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Public health response to an identified environmental toxin: managing risks to the James Bay Cree related to cadmium in caribou and moose.

At the request of Cree political and health authorities and using indirect measures of exposure, we estimated the risk to the James Bay Cree of renal impairment related to the long-term consumption of the liver and kidney of moose and caribou contaminated by environmental cadmium. The low risk of disease was weighed against the possible detriment from activities to convince the Crees to avoid a traditional albeit occasional component of their subsistence diet. Our approach to the assessment and management of this specific environmental hazard is of general interest.

Blood lymphocyte culture system: quantitative analysis of X-ray-induced chromosome aberrations in man, muntjac and cattle.

Peripheral blood lymphocytes of 3 mammalian species, man, muntjac and cattle, which have various amounts of DNA and divergent karyotypes, were exposed to 100-400 rad of X-rays, and frequencies of dicentrics and other aberrations were analysed at first post-irradiation metaphases. During experiments, various preparative or physical and biological factors that could influence the yield of chromosome aberrations were taken into account. The frequency of dicentrics scored at first post-irradiation metaphases showed best fit to both linear and quadratic dose-response curves, y = a + bD and y = bD +

Serologic survey for selected microbial pathogens in Alaskan wildlife.

Antibodies to Brucella spp. were detected in sera of seven of 67 (10%) caribou (Rangifer tarandus), one of 39 (3%) moose (Alces alces), and six of 122 (5%) grizzly bears (Ursus arctos). Antibodies to Leptospira spp. were found in sera of one of 61 (2%) caribou, one of 37 (3%) moose, six of 122 (5%) grizzly bears, and one of 28 (4%) black bears (Ursus americanus). Antibodies to contagious ecthyma virus were detected in sera of seven of 17 (41%) Dall sheep (Ovis dalli) and five of 53 (10%) caribou. Antibodies to epizootic hemorrhagic disease virus were found in sera of eight of 17 (47%) Dall she

Selected oxygen transport parameters in captive elk.

Five captive elk (cervus canadensis) were immobilized with a mixture of etorphine HC1-acepromazine maleate, and measurements were taken of selected oxygen transport paraments. Heart mass/body mass, hematocrit, hemoglobin, blood volume, mean corpuscular volume and airway resistance were measured and the values compared to other ungulates. It was concluded that the O2 transport system of elk is not as well developed as that in pronghorn but is superior to that found in the goat or ox.

Old nodes, new tricks: optimized methods for chronic wasting disease prion detection in preserved retropharyngeal lymph nodes.

Chronic wasting disease (CWD) is a highly transmissible, global prion disease of captive and wild cervids. The approved tests for the detect … ection in formalin-fixed (FF) and formalin-fixed paraffin-embedded tissues (FFPE) from white-tailed deer in Pennsylvania with various prion protein (PRNP) genotypes. Our proposed protocol differs from other publications because it does not require hazardous solvents such as xylene. We found that FF RPLN samples can be tested by rtQuIC with up to 96% se …

Tay-Sachs disease models: From cellular and animal models to treatment perspectives.

Tay-Sachs disease (TSD) is a lysosomal storage disorder caused by pathogenic variants in the HEXA gene, resulting in deficient activity of β … sional tissues. Animal models encompass naturally occurring TSD in species such as dogs, sheep, and deer, as well as genetically engineered mouse models, including single- and double-knockout strains. Given that mice partially bypass the Hex-A deficiency through neuraminidase-mediated GM2 degradation, double-knockout models have been crucial for dissec …

Melatonin testicular synthesis and its role in reproductive physiology in seasonal and non-seasonal breeders.

Melatonin (MT) is an indoleamine primarily produced by the pineal gland in a light-dark-dependent manner; however, it is also locally synthe … metabolism, thus modifying energetic support to germ cells. In seasonal breeders like rams and roe deer, MT1/MT2, N-acetyltransferase (AANAT), and acetylserotonin O-methyltransferase (ASMT) are found in testicular cells, spermatozoa, and the epididymis. Exogenous MT treatments are linked to advancements in the breeding season, increased testicular siz …

Hepatitis E virus in meat and meat products without liver contents - Detection methods, occurrence and implications for public health.

