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Barriers to clinical implementation for novel therapies and biomarker testing in the community practice oncology setting: A CLDN18.2 case study.

PURPOSE: Community-based practices often experience extended adoption times when implementing novel targeted agents, due to practical barriers. Delayed implementation of new therapies can potentially increase patient burden. This study aimed to objectively identify and quantify practice challenges to the implementation of new therapies in the community setting. METHODS: In this pilot study, challenges associated with zolbetuximab, a potential first-in-class claudin 18.2 (CLDN18.2) monoclonal antibody and companion diagnostic, was assessed. Between April and August 2024, 53 data-collection eve…

Barriers and facilitators to pre-exposure prophylaxis uptake among male sex workers in Mexico: an application of the RE-AIM framework.

BACKGROUND: The ImPrEP México demonstration project is the first to distribute free HIV pre-exposure prophylaxis (PrEP) to men who have sex … the current Reach of the ImPrEP program among MSWs in Mexico City and the potential for wider PrEP Adoption among other high-risk populations in Mexico. RESULTS: The Reach of the ImPrEP program was 10% of known HIV-negative MSWs in Mexico City. Program Reach was lowest among MSWs who were street-based sex workers, of lower socioeconomic status, migrants …

Organizational Factors Impacting Implementation of Evidence-based Practices for Autistic Youth: A Mixed Methods Evaluation of Virginia's Community Mental Health System.

Despite elevated rates of co-occurring mental health needs among autistic youth, availability of and access to mental and behavioral health evidence-based practices (EBPs) remain limited in U.S. community-based settings. Further, community-based service systems are complex, with client- and provider-level characteristics situated within broader system contexts that collectively influence adoption and implementation of EBPs. Thus, the current convergent mixed methods study aimed to evaluate agencies, or Community Service Boards (CSBs), in Virginia's statewide Department of Behavioral Health and…

Current status and 10-year trends of reimbursed robot-assisted surgery in Japan: a nationwide claims-based study using the NDB Open Data.

BACKGROUND: Since reimbursement under Japan's National Health Insurance system, robot-assisted surgery (RAS) has expanded rapidly. However, comprehensive cross-disciplinary analyses describing long-term adoption trends and regional variation remain limited. This study aimed to evaluate nationwide adoption and distribution of reimbursed RAS across surgical specialties in Japan. METHODS: We performed a population-based study using publicly available claims data from the National Database (NDB) Open Data (2014-2023). All procedures reimbursed as RAS as of fiscal year 2023, along with correspondi…

Bridging the Research-Practice Gap: Diffusion and User Experience of a Digital Health Platform in Swedish Athletics.

BACKGROUND: Evidence-based health information often fails to reach everyday sports practice, leaving a gap between research and real-world a … uctured interviews (n = 5) and analyzed thematically. Two dimensions from the Reach, Effectiveness, Adoption, Implementation and Maintenance Sports Setting Matrix (RE-AIM-SSM framework), reach and adoption, were used to evaluate diffusion, while constructs from the Technology Acceptance Model, perceived usefulness and perceived ease of use, were applied to …

Process evaluation of a cross-sectoral, coordinated follow-up care of stroke patients: a qualitative study.

BACKGROUND: Implementation of interventions to improve follow-up stroke care is complex due to the involvement of various stakeholders and c … ative content analysis. Contents were coded using eight a priori defined categories (acceptability, adoption, appropriateness, feasibility, fidelity, sustainability, patient-centeredness, satisfaction with treatment, and pandemic-related effects) with the possibility of inductively developed categories. RESULTS: Interviews with 21 patients and 34 intervie …

Culturally adapting and evaluating an evidence-based communication intervention with HPV self-sampling to improve cervical cancer screening among women living with HIV in Ghana: a mixed-methods study.

OBJECTIVES: We aimed to refine and culturally adapt an evidence-based communication intervention (EBCI), which consists of the 3R message framing model (Reframe, Reprioritise, Reform) and human papillomavirus self-sampling (HPVSS) for use in a teaching hospital in Ghana, and evaluated its acceptability, feasibility, appropriateness and adoption potential among stakeholders. DESIGN: Convergent mixed-methods design. SETTING: The study was conducted at a teaching hospital and its surrounding communities in the Central Region of Ghana. PARTICIPANTS: A 36-member stakeholder advisory board compri…

Use of Electronic Health Information Technology in a National Sample of Hospitals That Provide Specialty Substance Use Care.

OBJECTIVE: Most U.S. acute care hospitals have adopted basic electronic health record (EHR) functionality and health information exchange (HIE) (84% and 88%, respectively, in 2017). This study examined whether rates of EHR and HIE adoption by hospital-based substance use disorder programs are lower than rates by acute care hospitals. METHODS: Data from the 2017 National Survey on Substance Abuse Treatment Services were analyzed to examine adoption of basic EHR functionality (i.e., assessment, progress monitoring, discharge, labs, and prescription dispensing) and use of HIE by hospital-based p…

Emergence of Single-Week Adjuvant Radiation Therapy for Early-Stage Breast Cancer in the United States.

OBJECTIVES: Over the past 2 decades, adjuvant radiation therapy (RT) for early-stage breast cancer has shifted toward shorter regimens. While initially occurring over 5 to 6 weeks, level 1 evidence has supported the equivalence of 3 to 4 weeks of adjuvant RT. More recently, level 1 evidence has demonstrated equivalence of 1-week ultrahypofractionated RT (UHRT) to 3-week adjuvant RT. This study evaluates the adoption of UHRT in the United States before, during, and after the COVID-19 pandemic. METHODS: Patients with early-stage breast cancer who received lumpectomy and adjuvant RT from 2018 to…

ESR Essentials: Perfusion MRI-practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology.

