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Connectivity changes underlying recovery from pure alexia: a Korean single-case study.

Pure alexia (PA) is an isolated reading impairment following brain damage, yet the mechanisms underlying reading recovery remain unclear. We present a Korean patient with PA following a posterior cerebral artery infarction who showed severe impairment in Hangul reading despite preserved writing and spoken language, with substantial recovery of sentence-level reading within six months. Structural and functional connectivity were investigated using diffusion tensor tractography (DTT) and functional connectivity (FC) analyses. DTT revealed degeneration of affected white matter tracts, including t…

HRS Scientific Documents Methodology Manual: Executive summary.

The Heart Rhythm Society (HRS) Scientific Documents Pathway was established to support the development of high-quality, evidence-informed sc … s Methodology Manual, including document types, committee structure, proposal and review processes, writing committee expectations, conflict of interest management, and publication requirements. The manual is intended to support the HRS community, authors, and partners in understanding the process by which these documents are developed and how they serve …

Construction and validation of an educational booklet on HIV pre-exposure prophylaxis.

OBJECTIVES: to develop and validate an educational booklet on HIV Pre-Exposure Prophylaxis (PrEP). METHODS: quantitative validation study aimed at developing and validating an educational booklet by experts and the target audience. For validation with experts, we used the Health Education Content Validation Index developed in a virtual environment. For the target audience, we used a questionnaire with questions related to organization, writing style, appearance, and motivation. RESULTS: thirty-two experts and 13 PrEP users participated in the study. The analysis was structured on the princip…

Lying to your doctor: Exploring age differences and techniques to foster honest patient-doctor communication.

Honest communication between patients and doctors is essential for providing quality healthcare. The present study tested a sample of 158 younger and 149 older adults and assessed how often they lied to their doctor about their health behaviors (exercise, food/diet, alcohol use, illicit drug use, cigarette smoking). We also assessed perceptions of two communication strategies where patients reported their health concerns verbally to their doctor (direct communication) or by writing down their concerns before seeing the doctor (indirect communication). Lying to one's doctor was common across ad…

2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.

Chronic coronary disease (CCD) is the leading cause of death in the United States. There is an ongoing imperative to disseminate evidence-based and patient-centered care recommendations that further align the management of patients with CCD to updated evidence-based guidelines. The writing committee developed a comprehensive CCD measure set comprising 10 performance measures and 3 quality measures, the focus of which is to include practical steps to specifically advance care in the CCD population. The measure set begins with an assessment of tobacco use and evidence-based cessation interventio…

2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.

Chronic coronary disease (CCD) is the leading cause of death in the United States. There is an ongoing imperative to disseminate evidence-based and patient-centered care recommendations that further align the management of patients with CCD to updated evidence-based guidelines. The writing committee developed a comprehensive CCD measure set comprising 10 performance measures and 3 quality measures, the focus of which is to include practical steps to specifically advance care in the CCD population. The measure set begins with an assessment of tobacco use and evidence-based cessation interventio…

Word Choice Affects Social Judgments: Relational Messages Containing Low-Frequency Words Get Low Evaluations.

Prior research found a word complexity effect: Authors who use complex words are less favorably received when writing academic essays, business letters, and other relatively formal communications. The present study tested if word choice affects evaluations of messages between friends (Experiments 1-2) and spoken messages (Experiment 2). Three widespread dimensions of social judgments were studied - namely, persuasiveness, competence, and sincerity. Participants read/heard messages that varied (between-participants) by ordinary versus low-frequency words (sad vs. forlorn). Messages containing l…

Множественная миелома: личный отчет о моем путешествии с болезнью и о реакции на теклистамб.

Множественная миелома (ММ) остается неизлечимым гематологическим раком, приводящим к повреждению костного мозга, что, помимо многих других последствий, приводит к разрушительным повреждениям костей. Я пациент с MM, который прошел курс лечения с момента диагностики этой болезни в декабре. 2019. В настоящем документе рассматриваются методы лечения и замечания, сделанные в течение этого периода. Основные результаты такого лечения обсуждаются в хронологическом порядке. В этот период у меня случился рецидив MM, а потом меня познакомили с лечением теклистамб. Результаты лечения теклистамбов весьма м

Совпадение в аннотации оригинала
Multiple myeloma (MM) remains an incurable hematologic cancer leading to damage to the bone marrow that causes destructive bone lesions in a … d I anticipate a longer life at a maintenance dose of this drug with a better quality of life. When writing this article, I am still receiving the teclistamab treatment cycles that maintain a constant normal level of my kappa-free light chain (FLC) and kappa/lambda ratio, with no significant side effects.

Waldenström macroglobulinemia: a challenging case treated with anti-CD19 CAR-T cell therapy.

Waldenström macroglobulinemia (WM) is characterized by lymphoplasmacytic lymphoma associated with large amounts of monoclonal immunoglobulin … herapy, the tumor burden significantly decreased and the patient's condition remained stable at the writing of this report.

Challenges of managing anomalous mitral arcade with severe mitral regurgitation and hydrops fetalis in infants.

