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The recognition and characterisation of Finnish Clostridium difficile isolates resembling PCR-ribotype 027.

PURPOSE: To characterise and compare twenty-eight Finnish Clostridium difficile RT027-like isolates, selected based on the presence of 18 bp deletion in the tcdC gene and toxin gene profile (A, B, binary), with eleven RT027 isolates from different Finnish geographical areas and time periods. METHODS: Twenty-eight C. difficile RT027-like isolates and 11 RT027 comparative strains were characterised by capillary-electrophoresis (CE) ribotyping, multi-locus variable tandem-repeats analysis (MLVA), multi-locus sequence typing (MLST), and sequencing of tcdC and gyrA gene fragments. Susceptibility t

Outcomes of Clostridium difficile infection in hospitalized leukemia patients: a nationwide analysis.

BACKGROUND The incidence of Clostridium difficile infection (CDI) has increased among hospitalized patients and is a common complication of leukemia. We investigated the risks for and outcomes of CDI in hospitalized leukemia patients. METHODS Adults with a primary diagnosis of leukemia were extracted from the United States Nationwide Inpatient Sample database, 2005-2011. The primary outcomes of interest were CDI incidence, CDI-associated mortality, length of stay (LOS), and charges. In a secondary analysis, we sought to identify independent risk factors for CDI in leukemia patients. Logistic r

Effect of Quinolone Prophylaxis Discontinuation During Pre-engraftment Neutropenia on Incidence, Mortality, and Etiology of Bloodstream Infections in Hematopoietic Stem-cell Transplant Recipients: A Systematic Review and Meta-analysis.

BACKGROUND: Bloodstream infections (BSIs) are a major complication during pre-engraftment neutropenia in hematopoietic stem-cell transplant (HSCT) recipients. Quinolone prophylaxis reduces BSIs but increases multidrug-resistance bacterial infections. We aimed to assess the impact of discontinuing quinolone prophylaxis in adult HSCT recipients. METHODS: We performed a systematic review with meta-analysis. Five databases were searched on May 20, 2025. Studies were eligible for inclusion if they reported clinical characteristics of adult HSCT recipients and outcomes following the discontinuation

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… Outcomes: number of BSI before and after discontinuation of quinolone prophylaxis; number of infections caused by quinolone and carbapenem-resistant organisms before and after discontinuation; prevalence of Clostridioides difficile infection (CDI) before and after discontinuation; infection-related mortality … Prevalence of Bloodstream Infection, Antimicrobial Resistance, Clostridioides Difficile Infection and Death: Effect of Quinolone Prophylaxis Discontinuation in HSCT Patients Abbreviations: BSI, bloodstream infection; CDI, Clostridioides difficile infection; GN, Gram-negative; NA, not available. …

Gut Microbiota Dysbiosis and Dietary Interventions in Non-Hodgkin B-Cell Lymphomas: Implications for Treatment Response.

Non-Hodgkin B-cell lymphomas are a heterogeneous group of lymphoid malignancies with variable biological behavior, clinical presentation and treatment response. While chemoimmunotherapy remains the cornerstone of their management, growing evidence implicates the gut microbiota as a critical modulator of both lymphomagenesis and therapeutic efficacy. Gut microbiota dysbiosis, characterized by reduced microbial diversity and pathogenic taxonomic shifts, has been observed also in newly diagnosed patients and not just after therapy. This microbial imbalance contributes to mucosal barrier disruptio

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… Their depletion is paralleled by the overrepresentation of pro-inflammatory species such as Enterococcus , Escherichia coli , and Clostridioides difficile , which further exacerbate GI toxicity. … FMT is well-established in the treatment of recurrent Clostridioides difficile infection and is being increasingly explored in oncology. …

Morphofunctional parameters as predictors of autologous hematopoietic stem cell transplantation outcomes.

IntroductionThere is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional assessment is not usually performed before the procedure. Malnutrition is related to lower survival in cancer patients. Our aim is to identify both risk and protective factors for such complications to refine management and improve outcomes.MethodsWe have implemented the program 'RHeNutrir', which involves a systematic malnutrition and sarcopenia screening, as well as a complete nutritional and functional assessment

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… AC, Arm circumference; BCM, Body cell mass; CC, Calf circumference; CD, Clostridioides difficcile; CRP, C-reactive protein; CVRF, Cardiovascular risk factor; DM, Diabetes mellitus; EOM, Early onset mucositis; F, Female; FFM, Free fatty mass; FFMI, Free fatty mass index; HBP, High blood pressure; HCT-CI … Similarly, those with CVRF (−3.6 vs −2.5, p = 0.06) or Clostridioides difficcile colitis (−5.5 vs −2.7, p = 0.06) tended to have greater WL as well. …

Plant Antimicrobial Peptides as Potential Tool for Topic Treatment of Hidradenitis Suppurativa.

Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients' quality of life. HS is characterized by suppurative skin lesions in diverse body areas, including deep-seated painful nodules, abscesses, draining sinus, and bridged scars, among others, with typical topography. To date, HS is considered a refractory disease and medical treatments aim to reduce the incidence, the infection, and the pain of the lesions. For this purpose, different classes of drugs, including anti-inflammatory

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… difficile (diarrhea) | III Ramoplanin (NTI-851) | G(+) (VRE, Clostridioides difficile ) | III Friulimicin B | Pneumonia, MRSA | I MU1140 | G(+) bacteria (MRSA, Clostridioides difficile ) | Preclinical D2A21 | Skin infections (Pseudomonas aeruginosa, Staphylococcus aureus ) | Preclinical HB1275 | Fungal … skin infections | Preclinical HB1345 | Skin infections, acne | Preclinical Arenicin (AP139) | G(-) bacteria, UTI | Preclinical AP114 | Clostridioides difficile | Preclinical AP138 | MRSA | Preclinical Novamycin (NP339) | Fungal infections | Preclinical Novarifyn (NP432) | Broad-spectrum G(+) and G(- …

Comparison of Multiplex Gastrointestinal Pathogen Panel and Conventional Stool Testing for Evaluation of Diarrhea in Patients with Inflammatory Bowel Diseases.

BACKGROUND AND AIMS: Gastrointestinal pathogen panels (GPPs) are increasingly being used for evaluation of diarrhea. The impact of these tests on patients with inflammatory bowel diseases (IBD) is unknown. We performed a time-interrupted cohort study comparing GPPs and conventional stool evaluation in patients with IBD with diarrhea. METHODS: We included 268 consecutive patients with IBD who underwent GPP (BioFire Diagnostics®) (n = 134) or conventional stool culture and Clostridium difficile polymerase chain reaction testing (n = 134) during suspected IBD flare between 2012 and 2016. Primary

Do We Need Meropenem Treatment Beyond 7 Days in Febrile Neutropenic Patients: A Cost-Effectiveness Analysis.

BackgroundFebrile neutropenia is a critical complication in patients with hematological malignancies; immediate initiation of empirical treatment with a broad-spectrum agent is the standard of care. In this study, we aimed to evaluate the cost-effectiveness of long- and short-term antibiotic treatments.MethodsWe conducted a retrospective cohort study. We collected data on admissions between 1 January 2018 and 31 December 2022. Adult patients treated with meropenem were included and treatment duration was categorized. Short-term treatment (STT) was defined as a period of 7 days or less, and lon

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… Besides, prolonged antibiotic treatment is associated with longer hospitalization, and as for adverse effects, secondary infections, Clostridioides difficile colitis, and toxicities [ 27 ]. … fever, requirement of intensive care unit transfer, infection-related mortality, initiation of antibiotics within 48 h after meropenem discontinuation, detection of bloodstream infection at least 24 h after starting meropenem and within 14 days, escalation of meropenem treatment, 30-day mortality, Clostridioides …

Review Article: Immune Effector Cell-Mediated Enterocolitis Following CAR-T Cell Therapy-Clinical Features, Pathophysiology and Management.

BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of hematologic malignancies, and its use is expanding rapidly into numerous other disease states including autoimmune diseases. However, CAR-T therapy is associated with a spectrum of immune-related toxicities. In addition to the already well characterized cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, it has become apparent that rarely, CAR-T can cause gastrointestinal mucosal inflammation, termed immune effector cell-mediated enterocolitis (IEC-EC). AIMS: This

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… Gastrointestinal infections were seen in 56%, including norovirus and Clostridioides difficile . Bile acid malabsorption was seen in 100% of patients tested. … Thorough microbiological evaluation including stool cultures, PCR‐based enteric pathogen panels, CMV immunohistochemistry on mucosal biopsy tissue, and Clostridioides difficile testing should be pursued in parallel with endoscopic and histopathologic evaluation. …

Safety and Efficacy of Antibiotic De-escalation and Discontinuation in High-Risk Hematological Patients With Febrile Neutropenia: A Single-Center Experience.

