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Measurements and management of multiple sclerosis-related fatigue: an umbrella review and meta-analysis.

PURPOSE: This study aims to synthesize and appraise systematic reviews with meta-analyses that assessed pharmacological, non-pharmacological, and neuromodulatory interventions for MS-related fatigue. MATERIAL AND METHODS: PubMed, WOS, Scopus, Epistemonikos, and the Cochrane Database of Systematic Reviews were searched till Nov 2025. Effect sizes are reported as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Methodological quality was graded with AMSTAR-2. An exploratory meta-meta-analysis was also performed. RESULTS: Forty-six systematic reviews with meta-analyses …

Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue.

Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu et al, published in the World Journal of Psychiatry. We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment…

Short and Long-term effects of balneotherapy on musculoskeletal pain and fatigue associated with stress.

Balneotherapy has emerged as a promising therapeutic approach for managing musculoskeletal diseases (MSDs), offering evidence-based benefits in reducing pain, enhancing mobility, and improving quality of life. This study aims to evaluate the effects of balneotherapy on musculoskeletal pain, fatigue, and associated symptoms in individuals experiencing stress. A six-month randomized controlled parallel-group study was conducted at six medical spa centers in Lithuania, involving 373 patients with stress levels ≥ 3. Participants underwent 6-11 days of outpatient or inpatient balneotherapy programs…

Rasch analysis of the hospital anxiety and depression scale in patients with chronic fatigue syndrome.

BACKGROUND: The Hospital Anxiety and Depression Scale (HADS) is widely utilized for assessing psychological distress in medical populations, yet its clinimetric properties in chronic fatigue conditions remain underexplored. Given the complex symptom presentation in chronic fatigue syndrome (CFS), rigorous clinimetric validation is essential for accurate clinical assessment. OBJECTIVE: This study aimed to evaluate the clinimetric properties of the HADS using Rasch methodology in patients with CFS, with particular emphasis on dimensionality, item functioning, and measurement precision. METHODS…

Final Diagnoses of Elderly Emergency Patients Presenting with Weakness and Fatigue in Southeastern Iran.

INTRODUCTION: Weakness and fatigue in the elderly present major health challenges, highlighting the need for prompt diagnosis and accurate identification of their causes in emergency departments. This study aimed to investigate the final diagnoses of elderly patients presenting with symptoms of weakness and fatigue in the emergency department. METHODS: This cross-sectional study surveyed 200 elderly individuals (aged ≥60) with complaints of weakness and fatigue at Imam Khomeini Hospital in Jiroft, Kerman, Iran, in 2023. The collected data were extracted from patients' medical records using a …

The gut microbial composition is different in chronic fatigue syndrome than in healthy controls.

The pathogenesis of Chronic Fatigue Syndrome (CFS) is yet unknown. This study aimed to assess the gut microbial composition in CFS patients versus in healthy controls (HCs). The composition of fecal bacteria was examined in twenty-five CFS patients and sixteen HCs using Illumina sequencing of 16 S rRNA gene amplicons targeting the V3-V4 bacterial gene regions. 143 (46%) of the microbial genera were found only in the CFS. In addition, the gut microbial composition in the CFS patients contained a much higher proportion of the 10 most commonly found bacteria compared to the HCs group. A significa…

Fatigue in people with Parkinson's disease - its scale and consequences for activity and quality of life.

INTRODUCTION: Fatigue is one of the most common and distressing non-motor symptoms in Parkinson's disease, affecting up to half of patients. As a multidimensional symptom - encompassing physical, emotional, and cognitive aspects - it significantly reduces quality of life and daily functioning. It often appears in the early stages of the disease, and its subjective nature complicates its clear clinical definition. Despite its importance, fatigue is often underdiagnosed and rarely considered in routine care. CLINICAL RATIONALE FOR THE STUDY: Fatigue in Parkinson's disease is often an underestim…

Effects of swimming fatigue on neuromuscular parameters in young swimmers with unilateral shoulder pain.