Hepatitis E virus (HEV) is the causative agent of an acute or chronic hepatitis in humans. Genotypes 3 and 4 are zoonotic and mainly infect domestic pigs, wild boars and deer. Consumption of liver and liver-containing products from these animals pose a high risk of human infection. However, the role of undercooked meat and meat products in HEV transmission is less clear. This review therefore summarizes the current knowledge on HEV detection in meat and meat products and the infection risks associated with their consumption. Detection of HEV RNA in muscles of experimentally infected pigs and i…

DNA metabarcoding analysis of the North China and Amur Leopards' feeding habits.

Leopards Panthera pardus are top predators that play a crucial role in maintaining ecosystem balance and stability by exerting top-down cont … medium-sized prey (< 37 kg) comprising over 75% of biomass intake. Among all the prey species, roe deer (Capreolus pygargus) provided the highest biomass contribution-41.69% for the North China leopard and 29.2% for the Amur leopard. In addition, the frequent occurrence of domestic dogs (Canis familiaris) in their diet (> 5.8%) highlights the impact o …

Volatile Compounds in Musk and Their Anti-Stroke Mechanisms.

Background/Objectives: Musk is a widely used traditional Chinese medicine derived from musk deer that has the pharmacological effects of "activating blood dredging collateral" and "consciousness-restoring resuscitation". Its volatile compounds (VCs) play a key role in these effects, especially in the treatment of stroke. However, there have been no comprehensive studies on the differences in the VCs of these different musks. This study investigated the differences in the VCs of different musks and the potential targets and mechanisms of action for stroke. Methods: Different musks were studied …

Muscone inhibits the progression of atherosclerotic plaques in mice aorta by inhibiting the NF-κB/p65 pathway.

Atherosclerosis (AS) is considered to be one of the main pathogenic factors of coronary heart disease, cerebral infarction and peripheral vascular disease. Oxidative stress and inflammation run through the occurrence and development of atherosclerosis and related cardiovascular events. Muscone is a natural extract of deer musk and also the main physiological active substance of musk. This study investigated the impact of muscone on atherosclerosis. ApoE-/- mice were used to establised AS model and injected with low-dose (4 mg/kg/day) or high-dose (8 mg/kg/day) of muscone intraperitoneally for …

Hepatitis E Virus (HEV) Infection in Hemodialysis Patients: A Multicenter Epidemiological Cohort Study in North-Eastern Greece.

Hepatitis E virus (HEV), a common cause of viral hepatitis in developing countries, is mainly transmitted via the fecal-oral route, but also … tients was significantly associated with area of residence and contact with specific animals (pork, deer). No association was found with religion, gender distribution and hemodialysis duration. This study showed an increased seroprevalence of HEV among hemodialysis patients in Greece. Agricultural or livestock occupation and place of residence seem to …

A 13-Year-Old Male With Left Eye Swelling.

INTRODUCTION AND OBJECTIVE: In recent years, the geographical range of many tick species has expanded significantly, increasing the threat o … les. Innovative approaches, such as the TickBot robot and devices targeting reservoir hosts such as deer, show promise. Future directions include the development of vaccines targeting tick antigens, and translational biotechnological strategies for tick population control. SUMMARY: The prevention of tick-borne diseases involves various control methods …

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species.

Sin Nombre orthohantavirus (SNV), a negative-sense, single-stranded RNA virus that is carried and transmitted by the North American deer mouse Peromyscus maniculatus, can cause infection in humans through inhalation of aerosolized excreta from infected rodents. This infection can lead to hantavirus cardiopulmonary syndrome (HCPS), which has an ∼36% case-fatality rate. We used reverse transcriptase quantitative PCR (RT-qPCR) to confirm SNV infection in a patient and identified SNV in lung tissues in wild-caught rodents from potential sites of exposure. Using viral whole-genome sequencing (WGS),…

Bone dispersal by vertebrate taxa in an urban park environment in New England, USA.