Anomalous mitral arcade (MA) is a rare congenital anomaly. We report a case of MA in a newborn who presented with hydrops fetalis due to sev … tive pressure ventilation to promote growth. We have followed the patient until the current time of writing this report at the age of 2 years, and his outcome is favourable regarding heart failure symptoms, airway obstruction, growth and development. This case describes a challenging experience in the non-surgical management of MA with severe regurgitatio …

Telangiectasias, recurrent epistaxis and a strong family history-a case of Osler- Weber-Rendu Syndrome in Pakistan.

Osler-Weber-Rendu syndrome or Hereditary Haemorrhagic Telangiectasia (HHT) is a rare condition, with very few reported cases, especially in … as a case of Osler-Weber- Rendu Syndrome. Informed consent was taken from the patient prior to the writing of the manuscript.

Acute pancreatitis: Structured report template of magnetic resonance imaging.

Acute pancreatitis (AP) is a common acute abdomen disease of the digestive system. It has a potentially fatal risk because of its variable s … nter, which is intended to improve the systematic understanding of this disease and standardize the writing of MRI structured reports. In the meantime, we aim to promote the clinical diagnosis and assessment of MRI efficacy for AP and its multiple complications. It is further intended to facilitate academic exchanges and scientific research between differ …

Use of a telovelar approach for complete resection of a choroid plexus tumor in a dog.

OBJECTIVE: To describe a telovelar approach to the fourth ventricle for excision of a choroid plexus tumor within the ventricle. ANIMAL: A … ly. His neurological examination was normal 2 weeks after surgery and remained so until the time of writing this case report (28 months) without additional treatment. CONCLUSION: The telovelar approach allowed complete excision of a choroid plexus tumor located in the fourth ventricle of the dog reported here.

A case report of differentiated thyroid cancer presenting as a renal mass.

The kidney is an unconventional site for thyroid metastasis. As of the writing of this article, only about 30 cases have been reported. It presents like a renal mass. We are reporting a man with thyroid carcinoma presenting with distant metastasis to the kidney. He had complaints of abdominal pain and haematuria. Initial imaging suggested a left renal mass. A diagnosis of renal cell carcinoma was made and a nephrectomy was performed. Histopathology revealed it to be a metastasis from cancer of the thyroid gland. Subsequently, an ultrasound of the thyroid gland was performed, which showed a mal…

Word-Level Instruction for Deaf and Hard-of-Hearing Students: An Observation Study.

Despite the fact that children's word reading and spelling skills are crucial for developing text-level comprehension and composition, littl … word-level instruction during decoding and encoding contexts than they did during text reading and writing contexts. In addition, differences were found in teachers' use of strategies depending on the instructional contexts. Teachers utilized phonological strategies considerably more frequently than any other strategy in their word-level instruction.

Towards non-wettable neural electrodes for a minimized foreign body reaction.

Functionality of neural implants can be seriously impaired by scarring during the foreign body reaction (FBR). Tailoring of the material-tissue interface is supposed to modulate part of the FBR. Surface structures might physically modulate the foreign body reaction in the acute phase directly after implantation. This work focuses on fabrication and characterization of bioinspired microtextures comprising reentrant cavities with non-wettable surface characteristics. The Selected microstructure patterns were fabricated using direct laser writing and were characterized by means of contact angle m…

Performance in the accuracy task in children with Childhood Apraxia of Speech after an integrated intervention of literacy and motor skills.

Difficult in literacy skills are often seen in children with Childhood Apraxia of Speech (CAS). This occurs because oral language has direct relationship with reading and writing learning. The purpose of this study was to evaluate the performance in the accuracy task of an integrated phonoarticulatory awareness, motor skills and literacy intervention of three children with CAS. Three boys between 5;3 and 5;8 years of age, with CAS, were offered 2 hours per week of therapy sessions based on literacy and motor skills. The children were assessed before and after therapy and at a maintenance asses…

Updates in central nervous system malaria: literature review and considerations.

PURPOSE OF REVIEW: Cerebral malaria (CM) represents one of the most common and severe complications of Plasmodium falciparum infection, leading to high morbidity and mortality along with challenging sequelae, especially in children. RECENT FINDINGS: Although CM pathogenesis remains unclear due to the few studies made and the difficulty to analyze affected patients, there are valid theories involving P. falciparum endothelium interactions, and clinical manifestations have been better investigated and differentiated between adults and children. SUMMARY: At the time of writing, diagnostic manag…

Combating information chaos: a case for collaborative clinical guidelines in a pandemic.

The speed and scale of new information during the COVID-19 pandemic required a new approach toward developing best practices and evidence-based clinical guidance. To address this need, we produced COVIDProtocols.org, a collaborative, evidence-based, digital platform for the development and dissemination of COVID-19 clinical guidelines that has been used by over 500,000 people from 196 countries. We use a Collaborative Writing Application (CWA) to facilitate an expedited expert review process and a web platform that deploys content directly from the CWA to minimize any delays. Over 200 contribu…

Prenatal diagnosis of diastrophic dysplasia in the second trimester of pregnancy: Two- and three- dimensional ultrasonographic findings.

To present a prenatal diagnosis of diastrophic dysplasia in the second trimester of pregnancy using two- (2D) and three-dimensional (3D) ult … At birth, the newborn presented transient respiratory distress and neonatal sepsis. At the time of writing, the child is aged 31 months and under follow-up by the pediatrics department. 3D ultrasound allowed the parents to understand the fetal malformations better, and they received adequate counseling.