Scopus, Google Scholar), using search terms such as "Lifestyle and Multiple Sclerosis", "Diet and Multiple Scleros…

Parsing Neurometabolic Signatures of Multiple Sclerosis with MRSI and cPCA.

Magnetic Resonance Spectroscopy Imaging (MRSI) offers spatially-resolved, neurometabolic information, acquired non-invasively at whole-brain … f the potential of MRSI unrealized. We acquired MRSI data from 4 human subjects with a diagnosis of multiple sclerosis (MS), incorporating experimental design into an informed machine learning approach. MRSI acquisitions were registered to anatomical MRI to label 105k spectra from brain tissue and 162 spectra from white matter hyperintensities (WMHs), an imaging bio …

Contribution of new imaging sequences to the diagnosis of multiple sclerosis.

The 2024 revision of the McDonald criteria reinforces the central role of magnetic resonance imaging (MRI) in diagnosing multiple sclerosis (MS). Key updates include the addition of the optic nerve as a fifth typical region for dissemination in space (DIS), requiring dedicated orbital MRI with high-resolution coronal fat-suppressed T2/STIR sequences. The central vein sign (CVS), defined as a vein traversing a T2/FLAIR lesion, offers high diagnostic specificity and can substitute for dissemination in time (DIT) or cerebrospinal fluid analysis. Paramagnetic rim lesions (PRLs), although not neces…

Evaluating Outcomes of Sacral Neuromodulation in Patients With Multiple Sclerosis.

OBJECTIVE: To evaluate the revision and removal rates of sacral neuromodulation (SNM) in patients with multiple sclerosis (MS) using a large national administrative dataset. METHODS: This was a retrospective cohort study using the Premier Healthcare Database. There were 13 913 patients analyzed between the years of 2006 and 2022), 218 of whom had diagnosis of MS. Patients were categorized into two groups as with MS and without any neurological disorders including MS (controls). The primary outcome was the relationship of MS on the 1- and 5-year device revision/removal rates. Secondary outcome…

Neurofilaments: A Promising Diagnostic and Prognostic Biomarker in Multiple Sclerosis.

BACKGROUND: Axonal damage results in permanent cognitive and physical disability during the early as well as progressive stages of multiple sclerosis (MS). However, the mechanism of axonal damage may vary during different stages of MS. The extent and severity of the disease can be estimated by various clinical tests and imaging. However, these measures lack sensitivity and accuracy for understanding subclinical disease activity. Therefore, there is a need for a promising biomarker that can reflect on clinical and subclinical disease activities and have additional diagnostic applications, such …

Dental-amalgam exposure and the risk and progression of multiple sclerosis.

BACKGROUND: Concerns about the neurotoxic potential of dental amalgam in multiple sclerosis (MS) persists but its impact on disease risk and progression remains unclear. METHODS: We used data from a Swedish population-based case-control study (2386 cases, 4849 controls) to investigate the association between dental amalgam exposure and MS risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using logistic regression and interaction with smoking was evaluated. Relapsing-onset MS cases born between 1965 and 1985 (n = 1191) were followed longitudinally by using clinical …

Sedentary behavior and its correlates in adults with multiple sclerosis.

PURPOSE: We examined walking ability, fatigue, health-related quality of life, anxiety, depression, cognitive, and physical function as correlates of self-reported sedentary behavior in adults with multiple sclerosis (MS). METHODS: 465 adults with MS completed surveys including the Marshall Sitting Questionnaire (MSQ), Multiple Sclerosis Walking Scale (MSWS-12), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale, Short Form Health Survey-12 physical and mental (SF-12 PCS and MCS), along with clinical characteristics and demographics surveys (e.g., MS type, patient-determined …

Neurodegenerative and inflammatory biomarkers are detectable in saliva in multiple sclerosis.

The growing incidence of multiple sclerosis (MS), a neuroinflammatory and neurodegenerative disease, poses challenges for healthcare, as diagnosis and monitoring rely on expensive and/or invasive procedures, including MRI and lumbar puncture. Biomarkers in more accessible biofluids than CSF (serum, saliva, nasal secretion, tears) may aid early diagnosis and monitoring of progression and response to treatment. We investigated MS-associated biomarkers in accessible biofluids collected from 37 people living with MS and 23 healthy controls. Biomarkers analysed were neurofilament light chain (NfL),…

AI and radiomics for improving the medical workflow for Multiple Sclerosis.

BACKGROUND AND OBJECTIVE: Multiple Sclerosis (MS) is a chronic degenerative disorder that significantly affects the quality of life of patients. Magnetic Resonance Imaging (MRI) has become essential for diagnosis, monitoring, and treatment planning. However, variability in data acquisition and interpretation limits reproducibility. This study aims to design a standardized pipeline that integrates Artificial Intelligence (AI) and radiomics to improve precision, reproducibility, and clinical utility in the evaluation of MS. METHODS: We propose a pipeline that incorporates preprocessing to harmo…

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that is frequently accompanied by major depressive symptoms, which substantially worsen disease burden and quality of life. Increasing evidence suggests that this comorbidity is not solely a psychological reaction to neurological disability but may arise from shared neurobiological mechanisms. Ion channels play a central role in regulating neuronal excitability, synaptic transmission and immune cell function, and their dysregulation has emerged as a key feature of MS pathology. Demyelination a…

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors.

BACKGROUND AND OBJECTIVES: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline clinical and MRI predictors of worsening fatigue. METHODS: We conducted a prospective, single-center cohort study embedded in the Predicting Optimal INdividualised Treatment response in MS (POINT-MS) program at the Queen Square MS Centre (London, United Kingdom). Adults with RRMS initiating…

Колокольчик коерулус на перекрестке воспаления и нейродегенерации в множестве склерозов.