The questions of the frequency, distance, and maximum size of the bones that carnivores, rodents, and other common taxa can disperse have been little addressed, especially in the later phases of skeletonization when individual bones are more subject to transport and loss. The present research utilized a sample of dry white-tailed deer (Odocoileus virginianus) bones in two locations in a forested urban environment dense with eastern gray squirrels (Sciurus carolinensis), chipmunks (Tamias striatus), coyotes (Canis latrans), raccoons (Procyon lotor), and other potential scavenging taxa. Game cam…

Host infection and community composition predict vector burden.

Lyme disease is the most prevalent vector-borne disease in the United States, yet critical gaps remain in our understanding of tick and host interactions that shape disease dynamics. Rodents such as deer mice (Peromyscus spp.) and dusky-footed woodrats (Neotoma fuscipes) are key reservoirs for Borrelia burgdorferi, the etiological bacterium of Lyme disease, and can vary greatly in abundance between habitats. The aggregation of Ixodes pacificus, the western black-legged tick, on rodent hosts is often assumed to be constant across various habitats and not dependent on the rodent or predator comm…

Occurrence and molecular characterization of Cryptosporidium spp. and Giardia duodenalis among captive mammals in the Bangladesh National Zoo.

Cryptosporidium and Giardia are protozoan parasites capable of causing gastrointestinal illness in humans and animals. The purpose of this r … ies/genotypes of Cryptosporidium (C. hominis, C. andersoni, C. muris, C. felis, and Cryptosporidium deer genotype) were identified. C. hominis was subtyped as IbA12G3 by sequence analysis of the glycoprotein 60 (gp60) gene. Multilocus genotyping of G. duodenalis revealed assemblages A, B, and D. Mixed infections of assemblages B and D and A and B were …

Additional characterization of the adult worm Mammomonogamus laryngeus (Railliet, 1899) and the tissue lesions caused by the infection in buffaloes.

Mammomonogamus spp. are parasites with curious characteristics, such as the "Y" shape that results from male and female maintaining the permanent copulation position and the controversial presence or absence of spicules. These nematodes are hematophagous and cause damage to the upper respiratory tracts of cattle, sheep, goats, deer, wild yaks, and orangutans. Human infection is rare and most cases until now have been in the Caribbean Islands or in Brazil, and mainly in farmworkers but recently there have been reports affecting tourists. In the present work, the parasites were recovered from th…

Характеристика флавирусной инфекции в слюнных культурах желез от мужских клещей иксодов.

Зараженные иксодами лопатки (черные клещи) передают множество серьезных патогенов через их укусы, включая Боррелию Бурдорфери, Бабесию микроти и тикающиеся флавивирусы (ТБФВ), такие как вирус Повассан (POWV). Несмотря на то, что роль женщины I. &lt; &lt; лопаточные клещи &gt; &gt; в передаче болезней хорошо определена, роль &lt; &lt; клещей &gt; &gt; для мужчин недостаточно понятна. Поскольку патогены доставляются в слюне тика, мы изучали способность мужских слюнных желез (СГ) поддерживать репродукцию вируса. Экс-виво культуры SG от некорректированного мужчины I. лопаточка была жизнеспособна в

Совпадение в аннотации оригинала
Infected Ixodes scapularis (black-legged tick) transmit a host of serious pathogens via their bites, including Borrelia burgdorferi, Babesia … ts and acini. When SG cultures were infected with the TBFVs Langat virus (LGTV) or POWV lineage II (deer tick virus), the production of infectious virus was demonstrated. Using a green fluorescent protein-tagged LGTV and confocal microscopy, we demonstrated LGTV infection within SG acinus types II and III. The presence of LGTV in the acini and lobular …