BACKGROUND: There is currently no consensus on optimal duration of antibiotic treatment in febrile neutropenia. We report on the clinical impact of implementation of antibiotic de-escalation and discontinuation strategies based on the Fourth European Conference on Infections in Leukaemia (ECIL-4) recommendations in high-risk hematological patients. METHODS: We studied 446 admissions after introduction of an ECIL-4-based protocol (hereafter "ECIL-4 group") in comparison to a historic cohort of 512 admissions. Primary clinical endpoints were the incidence of infectious complications including s

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… However, taking measures to limit antibiotic exposure is clinically relevant and timely, as prolonged use of broad-spectrum antibiotics has been associated with development of multidrug-resistant (MDR) bacteria, Clostridioides difficile , and fungal infections [ 22 ]. … Clostridioides difficile was diagnosed in 2.8% (27/958) and equally distributed between groups. …

Is the Addition of Anaerobic Coverage to Perioperative Antibiotic Prophylaxis During Soft Tissue Sarcoma Resection Associated With a Reduction in the Proportion of Wound Complications?

BACKGROUND: Wound complications are common after resection of soft tissue sarcomas, with published infection rates ranging from 10% to 35%. … ts were found to have an adverse reaction to the augmented regimen, including allergic reactions or Clostridioides (formerly Clostridium) difficile infection. RESULTS: After controlling for other potentially confounding factors such as neoadjuvant radiation, tumor size and anatomic location, as well as patient BMI, anaerobic coverage was associated with smaller …

Роль Гут Микробиота в неврологических, психиатрических и неевроразвитых расстройствах.

АИМ: Эта статья направлена на изучение роли человеческого кишечного микробиота (ГМ) в патогенезе неврологических, психиатрических и нейроразвитых расстройств, с уделением особого внимания его влиянию на здоровье и болезни и изучением потенциальных терапевтических стратегий, ориентированных на модификацию ГМ. МАТЕРИАЛЫ И МЕТОДЫ: Предусмотрен всеобъемлющий анализ состава кишечного микробиота и его взаимодействия с человеческим телом, в частности его роли в неврологических и психиатрических условиях. В обзоре обсуждаются факторы, влияющие на состав ГМ, включая родовой режим, грудное вскармливание

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… Gastrointestinal pathogens such as Salmonella spp. or Clostridioides difficile are entrenched in public awareness, while research into the effects of the beneficial bacteria of the GM has been overshadowed until recently [ 6 , 7 , 8 , 9 ]. … Gut Microbiome and Clostridioides Difficile Infection: A Closer Look at the Microscopic Interface Ther. Adv. Gastroenterol. 2021 14 1756284821994736 10.1177/1756284821994736 PMC7905718 33747125 7. Seekatz A.M. Safdar N. Khanna S. …

Unmasking Sapovirus: Chronic Enteritis in an Immunocompromised Adult With Hypogammaglobulinemia.

Sapovirus is a recognized cause of acute viral gastroenteritis, predominantly affecting children and older adults. While typically self-limiting in immunocompetent individuals, sapovirus can result in persistent, severe gastrointestinal illness in immunocompromised patients. Chronic sapovirus enteritis remains underrecognized and lacks standardized treatment guidelines. We report the case of a 69-year-old woman with multiple myeloma and profound hypogammaglobulinemia secondary to chimeric antigen receptor (CAR) T-cell therapy who presented with a 10-month history of chronic watery diarrhea. Im

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… Stool studies were negative for common enteric pathogens, including enterotoxigenic Escherichia coli (ETEC), Clostridioides difficile , Vibrio species, and Cryptosporidium , but tested positive for sapovirus by PCR on hospital day 3. Repeat testing confirmed persistent viral shedding. … In our case, multiplex PCR facilitated rapid exclusion of other common pathogens, such as enterotoxigenic Escherichia coli (ETEC), Clostridioides difficile , Vibrio species, and Cryptosporidium , while confirming persistent sapovirus shedding. …

Risk of febrile neutropenia among patients with multiple myeloma or lymphoma who undergo inpatient versus outpatient autologous stem cell transplantation: a systematic review and meta-analysis.

BACKGROUND: Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This systematic review and meta-analysis was performed with the aim of comprehensively comparing the risk of febrile neutropenia developing in ASCT outpatients and inpatients who have multiple myeloma or lymphoma. METHODS: To be eligible for the meta-analysis, studies needed to be either randomized, controlled studies or cohort studies. They also need to have two groups of patient

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… The secondary outcomes of interest were the rate of septicemia, Clostridioides (C.) difficile infection, grade 2–3 mucositis, transplant-related mortality (TRM), and overall survival (OS). Although data on those items were also collected for analysis, they were not part of the inclusion criteria. … Fig. 2 Forest plot of the analysis of the odds of developing febrile neutropenia in the outpatient versus inpatient autologous stem cell transplantation groups Fig. 3 Forest plot of the analysis of the odds of developing septicemia ( a ) and Clostridioides difficile infection ( b ) in the outpatient …

Клинические характеристики и прогностические факторы инфекции Клостридий перфрингенов, осложненные массовым внутриваскулярным гемолизом у пациентов с гематологическими заболеваниями: ретроспективное тематическое исследование.