Perfusion MRI techniques-including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI-hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameters, remains variable across techniques. Key barriers to broader implementation include a lack of standardized acquisition and analysis protocols, leading to poor reproducibility and reduced clinical confidence. …

Glucocorticoid-prescribing trends in congenital adrenal hyperplasia, 2017 to 2023.

OBJECTIVE: This study investigates the utilisation of modern glucocorticoid medications (Acecort®, Alkindi®, Efmody®, and Plenadren®) for congenital adrenal hyperplasia due to 21-hydroxylase deficiency, examining prescribing patterns, barriers to adoption, and geographical and temporal trends. METHODS: A two-part study was conducted: a retrospective analysis of treatment regimens from the International Congenital Adrenal Hyperplasia Registry across 46 centres in 20 countries (2017-2023) and a qualitative survey of 39 centres regarding barriers to prescribing modern medications. Patients inclu…

Implant-agnostic, handheld wireless robotics: multicenter efficiency and learning curve for total knee arthroplasty.

As robotic total knee arthroplasty (TKA) adoption grows, the learning curve for new users remains a concern for both physicians and staff. Previous studies have reported on clinical outcomes for TKA with a novel implant-agnostic, handheld, wireless robotic TKA system (rTKA). This study investigates the rTKA adoption learning curve relevant to multiple clinical stakeholders. This multicenter, multi-surgeon observational study includes up to the first 25 rTKA procedures by 7 surgeons. Observers noted timing and workflow at 8/25 rTKA cases and 2 standard-of-care benchmark TKAs (prior manual or ro…

Responsible AI readiness in a humanitarian and development ecosystem: an exploratory case study.

Humanitarian and development organizations are increasingly exploring artificial intelligence (AI) to support information-intensive work, yet responsible adoption depends on both staff readiness and organizational enabling conditions. This study provides an exploratory stakeholder-based snapshot of AI readiness within Qatar's humanitarian and development ecosystem. A cross-sectional, bilingual online survey was administered to humanitarian-sector stakeholders (N = 83) using purposive and snowball recruitment initiated through a multi-stakeholder network. Readiness was examined using a dual con…

Utilisation of table-mounted versus floor-mounted robotic systems for thoracolumbar fusion: a before-and-after institutional experience.

Robot-assisted spinal fusion is increasingly prevalent, with floor-mounted and table-mounted systems available. Direct comparative data are limited, particularly regarding institutional adoption and utilization.This IRB-approved retrospective study analyzed a before-and-after institutional experience of 601 navigated thoracolumbar fusions at Changi General Hospital from May 2022 to April 2025. Cases were grouped by the system available during consecutive periods: table-mounted (May 2022-October 2023) or floor-mounted (November 2023 onwards). Demographic variables, operative time per fused leve…

Teaching Practitioners in Australia Culturally Responsive and Compassion-Based Functional Assessment Interviewing Skills.

PURPOSE: Adoption of international working group on the diabetic foot (IWGDF) guidance on prevention and management of foot problems in patients with diabetes was the study aim. METHODS: The ADAPTE process consisted of three main phases of set-up, adoption, and finalization with overall 24 steps was used. In set- up phase, organizing committee by a multidisciplinary approach was established. In adoption phase, comprehensive search in databases and guideline resources was done. According to the inclusion criteria, the 2015IWGDF guidance was selected for adoption process. Quality, currency, con…

Trends in using intraoperative parathyroid hormone monitoring during parathyroidectomy: Protocol and rationale for a cross-sectional survey study of North American surgeons.

Hyperparathyroidism is a common endocrine disorder that occurs secondary to abnormal parathyroid gland functioning. Depending on the type of hyperparathyroidism, surgical extirpation of hyperfunctioning parathyroid glands can be considered for disease cure. Intraoperative parathyroid hormone (IOPTH) monitoring improves outcomes in patients undergoing surgery for primary hyperparathyroidism, but studies are needed to characterize its institutional adoption and its role in surgery for secondary and tertiary hyperparathyroidism, as these entities can be difficult to cure. Hence, we will perform a…

Beyond BRCA: Patterns of risk-reducing surgery for non-BRCA, homologous recombination repair pathway gene variant carriers.

OBJECTIVE: The real-world management of patients with non-BRCA, homologous recombination repair pathway variants with increased or uncertain risks of ovarian cancer is unknown. The objective was to determine the adoption of risk-reducing salpingo-oophorectomy (RRSO) for carriers of variants with increased or uncertain risks of ovarian cancer beyond BRCA. METHODS: This was a retrospective cohort study of patients at three hospitals with non-BRCA, homologous recombination repair pathway variants with increased risk (BRIP1, RAD51C, RAD51D) and uncertain risk (ATM, BARD1, NBN, PALB2) of ovarian c…

Воздействие и профилактическое поведение по отношению к клещам и болезни Лайма в Канаде: результаты первого национального обследования.

В Канаде растет риск заболевания лаймов (LD). В 2014 году правительство Канады развернуло национальную коммуникационную кампанию, направленную на повышение осведомленности и поощрение индивидуального профилактического поведения в отношении клещей и ЛД. Цель этого исследования состояла в том, чтобы провести оценку и сопоставление практики принятия мер по предупреждению насилия в отношении женщин и воздействия канадцев на клещи в пяти основных целевых регионах (Британская Колумбия, провинции Прайри, Онтарио, Квебек и Атлантика). В декабре 2014 года было проведено национальное обследование (n=287

Совпадение в аннотации оригинала
Lyme disease (LD) risk is increasing in Canada. In 2014, the government of Canada launched a national communication campaign to raise awareness and promote the adoption of individual preventive behaviours toward ticks and LD. The objectives of this study were to evaluate and compare the adoption of LD preventive behaviours and the exposure to tick bites of C…