BACKGROUND: A cross-sectional study was conducted to investigate the effects of fatigue on isometric strength and surface electromyography (sEMG) in swimmers with unilateral shoulder pain compared to healthy controls. METHODS: Twenty front-crawl swimmers participated in the present study and were grouped according to the presence (PAIN, N.=10, 3 females, 23±3 years) or absence (controls, N.=10, 4 females, 22±5 years) of unilateral shoulder pain, based on subjective reporting and physiotherapy evaluation. Before and after swimming fatigue training, the sEMG signals were recorded during a funct…

Heterogeneity of Fatigue in Patients with Chronic Heart Failure: Latent Categories and Influencing Factors.

OBJECTIVE: The objective of this study was to analyze the latent categories of fatigue in patients with chronic heart failure (CHF), explore their characteristic differences, and identify the associated influencing factors. METHODS: This cross-sectional study included 289 patients with CHF who were enrolled at 2 tertiary-level hospitals in Shandong, China, from August to December 2023. The convenience sampling method was used to collect data. Furthermore, the level of fatigue, insomnia, anxiety, depression, and social support were evaluated using the Chinese version of the Multidimensional Fa…

Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.

PURPOSE: The purpose of this secondary analysis was to 1) examine trajectories of multidimensional cancer-related fatigue (CRF) in men with prostate cancer during and after radiation treatment completion, and 2) identify biobehavioral correlates (demographic, clinical, co-occurring symptoms, and biologic [inflammatory cytokines]) for the different CRF dimensions. METHODS: Data were obtained from a descriptive, longitudinal IRB-approved study investigating the biology of CRF in men with prostate cancer receiving radiation therapy. Data were included from 68 participant medical records, self-re…

Systematic Study of TiC Nanoparticle Effects on the Fatigue Behavior of Zn and Zn Alloys.

Zinc (Zn) is a promising material for biodegradable implants due to its moderate corrosion rate and superior biocompatibility over magnesium (Mg) and iron (Fe). However, its poor fatigue performance limits broader applications. While nanoparticles were discovered to enhance the fatigue performance of metals, the mechanisms remain underexplored. This study investigates nanoparticle-enabled mechanisms for fatigue improvement in Zn. Specifically, the microstructure, tensile, and fatigue performance of pure Zn and Zn nanocomposites containing 1 vol. % and 2 vol. % titanium carbide (TiC) nanopartic…

Sleep quality and fatigue level, clinical and demographic factors in women with rheumatoid arthritis.

BACKGROUND: Sleep, as one of the factors influencing people's lives, strongly impacts the standard of living of RA (rheumatoid arthritis) patients. The study aimed to determine the level of sleep quality in RA women and whether fatigue and selected demographic and clinical factors influence it. METHODS: The study included 110 female patients diagnosed with RA. Sleep was assessed using The Pittsburgh Sleep Quality Index (PSQI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) was used to evaluate fatigue, and a proprietary questionnaire was used to assess demographic and clin…

Impact of biodegradation on the mechanical and fatigue properties of 3D-printed PLA bone scaffolds.

A proper degradation rate of bone scaffolds ensures optimal mechanical support and effective tissue regeneration. The present study examines the degradation effects of simulated body fluids (SBF) on the compressive and fatigue strength of 3D-printed PLA bone scaffolds. Scaffolds with varying surface-to-volume (S/V) ratios and identical porosity (60 %) were immersed in Hanks' solution for a maximum period of 30 days. Static and dynamic compression tests were performed at different immersion times to assess how S/V ratio influences the degradation process. CT images showed that scaffold pore str…

Impact of gender, lunge direction, and fatigue on the lower limb biomechanics in badminton lunges.

BACKGROUND: The lunge is a crucial movement in badminton, influenced to different extents by factors such as lunge direction, fatigue, and gender. This study investigates the effects of these factors on lower limb biomechanics to inform strategies for injury prevention and performance optimization. METHODS: Twenty-four amateur badminton players (12 males, 12 females) performed forehand and backhand forward lunges under both fatigued and non-fatigued conditions. Lower limb kinematics and kinetics were recorded using an 8-camera Vicon system and two AMTI force plates. A three-way mixed-design A…

Pain and its relationship with fatigue in Sjögren disease: an Italian single-centre experience.