С пищевым отравлением и газовой гангреной обычно ассоциируются анаэробные бактерии с положительным гравием Clostridium perfringens (CP). В редких случаях он может вызывать смертельный массовый внутриваскулярный гемолиз (MIH) — состояние, связанное с чрезвычайно высокой смертностью, которое создает серьезную клиническую проблему. Ретроспективный анализ был проведен с использованием смертельного случая T-лимфоболической лимфомы/лейкемии, осложненной острым гемолизом, связанным с ХП, который лечился в нашем центре в ноябре 2024 , а также сообщения о связанных с КП MIG пациентах-гематологах с янва

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… Not only does Clostridioides difficile cause a spectrum of gastrointestinal disease ( 1 ), and Clostridium botulinum induce a life-threatening neuroparalysis ( 2 ), but some species, notably Clostridium perfringens (CP), can invade systemically with devastating consequences. … Clostridioides difficile infection: use of inflammatory biomarkers and hemogram-derived ratios to predict mortality risk in hospitalized patients. Antibiotics. (2024) 13:769. 10.3390/antibiotics13080769 2. Saravani K, Kamrava A, Poursamimi J. …

Колониальная ишемия без мезентерического оккулирования: случай, имплицитирующий интерферон-β.

Интерфероны типа I являются широко используемыми иммунодуляторными агентами. Интерферон-α (интерферон-α) связан с ишемическим колитом, но случаи, связывающие интерферон-β (IFN-β) с ишемическим колитом, редки. Мы представляем 66-year-old Женщина с множественным склерозом лечила IFN-β, у которой возникли острая боль в животе и диарея. Воображение продемонстрировало правую колонную воспаление пневматозом. Колоноскопия с биопсией тканей подтвердила ишемический колит, несмотря на патентную мезентерическую васкулатуру на ангиографической съемке. Ее симптомы устранены после прекращения действия IFN-β

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… Infectious evaluation, including Clostridioides difficile toxin, and multiplex gastrointestinal pathogen testing were negative. Empiric antimicrobial therapy with azithromycin 500 mg orally was administered on presentation while infectious etiologies were being excluded. …

Probiotics: Potential Benefits and Safety in Hematological Malignancies.

Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, probiotics have emerged as a promising alternative in the prevention and treatment of cancer and its associated complications, especially in gastrointestinal malignancies. Probiotics have been found to have several benefi

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… Cancer patients are at increased risk of recurrent Clostridioides difficile infection (rCDI) due to malignancy itself, cancer therapy, and frequent antibiotic use and have a lower response rate to standard oral antibiotics. … Safety and efficacy of fecal microbiota transplantation to treat and prevent recurrent Clostridioides difficile in cancer patients . J Cancer. 2021;21(12):6498–506. doi: 10.7150/jca.59251. Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, et al. …

The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever.

BackgroundAutologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal an

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… During follow-up, there was a case of Clostridioides difficile -associated diarrhea in each two groups (A and C), which responded to oral vancomycin treatment. 10.1371/journal.pone.0241778.g002 Fig 2 A. … Regarding Clostridioides difficile -associated diarrhea, we observed two cases, which agree with the 0 and 13% incidence rates published by other groups [ 8 , 12 , 14 , 15 , 43 ]. …

Evaluating the Use of Meropenem in Hematologic Patients with Febrile Neutropenia: A Retrospective Observational Single-Cohort Study.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… 2021 Feb 26 100 8 e24883 10.1097/MD.0000000000024883 33663117 PMC7909104 6 Regelink JC Godschalk PCR Russcher M Richtlijn infectiepreventie en antibioticabeleid hemato-oncologie Meander MC Personal communication 7 Ballo O Kreisel E Eladly F Use of carbapenems and glycopeptides increases risk for Clostridioides …

Colonoscopy Leading to the Diagnosis of AL Amyloidosis in the Gastrointestinal Tract Mimicking an Acute Ulcerative Colitis Flare.

The 2 most common types of amyloidosis are light chain (AL) and reactive (AA). AL is associated with plasma cell dyscrasias; reactive (AA) is associated with chronic inflammatory conditions. A few cases have described AL amyloidosis mimicking colitis. However, endoscopic findings leading to the diagnosis of AL amyloidosis are rare. We report a 77-year-old woman with a medical history of ulcerative colitis who presented with recurrent nonbloody watery diarrhea. Colonoscopy revealed features suspicious for amyloidosis. Bone marrow biopsy showed multiple myeloma and AL amyloidosis. This case demo

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… Colonoscopy was performed to assess the severity of the disease and exclude infectious etiologies such as Cytomegalovirus and Clostridioides difficile . A few areas of superficial erosions were found in the terminal ileum. …