Множественный склероз (MS) все чаще признается в качестве системного расстройства, включающего повреждения серой материи, разрыв сети и нейропсихиатрические симптомы наряду с демиелинацией. В этих рамках Colus coeruleus (LC), являющийся основным источником норадреналина (NA) в центральной нервной системе, появляется в качестве надежного центра регулирования в рамках распределенной моноаминергической сети. Основные элементы: С помощью ЛК формируется микроглиальная и астроцитическая реактивность, окислительный стресс, митохондриальная функция, дифференциация олигодендроцитов и устойчивость мозго

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is increasingly recognized as a systems-level disorder encompassing grey matter injury, network disconnection, and neuropsychiatric symptoms alongside demyelination. Within this framework, the locus coeruleus (LC), the principal source of noradrenaline (NA) in the central nervous system, emerges as a plausible regulatory h…

Апиген как потенциальный модулятор нейроинфламмации в многоразовом склерозе: обзор.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы (CNS), характеризующееся нейроинфламмацией и обезвоживанием. Несмотря на то, что в течение последнего десятилетия расширились возможности лечения MS, нынешняя терапия направлена главным образом на периферийные иммунные системы и часто связана со значительными побочными эффектами. Кроме того, эта терапия до сих пор не предлагает решений для последующего нейродегенерации, сопровождающего развитие болезни. Результаты исследований, проведенных с использованием клеточных и животных моделей и исследований

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by neuroinflammation and demyelination. Although treatment options for MS have increased over the past decade, current therapies primarily target the peripheral immune system and are often associated with significant side effects. Moreover, these thera…

An Updated Assessment of Patient Knowledge in Pregnancy and Multiple Sclerosis.

UNLABELLED: Abstract. BACKGROUND: Multiple sclerosis (MS) is more prevalent in women and is frequently diagnosed during their childbearing years. Prior inquiry into patient knowledge regarding family planning has revealed that patients feel inadequately informed about topics surrounding pregnancy. METHODS: We designed and implemented a 13-question survey to assess patient comprehension surrounding pregnancy and treatment options at the Duke Comprehensive MS Center. RESULTS: Forty-four surveys were returned, with responses from 1 survey not included in the analysis due to most of the questio…

Human herpesvirus 7 and the risk of developing multiple sclerosis.

Epstein-Barr virus is now regarded as the critical risk factor for multiple sclerosis. However, Cytomegalovirus and human herpesvirus 6A have also been associated with altered multiple sclerosis risk, suggesting a multifactorial aetiology. Here, we present the first large-scale study of the association between human herpesvirus 7 and the risk of developing multiple sclerosis. A nested case-control study was performed by crosslinking Swedish registries and biobanks, identifying blood samples from 981 cases who later developed multiple sclerosis and 1278 matched controls. Serological testing was…

Housing needs for people with multiple sclerosis: a rapid review.

The impact of Multiple Sclerosis (MS) on mobility and other functions varies considerably and the trajectory of the disease is unpredictable. People often need timely funding for home modifications, with some needing specialist disability housing and support. This rapid review examined existing literature on the housing needs of people with MS. A representative reference group guided our process. Concentrating on the home environment, we systematically searched peer-reviewed literature through three databases and grey literature using a focused web-based process. The inclusion of 19 peer-revie…

Not The Classic Waxing and Waning Multiple Sclerosis: A Case Report.

Retinoblastoma is the most common primary malignant intraocular tumor in children. Seeding, specifically the dispersion of the tumor into the adjacent compartments, represents a major parameter determining the degree of retinoblastoma according to the International Classification of Retinoblastoma. In this article we focused on vitreous seeding, one of the main limiting factors in the successful "eye preservation treatment" of retinoblastoma. This article presents an overview of the history of vitreous seeding of retinoblastoma, established treatment procedures and new-research modalities. The

Характеристика расширенной языковой сети у лиц с множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Лингвистическая дисфункция все чаще признается в качестве широко распространенной и ранее затронутой когнитивной области у лиц, имеющих MS. ЦЕЛИ: Разработка сетевой модели лингвистической дисфункции в РС. МЕТОДЫ: Когнитивные данные и 3Т функционального и структурного МРТ мозга были получены от 54 пациентов MS и 54 пациентов, отвечающих требованиям здорового образа жизни (HC). Были рассчитаны функциональные сводные показатели (объективность, сегрегация, взаимозависимость, внутреннюю связь) расширенной языковой сети (ЭЛН) и определены метрики структурной съемки. Была прове

Множественный склероз и первичная головная боль: существует ли связь?

БАККРЫТЫЙ: Педиатрический множественный склероз (POMS) является редкой, но зачастую более агрессивной формой множественного склероза, связанной с ранним когнитивным расстройством и значительным воздействием на качество жизни. Множественный склероз и первичная головная боль, особенно мигрень, хорошо зарекомендовали себя у взрослых, однако данные о педиатрии остаются ограниченными. Цель этого ретроспективного исследования состояла в том, чтобы изучить 64 пациента ПОМС, разделенных на группы с головной болью и без нее, для определения возможной корреляции между наличием головной боли, возрастом п

Совпадение в аннотации оригинала
BACKGROUND: Pediatric-onset multiple sclerosis (POMS) is a rare but often more aggressive form of multiple sclerosis, associated with early cognitive impairment and significant impact on quality of life. Multiple sclerosis and primary headaches, particularly migraine, are well established in adults, but data on pediatric populations remain limited. METHODS:…