OBJECTIVES: Pain is frequently reported by patients with primary Sjögren disease (SD). The 0-10 visual analogue scale (VAS) is broadly used … Sleep, rest, and mild exercise reduced pain in half of the patients, whereas damp weather changes, fatigue, and tension worsened the pain in up to 81% of patients. Thirty percent of patients reported that pain worsened by intercourse. CONCLUSIONS: Although VAS pain is reliable and broadly used in clinical practice and research, multidimensional tools su …

Fatigue and its contributing factors in people with multiple sclerosis: a cross-sectional study.

BACKGROUND: Fatigue is a common and debilitating symptom in people with multiple sclerosis (PwMS), yet its contributing factors are not fully understood. This study examined how fatigue severity relates to physical activity, limb function, mood, and demographics within a unified framework. METHODS: In this cross-sectional study, PwMS were recruited in Isfahan, Iran, from April 2023 to April 2024. Participants completed the Fatigue Severity Scale, and data were collected on demographics, cognitive processing speed (Symbol Digit Modalities Test), physical activity (IPAQ), upper limb function (9…

Assessment of changes in fatigue and cognitive functioning in the absence of progression independent of relapse activity.

BACKGROUND: Progression Independent of Relapse Activity (PIRA) has become an important new outcome measure in MS clinical studies since it identifies disability accumulation that this not relapse related. Since PIRA focuses on changes in the expanded disability status scale (EDSS), some aspects of MS are not measured. METHODS: Patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham Multiple Sclerosis Center completed a measure of fatigue (modified fatigue impact scale (MFIS)) and a brief cognitive screening measure (symbol digit modalities test (…

Воздействие усталости, вызванное функциональной задачей по контролю баланса у лиц с множественным склерозом.

Усталость, испытываемая лицами с множественным склерозом (МС) во время повседневной жизни, влияет на их баланс и повышает риск падения. Цель заключалась в том, чтобы оценить воздействие усталости, вызванной функциональной задачей, на контроль баланса у отдельных лиц, имеющих НР. В этом исследовании приняли участие 10 человек, имеющих MS, и 10 здоровых добровольцев, имеющих гендерный баланс, которые выполняли функциональную задачу по сидячим местам с использованием стандартизованного кресла и метронома до тех пор, пока они не сообщили о том, что они не смогли продолжить работу. Испытания систем

Совпадение в аннотации оригинала
Fatigue experienced by individuals with multiple sclerosis (MS) during activities of daily living affects their balance and increases the risk of falls. The aim was to assess the effect of fatigue induced by a functional task on balance control in individuals with MS. The study involved 10 individuals with MS and 10 gender-matched healthy volunteers who perf…

Копинг является движущей силой взаимоотношений между когнитивной усталостью и когнитивной изменчивостью при множественном склерозе.

ЦЕЛЬ: Средние уровни когнитивного функционирования, как правило, не показывают связи с саморегистрируемой когнитивной усталостью у лиц с множественным склерозом (PwMS), однако некоторые исследования показывают, что когнитивная изменчивость связана с когнитивной усталостью. Кроме того, было продемонстрировано, что решение этой проблемы является мощной движущей силой некоторых результатов, связанных с множественным склерозом (МС). Однако до настоящего времени решение этой проблемы не рассматривалось в качестве возможной движущей силы взаимосвязи между когнитивной усталостью и когнитивной изменчи

Совпадение в аннотации оригинала
OBJECTIVE: Mean levels of cognitive functioning typically do not show an association with self-reported cognitive fatigue in persons with multiple sclerosis (PwMS), but some studies indicate that cognitive variability has an association with cognitive fatigue. Additionally, coping has been shown to be a powerful moderator of some outcomes in multiple scleros…

Efficacy of pharmacologic treatments for fatigue in multiple sclerosis: A systematic review and meta-analysis.

BACKGROUND: Fatigue is commonly experienced amongst persons with multiple sclerosis (PwMS), decreasing quality of life and increasing the economic burden of care. Several pharmacologic treatments have been studied in randomized clinical trials (RCTs) for fatigue in MS, with conflicting results. METHODS: We performed a systematic search for RCTs through PubMed and CENTRAL to determine the efficacy and tolerability of amantadine, modafinil, methylphenidate, and 4-aminopyridine as treatments for fatigue in adults with MS in comparison to placebo or other interventions. Outcomes were fatigue seve…